Protein kinase domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WVK3_LEIDO

TriTrypDb:

LdBPK_191290.1 , LdCL_190018000 , LDHU3_19.1560

Length:

854

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVK3

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004672	protein kinase activity	3	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:0140096	catalytic activity, acting on a protein	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.823
CLV_C14_Caspase3-7	569	573	PF00656	0.801
CLV_C14_Caspase3-7	602	606	PF00656	0.740
CLV_C14_Caspase3-7	662	666	PF00656	0.711
CLV_NRD_NRD_1	135	137	PF00675	0.817
CLV_NRD_NRD_1	225	227	PF00675	0.801
CLV_NRD_NRD_1	451	453	PF00675	0.719
CLV_PCSK_KEX2_1	135	137	PF00082	0.817
CLV_PCSK_KEX2_1	225	227	PF00082	0.801
CLV_PCSK_KEX2_1	451	453	PF00082	0.719
CLV_PCSK_SKI1_1	135	139	PF00082	0.813
CLV_PCSK_SKI1_1	210	214	PF00082	0.730
CLV_PCSK_SKI1_1	225	229	PF00082	0.568
CLV_PCSK_SKI1_1	286	290	PF00082	0.626
CLV_PCSK_SKI1_1	307	311	PF00082	0.708
CLV_PCSK_SKI1_1	370	374	PF00082	0.762
CLV_PCSK_SKI1_1	598	602	PF00082	0.735
CLV_Separin_Metazoa	759	763	PF03568	0.750
DEG_APCC_DBOX_1	597	605	PF00400	0.735
DEG_APCC_DBOX_1	710	718	PF00400	0.602
DEG_SCF_FBW7_1	256	262	PF00400	0.724
DEG_SPOP_SBC_1	116	120	PF00917	0.846
DOC_CDC14_PxL_1	154	162	PF14671	0.606
DOC_CKS1_1	176	181	PF01111	0.786
DOC_CKS1_1	256	261	PF01111	0.724
DOC_CKS1_1	308	313	PF01111	0.697
DOC_CYCLIN_RxL_1	367	377	PF00134	0.766
DOC_CYCLIN_RxL_1	684	695	PF00134	0.763
DOC_CYCLIN_RxL_1	700	709	PF00134	0.739
DOC_CYCLIN_RxL_1	710	718	PF00134	0.571
DOC_CYCLIN_yClb3_PxF_3	179	187	PF00134	0.661
DOC_CYCLIN_yClb5_NLxxxL_5	338	347	PF00134	0.683
DOC_CYCLIN_yCln2_LP_2	127	133	PF00134	0.663
DOC_CYCLIN_yCln2_LP_2	24	27	PF00134	0.782
DOC_MAPK_gen_1	523	532	PF00069	0.607
DOC_MAPK_gen_1	790	798	PF00069	0.729
DOC_MAPK_MEF2A_6	762	769	PF00069	0.675
DOC_PP1_RVXF_1	588	594	PF00149	0.752
DOC_PP2B_LxvP_1	127	130	PF13499	0.722
DOC_PP2B_LxvP_1	155	158	PF13499	0.764
DOC_PP2B_LxvP_1	23	26	PF13499	0.783
DOC_PP2B_LxvP_1	758	761	PF13499	0.690
DOC_PP4_FxxP_1	28	31	PF00568	0.729
DOC_PP4_FxxP_1	308	311	PF00568	0.701
DOC_USP7_MATH_1	169	173	PF00917	0.748
DOC_USP7_MATH_1	278	282	PF00917	0.739
DOC_USP7_MATH_1	388	392	PF00917	0.775
DOC_USP7_MATH_1	419	423	PF00917	0.656
DOC_USP7_MATH_1	540	544	PF00917	0.828
DOC_USP7_MATH_1	732	736	PF00917	0.709
DOC_USP7_MATH_1	788	792	PF00917	0.736
DOC_USP7_MATH_1	831	835	PF00917	0.730
DOC_WW_Pin1_4	117	122	PF00397	0.841
DOC_WW_Pin1_4	175	180	PF00397	0.828
DOC_WW_Pin1_4	186	191	PF00397	0.657
DOC_WW_Pin1_4	211	216	PF00397	0.807
DOC_WW_Pin1_4	255	260	PF00397	0.723
DOC_WW_Pin1_4	307	312	PF00397	0.712
DOC_WW_Pin1_4	336	341	PF00397	0.707
DOC_WW_Pin1_4	374	379	PF00397	0.598
DOC_WW_Pin1_4	509	514	PF00397	0.788
DOC_WW_Pin1_4	630	635	PF00397	0.745
DOC_WW_Pin1_4	814	819	PF00397	0.699
LIG_14-3-3_CanoR_1	210	215	PF00244	0.700
LIG_14-3-3_CanoR_1	346	352	PF00244	0.741
LIG_14-3-3_CanoR_1	45	51	PF00244	0.723
LIG_14-3-3_CanoR_1	451	455	PF00244	0.736
LIG_14-3-3_CanoR_1	526	531	PF00244	0.644
LIG_14-3-3_CanoR_1	590	600	PF00244	0.743
LIG_14-3-3_CanoR_1	792	797	PF00244	0.718
LIG_Actin_WH2_2	196	212	PF00022	0.777
LIG_Actin_WH2_2	738	754	PF00022	0.524
LIG_AP2alpha_1	798	802	PF02296	0.705
LIG_BIR_III_2	699	703	PF00653	0.567
LIG_BIR_III_4	464	468	PF00653	0.670
LIG_BIR_III_4	572	576	PF00653	0.803
LIG_BRCT_BRCA1_1	141	145	PF00533	0.769
LIG_BRCT_BRCA1_1	180	184	PF00533	0.662
LIG_BRCT_BRCA1_1	528	532	PF00533	0.639
LIG_BRCT_BRCA1_1	663	667	PF00533	0.769
LIG_CaM_IQ_9	738	754	PF13499	0.699
LIG_Clathr_ClatBox_1	714	718	PF01394	0.731
LIG_CtBP_PxDLS_1	560	566	PF00389	0.736
LIG_deltaCOP1_diTrp_1	474	482	PF00928	0.710
LIG_deltaCOP1_diTrp_1	661	667	PF00928	0.764
LIG_FHA_1	406	412	PF00498	0.692
LIG_FHA_1	461	467	PF00498	0.723
LIG_FHA_1	536	542	PF00498	0.602
LIG_FHA_1	621	627	PF00498	0.770
LIG_FHA_1	684	690	PF00498	0.754
LIG_FHA_1	723	729	PF00498	0.408
LIG_FHA_1	753	759	PF00498	0.658
LIG_FHA_1	764	770	PF00498	0.579
LIG_FHA_2	240	246	PF00498	0.639
LIG_FHA_2	33	39	PF00498	0.737
LIG_FHA_2	434	440	PF00498	0.741
LIG_FHA_2	617	623	PF00498	0.779
LIG_LIR_Gen_1	599	608	PF02991	0.742
LIG_LIR_Gen_1	729	739	PF02991	0.718
LIG_LIR_Nem_3	185	191	PF02991	0.671
LIG_LIR_Nem_3	236	241	PF02991	0.482
LIG_LIR_Nem_3	29	33	PF02991	0.560
LIG_LIR_Nem_3	304	308	PF02991	0.686
LIG_LIR_Nem_3	599	603	PF02991	0.727
LIG_LIR_Nem_3	653	658	PF02991	0.693
LIG_LIR_Nem_3	729	734	PF02991	0.714
LIG_LIR_Nem_3	800	805	PF02991	0.702
LIG_MYND_1	130	134	PF01753	0.701
LIG_NRBOX	716	722	PF00104	0.727
LIG_PCNA_yPIPBox_3	395	405	PF02747	0.746
LIG_Pex14_1	476	480	PF04695	0.715
LIG_Pex14_1	663	667	PF04695	0.769
LIG_Pex14_2	184	188	PF04695	0.660
LIG_Pex14_2	798	802	PF04695	0.705
LIG_PTB_Apo_2	474	481	PF02174	0.714
LIG_SH2_CRK	366	370	PF00017	0.771
LIG_SH2_SRC	62	65	PF00017	0.595
LIG_SH2_STAT3	784	787	PF00017	0.726
LIG_SH2_STAT5	191	194	PF00017	0.814
LIG_SH2_STAT5	483	486	PF00017	0.573
LIG_SH2_STAT5	658	661	PF00017	0.603
LIG_SH2_STAT5	851	854	PF00017	0.764
LIG_SH3_1	102	108	PF00018	0.628
LIG_SH3_1	187	193	PF00018	0.819
LIG_SH3_2	130	135	PF14604	0.700
LIG_SH3_3	102	108	PF00018	0.628
LIG_SH3_3	127	133	PF00018	0.713
LIG_SH3_3	173	179	PF00018	0.810
LIG_SH3_3	187	193	PF00018	0.618
LIG_SH3_3	642	648	PF00018	0.743
LIG_SH3_3	66	72	PF00018	0.810
LIG_SH3_3	665	671	PF00018	0.773
LIG_SH3_3	812	818	PF00018	0.758
LIG_SUMO_SIM_anti_2	35	43	PF11976	0.635
LIG_SUMO_SIM_anti_2	599	606	PF11976	0.603
LIG_SUMO_SIM_anti_2	764	769	PF11976	0.729
LIG_SUMO_SIM_par_1	29	35	PF11976	0.711
LIG_SUMO_SIM_par_1	381	386	PF11976	0.620
LIG_SUMO_SIM_par_1	713	718	PF11976	0.728
LIG_TRAF2_1	193	196	PF00917	0.804
LIG_TRAF2_1	242	245	PF00917	0.720
LIG_TRAF2_1	783	786	PF00917	0.769
LIG_TRAF2_2	540	545	PF00917	0.778
LIG_WW_3	132	136	PF00397	0.745
MOD_CDK_SPK_2	211	216	PF00069	0.807
MOD_CDK_SPK_2	509	514	PF00069	0.613
MOD_CDK_SPxK_1	117	123	PF00069	0.843
MOD_CK1_1	171	177	PF00069	0.684
MOD_CK1_1	453	459	PF00069	0.823
MOD_CK1_1	791	797	PF00069	0.720
MOD_CK2_1	239	245	PF00069	0.629
MOD_CK2_1	547	553	PF00069	0.633
MOD_CK2_1	556	562	PF00069	0.579
MOD_CK2_1	616	622	PF00069	0.773
MOD_Cter_Amidation	223	226	PF01082	0.821
MOD_Cter_Amidation	449	452	PF01082	0.706
MOD_GlcNHglycan	171	174	PF01048	0.738
MOD_GlcNHglycan	293	296	PF01048	0.668
MOD_GlcNHglycan	378	381	PF01048	0.787
MOD_GlcNHglycan	390	393	PF01048	0.575
MOD_GlcNHglycan	401	404	PF01048	0.484
MOD_GlcNHglycan	412	415	PF01048	0.578
MOD_GlcNHglycan	444	447	PF01048	0.731
MOD_GlcNHglycan	46	49	PF01048	0.694
MOD_GlcNHglycan	549	552	PF01048	0.647
MOD_GlcNHglycan	558	561	PF01048	0.590
MOD_GlcNHglycan	572	576	PF01048	0.698
MOD_GlcNHglycan	694	697	PF01048	0.614
MOD_GlcNHglycan	736	739	PF01048	0.683
MOD_GlcNHglycan	742	745	PF01048	0.517
MOD_GSK3_1	115	122	PF00069	0.747
MOD_GSK3_1	171	178	PF00069	0.828
MOD_GSK3_1	182	189	PF00069	0.661
MOD_GSK3_1	255	262	PF00069	0.634
MOD_GSK3_1	40	47	PF00069	0.699
MOD_GSK3_1	616	623	PF00069	0.674
MOD_GSK3_1	659	666	PF00069	0.754
MOD_GSK3_1	788	795	PF00069	0.792
MOD_LATS_1	208	214	PF00433	0.624
MOD_N-GLC_1	291	296	PF02516	0.671
MOD_N-GLC_1	336	341	PF02516	0.707
MOD_N-GLC_1	388	393	PF02516	0.725
MOD_NEK2_1	12	17	PF00069	0.731
MOD_NEK2_1	160	165	PF00069	0.586
MOD_NEK2_1	301	306	PF00069	0.568
MOD_NEK2_1	32	37	PF00069	0.439
MOD_NEK2_1	399	404	PF00069	0.685
MOD_NEK2_1	40	45	PF00069	0.697
MOD_NEK2_1	405	410	PF00069	0.676
MOD_NEK2_1	442	447	PF00069	0.636
MOD_NEK2_1	519	524	PF00069	0.760
MOD_NEK2_1	591	596	PF00069	0.744
MOD_NEK2_1	659	664	PF00069	0.747
MOD_NEK2_1	740	745	PF00069	0.535
MOD_NEK2_1	769	774	PF00069	0.555
MOD_NEK2_2	390	395	PF00069	0.591
MOD_NEK2_2	450	455	PF00069	0.843
MOD_PIKK_1	182	188	PF00454	0.835
MOD_PIKK_1	405	411	PF00454	0.741
MOD_PIKK_1	746	752	PF00454	0.697
MOD_PKA_2	12	18	PF00069	0.782
MOD_PKA_2	345	351	PF00069	0.720
MOD_PKA_2	419	425	PF00069	0.650
MOD_PKA_2	44	50	PF00069	0.722
MOD_PKA_2	450	456	PF00069	0.718
MOD_PKA_2	616	622	PF00069	0.783
MOD_PKA_2	791	797	PF00069	0.719
MOD_PKB_1	790	798	PF00069	0.719
MOD_Plk_1	405	411	PF00069	0.741
MOD_Plk_1	763	769	PF00069	0.695
MOD_Plk_1	778	784	PF00069	0.536
MOD_Plk_4	233	239	PF00069	0.674
MOD_Plk_4	603	609	PF00069	0.479
MOD_Plk_4	663	669	PF00069	0.771
MOD_Plk_4	763	769	PF00069	0.650
MOD_ProDKin_1	117	123	PF00069	0.843
MOD_ProDKin_1	175	181	PF00069	0.830
MOD_ProDKin_1	186	192	PF00069	0.655
MOD_ProDKin_1	211	217	PF00069	0.809
MOD_ProDKin_1	255	261	PF00069	0.723
MOD_ProDKin_1	307	313	PF00069	0.702
MOD_ProDKin_1	336	342	PF00069	0.701
MOD_ProDKin_1	374	380	PF00069	0.597
MOD_ProDKin_1	509	515	PF00069	0.788
MOD_ProDKin_1	630	636	PF00069	0.743
MOD_ProDKin_1	814	820	PF00069	0.695
TRG_DiLeu_BaEn_1	202	207	PF01217	0.771
TRG_DiLeu_BaEn_1	406	411	PF01217	0.689
TRG_DiLeu_BaEn_1	622	627	PF01217	0.769
TRG_DiLeu_BaEn_1	716	721	PF01217	0.724
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.639
TRG_DiLeu_BaLyEn_6	587	592	PF01217	0.752
TRG_DiLeu_BaLyEn_6	710	715	PF01217	0.737
TRG_DiLeu_BaLyEn_6	816	821	PF01217	0.747
TRG_ENDOCYTIC_2	191	194	PF00928	0.814
TRG_ENDOCYTIC_2	305	308	PF00928	0.597
TRG_ENDOCYTIC_2	366	369	PF00928	0.773
TRG_ENDOCYTIC_2	483	486	PF00928	0.573
TRG_ENDOCYTIC_2	62	65	PF00928	0.595
TRG_ER_diArg_1	134	136	PF00400	0.811
TRG_ER_diArg_1	225	227	PF00400	0.778
TRG_ER_diArg_1	710	713	PF00400	0.737
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.805
TRG_Pf-PMV_PEXEL_1	370	374	PF00026	0.762
TRG_Pf-PMV_PEXEL_1	452	457	PF00026	0.852
TRG_Pf-PMV_PEXEL_1	679	683	PF00026	0.705
TRG_Pf-PMV_PEXEL_1	713	718	PF00026	0.730
TRG_Pf-PMV_PEXEL_1	746	750	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	775	779	PF00026	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HYE8	Leishmania infantum	99%	100%
E9AS81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QD85	Leishmania major	90%	100%