Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WVJ5_LEIDO

TriTrypDb:

LdBPK_191130.1 , LdCL_190016400 , LDHU3_19.1370

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 0
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVJ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.541
CLV_C14_Caspase3-7	43	47	PF00656	0.655
CLV_NRD_NRD_1	159	161	PF00675	0.681
CLV_NRD_NRD_1	187	189	PF00675	0.662
CLV_NRD_NRD_1	190	192	PF00675	0.625
CLV_NRD_NRD_1	227	229	PF00675	0.629
CLV_NRD_NRD_1	328	330	PF00675	0.514
CLV_NRD_NRD_1	387	389	PF00675	0.612
CLV_NRD_NRD_1	434	436	PF00675	0.638
CLV_NRD_NRD_1	517	519	PF00675	0.556
CLV_NRD_NRD_1	798	800	PF00675	0.591
CLV_PCSK_FUR_1	187	191	PF00082	0.594
CLV_PCSK_KEX2_1	158	160	PF00082	0.681
CLV_PCSK_KEX2_1	187	189	PF00082	0.662
CLV_PCSK_KEX2_1	190	192	PF00082	0.625
CLV_PCSK_KEX2_1	227	229	PF00082	0.629
CLV_PCSK_KEX2_1	387	389	PF00082	0.612
CLV_PCSK_KEX2_1	517	519	PF00082	0.556
CLV_PCSK_KEX2_1	798	800	PF00082	0.591
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.565
CLV_PCSK_SKI1_1	329	333	PF00082	0.497
CLV_PCSK_SKI1_1	374	378	PF00082	0.594
CLV_PCSK_SKI1_1	687	691	PF00082	0.526
DEG_Nend_UBRbox_2	1	3	PF02207	0.663
DEG_SPOP_SBC_1	264	268	PF00917	0.623
DOC_CYCLIN_yCln2_LP_2	335	341	PF00134	0.642
DOC_MAPK_DCC_7	435	443	PF00069	0.588
DOC_MAPK_gen_1	435	443	PF00069	0.588
DOC_MAPK_gen_1	673	681	PF00069	0.594
DOC_MAPK_MEF2A_6	435	443	PF00069	0.588
DOC_PP2B_LxvP_1	688	691	PF13499	0.522
DOC_PP4_FxxP_1	601	604	PF00568	0.668
DOC_PP4_FxxP_1	693	696	PF00568	0.588
DOC_PP4_FxxP_1	9	12	PF00568	0.649
DOC_USP7_MATH_1	110	114	PF00917	0.678
DOC_USP7_MATH_1	117	121	PF00917	0.626
DOC_USP7_MATH_1	135	139	PF00917	0.497
DOC_USP7_MATH_1	264	268	PF00917	0.623
DOC_USP7_MATH_1	295	299	PF00917	0.605
DOC_USP7_MATH_1	398	402	PF00917	0.575
DOC_USP7_MATH_1	501	505	PF00917	0.618
DOC_USP7_MATH_1	559	563	PF00917	0.647
DOC_USP7_MATH_1	595	599	PF00917	0.650
DOC_USP7_MATH_1	722	726	PF00917	0.594
DOC_USP7_MATH_1	727	731	PF00917	0.571
DOC_USP7_MATH_1	743	747	PF00917	0.539
DOC_USP7_MATH_1	81	85	PF00917	0.632
DOC_WW_Pin1_4	113	118	PF00397	0.686
DOC_WW_Pin1_4	119	124	PF00397	0.639
DOC_WW_Pin1_4	247	252	PF00397	0.644
DOC_WW_Pin1_4	334	339	PF00397	0.629
DOC_WW_Pin1_4	468	473	PF00397	0.633
DOC_WW_Pin1_4	553	558	PF00397	0.583
DOC_WW_Pin1_4	82	87	PF00397	0.631
LIG_14-3-3_CanoR_1	159	165	PF00244	0.680
LIG_14-3-3_CanoR_1	228	234	PF00244	0.650
LIG_14-3-3_CanoR_1	329	338	PF00244	0.530
LIG_14-3-3_CanoR_1	507	516	PF00244	0.597
LIG_14-3-3_CanoR_1	537	546	PF00244	0.646
LIG_14-3-3_CanoR_1	712	717	PF00244	0.598
LIG_14-3-3_CanoR_1	718	727	PF00244	0.566
LIG_BRCT_BRCA1_1	597	601	PF00533	0.658
LIG_BRCT_BRCA1_1	693	697	PF00533	0.588
LIG_deltaCOP1_diTrp_1	683	693	PF00928	0.526
LIG_FHA_1	244	250	PF00498	0.586
LIG_FHA_1	330	336	PF00498	0.524
LIG_FHA_1	67	73	PF00498	0.561
LIG_FHA_2	207	213	PF00498	0.536
LIG_FHA_2	238	244	PF00498	0.657
LIG_FHA_2	348	354	PF00498	0.586
LIG_FHA_2	432	438	PF00498	0.572
LIG_FHA_2	536	542	PF00498	0.650
LIG_FHA_2	600	606	PF00498	0.781
LIG_GBD_Chelix_1	445	453	PF00786	0.525
LIG_Integrin_RGD_1	763	765	PF01839	0.563
LIG_LIR_Apic_2	598	604	PF02991	0.665
LIG_LIR_Apic_2	692	696	PF02991	0.582
LIG_LIR_Gen_1	20	31	PF02991	0.474
LIG_LIR_Gen_1	674	684	PF02991	0.575
LIG_LIR_Nem_3	20	26	PF02991	0.461
LIG_LIR_Nem_3	371	376	PF02991	0.592
LIG_LIR_Nem_3	526	530	PF02991	0.618
LIG_LIR_Nem_3	540	546	PF02991	0.583
LIG_LIR_Nem_3	674	679	PF02991	0.597
LIG_LIR_Nem_3	683	689	PF02991	0.447
LIG_LIR_Nem_3	756	762	PF02991	0.603
LIG_NRBOX	298	304	PF00104	0.595
LIG_NRBOX	448	454	PF00104	0.525
LIG_NRBOX	570	576	PF00104	0.571
LIG_PCNA_yPIPBox_3	782	793	PF02747	0.541
LIG_Pex14_2	693	697	PF04695	0.588
LIG_RPA_C_Fungi	446	458	PF08784	0.532
LIG_RPA_C_Fungi	707	719	PF08784	0.537
LIG_SH2_NCK_1	34	38	PF00017	0.524
LIG_SH2_SRC	649	652	PF00017	0.582
LIG_SH2_STAP1	17	21	PF00017	0.522
LIG_SH2_STAT3	139	142	PF00017	0.641
LIG_SH2_STAT5	139	142	PF00017	0.641
LIG_SH2_STAT5	349	352	PF00017	0.583
LIG_SH2_STAT5	478	481	PF00017	0.656
LIG_SH3_1	8	14	PF00018	0.650
LIG_SH3_3	248	254	PF00018	0.612
LIG_SH3_3	392	398	PF00018	0.635
LIG_SH3_3	412	418	PF00018	0.477
LIG_SH3_3	466	472	PF00018	0.625
LIG_SH3_3	522	528	PF00018	0.650
LIG_SH3_3	8	14	PF00018	0.650
LIG_SUMO_SIM_anti_2	298	303	PF11976	0.734
LIG_SUMO_SIM_par_1	243	250	PF11976	0.623
LIG_TRAF2_1	123	126	PF00917	0.657
LIG_TRAF2_1	350	353	PF00917	0.619
LIG_TRAF2_1	562	565	PF00917	0.645
LIG_TRAF2_1	604	607	PF00917	0.670
LIG_WRC_WIRS_1	690	695	PF05994	0.564
LIG_WW_3	10	14	PF00397	0.617
MOD_CDK_SPK_2	119	124	PF00069	0.600
MOD_CDK_SPxK_1	247	253	PF00069	0.556
MOD_CK1_1	113	119	PF00069	0.680
MOD_CK1_1	138	144	PF00069	0.573
MOD_CK1_1	162	168	PF00069	0.680
MOD_CK1_1	180	186	PF00069	0.526
MOD_CK1_1	241	247	PF00069	0.626
MOD_CK1_1	263	269	PF00069	0.648
MOD_CK1_1	337	343	PF00069	0.627
MOD_CK1_1	380	386	PF00069	0.636
MOD_CK1_1	41	47	PF00069	0.567
MOD_CK1_1	481	487	PF00069	0.559
MOD_CK1_1	508	514	PF00069	0.663
MOD_CK1_1	547	553	PF00069	0.640
MOD_CK1_1	590	596	PF00069	0.641
MOD_CK1_1	677	683	PF00069	0.480
MOD_CK1_1	699	705	PF00069	0.637
MOD_CK1_1	746	752	PF00069	0.652
MOD_CK2_1	180	186	PF00069	0.673
MOD_CK2_1	237	243	PF00069	0.661
MOD_CK2_1	347	353	PF00069	0.596
MOD_CK2_1	365	371	PF00069	0.534
MOD_CK2_1	403	409	PF00069	0.576
MOD_CK2_1	431	437	PF00069	0.581
MOD_CK2_1	559	565	PF00069	0.649
MOD_CK2_1	677	683	PF00069	0.564
MOD_CK2_1	70	76	PF00069	0.646
MOD_CK2_1	800	806	PF00069	0.630
MOD_GlcNHglycan	112	115	PF01048	0.685
MOD_GlcNHglycan	182	185	PF01048	0.673
MOD_GlcNHglycan	196	199	PF01048	0.536
MOD_GlcNHglycan	262	265	PF01048	0.629
MOD_GlcNHglycan	283	286	PF01048	0.643
MOD_GlcNHglycan	339	342	PF01048	0.629
MOD_GlcNHglycan	405	408	PF01048	0.620
MOD_GlcNHglycan	503	506	PF01048	0.771
MOD_GlcNHglycan	507	510	PF01048	0.740
MOD_GlcNHglycan	546	549	PF01048	0.664
MOD_GlcNHglycan	56	59	PF01048	0.672
MOD_GlcNHglycan	561	564	PF01048	0.564
MOD_GlcNHglycan	592	596	PF01048	0.665
MOD_GlcNHglycan	630	636	PF01048	0.650
MOD_GlcNHglycan	693	696	PF01048	0.575
MOD_GlcNHglycan	720	723	PF01048	0.621
MOD_GlcNHglycan	736	739	PF01048	0.498
MOD_GlcNHglycan	749	752	PF01048	0.540
MOD_GSK3_1	109	116	PF00069	0.671
MOD_GSK3_1	138	145	PF00069	0.606
MOD_GSK3_1	162	169	PF00069	0.623
MOD_GSK3_1	194	201	PF00069	0.646
MOD_GSK3_1	228	235	PF00069	0.725
MOD_GSK3_1	237	244	PF00069	0.521
MOD_GSK3_1	260	267	PF00069	0.578
MOD_GSK3_1	281	288	PF00069	0.662
MOD_GSK3_1	377	384	PF00069	0.574
MOD_GSK3_1	403	410	PF00069	0.637
MOD_GSK3_1	474	481	PF00069	0.615
MOD_GSK3_1	48	55	PF00069	0.665
MOD_GSK3_1	501	508	PF00069	0.759
MOD_GSK3_1	542	549	PF00069	0.636
MOD_GSK3_1	587	594	PF00069	0.652
MOD_GSK3_1	595	602	PF00069	0.665
MOD_GSK3_1	649	656	PF00069	0.641
MOD_GSK3_1	66	73	PF00069	0.504
MOD_GSK3_1	675	682	PF00069	0.556
MOD_GSK3_1	698	705	PF00069	0.611
MOD_GSK3_1	718	725	PF00069	0.474
MOD_GSK3_1	743	750	PF00069	0.652
MOD_GSK3_1	82	89	PF00069	0.555
MOD_LATS_1	542	548	PF00433	0.660
MOD_N-GLC_1	133	138	PF02516	0.650
MOD_N-GLC_1	241	246	PF02516	0.646
MOD_N-GLC_1	279	284	PF02516	0.578
MOD_N-GLC_1	407	412	PF02516	0.629
MOD_N-GLC_2	422	424	PF02516	0.617
MOD_NEK2_1	237	242	PF00069	0.651
MOD_NEK2_1	281	286	PF00069	0.669
MOD_NEK2_1	377	382	PF00069	0.615
MOD_NEK2_1	459	464	PF00069	0.504
MOD_NEK2_1	48	53	PF00069	0.663
MOD_NEK2_1	546	551	PF00069	0.661
MOD_NEK2_1	575	580	PF00069	0.569
MOD_NEK2_1	591	596	PF00069	0.625
MOD_NEK2_1	659	664	PF00069	0.634
MOD_NEK2_1	66	71	PF00069	0.505
MOD_NEK2_1	697	702	PF00069	0.631
MOD_NEK2_1	744	749	PF00069	0.516
MOD_NEK2_1	94	99	PF00069	0.583
MOD_NEK2_2	665	670	PF00069	0.528
MOD_PIKK_1	138	144	PF00454	0.576
MOD_PIKK_1	2	8	PF00454	0.664
MOD_PIKK_1	407	413	PF00454	0.768
MOD_PIKK_1	94	100	PF00454	0.660
MOD_PK_1	160	166	PF00069	0.682
MOD_PK_1	675	681	PF00069	0.585
MOD_PK_1	712	718	PF00069	0.539
MOD_PKA_1	159	165	PF00069	0.680
MOD_PKA_1	329	335	PF00069	0.508
MOD_PKA_2	127	133	PF00069	0.679
MOD_PKA_2	159	165	PF00069	0.646
MOD_PKA_2	166	172	PF00069	0.581
MOD_PKA_2	381	387	PF00069	0.601
MOD_PKA_2	523	529	PF00069	0.659
MOD_PKA_2	536	542	PF00069	0.544
MOD_PKA_2	711	717	PF00069	0.598
MOD_PKB_1	158	166	PF00069	0.680
MOD_Plk_1	206	212	PF00069	0.581
MOD_Plk_1	242	248	PF00069	0.647
MOD_Plk_1	48	54	PF00069	0.663
MOD_Plk_1	564	570	PF00069	0.570
MOD_Plk_1	606	612	PF00069	0.578
MOD_Plk_1	631	637	PF00069	0.588
MOD_Plk_2-3	206	212	PF00069	0.537
MOD_Plk_2-3	345	351	PF00069	0.568
MOD_Plk_2-3	800	806	PF00069	0.605
MOD_Plk_4	135	141	PF00069	0.643
MOD_Plk_4	17	23	PF00069	0.500
MOD_Plk_4	265	271	PF00069	0.737
MOD_Plk_4	474	480	PF00069	0.563
MOD_Plk_4	570	576	PF00069	0.571
MOD_Plk_4	595	601	PF00069	0.592
MOD_Plk_4	727	733	PF00069	0.587
MOD_ProDKin_1	113	119	PF00069	0.687
MOD_ProDKin_1	247	253	PF00069	0.643
MOD_ProDKin_1	334	340	PF00069	0.632
MOD_ProDKin_1	468	474	PF00069	0.635
MOD_ProDKin_1	553	559	PF00069	0.584
MOD_ProDKin_1	82	88	PF00069	0.633
MOD_SUMO_rev_2	201	210	PF00179	0.537
TRG_DiLeu_BaLyEn_6	448	453	PF01217	0.549
TRG_ENDOCYTIC_2	396	399	PF00928	0.635
TRG_ENDOCYTIC_2	759	762	PF00928	0.587
TRG_ER_diArg_1	12	15	PF00400	0.612
TRG_ER_diArg_1	158	160	PF00400	0.681
TRG_ER_diArg_1	187	190	PF00400	0.599
TRG_ER_diArg_1	386	388	PF00400	0.613
TRG_ER_diArg_1	516	518	PF00400	0.549
TRG_ER_diArg_1	797	799	PF00400	0.593
TRG_Pf-PMV_PEXEL_1	646	650	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HYD2	Leishmania infantum	99%	100%
E9AS65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	95%
Q4QDA1	Leishmania major	85%	100%