Triose-phosphate_Transporter_family_putative/Pfam:PF03151

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Triose-phosphate Transporter family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WVL9_LEIDO

TriTrypDb:

LdBPK_191540.1 , LdCL_190021200 , LDHU3_19.1870

Length:

321

Annotations

LeishMANIAdb annotations

Related to plant and animal nucleoside-sugar transporters, often localized to the Golgi apparatus.. An expanded family in kinetoplastids, possibly to cover the need for expanded proteoglycan biosynthesis. Localization: Golgi (by homology)

Annotations by Jardim et al.

Transporters, Triose-phosphate Transporter

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WVL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVL9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	1
GO:0015291	secondary active transmembrane transporter activity	4	1
GO:0015297	antiporter activity	5	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	65	67	PF00082	0.232
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.239
CLV_PCSK_SKI1_1	102	106	PF00082	0.243
CLV_PCSK_SKI1_1	27	31	PF00082	0.324
CLV_PCSK_SKI1_1	271	275	PF00082	0.300
CLV_PCSK_SKI1_1	7	11	PF00082	0.255
DEG_APCC_DBOX_1	270	278	PF00400	0.388
DEG_MDM2_SWIB_1	281	289	PF02201	0.285
DOC_CKS1_1	104	109	PF01111	0.243
DOC_CKS1_1	208	213	PF01111	0.301
DOC_CYCLIN_yCln2_LP_2	104	110	PF00134	0.244
DOC_MAPK_gen_1	124	131	PF00069	0.263
DOC_MAPK_gen_1	65	72	PF00069	0.418
DOC_MAPK_MEF2A_6	102	111	PF00069	0.243
DOC_MAPK_MEF2A_6	124	131	PF00069	0.277
DOC_MAPK_MEF2A_6	252	261	PF00069	0.243
DOC_MAPK_MEF2A_6	271	280	PF00069	0.243
DOC_MAPK_MEF2A_6	65	72	PF00069	0.425
DOC_MAPK_MEF2A_6	7	14	PF00069	0.425
DOC_MAPK_NFAT4_5	124	132	PF00069	0.256
DOC_MAPK_NFAT4_5	7	15	PF00069	0.425
DOC_PP1_RVXF_1	25	31	PF00149	0.219
DOC_PP2B_PxIxI_1	213	219	PF00149	0.212
DOC_USP7_MATH_1	16	20	PF00917	0.254
DOC_USP7_UBL2_3	301	305	PF12436	0.549
DOC_WW_Pin1_4	103	108	PF00397	0.243
DOC_WW_Pin1_4	207	212	PF00397	0.308
DOC_WW_Pin1_4	238	243	PF00397	0.409
LIG_14-3-3_CanoR_1	32	38	PF00244	0.352
LIG_BIR_II_1	1	5	PF00653	0.562
LIG_BRCT_BRCA1_1	257	261	PF00533	0.328
LIG_FHA_1	104	110	PF00498	0.262
LIG_FHA_1	213	219	PF00498	0.228
LIG_FHA_1	23	29	PF00498	0.359
LIG_FHA_1	238	244	PF00498	0.409
LIG_FHA_1	48	54	PF00498	0.317
LIG_FHA_2	138	144	PF00498	0.291
LIG_LIR_Gen_1	178	188	PF02991	0.421
LIG_LIR_Gen_1	232	242	PF02991	0.228
LIG_LIR_Gen_1	244	253	PF02991	0.243
LIG_LIR_Gen_1	258	268	PF02991	0.243
LIG_LIR_Gen_1	8	17	PF02991	0.322
LIG_LIR_Gen_1	89	100	PF02991	0.258
LIG_LIR_LC3C_4	106	111	PF02991	0.336
LIG_LIR_Nem_3	178	183	PF02991	0.421
LIG_LIR_Nem_3	210	216	PF02991	0.297
LIG_LIR_Nem_3	232	237	PF02991	0.256
LIG_LIR_Nem_3	244	248	PF02991	0.243
LIG_LIR_Nem_3	258	264	PF02991	0.243
LIG_LIR_Nem_3	279	284	PF02991	0.375
LIG_LIR_Nem_3	36	40	PF02991	0.283
LIG_LIR_Nem_3	8	14	PF02991	0.322
LIG_LIR_Nem_3	89	95	PF02991	0.359
LIG_NRBOX	154	160	PF00104	0.316
LIG_Pex14_2	281	285	PF04695	0.285
LIG_PTB_Apo_2	203	210	PF02174	0.225
LIG_PTB_Phospho_1	203	209	PF10480	0.225
LIG_SH2_CRK	245	249	PF00017	0.243
LIG_SH2_CRK	37	41	PF00017	0.287
LIG_SH2_CRK	92	96	PF00017	0.240
LIG_SH2_CRK	98	102	PF00017	0.271
LIG_SH2_GRB2like	24	27	PF00017	0.388
LIG_SH2_NCK_1	184	188	PF00017	0.304
LIG_SH2_NCK_1	92	96	PF00017	0.219
LIG_SH2_STAP1	24	28	PF00017	0.388
LIG_SH2_STAT5	11	14	PF00017	0.282
LIG_SH2_STAT5	199	202	PF00017	0.271
LIG_SH2_STAT5	209	212	PF00017	0.233
LIG_SH2_STAT5	24	27	PF00017	0.324
LIG_SH2_STAT5	286	289	PF00017	0.243
LIG_SH3_1	208	214	PF00018	0.252
LIG_SH3_3	208	214	PF00018	0.313
LIG_SH3_3	58	64	PF00018	0.476
LIG_SUMO_SIM_anti_2	215	222	PF11976	0.307
LIG_SUMO_SIM_anti_2	39	45	PF11976	0.260
LIG_SUMO_SIM_par_1	108	114	PF11976	0.265
LIG_SUMO_SIM_par_1	151	156	PF11976	0.281
LIG_SUMO_SIM_par_1	215	222	PF11976	0.345
LIG_TYR_ITIM	243	248	PF00017	0.243
LIG_TYR_ITIM	9	14	PF00017	0.304
LIG_TYR_ITIM	90	95	PF00017	0.297
LIG_UBA3_1	233	239	PF00899	0.258
LIG_Vh1_VBS_1	148	166	PF01044	0.247
MOD_CK1_1	241	247	PF00069	0.409
MOD_CK1_1	36	42	PF00069	0.233
MOD_CK2_1	309	315	PF00069	0.508
MOD_GlcNHglycan	121	124	PF01048	0.225
MOD_GlcNHglycan	143	147	PF01048	0.491
MOD_GlcNHglycan	155	158	PF01048	0.194
MOD_GlcNHglycan	221	224	PF01048	0.301
MOD_GSK3_1	125	132	PF00069	0.295
MOD_GSK3_1	137	144	PF00069	0.281
MOD_GSK3_1	237	244	PF00069	0.409
MOD_N-GLC_1	141	146	PF02516	0.414
MOD_N-GLC_1	229	234	PF02516	0.270
MOD_N-GLC_1	86	91	PF02516	0.243
MOD_NEK2_1	127	132	PF00069	0.319
MOD_NEK2_1	148	153	PF00069	0.358
MOD_NEK2_1	158	163	PF00069	0.243
MOD_NEK2_1	284	289	PF00069	0.239
MOD_NEK2_1	46	51	PF00069	0.269
MOD_Plk_1	229	235	PF00069	0.270
MOD_Plk_1	86	92	PF00069	0.243
MOD_Plk_2-3	309	315	PF00069	0.688
MOD_Plk_4	111	117	PF00069	0.243
MOD_Plk_4	148	154	PF00069	0.258
MOD_Plk_4	212	218	PF00069	0.231
MOD_Plk_4	36	42	PF00069	0.249
MOD_Plk_4	86	92	PF00069	0.317
MOD_ProDKin_1	103	109	PF00069	0.243
MOD_ProDKin_1	207	213	PF00069	0.308
MOD_ProDKin_1	238	244	PF00069	0.409
MOD_SUMO_for_1	304	307	PF00179	0.609
MOD_SUMO_rev_2	293	303	PF00179	0.515
MOD_SUMO_rev_2	312	321	PF00179	0.659
TRG_DiLeu_BaEn_3	297	303	PF01217	0.512
TRG_ENDOCYTIC_2	11	14	PF00928	0.276
TRG_ENDOCYTIC_2	245	248	PF00928	0.243
TRG_ENDOCYTIC_2	286	289	PF00928	0.299
TRG_ENDOCYTIC_2	37	40	PF00928	0.282
TRG_ENDOCYTIC_2	92	95	PF00928	0.240
TRG_ENDOCYTIC_2	98	101	PF00928	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N6	Leptomonas seymouri	73%	99%
A0A0N1PAW1	Leptomonas seymouri	36%	99%
A0A0S4IKV6	Bodo saltans	23%	91%
A0A0S4IKX4	Bodo saltans	63%	100%
A0A0S4JRZ1	Bodo saltans	58%	100%
A0A1X0P276	Trypanosomatidae	37%	100%
A0A1X0P5Z4	Trypanosomatidae	61%	100%
A0A3R7NGZ9	Trypanosoma rangeli	39%	100%
A0A3S7X3R1	Leishmania donovani	38%	99%
A0A422NUS0	Trypanosoma rangeli	58%	100%
A4HAA0	Leishmania braziliensis	79%	100%
A4HYI0	Leishmania infantum	100%	100%
A4I5U5	Leishmania infantum	38%	100%
A4IFK2	Bos taurus	45%	100%
A9UUB8	Monosiga brevicollis	23%	96%
C9ZR66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ASA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B140	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
F4IHS9	Arabidopsis thaliana	35%	94%
O94695	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	71%
P0C6B1	Rattus norvegicus	24%	78%
P0CK96	Homo sapiens	23%	79%
Q1JQ66	Danio rerio	46%	100%
Q3E6T0	Arabidopsis thaliana	24%	92%
Q4Q726	Leishmania major	37%	100%
Q4QD58	Leishmania major	95%	100%
Q550W6	Dictyostelium discoideum	24%	87%
Q5RKL7	Rattus norvegicus	25%	92%
Q5XF09	Arabidopsis thaliana	27%	100%
Q6DBP3	Arabidopsis thaliana	26%	100%
Q6ICL7	Homo sapiens	26%	92%
Q6PGC7	Mus musculus	44%	100%
Q7Z769	Homo sapiens	45%	100%
Q8BLX4	Mus musculus	23%	88%
Q8C811	Mus musculus	21%	79%
Q8CD26	Mus musculus	24%	78%
Q8GUJ1	Arabidopsis thaliana	36%	91%
Q8H184	Arabidopsis thaliana	24%	78%
Q8RWW7	Arabidopsis thaliana	32%	95%
Q8RXL8	Arabidopsis thaliana	35%	90%
Q94B65	Arabidopsis thaliana	25%	99%
Q94EI9	Arabidopsis thaliana	23%	94%
Q96K37	Homo sapiens	23%	78%
Q9C521	Arabidopsis thaliana	28%	96%
Q9C8M1	Arabidopsis thaliana	23%	97%
Q9FDZ5	Arabidopsis thaliana	31%	96%
Q9FG70	Arabidopsis thaliana	27%	81%
Q9FIH5	Arabidopsis thaliana	33%	92%
Q9FYE5	Arabidopsis thaliana	25%	100%
Q9LDH3	Arabidopsis thaliana	27%	89%
Q9LFN3	Arabidopsis thaliana	22%	91%
Q9LPU2	Arabidopsis thaliana	33%	92%
Q9LU76	Arabidopsis thaliana	31%	82%
Q9SFE9	Arabidopsis thaliana	28%	94%
Q9SKJ7	Arabidopsis thaliana	22%	93%
Q9SRE4	Arabidopsis thaliana	33%	93%
Q9SS40	Arabidopsis thaliana	23%	90%
Q9SUV2	Arabidopsis thaliana	22%	92%
Q9SZ96	Arabidopsis thaliana	32%	96%
Q9VHT4	Drosophila melanogaster	24%	95%
V5BJU5	Trypanosoma cruzi	22%	83%
V5BMW3	Trypanosoma cruzi	41%	100%
V5D4Q6	Trypanosoma cruzi	57%	100%