Cir_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVP3_LEIDO

TriTrypDb:

LdBPK_191000.1 , LdCL_190015300 , LDHU3_19.1240

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WVP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVP3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.561
CLV_NRD_NRD_1	168	170	PF00675	0.663
CLV_NRD_NRD_1	197	199	PF00675	0.621
CLV_NRD_NRD_1	219	221	PF00675	0.546
CLV_NRD_NRD_1	24	26	PF00675	0.524
CLV_NRD_NRD_1	54	56	PF00675	0.490
CLV_PCSK_KEX2_1	170	172	PF00082	0.638
CLV_PCSK_KEX2_1	196	198	PF00082	0.736
CLV_PCSK_KEX2_1	24	26	PF00082	0.530
CLV_PCSK_KEX2_1	54	56	PF00082	0.474
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.638
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.736
CLV_PCSK_SKI1_1	128	132	PF00082	0.468
CLV_PCSK_SKI1_1	277	281	PF00082	0.577
CLV_PCSK_SKI1_1	79	83	PF00082	0.530
DEG_Nend_Nbox_1	1	3	PF02207	0.573
DOC_MAPK_gen_1	228	237	PF00069	0.625
DOC_MAPK_gen_1	275	282	PF00069	0.572
DOC_MAPK_gen_1	54	61	PF00069	0.443
DOC_USP7_MATH_1	104	108	PF00917	0.709
DOC_USP7_MATH_1	122	126	PF00917	0.482
DOC_USP7_MATH_1	153	157	PF00917	0.783
DOC_USP7_MATH_1	164	168	PF00917	0.709
DOC_WW_Pin1_4	177	182	PF00397	0.619
DOC_WW_Pin1_4	97	102	PF00397	0.743
LIG_14-3-3_CanoR_1	11	16	PF00244	0.423
LIG_14-3-3_CanoR_1	157	163	PF00244	0.540
LIG_FHA_1	206	212	PF00498	0.560
LIG_FHA_1	257	263	PF00498	0.559
LIG_FHA_1	76	82	PF00498	0.574
LIG_FHA_2	210	216	PF00498	0.526
LIG_Integrin_RGD_1	198	200	PF01839	0.570
LIG_LIR_Gen_1	53	61	PF02991	0.558
LIG_LIR_Nem_3	14	18	PF02991	0.438
LIG_LIR_Nem_3	19	23	PF02991	0.433
LIG_LIR_Nem_3	53	59	PF02991	0.565
LIG_PCNA_yPIPBox_3	269	280	PF02747	0.579
LIG_Pex14_2	126	130	PF04695	0.629
LIG_SH2_CRK	20	24	PF00017	0.457
LIG_SH2_GRB2like	240	243	PF00017	0.556
LIG_SH2_SRC	240	243	PF00017	0.556
LIG_SH2_STAP1	56	60	PF00017	0.441
LIG_SH2_STAP1	86	90	PF00017	0.605
LIG_SH3_3	103	109	PF00018	0.695
LIG_SH3_3	95	101	PF00018	0.767
LIG_SH3_4	108	115	PF00018	0.606
LIG_TYR_ITIM	18	23	PF00017	0.453
LIG_UBA3_1	279	286	PF00899	0.481
LIG_WRC_WIRS_1	123	128	PF05994	0.527
MOD_CK1_1	100	106	PF00069	0.671
MOD_CK1_1	135	141	PF00069	0.690
MOD_CK1_1	180	186	PF00069	0.652
MOD_CK1_1	64	70	PF00069	0.455
MOD_CK2_1	104	110	PF00069	0.771
MOD_CK2_1	209	215	PF00069	0.598
MOD_GlcNHglycan	187	190	PF01048	0.702
MOD_GlcNHglycan	202	206	PF01048	0.601
MOD_GlcNHglycan	212	215	PF01048	0.512
MOD_GlcNHglycan	63	66	PF01048	0.491
MOD_GlcNHglycan	68	71	PF01048	0.454
MOD_GSK3_1	100	107	PF00069	0.688
MOD_GSK3_1	113	120	PF00069	0.586
MOD_GSK3_1	132	139	PF00069	0.453
MOD_GSK3_1	175	182	PF00069	0.753
MOD_GSK3_1	201	208	PF00069	0.604
MOD_N-GLC_1	11	16	PF02516	0.461
MOD_N-GLC_1	185	190	PF02516	0.728
MOD_N-GLC_2	242	244	PF02516	0.544
MOD_NEK2_1	113	118	PF00069	0.606
MOD_NEK2_1	59	64	PF00069	0.377
MOD_NEK2_2	164	169	PF00069	0.576
MOD_PKA_2	75	81	PF00069	0.560
MOD_Plk_1	11	17	PF00069	0.533
MOD_Plk_1	132	138	PF00069	0.595
MOD_Plk_1	164	170	PF00069	0.601
MOD_Plk_4	122	128	PF00069	0.618
MOD_ProDKin_1	177	183	PF00069	0.619
MOD_ProDKin_1	97	103	PF00069	0.742
MOD_SUMO_for_1	130	133	PF00179	0.590
MOD_SUMO_for_1	143	146	PF00179	0.652
MOD_SUMO_for_1	263	266	PF00179	0.533
MOD_SUMO_for_1	29	32	PF00179	0.487
MOD_SUMO_rev_2	174	178	PF00179	0.791
TRG_ENDOCYTIC_2	20	23	PF00928	0.456
TRG_ENDOCYTIC_2	56	59	PF00928	0.446
TRG_ER_diArg_1	168	171	PF00400	0.715
TRG_ER_diArg_1	23	25	PF00400	0.533
TRG_ER_diArg_1	54	56	PF00400	0.469
TRG_NLS_MonoCore_2	282	287	PF00514	0.567
TRG_NLS_MonoExtC_3	127	132	PF00514	0.464
TRG_NLS_MonoExtC_3	168	173	PF00514	0.663
TRG_NLS_MonoExtC_3	282	288	PF00514	0.573
TRG_Pf-PMV_PEXEL_1	251	256	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD46	Leptomonas seymouri	52%	100%
A0A422NC58	Trypanosoma rangeli	40%	100%
A4HA55	Leishmania braziliensis	77%	99%
A4HYC0	Leishmania infantum	99%	100%
D0A642	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AS54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QDB2	Leishmania major	92%	100%
V5BKZ5	Trypanosoma cruzi	41%	100%