Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVR4_LEIDO

TriTrypDb:

LdBPK_200370.1 , LdCL_200008500 , LDHU3_20.0420

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	212	214	PF00675	0.782
CLV_NRD_NRD_1	228	230	PF00675	0.564
CLV_PCSK_FUR_1	209	213	PF00082	0.747
CLV_PCSK_KEX2_1	209	211	PF00082	0.719
CLV_PCSK_KEX2_1	212	214	PF00082	0.720
CLV_PCSK_KEX2_1	228	230	PF00082	0.622
CLV_PCSK_SKI1_1	337	341	PF00082	0.553
CLV_PCSK_SKI1_1	343	347	PF00082	0.461
DEG_Nend_UBRbox_3	1	3	PF02207	0.474
DEG_SPOP_SBC_1	73	77	PF00917	0.487
DOC_ANK_TNKS_1	157	164	PF00023	0.617
DOC_CKS1_1	380	385	PF01111	0.684
DOC_CYCLIN_yClb5_NLxxxL_5	266	274	PF00134	0.426
DOC_CYCLIN_yCln2_LP_2	328	334	PF00134	0.568
DOC_MAPK_gen_1	209	216	PF00069	0.791
DOC_MAPK_gen_1	340	350	PF00069	0.585
DOC_PIKK_1	253	261	PF02985	0.524
DOC_PP1_RVXF_1	63	70	PF00149	0.527
DOC_PP2B_LxvP_1	328	331	PF13499	0.566
DOC_PP2B_LxvP_1	351	354	PF13499	0.496
DOC_PP4_FxxP_1	377	380	PF00568	0.686
DOC_USP7_MATH_1	202	206	PF00917	0.583
DOC_USP7_MATH_1	223	227	PF00917	0.796
DOC_USP7_MATH_1	32	36	PF00917	0.656
DOC_USP7_MATH_1	73	77	PF00917	0.564
DOC_WW_Pin1_4	229	234	PF00397	0.719
DOC_WW_Pin1_4	303	308	PF00397	0.514
DOC_WW_Pin1_4	370	375	PF00397	0.623
DOC_WW_Pin1_4	379	384	PF00397	0.646
DOC_WW_Pin1_4	69	74	PF00397	0.527
LIG_14-3-3_CanoR_1	363	372	PF00244	0.759
LIG_Actin_WH2_2	344	362	PF00022	0.601
LIG_FHA_1	380	386	PF00498	0.677
LIG_FHA_1	75	81	PF00498	0.691
LIG_FHA_2	137	143	PF00498	0.518
LIG_LIR_Gen_1	84	92	PF02991	0.618
LIG_LIR_LC3C_4	132	137	PF02991	0.529
LIG_LIR_Nem_3	119	125	PF02991	0.442
LIG_LIR_Nem_3	84	90	PF02991	0.625
LIG_MYND_1	376	380	PF01753	0.745
LIG_SH2_CRK	283	287	PF00017	0.564
LIG_SH2_CRK	46	50	PF00017	0.611
LIG_SH2_STAP1	140	144	PF00017	0.665
LIG_SH2_STAP1	46	50	PF00017	0.708
LIG_SH2_STAT3	352	355	PF00017	0.481
LIG_SH2_STAT5	352	355	PF00017	0.606
LIG_SH3_3	156	162	PF00018	0.610
LIG_SH3_3	302	308	PF00018	0.435
LIG_SH3_3	324	330	PF00018	0.562
LIG_SH3_3	366	372	PF00018	0.655
LIG_SH3_3	377	383	PF00018	0.633
LIG_SUMO_SIM_par_1	286	291	PF11976	0.480
LIG_SUMO_SIM_par_1	75	81	PF11976	0.687
MOD_CDK_SPK_2	384	389	PF00069	0.691
MOD_CK1_1	196	202	PF00069	0.761
MOD_CK1_1	232	238	PF00069	0.707
MOD_CK1_1	248	254	PF00069	0.515
MOD_CK1_1	28	34	PF00069	0.562
MOD_CK1_1	72	78	PF00069	0.577
MOD_CK2_1	136	142	PF00069	0.616
MOD_CK2_1	330	336	PF00069	0.588
MOD_GlcNHglycan	247	250	PF01048	0.564
MOD_GlcNHglycan	313	316	PF01048	0.646
MOD_GlcNHglycan	365	368	PF01048	0.711
MOD_GlcNHglycan	46	49	PF01048	0.700
MOD_GlcNHglycan	59	62	PF01048	0.395
MOD_GSK3_1	28	35	PF00069	0.557
MOD_GSK3_1	286	293	PF00069	0.395
MOD_GSK3_1	359	366	PF00069	0.602
MOD_GSK3_1	69	76	PF00069	0.526
MOD_NEK2_1	288	293	PF00069	0.403
MOD_NEK2_1	359	364	PF00069	0.653
MOD_NEK2_1	57	62	PF00069	0.508
MOD_NEK2_1	74	79	PF00069	0.339
MOD_NEK2_1	91	96	PF00069	0.566
MOD_PKA_1	44	50	PF00069	0.675
MOD_PKA_2	224	230	PF00069	0.685
MOD_PKA_2	272	278	PF00069	0.459
MOD_PKA_2	28	34	PF00069	0.549
MOD_PKA_2	359	365	PF00069	0.557
MOD_Plk_1	83	89	PF00069	0.566
MOD_Plk_4	232	238	PF00069	0.710
MOD_ProDKin_1	229	235	PF00069	0.714
MOD_ProDKin_1	303	309	PF00069	0.523
MOD_ProDKin_1	370	376	PF00069	0.619
MOD_ProDKin_1	379	385	PF00069	0.645
MOD_ProDKin_1	69	75	PF00069	0.532
MOD_SUMO_rev_2	248	258	PF00179	0.569
MOD_SUMO_rev_2	260	268	PF00179	0.634
MOD_SUMO_rev_2	333	342	PF00179	0.629
TRG_DiLeu_BaEn_1	257	262	PF01217	0.512
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.494
TRG_ENDOCYTIC_2	46	49	PF00928	0.617
TRG_ER_diArg_1	209	212	PF00400	0.794
TRG_ER_diArg_1	228	230	PF00400	0.675
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWV5	Leptomonas seymouri	58%	95%
A4HYS0	Leishmania infantum	100%	100%
E9AI90	Leishmania braziliensis	78%	100%
E9AUH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QD09	Leishmania major	92%	100%
V5BVI5	Trypanosoma cruzi	31%	100%