LeishMANIAdb
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MBOAT, membrane-bound O-acyltransferase family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MBOAT, membrane-bound O-acyltransferase family protein
Gene product:
glycerol uptake protein, putative (fragment)
Species:
Leishmania donovani
UniProt:
A0A3S7WVK4_LEIDO
TriTrypDb:
LdBPK_191350.1 , LdCL_190018800 , LDHU3_19.1630
Length:
777

Annotations

LeishMANIAdb annotations

Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Related to fungal GUP1 proteins.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 30
NetGPI no yes: 0, no: 30
Cellular components
Term Name Level Count
GO:0016020 membrane 2 31
GO:0110165 cellular anatomical entity 1 31
GO:0005737 cytoplasm 2 4
GO:0005783 endoplasmic reticulum 5 4
GO:0043226 organelle 2 4
GO:0043227 membrane-bounded organelle 3 4
GO:0043229 intracellular organelle 3 4
GO:0043231 intracellular membrane-bounded organelle 4 4

Expansion

Sequence features

A0A3S7WVK4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVK4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016740 transferase activity 2 6
GO:0016746 acyltransferase activity 3 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 302 306 PF00656 0.362
CLV_C14_Caspase3-7 721 725 PF00656 0.403
CLV_NRD_NRD_1 228 230 PF00675 0.392
CLV_NRD_NRD_1 459 461 PF00675 0.328
CLV_NRD_NRD_1 541 543 PF00675 0.287
CLV_NRD_NRD_1 629 631 PF00675 0.396
CLV_NRD_NRD_1 657 659 PF00675 0.410
CLV_NRD_NRD_1 670 672 PF00675 0.351
CLV_PCSK_KEX2_1 147 149 PF00082 0.235
CLV_PCSK_KEX2_1 227 229 PF00082 0.371
CLV_PCSK_KEX2_1 541 543 PF00082 0.287
CLV_PCSK_KEX2_1 629 631 PF00082 0.396
CLV_PCSK_KEX2_1 657 659 PF00082 0.411
CLV_PCSK_KEX2_1 670 672 PF00082 0.370
CLV_PCSK_PC1ET2_1 147 149 PF00082 0.228
CLV_PCSK_PC7_1 666 672 PF00082 0.396
CLV_PCSK_SKI1_1 107 111 PF00082 0.569
CLV_PCSK_SKI1_1 147 151 PF00082 0.264
CLV_PCSK_SKI1_1 164 168 PF00082 0.401
CLV_PCSK_SKI1_1 464 468 PF00082 0.328
CLV_PCSK_SKI1_1 578 582 PF00082 0.501
CLV_PCSK_SKI1_1 658 662 PF00082 0.401
CLV_PCSK_SKI1_1 730 734 PF00082 0.556
DEG_APCC_DBOX_1 577 585 PF00400 0.391
DEG_APCC_DBOX_1 657 665 PF00400 0.605
DEG_MDM2_SWIB_1 110 117 PF02201 0.338
DEG_Nend_UBRbox_2 1 3 PF02207 0.652
DEG_SCF_FBW7_1 736 741 PF00400 0.335
DEG_SPOP_SBC_1 452 456 PF00917 0.538
DOC_CDC14_PxL_1 482 490 PF14671 0.387
DOC_CYCLIN_RxL_1 161 171 PF00134 0.400
DOC_CYCLIN_yCln2_LP_2 430 436 PF00134 0.395
DOC_MAPK_DCC_7 578 588 PF00069 0.331
DOC_MAPK_gen_1 147 154 PF00069 0.230
DOC_MAPK_gen_1 337 346 PF00069 0.425
DOC_MAPK_gen_1 576 583 PF00069 0.479
DOC_MAPK_MEF2A_6 147 156 PF00069 0.407
DOC_MAPK_MEF2A_6 576 583 PF00069 0.496
DOC_MAPK_NFAT4_5 147 155 PF00069 0.254
DOC_PP1_RVXF_1 320 326 PF00149 0.454
DOC_PP1_RVXF_1 350 357 PF00149 0.294
DOC_PP1_RVXF_1 52 58 PF00149 0.656
DOC_PP1_SILK_1 467 472 PF00149 0.349
DOC_PP2B_LxvP_1 430 433 PF13499 0.395
DOC_PP4_FxxP_1 260 263 PF00568 0.352
DOC_PP4_FxxP_1 57 60 PF00568 0.631
DOC_USP7_MATH_1 176 180 PF00917 0.819
DOC_USP7_MATH_1 187 191 PF00917 0.638
DOC_USP7_MATH_1 37 41 PF00917 0.641
DOC_USP7_MATH_1 439 443 PF00917 0.331
DOC_USP7_MATH_1 445 449 PF00917 0.489
DOC_USP7_MATH_1 453 457 PF00917 0.489
DOC_USP7_MATH_1 656 660 PF00917 0.610
DOC_WW_Pin1_4 172 177 PF00397 0.679
DOC_WW_Pin1_4 183 188 PF00397 0.646
DOC_WW_Pin1_4 19 24 PF00397 0.795
DOC_WW_Pin1_4 219 224 PF00397 0.629
DOC_WW_Pin1_4 33 38 PF00397 0.784
DOC_WW_Pin1_4 56 61 PF00397 0.731
DOC_WW_Pin1_4 670 675 PF00397 0.641
DOC_WW_Pin1_4 734 739 PF00397 0.439
LIG_14-3-3_CanoR_1 164 170 PF00244 0.598
LIG_14-3-3_CanoR_1 216 221 PF00244 0.782
LIG_14-3-3_CanoR_1 347 352 PF00244 0.346
LIG_14-3-3_CanoR_1 451 459 PF00244 0.581
LIG_14-3-3_CanoR_1 471 480 PF00244 0.458
LIG_14-3-3_CanoR_1 497 501 PF00244 0.309
LIG_14-3-3_CanoR_1 578 584 PF00244 0.403
LIG_14-3-3_CanoR_1 657 661 PF00244 0.594
LIG_14-3-3_CanoR_1 666 674 PF00244 0.695
LIG_14-3-3_CanoR_1 763 769 PF00244 0.532
LIG_Actin_WH2_2 337 354 PF00022 0.333
LIG_Actin_WH2_2 503 519 PF00022 0.322
LIG_BRCT_BRCA1_1 489 493 PF00533 0.301
LIG_BRCT_BRCA1_1 524 528 PF00533 0.595
LIG_BRCT_BRCA1_1 617 621 PF00533 0.391
LIG_CSL_BTD_1 203 206 PF09270 0.606
LIG_CtBP_PxDLS_1 537 541 PF00389 0.489
LIG_deltaCOP1_diTrp_1 136 142 PF00928 0.341
LIG_deltaCOP1_diTrp_1 556 564 PF00928 0.500
LIG_EH_1 119 123 PF12763 0.331
LIG_eIF4E_1 425 431 PF01652 0.399
LIG_FHA_1 229 235 PF00498 0.683
LIG_FHA_1 308 314 PF00498 0.494
LIG_FHA_1 348 354 PF00498 0.349
LIG_FHA_1 378 384 PF00498 0.355
LIG_FHA_1 545 551 PF00498 0.482
LIG_FHA_1 59 65 PF00498 0.672
LIG_FHA_1 636 642 PF00498 0.631
LIG_FHA_1 689 695 PF00498 0.389
LIG_FHA_1 739 745 PF00498 0.461
LIG_FHA_2 12 18 PF00498 0.651
LIG_FHA_2 497 503 PF00498 0.302
LIG_FHA_2 60 66 PF00498 0.729
LIG_FHA_2 721 727 PF00498 0.419
LIG_Integrin_isoDGR_2 648 650 PF01839 0.454
LIG_LIR_Apic_2 237 241 PF02991 0.295
LIG_LIR_Gen_1 111 122 PF02991 0.439
LIG_LIR_Gen_1 419 428 PF02991 0.293
LIG_LIR_Gen_1 441 450 PF02991 0.360
LIG_LIR_Gen_1 475 485 PF02991 0.410
LIG_LIR_Gen_1 490 501 PF02991 0.279
LIG_LIR_Gen_1 525 536 PF02991 0.567
LIG_LIR_Gen_1 70 78 PF02991 0.687
LIG_LIR_Gen_1 767 775 PF02991 0.519
LIG_LIR_Nem_3 103 109 PF02991 0.374
LIG_LIR_Nem_3 111 117 PF02991 0.419
LIG_LIR_Nem_3 136 142 PF02991 0.337
LIG_LIR_Nem_3 144 149 PF02991 0.336
LIG_LIR_Nem_3 160 166 PF02991 0.473
LIG_LIR_Nem_3 310 315 PF02991 0.390
LIG_LIR_Nem_3 419 425 PF02991 0.301
LIG_LIR_Nem_3 441 446 PF02991 0.367
LIG_LIR_Nem_3 475 480 PF02991 0.397
LIG_LIR_Nem_3 490 496 PF02991 0.241
LIG_LIR_Nem_3 525 531 PF02991 0.585
LIG_LIR_Nem_3 678 684 PF02991 0.601
LIG_LIR_Nem_3 70 74 PF02991 0.638
LIG_LIR_Nem_3 767 771 PF02991 0.573
LIG_LYPXL_S_1 74 78 PF13949 0.474
LIG_LYPXL_yS_3 75 78 PF13949 0.592
LIG_MYND_1 33 37 PF01753 0.635
LIG_NRBOX 151 157 PF00104 0.419
LIG_PAM2_1 670 682 PF00658 0.547
LIG_Pex14_1 312 316 PF04695 0.406
LIG_Pex14_1 342 346 PF04695 0.332
LIG_Pex14_1 557 561 PF04695 0.493
LIG_Pex14_1 564 568 PF04695 0.501
LIG_Pex14_2 110 114 PF04695 0.338
LIG_Pex14_2 518 522 PF04695 0.338
LIG_Pex14_2 553 557 PF04695 0.489
LIG_Pex14_2 589 593 PF04695 0.337
LIG_PTB_Apo_2 117 124 PF02174 0.341
LIG_REV1ctd_RIR_1 120 129 PF16727 0.346
LIG_SH2_CRK 163 167 PF00017 0.520
LIG_SH2_CRK 244 248 PF00017 0.328
LIG_SH2_CRK 420 424 PF00017 0.292
LIG_SH2_CRK 477 481 PF00017 0.444
LIG_SH2_CRK 491 495 PF00017 0.319
LIG_SH2_CRK 568 572 PF00017 0.487
LIG_SH2_CRK 71 75 PF00017 0.689
LIG_SH2_NCK_1 244 248 PF00017 0.345
LIG_SH2_NCK_1 71 75 PF00017 0.630
LIG_SH2_SRC 131 134 PF00017 0.321
LIG_SH2_STAP1 131 135 PF00017 0.359
LIG_SH2_STAP1 425 429 PF00017 0.349
LIG_SH2_STAP1 491 495 PF00017 0.296
LIG_SH2_STAP1 71 75 PF00017 0.728
LIG_SH2_STAP1 749 753 PF00017 0.297
LIG_SH2_STAT3 311 314 PF00017 0.401
LIG_SH2_STAT5 244 247 PF00017 0.357
LIG_SH2_STAT5 271 274 PF00017 0.423
LIG_SH2_STAT5 299 302 PF00017 0.485
LIG_SH2_STAT5 315 318 PF00017 0.397
LIG_SH2_STAT5 428 431 PF00017 0.356
LIG_SH2_STAT5 435 438 PF00017 0.347
LIG_SH2_STAT5 473 476 PF00017 0.344
LIG_SH2_STAT5 477 480 PF00017 0.346
LIG_SH2_STAT5 513 516 PF00017 0.405
LIG_SH2_STAT5 570 573 PF00017 0.490
LIG_SH2_STAT5 768 771 PF00017 0.553
LIG_SH2_STAT5 83 86 PF00017 0.325
LIG_SH3_3 12 18 PF00018 0.663
LIG_SH3_3 200 206 PF00018 0.640
LIG_SH3_3 252 258 PF00018 0.448
LIG_SH3_3 328 334 PF00018 0.535
LIG_SH3_3 38 44 PF00018 0.784
LIG_SH3_3 426 432 PF00018 0.441
LIG_SH3_3 480 486 PF00018 0.390
LIG_SUMO_SIM_par_1 299 305 PF11976 0.524
LIG_TRFH_1 428 432 PF08558 0.447
LIG_TYR_ITIM 511 516 PF00017 0.418
LIG_TYR_ITIM 566 571 PF00017 0.326
LIG_UBA3_1 510 517 PF00899 0.349
LIG_UBA3_1 771 776 PF00899 0.506
LIG_WRC_WIRS_1 101 106 PF05994 0.377
LIG_WRC_WIRS_1 440 445 PF05994 0.350
LIG_WW_1 432 435 PF00397 0.395
LIG_WW_3 205 209 PF00397 0.442
LIG_WW_3 43 47 PF00397 0.527
MOD_CK1_1 168 174 PF00069 0.538
MOD_CK1_1 179 185 PF00069 0.564
MOD_CK1_1 188 194 PF00069 0.569
MOD_CK1_1 19 25 PF00069 0.704
MOD_CK1_1 36 42 PF00069 0.752
MOD_CK1_1 59 65 PF00069 0.671
MOD_CK1_1 720 726 PF00069 0.656
MOD_CK2_1 496 502 PF00069 0.411
MOD_CK2_1 529 535 PF00069 0.354
MOD_CMANNOS 554 557 PF00535 0.331
MOD_GlcNHglycan 159 162 PF01048 0.450
MOD_GlcNHglycan 172 175 PF01048 0.545
MOD_GlcNHglycan 187 190 PF01048 0.749
MOD_GlcNHglycan 192 196 PF01048 0.592
MOD_GlcNHglycan 223 226 PF01048 0.682
MOD_GlcNHglycan 29 32 PF01048 0.716
MOD_GlcNHglycan 394 397 PF01048 0.464
MOD_GlcNHglycan 531 534 PF01048 0.399
MOD_GlcNHglycan 617 620 PF01048 0.353
MOD_GlcNHglycan 667 670 PF01048 0.439
MOD_GlcNHglycan 720 723 PF01048 0.675
MOD_GlcNHglycan 751 754 PF01048 0.357
MOD_GSK3_1 165 172 PF00069 0.599
MOD_GSK3_1 178 185 PF00069 0.698
MOD_GSK3_1 187 194 PF00069 0.756
MOD_GSK3_1 212 219 PF00069 0.526
MOD_GSK3_1 33 40 PF00069 0.770
MOD_GSK3_1 635 642 PF00069 0.499
MOD_GSK3_1 734 741 PF00069 0.490
MOD_GSK3_1 86 93 PF00069 0.486
MOD_LATS_1 449 455 PF00433 0.299
MOD_NEK2_1 167 172 PF00069 0.526
MOD_NEK2_1 234 239 PF00069 0.480
MOD_NEK2_1 27 32 PF00069 0.784
MOD_NEK2_1 307 312 PF00069 0.532
MOD_NEK2_1 346 351 PF00069 0.367
MOD_NEK2_1 496 501 PF00069 0.352
MOD_NEK2_1 516 521 PF00069 0.312
MOD_NEK2_1 544 549 PF00069 0.346
MOD_NEK2_1 675 680 PF00069 0.504
MOD_NEK2_1 747 752 PF00069 0.368
MOD_NEK2_2 49 54 PF00069 0.507
MOD_PIKK_1 39 45 PF00454 0.710
MOD_PK_1 77 83 PF00069 0.528
MOD_PKA_1 228 234 PF00069 0.413
MOD_PKA_2 228 234 PF00069 0.464
MOD_PKA_2 346 352 PF00069 0.445
MOD_PKA_2 496 502 PF00069 0.350
MOD_PKA_2 649 655 PF00069 0.528
MOD_PKA_2 656 662 PF00069 0.446
MOD_PKA_2 665 671 PF00069 0.556
MOD_PKB_1 214 222 PF00069 0.472
MOD_Plk_1 11 17 PF00069 0.557
MOD_Plk_1 131 137 PF00069 0.409
MOD_Plk_1 307 313 PF00069 0.407
MOD_Plk_1 475 481 PF00069 0.497
MOD_Plk_1 69 75 PF00069 0.506
MOD_Plk_4 16 22 PF00069 0.552
MOD_Plk_4 242 248 PF00069 0.437
MOD_Plk_4 293 299 PF00069 0.367
MOD_Plk_4 307 313 PF00069 0.482
MOD_Plk_4 475 481 PF00069 0.435
MOD_Plk_4 496 502 PF00069 0.378
MOD_Plk_4 579 585 PF00069 0.407
MOD_Plk_4 675 681 PF00069 0.566
MOD_Plk_4 689 695 PF00069 0.336
MOD_Plk_4 70 76 PF00069 0.688
MOD_Plk_4 764 770 PF00069 0.384
MOD_Plk_4 90 96 PF00069 0.347
MOD_ProDKin_1 172 178 PF00069 0.601
MOD_ProDKin_1 183 189 PF00069 0.552
MOD_ProDKin_1 19 25 PF00069 0.756
MOD_ProDKin_1 219 225 PF00069 0.523
MOD_ProDKin_1 33 39 PF00069 0.745
MOD_ProDKin_1 56 62 PF00069 0.677
MOD_ProDKin_1 670 676 PF00069 0.539
MOD_ProDKin_1 734 740 PF00069 0.532
TRG_DiLeu_BaEn_2 501 507 PF01217 0.391
TRG_DiLeu_BaLyEn_6 260 265 PF01217 0.395
TRG_DiLeu_BaLyEn_6 30 35 PF01217 0.535
TRG_DiLeu_BaLyEn_6 349 354 PF01217 0.422
TRG_ENDOCYTIC_2 106 109 PF00928 0.520
TRG_ENDOCYTIC_2 146 149 PF00928 0.404
TRG_ENDOCYTIC_2 163 166 PF00928 0.284
TRG_ENDOCYTIC_2 244 247 PF00928 0.342
TRG_ENDOCYTIC_2 271 274 PF00928 0.349
TRG_ENDOCYTIC_2 283 286 PF00928 0.315
TRG_ENDOCYTIC_2 420 423 PF00928 0.340
TRG_ENDOCYTIC_2 428 431 PF00928 0.347
TRG_ENDOCYTIC_2 477 480 PF00928 0.362
TRG_ENDOCYTIC_2 491 494 PF00928 0.345
TRG_ENDOCYTIC_2 513 516 PF00928 0.384
TRG_ENDOCYTIC_2 568 571 PF00928 0.328
TRG_ENDOCYTIC_2 681 684 PF00928 0.364
TRG_ENDOCYTIC_2 71 74 PF00928 0.543
TRG_ENDOCYTIC_2 75 78 PF00928 0.522
TRG_ENDOCYTIC_2 768 771 PF00928 0.444
TRG_ER_diArg_1 213 216 PF00400 0.523
TRG_ER_diArg_1 227 229 PF00400 0.400
TRG_ER_diArg_1 339 342 PF00400 0.447
TRG_ER_diArg_1 540 542 PF00400 0.328
TRG_ER_diArg_1 576 579 PF00400 0.341
TRG_ER_diArg_1 628 630 PF00400 0.475
TRG_ER_diArg_1 656 658 PF00400 0.520
TRG_ER_diArg_1 670 672 PF00400 0.411

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IRP6 Bodo saltans 35% 100%
A0A1X0P614 Trypanosomatidae 34% 100%
A0A1X0P616 Trypanosomatidae 41% 100%
A0A3Q8IAC1 Leishmania donovani 97% 100%
A0A3Q8IBC3 Leishmania donovani 88% 99%
A0A3Q8IBE0 Leishmania donovani 74% 100%
A0A3Q8IDD7 Leishmania donovani 97% 100%
A0A3S5H769 Leishmania donovani 97% 100%
A0A3S5IRW9 Trypanosoma rangeli 35% 100%
A0A3S7WVJ2 Leishmania donovani 74% 100%
A4HA75 Leishmania braziliensis 62% 99%
A4HA76 Leishmania braziliensis 61% 100%
A4HA77 Leishmania braziliensis 64% 100%
A4HA80 Leishmania braziliensis 58% 100%
A4HA81 Leishmania braziliensis 65% 100%
A4HA82 Leishmania braziliensis 67% 100%
D0A0T4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E8NHJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9AGT0 Leishmania infantum 74% 100%
E9AGT1 Leishmania infantum 99% 100%
E9AGT2 Leishmania infantum 95% 100%
E9AGT3 Leishmania infantum 99% 100%
E9AGT4 Leishmania infantum 96% 100%
E9AS85 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9AS86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
Q4QD78 Leishmania major 90% 100%
Q4QD79 Leishmania major 92% 100%
Q4QD80 Leishmania major 92% 100%
Q4QD81 Leishmania major 71% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS