LeishMANIAdb
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Membrane-bound O-acyltransferase, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-bound O-acyltransferase, putative
Gene product:
membrane-bound O-acyltransferase, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WVM5_LEIDO
TriTrypDb:
LdBPK_191370.1 , LdCL_190019400 , LDHU3_19.1650
Length:
734

Annotations

LeishMANIAdb annotations

Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Related to fungal GUP1 proteins.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0005737 cytoplasm 2 1
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A0A3S7WVM5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVM5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0016740 transferase activity 2 3
GO:0016746 acyltransferase activity 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 17 21 PF00656 0.611
CLV_C14_Caspase3-7 281 285 PF00656 0.274
CLV_C14_Caspase3-7 43 47 PF00656 0.564
CLV_C14_Caspase3-7 713 717 PF00656 0.237
CLV_NRD_NRD_1 141 143 PF00675 0.271
CLV_NRD_NRD_1 144 146 PF00675 0.277
CLV_NRD_NRD_1 199 201 PF00675 0.318
CLV_NRD_NRD_1 321 323 PF00675 0.487
CLV_PCSK_FUR_1 142 146 PF00082 0.273
CLV_PCSK_FUR_1 645 649 PF00082 0.214
CLV_PCSK_KEX2_1 141 143 PF00082 0.269
CLV_PCSK_KEX2_1 144 146 PF00082 0.276
CLV_PCSK_KEX2_1 245 247 PF00082 0.293
CLV_PCSK_KEX2_1 321 323 PF00082 0.487
CLV_PCSK_KEX2_1 647 649 PF00082 0.214
CLV_PCSK_PC1ET2_1 245 247 PF00082 0.293
CLV_PCSK_PC1ET2_1 647 649 PF00082 0.214
CLV_PCSK_SKI1_1 150 154 PF00082 0.311
CLV_PCSK_SKI1_1 614 618 PF00082 0.414
DEG_APCC_DBOX_1 57 65 PF00400 0.468
DEG_APCC_KENBOX_2 93 97 PF00400 0.290
DEG_MDM2_SWIB_1 604 611 PF02201 0.222
DEG_ODPH_VHL_1 240 253 PF01847 0.305
DEG_ODPH_VHL_1 701 714 PF01847 0.202
DEG_SCF_FBW7_1 439 446 PF00400 0.293
DEG_SPOP_SBC_1 4 8 PF00917 0.614
DEG_SPOP_SBC_1 475 479 PF00917 0.397
DEG_SPOP_SBC_1 491 495 PF00917 0.396
DOC_CKS1_1 440 445 PF01111 0.291
DOC_CYCLIN_yCln2_LP_2 97 103 PF00134 0.280
DOC_MAPK_DCC_7 594 603 PF00069 0.224
DOC_MAPK_gen_1 200 208 PF00069 0.469
DOC_MAPK_MEF2A_6 190 199 PF00069 0.561
DOC_MAPK_RevD_3 128 142 PF00069 0.228
DOC_PP1_RVXF_1 301 308 PF00149 0.220
DOC_PP1_RVXF_1 612 619 PF00149 0.214
DOC_PP2B_LxvP_1 239 242 PF13499 0.297
DOC_PP2B_LxvP_1 97 100 PF13499 0.280
DOC_PP2B_PxIxI_1 627 633 PF00149 0.220
DOC_PP4_FxxP_1 381 384 PF00568 0.222
DOC_PP4_FxxP_1 549 552 PF00568 0.406
DOC_USP7_MATH_1 16 20 PF00917 0.593
DOC_USP7_MATH_1 346 350 PF00917 0.440
DOC_USP7_MATH_1 390 394 PF00917 0.222
DOC_USP7_MATH_1 396 400 PF00917 0.425
DOC_USP7_MATH_1 4 8 PF00917 0.611
DOC_USP7_MATH_1 443 447 PF00917 0.335
DOC_USP7_MATH_1 468 472 PF00917 0.320
DOC_USP7_MATH_1 47 51 PF00917 0.542
DOC_USP7_MATH_2 351 357 PF00917 0.257
DOC_USP7_UBL2_3 324 328 PF12436 0.280
DOC_USP7_UBL2_3 94 98 PF12436 0.298
DOC_WW_Pin1_4 191 196 PF00397 0.562
DOC_WW_Pin1_4 285 290 PF00397 0.285
DOC_WW_Pin1_4 439 444 PF00397 0.389
DOC_WW_Pin1_4 478 483 PF00397 0.399
DOC_WW_Pin1_4 496 501 PF00397 0.380
DOC_WW_Pin1_4 646 651 PF00397 0.481
LIG_14-3-3_CanoR_1 246 250 PF00244 0.484
LIG_14-3-3_CanoR_1 303 308 PF00244 0.334
LIG_14-3-3_CanoR_1 321 327 PF00244 0.254
LIG_14-3-3_CanoR_1 344 352 PF00244 0.295
LIG_14-3-3_CanoR_1 41 45 PF00244 0.561
LIG_14-3-3_CanoR_1 58 62 PF00244 0.460
LIG_14-3-3_CanoR_1 592 597 PF00244 0.395
LIG_Actin_RPEL_3 408 427 PF02755 0.449
LIG_Actin_WH2_2 598 616 PF00022 0.228
LIG_BIR_II_1 1 5 PF00653 0.739
LIG_BIR_III_3 1 5 PF00653 0.603
LIG_BRCT_BRCA1_1 694 698 PF00533 0.236
LIG_CSL_BTD_1 286 289 PF09270 0.285
LIG_deltaCOP1_diTrp_1 284 293 PF00928 0.275
LIG_deltaCOP1_diTrp_1 534 543 PF00928 0.228
LIG_deltaCOP1_diTrp_1 571 579 PF00928 0.416
LIG_EH1_1 209 217 PF00400 0.190
LIG_EH1_1 227 235 PF00400 0.370
LIG_eIF4E_1 132 138 PF01652 0.228
LIG_FHA_1 194 200 PF00498 0.541
LIG_FHA_1 31 37 PF00498 0.616
LIG_FHA_1 499 505 PF00498 0.380
LIG_FHA_1 560 566 PF00498 0.395
LIG_FHA_1 591 597 PF00498 0.414
LIG_FHA_1 695 701 PF00498 0.288
LIG_FHA_2 41 47 PF00498 0.569
LIG_FHA_2 57 63 PF00498 0.447
LIG_LIR_Apic_2 547 552 PF02991 0.410
LIG_LIR_Gen_1 205 216 PF02991 0.395
LIG_LIR_Gen_1 309 319 PF02991 0.258
LIG_LIR_Nem_3 205 211 PF02991 0.395
LIG_LIR_Nem_3 284 290 PF02991 0.350
LIG_LIR_Nem_3 309 315 PF02991 0.242
LIG_LIR_Nem_3 374 379 PF02991 0.216
LIG_LIR_Nem_3 392 397 PF02991 0.180
LIG_LIR_Nem_3 399 403 PF02991 0.435
LIG_LIR_Nem_3 534 540 PF02991 0.223
LIG_LIR_Nem_3 597 602 PF02991 0.223
LIG_LIR_Nem_3 695 701 PF02991 0.225
LIG_Pex14_1 293 297 PF04695 0.241
LIG_Pex14_1 414 418 PF04695 0.446
LIG_Pex14_1 572 576 PF04695 0.410
LIG_Pex14_1 579 583 PF04695 0.410
LIG_Pex14_2 278 282 PF04695 0.263
LIG_Pex14_2 533 537 PF04695 0.218
LIG_Pex14_2 539 543 PF04695 0.414
LIG_Pex14_2 568 572 PF04695 0.410
LIG_Pex14_2 599 603 PF04695 0.218
LIG_Pex14_2 604 608 PF04695 0.216
LIG_REV1ctd_RIR_1 537 545 PF16727 0.410
LIG_SH2_CRK 583 587 PF00017 0.410
LIG_SH2_CRK 76 80 PF00017 0.228
LIG_SH2_NCK_1 76 80 PF00017 0.220
LIG_SH2_PTP2 433 436 PF00017 0.222
LIG_SH2_SRC 238 241 PF00017 0.228
LIG_SH2_SRC 433 436 PF00017 0.222
LIG_SH2_STAP1 76 80 PF00017 0.228
LIG_SH2_STAT3 722 725 PF00017 0.485
LIG_SH2_STAT3 731 734 PF00017 0.461
LIG_SH2_STAT5 121 124 PF00017 0.228
LIG_SH2_STAT5 238 241 PF00017 0.228
LIG_SH2_STAT5 376 379 PF00017 0.222
LIG_SH2_STAT5 382 385 PF00017 0.222
LIG_SH2_STAT5 397 400 PF00017 0.414
LIG_SH2_STAT5 433 436 PF00017 0.222
LIG_SH2_STAT5 55 58 PF00017 0.481
LIG_SH2_STAT5 585 588 PF00017 0.410
LIG_SH2_STAT5 63 66 PF00017 0.206
LIG_SH2_STAT5 655 658 PF00017 0.433
LIG_SH2_STAT5 706 709 PF00017 0.224
LIG_SH3_3 121 127 PF00018 0.228
LIG_SUMO_SIM_anti_2 506 511 PF11976 0.289
LIG_SUMO_SIM_anti_2 661 667 PF11976 0.228
LIG_SUMO_SIM_par_1 503 508 PF11976 0.337
LIG_SUMO_SIM_par_1 710 718 PF11976 0.236
LIG_TYR_ITIM 380 385 PF00017 0.222
LIG_TYR_ITIM 581 586 PF00017 0.410
LIG_TYR_ITIM 74 79 PF00017 0.228
LIG_UBA3_1 239 245 PF00899 0.303
LIG_UBA3_1 690 699 PF00899 0.209
LIG_WRC_WIRS_1 304 309 PF05994 0.225
LIG_WRC_WIRS_1 391 396 PF05994 0.222
LIG_WRC_WIRS_1 565 570 PF05994 0.401
MOD_CK1_1 14 20 PF00069 0.603
MOD_CK1_1 172 178 PF00069 0.607
MOD_CK1_1 306 312 PF00069 0.230
MOD_CK1_1 404 410 PF00069 0.471
MOD_CK1_1 492 498 PF00069 0.530
MOD_CK1_1 57 63 PF00069 0.470
MOD_CK1_1 677 683 PF00069 0.402
MOD_CK1_1 7 13 PF00069 0.616
MOD_CK2_1 313 319 PF00069 0.346
MOD_CK2_1 56 62 PF00069 0.472
MOD_CMANNOS 569 572 PF00535 0.210
MOD_GlcNHglycan 157 160 PF01048 0.322
MOD_GlcNHglycan 168 172 PF01048 0.399
MOD_GlcNHglycan 373 376 PF01048 0.433
MOD_GlcNHglycan 403 406 PF01048 0.280
MOD_GlcNHglycan 445 448 PF01048 0.609
MOD_GlcNHglycan 470 473 PF01048 0.522
MOD_GSK3_1 146 153 PF00069 0.509
MOD_GSK3_1 189 196 PF00069 0.581
MOD_GSK3_1 245 252 PF00069 0.478
MOD_GSK3_1 3 10 PF00069 0.613
MOD_GSK3_1 439 446 PF00069 0.353
MOD_GSK3_1 474 481 PF00069 0.381
MOD_GSK3_1 490 497 PF00069 0.404
MOD_GSK3_1 513 520 PF00069 0.259
MOD_GSK3_1 588 595 PF00069 0.412
MOD_GSK3_1 630 637 PF00069 0.218
MOD_GSK3_1 674 681 PF00069 0.363
MOD_GSK3_1 710 717 PF00069 0.287
MOD_N-GLC_1 297 302 PF02516 0.428
MOD_NEK2_1 137 142 PF00069 0.282
MOD_NEK2_1 249 254 PF00069 0.421
MOD_NEK2_1 278 283 PF00069 0.310
MOD_NEK2_1 311 316 PF00069 0.259
MOD_NEK2_1 371 376 PF00069 0.237
MOD_NEK2_1 426 431 PF00069 0.315
MOD_NEK2_1 467 472 PF00069 0.456
MOD_NEK2_1 474 479 PF00069 0.569
MOD_NEK2_1 490 495 PF00069 0.436
MOD_NEK2_1 559 564 PF00069 0.399
MOD_NEK2_1 56 61 PF00069 0.474
MOD_NEK2_1 588 593 PF00069 0.414
MOD_NEK2_1 617 622 PF00069 0.239
MOD_NEK2_1 666 671 PF00069 0.202
MOD_NEK2_1 694 699 PF00069 0.268
MOD_PIKK_1 292 298 PF00454 0.251
MOD_PIKK_1 658 664 PF00454 0.228
MOD_PK_1 594 600 PF00069 0.228
MOD_PKA_1 245 251 PF00069 0.486
MOD_PKA_2 189 195 PF00069 0.583
MOD_PKA_2 245 251 PF00069 0.486
MOD_PKA_2 40 46 PF00069 0.654
MOD_PKA_2 468 474 PF00069 0.321
MOD_PKA_2 57 63 PF00069 0.445
MOD_Plk_1 184 190 PF00069 0.595
MOD_Plk_1 201 207 PF00069 0.436
MOD_Plk_1 297 303 PF00069 0.226
MOD_Plk_1 369 375 PF00069 0.247
MOD_Plk_1 47 53 PF00069 0.522
MOD_Plk_1 666 672 PF00069 0.228
MOD_Plk_1 692 698 PF00069 0.201
MOD_Plk_4 193 199 PF00069 0.550
MOD_Plk_4 251 257 PF00069 0.234
MOD_Plk_4 278 284 PF00069 0.309
MOD_Plk_4 297 303 PF00069 0.209
MOD_Plk_4 32 38 PF00069 0.617
MOD_Plk_4 426 432 PF00069 0.298
MOD_Plk_4 505 511 PF00069 0.301
MOD_Plk_4 517 523 PF00069 0.193
MOD_Plk_4 564 570 PF00069 0.401
MOD_Plk_4 594 600 PF00069 0.228
MOD_Plk_4 617 623 PF00069 0.211
MOD_Plk_4 630 636 PF00069 0.213
MOD_ProDKin_1 191 197 PF00069 0.555
MOD_ProDKin_1 285 291 PF00069 0.280
MOD_ProDKin_1 439 445 PF00069 0.396
MOD_ProDKin_1 478 484 PF00069 0.399
MOD_ProDKin_1 496 502 PF00069 0.378
MOD_ProDKin_1 646 652 PF00069 0.480
MOD_SUMO_rev_2 404 413 PF00179 0.472
MOD_SUMO_rev_2 713 721 PF00179 0.256
TRG_DiLeu_BaLyEn_6 286 291 PF01217 0.278
TRG_DiLeu_BaLyEn_6 416 421 PF01217 0.451
TRG_DiLeu_BaLyEn_6 611 616 PF01217 0.214
TRG_ENDOCYTIC_2 104 107 PF00928 0.278
TRG_ENDOCYTIC_2 120 123 PF00928 0.189
TRG_ENDOCYTIC_2 382 385 PF00928 0.279
TRG_ENDOCYTIC_2 433 436 PF00928 0.222
TRG_ENDOCYTIC_2 583 586 PF00928 0.410
TRG_ENDOCYTIC_2 655 658 PF00928 0.435
TRG_ENDOCYTIC_2 76 79 PF00928 0.228
TRG_ER_diArg_1 141 144 PF00400 0.462
TRG_NES_CRM1_1 553 566 PF08389 0.395
TRG_Pf-PMV_PEXEL_1 657 662 PF00026 0.228

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5IRW9 Trypanosoma rangeli 34% 100%
A4HYG3 Leishmania infantum 100% 100%
E9AS86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4QD77 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS