Extracellular receptor, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

extracellular receptor, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WVK2_LEIDO

TriTrypDb:

LdBPK_190640.1 , LdCL_190011400 , LDHU3_19.0720

Length:

862

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7WVK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVK2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0004888	transmembrane signaling receptor activity	3	4
GO:0004930	G protein-coupled receptor activity	4	4
GO:0004965	G protein-coupled GABA receptor activity	5	2
GO:0016917	GABA receptor activity	4	2
GO:0038023	signaling receptor activity	2	4
GO:0060089	molecular transducer activity	1	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.377
CLV_C14_Caspase3-7	723	727	PF00656	0.342
CLV_C14_Caspase3-7	790	794	PF00656	0.452
CLV_NRD_NRD_1	205	207	PF00675	0.619
CLV_NRD_NRD_1	215	217	PF00675	0.629
CLV_NRD_NRD_1	661	663	PF00675	0.586
CLV_PCSK_FUR_1	213	217	PF00082	0.614
CLV_PCSK_KEX2_1	205	207	PF00082	0.604
CLV_PCSK_KEX2_1	215	217	PF00082	0.580
CLV_PCSK_SKI1_1	120	124	PF00082	0.510
CLV_PCSK_SKI1_1	377	381	PF00082	0.528
CLV_PCSK_SKI1_1	856	860	PF00082	0.498
DEG_APCC_DBOX_1	119	127	PF00400	0.322
DEG_APCC_DBOX_1	226	234	PF00400	0.371
DEG_SPOP_SBC_1	174	178	PF00917	0.481
DOC_CDC14_PxL_1	230	238	PF14671	0.449
DOC_CYCLIN_yCln2_LP_2	27	33	PF00134	0.473
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	577	583	PF00134	0.330
DOC_MAPK_gen_1	213	223	PF00069	0.359
DOC_MAPK_gen_1	624	633	PF00069	0.313
DOC_MAPK_HePTP_8	566	578	PF00069	0.334
DOC_MAPK_MEF2A_6	569	578	PF00069	0.290
DOC_MAPK_MEF2A_6	765	772	PF00069	0.436
DOC_PP4_FxxP_1	467	470	PF00568	0.334
DOC_USP7_MATH_1	151	155	PF00917	0.488
DOC_USP7_MATH_1	217	221	PF00917	0.392
DOC_USP7_MATH_1	319	323	PF00917	0.438
DOC_USP7_MATH_1	384	388	PF00917	0.337
DOC_USP7_MATH_1	614	618	PF00917	0.347
DOC_USP7_MATH_1	68	72	PF00917	0.379
DOC_USP7_MATH_1	92	96	PF00917	0.368
DOC_USP7_MATH_2	258	264	PF00917	0.454
DOC_USP7_UBL2_3	565	569	PF12436	0.386
DOC_WW_Pin1_4	253	258	PF00397	0.378
DOC_WW_Pin1_4	371	376	PF00397	0.351
DOC_WW_Pin1_4	382	387	PF00397	0.311
DOC_WW_Pin1_4	458	463	PF00397	0.282
DOC_WW_Pin1_4	680	685	PF00397	0.362
DOC_WW_Pin1_4	764	769	PF00397	0.372
DOC_WW_Pin1_4	802	807	PF00397	0.440
LIG_14-3-3_CanoR_1	216	222	PF00244	0.382
LIG_14-3-3_CanoR_1	443	448	PF00244	0.282
LIG_14-3-3_CanoR_1	530	535	PF00244	0.334
LIG_14-3-3_CanoR_1	591	599	PF00244	0.386
LIG_14-3-3_CanoR_1	662	671	PF00244	0.336
LIG_14-3-3_CanoR_1	721	728	PF00244	0.296
LIG_Actin_WH2_2	363	379	PF00022	0.447
LIG_BRCT_BRCA1_1	262	266	PF00533	0.470
LIG_BRCT_BRCA1_1	396	400	PF00533	0.395
LIG_BRCT_BRCA1_1	59	63	PF00533	0.403
LIG_BRCT_BRCA1_1	754	758	PF00533	0.415
LIG_BRCT_BRCA1_1	798	802	PF00533	0.458
LIG_Clathr_ClatBox_1	290	294	PF01394	0.387
LIG_deltaCOP1_diTrp_1	774	779	PF00928	0.353
LIG_DLG_GKlike_1	792	800	PF00625	0.457
LIG_EH_1	578	582	PF12763	0.386
LIG_EH1_1	829	837	PF00400	0.606
LIG_eIF4E_1	830	836	PF01652	0.551
LIG_FHA_1	160	166	PF00498	0.408
LIG_FHA_1	202	208	PF00498	0.411
LIG_FHA_1	235	241	PF00498	0.467
LIG_FHA_1	313	319	PF00498	0.321
LIG_FHA_1	345	351	PF00498	0.369
LIG_FHA_1	365	371	PF00498	0.219
LIG_FHA_1	376	382	PF00498	0.320
LIG_FHA_1	459	465	PF00498	0.280
LIG_FHA_1	47	53	PF00498	0.409
LIG_FHA_1	480	486	PF00498	0.353
LIG_FHA_1	546	552	PF00498	0.342
LIG_FHA_1	65	71	PF00498	0.249
LIG_FHA_1	817	823	PF00498	0.390
LIG_FHA_1	82	88	PF00498	0.313
LIG_FHA_1	9	15	PF00498	0.424
LIG_FHA_2	175	181	PF00498	0.387
LIG_FHA_2	271	277	PF00498	0.481
LIG_FHA_2	497	503	PF00498	0.339
LIG_FHA_2	519	525	PF00498	0.386
LIG_FHA_2	556	562	PF00498	0.386
LIG_FHA_2	648	654	PF00498	0.338
LIG_FHA_2	655	661	PF00498	0.295
LIG_FHA_2	721	727	PF00498	0.313
LIG_FHA_2	788	794	PF00498	0.430
LIG_FHA_2	81	87	PF00498	0.407
LIG_FHA_2	846	852	PF00498	0.621
LIG_LIR_Apic_2	253	258	PF02991	0.389
LIG_LIR_Apic_2	466	470	PF02991	0.321
LIG_LIR_Gen_1	322	332	PF02991	0.376
LIG_LIR_Gen_1	499	508	PF02991	0.304
LIG_LIR_Gen_1	564	575	PF02991	0.362
LIG_LIR_Gen_1	691	700	PF02991	0.301
LIG_LIR_Gen_1	773	780	PF02991	0.431
LIG_LIR_Nem_3	276	281	PF02991	0.379
LIG_LIR_Nem_3	322	328	PF02991	0.385
LIG_LIR_Nem_3	329	335	PF02991	0.317
LIG_LIR_Nem_3	415	421	PF02991	0.356
LIG_LIR_Nem_3	487	491	PF02991	0.321
LIG_LIR_Nem_3	499	503	PF02991	0.251
LIG_LIR_Nem_3	564	570	PF02991	0.358
LIG_LIR_Nem_3	57	61	PF02991	0.417
LIG_LIR_Nem_3	587	592	PF02991	0.334
LIG_LIR_Nem_3	593	598	PF02991	0.310
LIG_LIR_Nem_3	683	688	PF02991	0.315
LIG_LIR_Nem_3	691	697	PF02991	0.276
LIG_LIR_Nem_3	773	778	PF02991	0.393
LIG_LYPXL_S_1	633	637	PF13949	0.586
LIG_LYPXL_yS_3	634	637	PF13949	0.386
LIG_NRBOX	282	288	PF00104	0.377
LIG_OCRL_FandH_1	824	836	PF00620	0.444
LIG_PDZ_Class_3	857	862	PF00595	0.707
LIG_Pex14_1	247	251	PF04695	0.328
LIG_Pex14_2	758	762	PF04695	0.408
LIG_PTB_Apo_2	138	145	PF02174	0.373
LIG_PTB_Apo_2	22	29	PF02174	0.318
LIG_PTB_Apo_2	475	482	PF02174	0.353
LIG_PTB_Phospho_1	138	144	PF10480	0.373
LIG_REV1ctd_RIR_1	587	595	PF16727	0.395
LIG_SH2_CRK	255	259	PF00017	0.395
LIG_SH2_CRK	567	571	PF00017	0.358
LIG_SH2_GRB2like	23	26	PF00017	0.429
LIG_SH2_NCK_1	255	259	PF00017	0.372
LIG_SH2_PTP2	694	697	PF00017	0.362
LIG_SH2_SRC	544	547	PF00017	0.358
LIG_SH2_STAP1	133	137	PF00017	0.355
LIG_SH2_STAP1	353	357	PF00017	0.442
LIG_SH2_STAP1	567	571	PF00017	0.332
LIG_SH2_STAP1	745	749	PF00017	0.362
LIG_SH2_STAT3	598	601	PF00017	0.386
LIG_SH2_STAT3	830	833	PF00017	0.564
LIG_SH2_STAT5	23	26	PF00017	0.414
LIG_SH2_STAT5	255	258	PF00017	0.341
LIG_SH2_STAT5	314	317	PF00017	0.398
LIG_SH2_STAT5	480	483	PF00017	0.342
LIG_SH2_STAT5	490	493	PF00017	0.268
LIG_SH2_STAT5	544	547	PF00017	0.386
LIG_SH2_STAT5	550	553	PF00017	0.315
LIG_SH2_STAT5	595	598	PF00017	0.306
LIG_SH2_STAT5	602	605	PF00017	0.242
LIG_SH2_STAT5	649	652	PF00017	0.342
LIG_SH2_STAT5	694	697	PF00017	0.311
LIG_SH2_STAT5	719	722	PF00017	0.362
LIG_SH2_STAT5	824	827	PF00017	0.545
LIG_SH3_3	338	344	PF00018	0.372
LIG_SH3_5	470	474	PF00018	0.334
LIG_SUMO_SIM_anti_2	46	53	PF11976	0.411
LIG_SUMO_SIM_anti_2	515	522	PF11976	0.282
LIG_SUMO_SIM_anti_2	572	578	PF11976	0.313
LIG_SUMO_SIM_anti_2	82	91	PF11976	0.365
LIG_SUMO_SIM_par_1	121	127	PF11976	0.386
LIG_SUMO_SIM_par_1	288	294	PF11976	0.383
LIG_SUMO_SIM_par_1	31	37	PF11976	0.399
LIG_SUMO_SIM_par_1	421	427	PF11976	0.341
LIG_SUMO_SIM_par_1	48	53	PF11976	0.386
LIG_SUMO_SIM_par_1	515	522	PF11976	0.334
LIG_SUMO_SIM_par_1	82	91	PF11976	0.426
LIG_SxIP_EBH_1	432	443	PF03271	0.399
LIG_TRAF2_1	657	660	PF00917	0.387
LIG_TRAF2_1	848	851	PF00917	0.639
LIG_TYR_ITIM	323	328	PF00017	0.366
LIG_UBA3_1	290	297	PF00899	0.367
LIG_WRC_WIRS_1	788	793	PF05994	0.432
MOD_CDC14_SPxK_1	374	377	PF00782	0.340
MOD_CDK_SPxK_1	371	377	PF00069	0.350
MOD_CK1_1	226	232	PF00069	0.385
MOD_CK1_1	253	259	PF00069	0.370
MOD_CK1_1	333	339	PF00069	0.341
MOD_CK1_1	533	539	PF00069	0.397
MOD_CK1_1	673	679	PF00069	0.340
MOD_CK1_1	680	686	PF00069	0.296
MOD_CK1_1	764	770	PF00069	0.364
MOD_CK1_1	91	97	PF00069	0.360
MOD_CK2_1	2	8	PF00069	0.412
MOD_CK2_1	654	660	PF00069	0.338
MOD_CK2_1	669	675	PF00069	0.209
MOD_CK2_1	845	851	PF00069	0.625
MOD_GlcNHglycan	17	20	PF01048	0.654
MOD_GlcNHglycan	252	255	PF01048	0.571
MOD_GlcNHglycan	303	306	PF01048	0.570
MOD_GlcNHglycan	367	370	PF01048	0.640
MOD_GlcNHglycan	429	432	PF01048	0.539
MOD_GlcNHglycan	607	610	PF01048	0.562
MOD_GlcNHglycan	616	619	PF01048	0.562
MOD_GlcNHglycan	69	73	PF01048	0.577
MOD_GlcNHglycan	802	805	PF01048	0.654
MOD_GlcNHglycan	90	93	PF01048	0.549
MOD_GSK3_1	101	108	PF00069	0.382
MOD_GSK3_1	133	140	PF00069	0.333
MOD_GSK3_1	151	158	PF00069	0.312
MOD_GSK3_1	266	273	PF00069	0.496
MOD_GSK3_1	333	340	PF00069	0.321
MOD_GSK3_1	371	378	PF00069	0.388
MOD_GSK3_1	4	11	PF00069	0.423
MOD_GSK3_1	423	430	PF00069	0.357
MOD_GSK3_1	446	453	PF00069	0.340
MOD_GSK3_1	46	53	PF00069	0.375
MOD_GSK3_1	526	533	PF00069	0.285
MOD_GSK3_1	545	552	PF00069	0.205
MOD_GSK3_1	590	597	PF00069	0.355
MOD_GSK3_1	64	71	PF00069	0.315
MOD_GSK3_1	644	651	PF00069	0.392
MOD_GSK3_1	669	676	PF00069	0.286
MOD_GSK3_1	730	737	PF00069	0.308
MOD_GSK3_1	792	799	PF00069	0.430
MOD_GSK3_1	88	95	PF00069	0.363
MOD_N-GLC_1	15	20	PF02516	0.667
MOD_N-GLC_1	240	245	PF02516	0.697
MOD_N-GLC_1	301	306	PF02516	0.577
MOD_N-GLC_1	351	356	PF02516	0.556
MOD_N-GLC_1	364	369	PF02516	0.621
MOD_N-GLC_1	411	416	PF02516	0.656
MOD_N-GLC_1	555	560	PF02516	0.527
MOD_N-GLC_1	635	640	PF02516	0.564
MOD_N-GLC_1	706	711	PF02516	0.504
MOD_N-GLC_1	752	757	PF02516	0.553
MOD_N-GLC_1	781	786	PF02516	0.631
MOD_N-GLC_1	80	85	PF02516	0.637
MOD_NEK2_1	14	19	PF00069	0.459
MOD_NEK2_1	281	286	PF00069	0.323
MOD_NEK2_1	370	375	PF00069	0.394
MOD_NEK2_1	394	399	PF00069	0.391
MOD_NEK2_1	400	405	PF00069	0.418
MOD_NEK2_1	491	496	PF00069	0.282
MOD_NEK2_1	526	531	PF00069	0.356
MOD_NEK2_1	605	610	PF00069	0.359
MOD_NEK2_1	696	701	PF00069	0.345
MOD_NEK2_1	752	757	PF00069	0.428
MOD_NEK2_1	758	763	PF00069	0.332
MOD_NEK2_1	780	785	PF00069	0.421
MOD_NEK2_1	796	801	PF00069	0.345
MOD_NEK2_1	816	821	PF00069	0.278
MOD_NEK2_1	88	93	PF00069	0.387
MOD_NEK2_2	217	222	PF00069	0.409
MOD_NEK2_2	23	28	PF00069	0.406
MOD_NEK2_2	319	324	PF00069	0.443
MOD_NEK2_2	337	342	PF00069	0.293
MOD_NEK2_2	644	649	PF00069	0.388
MOD_NEK2_2	787	792	PF00069	0.348
MOD_PIKK_1	260	266	PF00454	0.383
MOD_PIKK_1	389	395	PF00454	0.408
MOD_PIKK_1	43	49	PF00454	0.437
MOD_PIKK_1	503	509	PF00454	0.330
MOD_PIKK_1	635	641	PF00454	0.374
MOD_PK_1	721	727	PF00069	0.308
MOD_PKA_2	226	232	PF00069	0.395
MOD_PKA_2	590	596	PF00069	0.386
MOD_PKA_2	720	726	PF00069	0.282
MOD_PKB_1	310	318	PF00069	0.403
MOD_Plk_1	2	8	PF00069	0.410
MOD_Plk_1	301	307	PF00069	0.394
MOD_Plk_1	545	551	PF00069	0.304
MOD_Plk_1	555	561	PF00069	0.286
MOD_Plk_1	677	683	PF00069	0.285
MOD_Plk_1	706	712	PF00069	0.319
MOD_Plk_1	730	736	PF00069	0.377
MOD_Plk_1	773	779	PF00069	0.428
MOD_Plk_1	781	787	PF00069	0.443
MOD_Plk_1	792	798	PF00069	0.276
MOD_Plk_4	161	167	PF00069	0.404
MOD_Plk_4	183	189	PF00069	0.379
MOD_Plk_4	217	223	PF00069	0.414
MOD_Plk_4	23	29	PF00069	0.406
MOD_Plk_4	319	325	PF00069	0.380
MOD_Plk_4	327	333	PF00069	0.294
MOD_Plk_4	413	419	PF00069	0.323
MOD_Plk_4	434	440	PF00069	0.383
MOD_Plk_4	443	449	PF00069	0.264
MOD_Plk_4	545	551	PF00069	0.350
MOD_Plk_4	57	63	PF00069	0.360
MOD_Plk_4	585	591	PF00069	0.346
MOD_Plk_4	594	600	PF00069	0.316
MOD_Plk_4	644	650	PF00069	0.365
MOD_Plk_4	70	76	PF00069	0.389
MOD_Plk_4	753	759	PF00069	0.316
MOD_Plk_4	792	798	PF00069	0.468
MOD_ProDKin_1	253	259	PF00069	0.387
MOD_ProDKin_1	371	377	PF00069	0.348
MOD_ProDKin_1	382	388	PF00069	0.313
MOD_ProDKin_1	458	464	PF00069	0.282
MOD_ProDKin_1	680	686	PF00069	0.362
MOD_ProDKin_1	764	770	PF00069	0.366
MOD_ProDKin_1	802	808	PF00069	0.436
MOD_SUMO_rev_2	95	104	PF00179	0.418
TRG_DiLeu_BaEn_1	660	665	PF01217	0.330
TRG_DiLeu_BaEn_2	276	282	PF01217	0.393
TRG_DiLeu_BaEn_4	850	856	PF01217	0.639
TRG_ENDOCYTIC_2	278	281	PF00928	0.355
TRG_ENDOCYTIC_2	325	328	PF00928	0.349
TRG_ENDOCYTIC_2	488	491	PF00928	0.282
TRG_ENDOCYTIC_2	567	570	PF00928	0.362
TRG_ENDOCYTIC_2	602	605	PF00928	0.275
TRG_ENDOCYTIC_2	634	637	PF00928	0.386
TRG_ENDOCYTIC_2	685	688	PF00928	0.309
TRG_ENDOCYTIC_2	694	697	PF00928	0.265
TRG_ER_diArg_1	190	193	PF00400	0.369
TRG_ER_diArg_1	205	207	PF00400	0.283
TRG_ER_diArg_1	213	216	PF00400	0.374
TRG_NES_CRM1_1	115	129	PF08389	0.368
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	662	667	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	856	860	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK8	Leptomonas seymouri	66%	87%
A0A0S4ITA9	Bodo saltans	36%	100%
A0A1X0P7Q8	Trypanosomatidae	42%	97%
A0A422NN34	Trypanosoma rangeli	41%	97%
A4HA22	Leishmania braziliensis	83%	100%
A4HY85	Leishmania infantum	100%	100%
E9AS16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QDF7	Leishmania major	97%	100%
V5C1V3	Trypanosoma cruzi	43%	97%