Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVJ6_LEIDO

TriTrypDb:

LdBPK_191400.1 , LdCL_190019700 , LDHU3_19.1690

Length:

164

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.573
CLV_NRD_NRD_1	4	6	PF00675	0.632
CLV_PCSK_KEX2_1	4	6	PF00082	0.632
CLV_PCSK_SKI1_1	4	8	PF00082	0.646
DEG_Nend_Nbox_1	1	3	PF02207	0.650
DEG_SCF_FBW7_1	99	105	PF00400	0.491
DOC_CKS1_1	99	104	PF01111	0.493
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.451
DOC_MAPK_MEF2A_6	137	146	PF00069	0.464
DOC_PP2B_LxvP_1	142	145	PF13499	0.451
DOC_USP7_MATH_1	102	106	PF00917	0.593
DOC_USP7_MATH_1	130	134	PF00917	0.500
DOC_USP7_MATH_1	37	41	PF00917	0.591
DOC_WW_Pin1_4	131	136	PF00397	0.501
DOC_WW_Pin1_4	98	103	PF00397	0.492
LIG_14-3-3_CanoR_1	131	135	PF00244	0.504
LIG_14-3-3_CanoR_1	137	146	PF00244	0.430
LIG_14-3-3_CanoR_1	5	11	PF00244	0.653
LIG_BRCT_BRCA1_1	86	90	PF00533	0.575
LIG_FHA_1	44	50	PF00498	0.560
LIG_FHA_1	94	100	PF00498	0.512
LIG_LIR_Gen_1	105	113	PF02991	0.523
LIG_LIR_Nem_3	105	109	PF02991	0.526
LIG_LIR_Nem_3	87	93	PF02991	0.532
LIG_MYND_1	33	37	PF01753	0.593
LIG_SH3_1	124	130	PF00018	0.516
LIG_SH3_3	124	130	PF00018	0.516
LIG_SH3_3	86	92	PF00018	0.511
LIG_SH3_3	96	102	PF00018	0.525
LIG_SUMO_SIM_anti_2	105	111	PF11976	0.443
LIG_SUMO_SIM_par_1	95	101	PF11976	0.501
LIG_TRAF2_1	69	72	PF00917	0.555
LIG_UBA3_1	109	116	PF00899	0.448
LIG_UBA3_1	142	150	PF00899	0.452
LIG_WRC_WIRS_1	103	108	PF05994	0.517
MOD_CDC14_SPxK_1	134	137	PF00782	0.491
MOD_CDK_SPxK_1	131	137	PF00069	0.500
MOD_CK1_1	63	69	PF00069	0.580
MOD_CK1_1	81	87	PF00069	0.562
MOD_CK1_1	98	104	PF00069	0.547
MOD_CK2_1	102	108	PF00069	0.518
MOD_CK2_1	66	72	PF00069	0.563
MOD_Cter_Amidation	2	5	PF01082	0.637
MOD_DYRK1A_RPxSP_1	131	135	PF00069	0.504
MOD_GlcNHglycan	64	68	PF01048	0.653
MOD_GlcNHglycan	78	81	PF01048	0.601
MOD_GlcNHglycan	8	11	PF01048	0.686
MOD_GSK3_1	38	45	PF00069	0.654
MOD_GSK3_1	48	55	PF00069	0.635
MOD_GSK3_1	76	83	PF00069	0.566
MOD_GSK3_1	93	100	PF00069	0.510
MOD_NEK2_1	38	43	PF00069	0.615
MOD_NEK2_1	78	83	PF00069	0.560
MOD_NEK2_1	95	100	PF00069	0.505
MOD_PIKK_1	137	143	PF00454	0.468
MOD_PIKK_1	48	54	PF00454	0.568
MOD_PKA_2	130	136	PF00069	0.497
MOD_PKA_2	43	49	PF00069	0.570
MOD_Plk_1	71	77	PF00069	0.581
MOD_Plk_4	102	108	PF00069	0.603
MOD_Plk_4	84	90	PF00069	0.512
MOD_ProDKin_1	131	137	PF00069	0.500
MOD_ProDKin_1	98	104	PF00069	0.494
TRG_ER_diArg_1	4	6	PF00400	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBH0	Leishmania donovani	53%	100%
A4HA86	Leishmania braziliensis	74%	100%
A4HYG5	Leishmania infantum	100%	100%
E9AHU8	Leishmania infantum	52%	100%
E9AS83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AS90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QD74	Leishmania major	93%	99%
Q4QD83	Leishmania major	51%	100%