LeishMANIAdb
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Glycerol uptake protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glycerol uptake protein, putative
Gene product:
glycerol uptake protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WVJ2_LEIDO
TriTrypDb:
LdCL_190018600 , LDHU3_19.1600
Length:
840

Annotations

LeishMANIAdb annotations

Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Related to fungal GUP1 proteins.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 25
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0016020 membrane 2 26
GO:0110165 cellular anatomical entity 1 26
GO:0005737 cytoplasm 2 4
GO:0005783 endoplasmic reticulum 5 4
GO:0043226 organelle 2 4
GO:0043227 membrane-bounded organelle 3 4
GO:0043229 intracellular organelle 3 4
GO:0043231 intracellular membrane-bounded organelle 4 4

Expansion

Sequence features

A0A3S7WVJ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVJ2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0016740 transferase activity 2 5
GO:0016746 acyltransferase activity 3 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 353 357 PF00656 0.362
CLV_MEL_PAP_1 64 70 PF00089 0.602
CLV_NRD_NRD_1 258 260 PF00675 0.420
CLV_NRD_NRD_1 510 512 PF00675 0.306
CLV_NRD_NRD_1 592 594 PF00675 0.284
CLV_NRD_NRD_1 680 682 PF00675 0.404
CLV_NRD_NRD_1 708 710 PF00675 0.432
CLV_NRD_NRD_1 721 723 PF00675 0.376
CLV_PCSK_KEX2_1 258 260 PF00082 0.437
CLV_PCSK_KEX2_1 592 594 PF00082 0.284
CLV_PCSK_KEX2_1 680 682 PF00082 0.404
CLV_PCSK_KEX2_1 708 710 PF00082 0.432
CLV_PCSK_KEX2_1 721 723 PF00082 0.394
CLV_PCSK_KEX2_1 828 830 PF00082 0.406
CLV_PCSK_PC1ET2_1 828 830 PF00082 0.477
CLV_PCSK_PC7_1 717 723 PF00082 0.421
CLV_PCSK_SKI1_1 171 175 PF00082 0.583
CLV_PCSK_SKI1_1 282 286 PF00082 0.381
CLV_PCSK_SKI1_1 515 519 PF00082 0.300
CLV_PCSK_SKI1_1 629 633 PF00082 0.326
CLV_PCSK_SKI1_1 709 713 PF00082 0.421
DEG_APCC_DBOX_1 628 636 PF00400 0.395
DEG_APCC_DBOX_1 708 716 PF00400 0.627
DEG_SCF_FBW7_1 260 267 PF00400 0.590
DEG_SPOP_SBC_1 235 239 PF00917 0.622
DEG_SPOP_SBC_1 503 507 PF00917 0.544
DOC_CDC14_PxL_1 533 541 PF14671 0.391
DOC_CKS1_1 182 187 PF01111 0.284
DOC_CKS1_1 261 266 PF01111 0.612
DOC_CKS1_1 786 791 PF01111 0.291
DOC_CYCLIN_yCln2_LP_2 481 487 PF00134 0.403
DOC_MAPK_DCC_7 179 188 PF00069 0.290
DOC_MAPK_DCC_7 629 639 PF00069 0.337
DOC_MAPK_gen_1 171 180 PF00069 0.289
DOC_MAPK_gen_1 388 397 PF00069 0.349
DOC_MAPK_gen_1 627 634 PF00069 0.476
DOC_MAPK_MEF2A_6 212 220 PF00069 0.294
DOC_MAPK_MEF2A_6 55 64 PF00069 0.412
DOC_MAPK_MEF2A_6 627 634 PF00069 0.503
DOC_PP1_RVXF_1 116 122 PF00149 0.454
DOC_PP1_RVXF_1 371 377 PF00149 0.360
DOC_PP1_RVXF_1 401 408 PF00149 0.304
DOC_PP1_SILK_1 518 523 PF00149 0.354
DOC_PP2B_LxvP_1 481 484 PF13499 0.403
DOC_PP4_FxxP_1 121 124 PF00568 0.309
DOC_PP4_FxxP_1 311 314 PF00568 0.338
DOC_USP7_MATH_1 236 240 PF00917 0.691
DOC_USP7_MATH_1 264 268 PF00917 0.604
DOC_USP7_MATH_1 29 33 PF00917 0.455
DOC_USP7_MATH_1 40 44 PF00917 0.436
DOC_USP7_MATH_1 490 494 PF00917 0.340
DOC_USP7_MATH_1 496 500 PF00917 0.499
DOC_USP7_MATH_1 504 508 PF00917 0.499
DOC_USP7_MATH_1 56 60 PF00917 0.397
DOC_USP7_MATH_1 707 711 PF00917 0.631
DOC_USP7_MATH_1 78 82 PF00917 0.419
DOC_USP7_MATH_1 91 95 PF00917 0.434
DOC_WW_Pin1_4 102 107 PF00397 0.490
DOC_WW_Pin1_4 108 113 PF00397 0.429
DOC_WW_Pin1_4 120 125 PF00397 0.317
DOC_WW_Pin1_4 181 186 PF00397 0.289
DOC_WW_Pin1_4 20 25 PF00397 0.419
DOC_WW_Pin1_4 231 236 PF00397 0.648
DOC_WW_Pin1_4 238 243 PF00397 0.688
DOC_WW_Pin1_4 260 265 PF00397 0.652
DOC_WW_Pin1_4 288 293 PF00397 0.204
DOC_WW_Pin1_4 5 10 PF00397 0.446
DOC_WW_Pin1_4 721 726 PF00397 0.659
DOC_WW_Pin1_4 785 790 PF00397 0.391
DOC_WW_Pin1_4 831 836 PF00397 0.633
LIG_14-3-3_CanoR_1 141 146 PF00244 0.565
LIG_14-3-3_CanoR_1 18 24 PF00244 0.418
LIG_14-3-3_CanoR_1 231 235 PF00244 0.667
LIG_14-3-3_CanoR_1 287 295 PF00244 0.430
LIG_14-3-3_CanoR_1 38 48 PF00244 0.443
LIG_14-3-3_CanoR_1 398 403 PF00244 0.349
LIG_14-3-3_CanoR_1 502 510 PF00244 0.544
LIG_14-3-3_CanoR_1 522 531 PF00244 0.211
LIG_14-3-3_CanoR_1 548 552 PF00244 0.309
LIG_14-3-3_CanoR_1 629 635 PF00244 0.410
LIG_14-3-3_CanoR_1 67 71 PF00244 0.406
LIG_14-3-3_CanoR_1 708 712 PF00244 0.616
LIG_14-3-3_CanoR_1 717 725 PF00244 0.582
LIG_14-3-3_CanoR_1 782 791 PF00244 0.304
LIG_Actin_WH2_2 174 191 PF00022 0.289
LIG_Actin_WH2_2 388 405 PF00022 0.318
LIG_Actin_WH2_2 554 570 PF00022 0.309
LIG_BRCT_BRCA1_1 540 544 PF00533 0.300
LIG_BRCT_BRCA1_1 575 579 PF00533 0.529
LIG_BRCT_BRCA1_1 668 672 PF00533 0.395
LIG_BRCT_BRCA1_1 741 745 PF00533 0.252
LIG_CtBP_PxDLS_1 588 592 PF00389 0.486
LIG_deltaCOP1_diTrp_1 200 206 PF00928 0.341
LIG_deltaCOP1_diTrp_1 607 615 PF00928 0.494
LIG_DLG_GKlike_1 141 148 PF00625 0.507
LIG_eIF4E_1 175 181 PF01652 0.304
LIG_eIF4E_1 476 482 PF01652 0.403
LIG_FHA_1 123 129 PF00498 0.364
LIG_FHA_1 20 26 PF00498 0.417
LIG_FHA_1 359 365 PF00498 0.399
LIG_FHA_1 399 405 PF00498 0.354
LIG_FHA_1 429 435 PF00498 0.391
LIG_FHA_1 596 602 PF00498 0.497
LIG_FHA_1 687 693 PF00498 0.649
LIG_FHA_1 791 797 PF00498 0.385
LIG_FHA_2 124 130 PF00498 0.458
LIG_FHA_2 276 282 PF00498 0.543
LIG_FHA_2 548 554 PF00498 0.336
LIG_FHA_2 767 773 PF00498 0.442
LIG_FHA_2 832 838 PF00498 0.637
LIG_GBD_Chelix_1 749 757 PF00786 0.232
LIG_Integrin_isoDGR_2 699 701 PF01839 0.458
LIG_LIR_Gen_1 134 140 PF02991 0.540
LIG_LIR_Gen_1 184 195 PF02991 0.394
LIG_LIR_Gen_1 470 479 PF02991 0.305
LIG_LIR_Gen_1 492 501 PF02991 0.403
LIG_LIR_Gen_1 526 536 PF02991 0.338
LIG_LIR_Gen_1 541 552 PF02991 0.242
LIG_LIR_Gen_1 576 587 PF02991 0.553
LIG_LIR_Gen_1 742 753 PF02991 0.235
LIG_LIR_Gen_1 783 792 PF02991 0.293
LIG_LIR_Nem_3 134 138 PF02991 0.548
LIG_LIR_Nem_3 184 190 PF02991 0.359
LIG_LIR_Nem_3 192 198 PF02991 0.321
LIG_LIR_Nem_3 200 206 PF02991 0.331
LIG_LIR_Nem_3 291 297 PF02991 0.257
LIG_LIR_Nem_3 361 366 PF02991 0.409
LIG_LIR_Nem_3 470 476 PF02991 0.312
LIG_LIR_Nem_3 492 497 PF02991 0.315
LIG_LIR_Nem_3 526 531 PF02991 0.338
LIG_LIR_Nem_3 541 547 PF02991 0.269
LIG_LIR_Nem_3 576 582 PF02991 0.561
LIG_LIR_Nem_3 742 748 PF02991 0.296
LIG_LIR_Nem_3 783 787 PF02991 0.318
LIG_LYPXL_yS_3 210 213 PF13949 0.213
LIG_OCRL_FandH_1 167 179 PF00620 0.287
LIG_Pex14_1 363 367 PF04695 0.429
LIG_Pex14_1 393 397 PF04695 0.325
LIG_Pex14_1 608 612 PF04695 0.497
LIG_Pex14_1 615 619 PF04695 0.497
LIG_Pex14_2 569 573 PF04695 0.339
LIG_Pex14_2 604 608 PF04695 0.499
LIG_Pex14_2 640 644 PF04695 0.357
LIG_SH2_CRK 135 139 PF00017 0.541
LIG_SH2_CRK 195 199 PF00017 0.322
LIG_SH2_CRK 295 299 PF00017 0.334
LIG_SH2_CRK 471 475 PF00017 0.289
LIG_SH2_CRK 528 532 PF00017 0.321
LIG_SH2_CRK 542 546 PF00017 0.242
LIG_SH2_CRK 619 623 PF00017 0.497
LIG_SH2_GRB2like 195 198 PF00017 0.339
LIG_SH2_NCK_1 135 139 PF00017 0.541
LIG_SH2_NCK_1 295 299 PF00017 0.350
LIG_SH2_PTP2 156 159 PF00017 0.339
LIG_SH2_STAP1 476 480 PF00017 0.354
LIG_SH2_STAP1 542 546 PF00017 0.304
LIG_SH2_STAT3 362 365 PF00017 0.409
LIG_SH2_STAT5 120 123 PF00017 0.229
LIG_SH2_STAT5 147 150 PF00017 0.317
LIG_SH2_STAT5 156 159 PF00017 0.311
LIG_SH2_STAT5 295 298 PF00017 0.399
LIG_SH2_STAT5 322 325 PF00017 0.491
LIG_SH2_STAT5 350 353 PF00017 0.481
LIG_SH2_STAT5 366 369 PF00017 0.380
LIG_SH2_STAT5 479 482 PF00017 0.352
LIG_SH2_STAT5 486 489 PF00017 0.360
LIG_SH2_STAT5 524 527 PF00017 0.383
LIG_SH2_STAT5 528 531 PF00017 0.344
LIG_SH2_STAT5 564 567 PF00017 0.326
LIG_SH2_STAT5 621 624 PF00017 0.497
LIG_SH2_STAT5 800 803 PF00017 0.272
LIG_SH3_1 258 264 PF00018 0.599
LIG_SH3_3 258 264 PF00018 0.651
LIG_SH3_3 303 309 PF00018 0.437
LIG_SH3_3 34 40 PF00018 0.431
LIG_SH3_3 379 385 PF00018 0.376
LIG_SH3_3 477 483 PF00018 0.432
LIG_SH3_3 531 537 PF00018 0.391
LIG_SH3_3 65 71 PF00018 0.432
LIG_Sin3_3 215 222 PF02671 0.216
LIG_SUMO_SIM_anti_2 803 809 PF11976 0.251
LIG_SUMO_SIM_par_1 21 28 PF11976 0.415
LIG_SUMO_SIM_par_1 350 356 PF11976 0.435
LIG_SUMO_SIM_par_1 795 801 PF11976 0.247
LIG_TRAF2_1 87 90 PF00917 0.397
LIG_TRFH_1 479 483 PF08558 0.403
LIG_TYR_ITIM 562 567 PF00017 0.350
LIG_TYR_ITIM 617 622 PF00017 0.335
LIG_UBA3_1 561 568 PF00899 0.354
LIG_UBA3_1 816 825 PF00899 0.403
LIG_WRC_WIRS_1 491 496 PF05994 0.340
LIG_WW_1 483 486 PF00397 0.403
MOD_CDK_SPK_2 721 726 PF00069 0.403
MOD_CDK_SPxxK_3 108 115 PF00069 0.485
MOD_CDK_SPxxK_3 721 728 PF00069 0.390
MOD_CK1_1 123 129 PF00069 0.345
MOD_CK1_1 230 236 PF00069 0.614
MOD_CK1_1 237 243 PF00069 0.661
MOD_CK1_1 244 250 PF00069 0.576
MOD_CK1_1 28 34 PF00069 0.525
MOD_CK1_1 288 294 PF00069 0.204
MOD_CK1_1 724 730 PF00069 0.397
MOD_CK1_1 760 766 PF00069 0.505
MOD_CK1_1 785 791 PF00069 0.371
MOD_CK1_1 798 804 PF00069 0.222
MOD_CK1_1 81 87 PF00069 0.535
MOD_CK1_1 831 837 PF00069 0.549
MOD_CK1_1 94 100 PF00069 0.559
MOD_CK2_1 275 281 PF00069 0.407
MOD_CK2_1 44 50 PF00069 0.535
MOD_CK2_1 547 553 PF00069 0.414
MOD_CK2_1 580 586 PF00069 0.346
MOD_CK2_1 766 772 PF00069 0.458
MOD_CK2_1 83 89 PF00069 0.475
MOD_CK2_1 831 837 PF00069 0.526
MOD_CMANNOS 605 608 PF00535 0.340
MOD_DYRK1A_RPxSP_1 231 235 PF00069 0.442
MOD_GlcNHglycan 10 13 PF01048 0.548
MOD_GlcNHglycan 106 109 PF01048 0.501
MOD_GlcNHglycan 223 226 PF01048 0.399
MOD_GlcNHglycan 243 246 PF01048 0.618
MOD_GlcNHglycan 27 30 PF01048 0.523
MOD_GlcNHglycan 445 448 PF01048 0.472
MOD_GlcNHglycan 582 585 PF01048 0.403
MOD_GlcNHglycan 668 671 PF01048 0.338
MOD_GlcNHglycan 718 721 PF01048 0.477
MOD_GlcNHglycan 760 763 PF01048 0.452
MOD_GlcNHglycan 830 833 PF01048 0.508
MOD_GlcNHglycan 85 88 PF01048 0.499
MOD_GSK3_1 104 111 PF00069 0.610
MOD_GSK3_1 227 234 PF00069 0.548
MOD_GSK3_1 237 244 PF00069 0.634
MOD_GSK3_1 25 32 PF00069 0.519
MOD_GSK3_1 260 267 PF00069 0.557
MOD_GSK3_1 40 47 PF00069 0.539
MOD_GSK3_1 62 69 PF00069 0.490
MOD_GSK3_1 686 693 PF00069 0.520
MOD_GSK3_1 753 760 PF00069 0.431
MOD_GSK3_1 767 774 PF00069 0.465
MOD_GSK3_1 78 85 PF00069 0.491
MOD_GSK3_1 827 834 PF00069 0.484
MOD_LATS_1 500 506 PF00433 0.305
MOD_N-GLC_1 196 201 PF02516 0.354
MOD_N-GLC_1 758 763 PF02516 0.389
MOD_NEK2_1 19 24 PF00069 0.509
MOD_NEK2_1 285 290 PF00069 0.627
MOD_NEK2_1 358 363 PF00069 0.464
MOD_NEK2_1 397 402 PF00069 0.387
MOD_NEK2_1 547 552 PF00069 0.410
MOD_NEK2_1 567 572 PF00069 0.361
MOD_NEK2_1 595 600 PF00069 0.335
MOD_NEK2_1 757 762 PF00069 0.436
MOD_NEK2_1 795 800 PF00069 0.359
MOD_NEK2_1 82 87 PF00069 0.490
MOD_NEK2_2 264 269 PF00069 0.466
MOD_NEK2_2 29 34 PF00069 0.519
MOD_NEK2_2 740 745 PF00069 0.261
MOD_PIKK_1 782 788 PF00454 0.346
MOD_PKA_1 828 834 PF00069 0.493
MOD_PKA_2 227 233 PF00069 0.398
MOD_PKA_2 286 292 PF00069 0.299
MOD_PKA_2 397 403 PF00069 0.401
MOD_PKA_2 547 553 PF00069 0.354
MOD_PKA_2 66 72 PF00069 0.482
MOD_PKA_2 700 706 PF00069 0.543
MOD_PKA_2 707 713 PF00069 0.472
MOD_PKA_2 716 722 PF00069 0.410
MOD_PKA_2 828 834 PF00069 0.498
MOD_Plk_1 29 35 PF00069 0.510
MOD_Plk_1 358 364 PF00069 0.405
MOD_Plk_1 526 532 PF00069 0.342
MOD_Plk_4 134 140 PF00069 0.628
MOD_Plk_4 264 270 PF00069 0.491
MOD_Plk_4 293 299 PF00069 0.358
MOD_Plk_4 344 350 PF00069 0.333
MOD_Plk_4 358 364 PF00069 0.450
MOD_Plk_4 526 532 PF00069 0.411
MOD_Plk_4 547 553 PF00069 0.382
MOD_Plk_4 630 636 PF00069 0.338
MOD_Plk_4 740 746 PF00069 0.262
MOD_Plk_4 795 801 PF00069 0.336
MOD_Plk_4 815 821 PF00069 0.412
MOD_ProDKin_1 102 108 PF00069 0.606
MOD_ProDKin_1 120 126 PF00069 0.331
MOD_ProDKin_1 181 187 PF00069 0.319
MOD_ProDKin_1 20 26 PF00069 0.508
MOD_ProDKin_1 231 237 PF00069 0.556
MOD_ProDKin_1 238 244 PF00069 0.603
MOD_ProDKin_1 260 266 PF00069 0.551
MOD_ProDKin_1 288 294 PF00069 0.204
MOD_ProDKin_1 5 11 PF00069 0.547
MOD_ProDKin_1 721 727 PF00069 0.562
MOD_ProDKin_1 785 791 PF00069 0.461
MOD_ProDKin_1 831 837 PF00069 0.531
TRG_DiLeu_BaEn_2 552 558 PF01217 0.395
TRG_DiLeu_BaLyEn_6 311 316 PF01217 0.399
TRG_DiLeu_BaLyEn_6 400 405 PF01217 0.424
TRG_ENDOCYTIC_2 135 138 PF00928 0.545
TRG_ENDOCYTIC_2 156 159 PF00928 0.277
TRG_ENDOCYTIC_2 175 178 PF00928 0.558
TRG_ENDOCYTIC_2 195 198 PF00928 0.404
TRG_ENDOCYTIC_2 210 213 PF00928 0.388
TRG_ENDOCYTIC_2 295 298 PF00928 0.334
TRG_ENDOCYTIC_2 322 325 PF00928 0.328
TRG_ENDOCYTIC_2 334 337 PF00928 0.335
TRG_ENDOCYTIC_2 471 474 PF00928 0.333
TRG_ENDOCYTIC_2 479 482 PF00928 0.346
TRG_ENDOCYTIC_2 528 531 PF00928 0.342
TRG_ENDOCYTIC_2 542 545 PF00928 0.314
TRG_ENDOCYTIC_2 564 567 PF00928 0.349
TRG_ENDOCYTIC_2 619 622 PF00928 0.338
TRG_ER_diArg_1 258 260 PF00400 0.572
TRG_ER_diArg_1 390 393 PF00400 0.420
TRG_ER_diArg_1 591 593 PF00400 0.319
TRG_ER_diArg_1 627 630 PF00400 0.346
TRG_ER_diArg_1 679 681 PF00400 0.488
TRG_ER_diArg_1 707 709 PF00400 0.551
TRG_ER_diArg_1 721 723 PF00400 0.440
TRG_ER_diArg_1 725 728 PF00400 0.383

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0P614 Trypanosomatidae 32% 100%
A0A3Q8IAC1 Leishmania donovani 69% 100%
A0A3Q8IBC3 Leishmania donovani 71% 99%
A0A3Q8IBE0 Leishmania donovani 100% 100%
A0A3Q8IDD7 Leishmania donovani 71% 100%
A0A3S5H769 Leishmania donovani 74% 100%
A0A3S7WVK4 Leishmania donovani 74% 100%
A4HA75 Leishmania braziliensis 61% 100%
A4HA76 Leishmania braziliensis 63% 100%
A4HA77 Leishmania braziliensis 57% 100%
A4HA80 Leishmania braziliensis 59% 100%
A4HA81 Leishmania braziliensis 61% 100%
A4HA82 Leishmania braziliensis 62% 100%
E8NHJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
E9AGT0 Leishmania infantum 99% 100%
E9AGT1 Leishmania infantum 82% 100%
E9AGT3 Leishmania infantum 74% 100%
E9AGT4 Leishmania infantum 71% 100%
E9AS85 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 97%
E9AS86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
Q4QD78 Leishmania major 68% 100%
Q4QD79 Leishmania major 70% 100%
Q4QD80 Leishmania major 73% 100%
Q4QD81 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS