TFIIH_basal_transcription_factor_subunit_putative /GeneDB:LmjF.20.0400

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TFIIH basal transcription factor subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WVS1_LEIDO

TriTrypDb:

LdBPK_200470.1 , LdCL_200009400 , LDHU3_20.0550

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WVS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.537
CLV_NRD_NRD_1	245	247	PF00675	0.548
CLV_NRD_NRD_1	328	330	PF00675	0.601
CLV_NRD_NRD_1	520	522	PF00675	0.554
CLV_NRD_NRD_1	537	539	PF00675	0.548
CLV_NRD_NRD_1	566	568	PF00675	0.630
CLV_PCSK_FUR_1	326	330	PF00082	0.571
CLV_PCSK_FUR_1	518	522	PF00082	0.607
CLV_PCSK_FUR_1	535	539	PF00082	0.544
CLV_PCSK_KEX2_1	142	144	PF00082	0.537
CLV_PCSK_KEX2_1	245	247	PF00082	0.548
CLV_PCSK_KEX2_1	328	330	PF00082	0.613
CLV_PCSK_KEX2_1	520	522	PF00082	0.589
CLV_PCSK_KEX2_1	534	536	PF00082	0.561
CLV_PCSK_KEX2_1	537	539	PF00082	0.543
CLV_PCSK_KEX2_1	566	568	PF00082	0.630
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.630
CLV_PCSK_PC7_1	241	247	PF00082	0.606
CLV_PCSK_SKI1_1	241	245	PF00082	0.644
CLV_PCSK_SKI1_1	265	269	PF00082	0.464
CLV_PCSK_SKI1_1	371	375	PF00082	0.500
CLV_PCSK_SKI1_1	413	417	PF00082	0.656
CLV_PCSK_SKI1_1	482	486	PF00082	0.525
CLV_PCSK_SKI1_1	494	498	PF00082	0.483
CLV_PCSK_SKI1_1	550	554	PF00082	0.619
CLV_PCSK_SKI1_1	94	98	PF00082	0.583
DEG_Kelch_Keap1_1	440	445	PF01344	0.598
DEG_SPOP_SBC_1	339	343	PF00917	0.596
DEG_SPOP_SBC_1	437	441	PF00917	0.689
DEG_SPOP_SBC_1	82	86	PF00917	0.621
DOC_MAPK_gen_1	142	149	PF00069	0.476
DOC_MAPK_gen_1	326	334	PF00069	0.580
DOC_PP1_RVXF_1	284	290	PF00149	0.565
DOC_PP2B_LxvP_1	279	282	PF13499	0.570
DOC_PP4_FxxP_1	408	411	PF00568	0.633
DOC_PP4_FxxP_1	559	562	PF00568	0.643
DOC_SPAK_OSR1_1	259	263	PF12202	0.546
DOC_USP7_MATH_1	170	174	PF00917	0.732
DOC_USP7_MATH_1	411	415	PF00917	0.710
DOC_USP7_MATH_1	423	427	PF00917	0.651
DOC_USP7_MATH_1	430	434	PF00917	0.522
DOC_USP7_MATH_1	437	441	PF00917	0.667
DOC_USP7_MATH_1	541	545	PF00917	0.530
DOC_USP7_MATH_1	82	86	PF00917	0.685
DOC_USP7_UBL2_3	159	163	PF12436	0.629
DOC_WW_Pin1_4	113	118	PF00397	0.487
DOC_WW_Pin1_4	421	426	PF00397	0.664
DOC_WW_Pin1_4	472	477	PF00397	0.533
DOC_WW_Pin1_4	6	11	PF00397	0.552
DOC_WW_Pin1_4	78	83	PF00397	0.723
LIG_14-3-3_CanoR_1	498	506	PF00244	0.620
LIG_14-3-3_CanoR_1	542	546	PF00244	0.663
LIG_Actin_WH2_2	284	299	PF00022	0.546
LIG_Actin_WH2_2	355	373	PF00022	0.434
LIG_APCC_ABBA_1	127	132	PF00400	0.445
LIG_BIR_II_1	1	5	PF00653	0.485
LIG_BRCT_BRCA1_1	559	563	PF00533	0.559
LIG_Clathr_ClatBox_1	267	271	PF01394	0.453
LIG_FHA_1	129	135	PF00498	0.423
LIG_FHA_1	201	207	PF00498	0.691
LIG_FHA_1	309	315	PF00498	0.720
LIG_FHA_1	367	373	PF00498	0.436
LIG_FHA_1	461	467	PF00498	0.723
LIG_FHA_1	486	492	PF00498	0.626
LIG_FHA_1	495	501	PF00498	0.554
LIG_FHA_2	104	110	PF00498	0.355
LIG_FHA_2	117	123	PF00498	0.565
LIG_FHA_2	86	92	PF00498	0.673
LIG_LIR_Apic_2	406	411	PF02991	0.643
LIG_LIR_Apic_2	424	430	PF02991	0.410
LIG_LIR_Apic_2	558	562	PF02991	0.644
LIG_LIR_Gen_1	14	23	PF02991	0.375
LIG_LIR_Gen_1	2	11	PF02991	0.523
LIG_LIR_Gen_1	226	236	PF02991	0.585
LIG_LIR_Gen_1	460	469	PF02991	0.691
LIG_LIR_Gen_1	52	61	PF02991	0.470
LIG_LIR_Nem_3	14	20	PF02991	0.382
LIG_LIR_Nem_3	160	165	PF02991	0.610
LIG_LIR_Nem_3	2	7	PF02991	0.507
LIG_LIR_Nem_3	226	232	PF02991	0.568
LIG_LIR_Nem_3	460	465	PF02991	0.692
LIG_LIR_Nem_3	52	57	PF02991	0.409
LIG_Pex14_1	427	431	PF04695	0.653
LIG_Pex14_2	49	53	PF04695	0.383
LIG_Pex14_2	555	559	PF04695	0.634
LIG_Rb_pABgroove_1	264	272	PF01858	0.504
LIG_SH2_NCK_1	31	35	PF00017	0.481
LIG_SH2_PTP2	229	232	PF00017	0.581
LIG_SH2_PTP2	95	98	PF00017	0.498
LIG_SH2_STAP1	431	435	PF00017	0.655
LIG_SH2_STAT3	486	489	PF00017	0.642
LIG_SH2_STAT5	152	155	PF00017	0.407
LIG_SH2_STAT5	229	232	PF00017	0.581
LIG_SH2_STAT5	261	264	PF00017	0.561
LIG_SH2_STAT5	31	34	PF00017	0.403
LIG_SH2_STAT5	95	98	PF00017	0.514
LIG_SH3_3	24	30	PF00018	0.551
LIG_SH3_3	389	395	PF00018	0.503
LIG_SH3_3	463	469	PF00018	0.700
LIG_SUMO_SIM_anti_2	264	271	PF11976	0.436
LIG_SUMO_SIM_par_1	264	271	PF11976	0.382
LIG_SUMO_SIM_par_1	396	402	PF11976	0.551
LIG_SUMO_SIM_par_1	477	483	PF11976	0.570
LIG_TRAF2_1	249	252	PF00917	0.640
LIG_TRAF2_1	88	91	PF00917	0.675
LIG_UBA3_1	269	278	PF00899	0.488
LIG_Vh1_VBS_1	96	114	PF01044	0.351
LIG_WRC_WIRS_1	405	410	PF05994	0.639
MOD_CDK_SPxxK_3	421	428	PF00069	0.556
MOD_CK1_1	116	122	PF00069	0.548
MOD_CK1_1	172	178	PF00069	0.746
MOD_CK1_1	255	261	PF00069	0.502
MOD_CK1_1	338	344	PF00069	0.622
MOD_CK1_1	390	396	PF00069	0.500
MOD_CK1_1	439	445	PF00069	0.687
MOD_CK1_1	447	453	PF00069	0.732
MOD_CK1_1	502	508	PF00069	0.643
MOD_CK1_1	74	80	PF00069	0.638
MOD_CK1_1	81	87	PF00069	0.703
MOD_CK2_1	103	109	PF00069	0.344
MOD_CK2_1	202	208	PF00069	0.675
MOD_CK2_1	309	315	PF00069	0.728
MOD_CK2_1	411	417	PF00069	0.653
MOD_CK2_1	439	445	PF00069	0.625
MOD_CK2_1	85	91	PF00069	0.626
MOD_Cter_Amidation	532	535	PF01082	0.739
MOD_GlcNHglycan	136	139	PF01048	0.464
MOD_GlcNHglycan	172	175	PF01048	0.690
MOD_GlcNHglycan	189	192	PF01048	0.679
MOD_GlcNHglycan	337	340	PF01048	0.655
MOD_GlcNHglycan	342	345	PF01048	0.657
MOD_GlcNHglycan	389	392	PF01048	0.504
MOD_GlcNHglycan	442	445	PF01048	0.674
MOD_GlcNHglycan	501	504	PF01048	0.603
MOD_GSK3_1	153	160	PF00069	0.600
MOD_GSK3_1	168	175	PF00069	0.694
MOD_GSK3_1	202	209	PF00069	0.717
MOD_GSK3_1	299	306	PF00069	0.675
MOD_GSK3_1	334	341	PF00069	0.633
MOD_GSK3_1	436	443	PF00069	0.691
MOD_GSK3_1	468	475	PF00069	0.584
MOD_GSK3_1	485	492	PF00069	0.480
MOD_GSK3_1	541	548	PF00069	0.503
MOD_GSK3_1	71	78	PF00069	0.674
MOD_GSK3_1	81	88	PF00069	0.716
MOD_N-GLC_1	335	340	PF02516	0.534
MOD_NEK2_1	206	211	PF00069	0.689
MOD_NEK2_1	353	358	PF00069	0.485
MOD_NEK2_1	372	377	PF00069	0.361
MOD_NEK2_1	545	550	PF00069	0.559
MOD_NEK2_1	557	562	PF00069	0.523
MOD_NEK2_1	69	74	PF00069	0.540
MOD_PIKK_1	468	474	PF00454	0.643
MOD_PIKK_1	485	491	PF00454	0.643
MOD_PKA_1	520	526	PF00069	0.616
MOD_PKA_2	206	212	PF00069	0.714
MOD_PKA_2	334	340	PF00069	0.639
MOD_PKA_2	512	518	PF00069	0.560
MOD_PKA_2	520	526	PF00069	0.524
MOD_PKA_2	541	547	PF00069	0.644
MOD_PKB_1	518	526	PF00069	0.718
MOD_Plk_1	225	231	PF00069	0.535
MOD_Plk_1	287	293	PF00069	0.545
MOD_Plk_1	411	417	PF00069	0.621
MOD_Plk_1	482	488	PF00069	0.518
MOD_Plk_1	489	495	PF00069	0.505
MOD_Plk_1	557	563	PF00069	0.532
MOD_Plk_4	116	122	PF00069	0.637
MOD_Plk_4	206	212	PF00069	0.710
MOD_Plk_4	35	41	PF00069	0.590
MOD_Plk_4	411	417	PF00069	0.629
MOD_Plk_4	430	436	PF00069	0.493
MOD_Plk_4	541	547	PF00069	0.513
MOD_ProDKin_1	113	119	PF00069	0.488
MOD_ProDKin_1	421	427	PF00069	0.664
MOD_ProDKin_1	472	478	PF00069	0.529
MOD_ProDKin_1	6	12	PF00069	0.545
MOD_ProDKin_1	78	84	PF00069	0.723
MOD_SUMO_for_1	358	361	PF00179	0.513
MOD_SUMO_rev_2	155	165	PF00179	0.613
TRG_DiLeu_BaEn_1	264	269	PF01217	0.493
TRG_DiLeu_BaEn_1	52	57	PF01217	0.504
TRG_DiLeu_BaEn_2	17	23	PF01217	0.432
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.553
TRG_ENDOCYTIC_2	17	20	PF00928	0.409
TRG_ENDOCYTIC_2	229	232	PF00928	0.581
TRG_ENDOCYTIC_2	431	434	PF00928	0.652
TRG_ENDOCYTIC_2	95	98	PF00928	0.527
TRG_ER_diArg_1	141	143	PF00400	0.539
TRG_ER_diArg_1	325	328	PF00400	0.560
TRG_ER_diArg_1	518	521	PF00400	0.672
TRG_ER_diArg_1	535	538	PF00400	0.533
TRG_ER_diArg_1	92	95	PF00400	0.468
TRG_NLS_Bipartite_1	520	538	PF00514	0.589
TRG_NLS_MonoCore_2	533	538	PF00514	0.691
TRG_NLS_MonoExtC_3	533	538	PF00514	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC36	Leptomonas seymouri	53%	91%
A0A1X0NWG5	Trypanosomatidae	32%	100%
A0A3R7MIM2	Trypanosoma rangeli	33%	100%
A4HYM7	Leishmania infantum	99%	100%
C9ZI60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AI99	Leishmania braziliensis	78%	100%
E9AUI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QD00	Leishmania major	92%	100%
V5BAC8	Trypanosoma cruzi	30%	100%