Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVI2_LEIDO

TriTrypDb:

LdBPK_191250.1 , LdCL_190017600 , LDHU3_19.1510

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WVI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVI2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.481
CLV_NRD_NRD_1	36	38	PF00675	0.415
CLV_NRD_NRD_1	51	53	PF00675	0.485
CLV_PCSK_KEX2_1	113	115	PF00082	0.428
CLV_PCSK_KEX2_1	125	127	PF00082	0.391
CLV_PCSK_KEX2_1	17	19	PF00082	0.481
CLV_PCSK_KEX2_1	36	38	PF00082	0.400
CLV_PCSK_KEX2_1	51	53	PF00082	0.512
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.415
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.391
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.425
CLV_PCSK_SKI1_1	139	143	PF00082	0.398
CLV_PCSK_SKI1_1	27	31	PF00082	0.498
DEG_APCC_DBOX_1	138	146	PF00400	0.317
DOC_MAPK_FxFP_2	40	43	PF00069	0.462
DOC_MAPK_gen_1	113	119	PF00069	0.386
DOC_PP4_FxxP_1	29	32	PF00568	0.530
DOC_PP4_FxxP_1	40	43	PF00568	0.384
DOC_USP7_MATH_1	137	141	PF00917	0.321
DOC_USP7_MATH_1	20	24	PF00917	0.468
DOC_USP7_MATH_1	94	98	PF00917	0.633
DOC_WW_Pin1_4	58	63	PF00397	0.475
DOC_WW_Pin1_4	88	93	PF00397	0.663
LIG_14-3-3_CanoR_1	17	24	PF00244	0.579
LIG_14-3-3_CanoR_1	37	41	PF00244	0.512
LIG_14-3-3_CterR_2	169	171	PF00244	0.530
LIG_Actin_WH2_2	4	19	PF00022	0.511
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_BRCT_BRCA1_1	82	86	PF00533	0.498
LIG_FHA_1	158	164	PF00498	0.404
LIG_FHA_2	163	169	PF00498	0.516
LIG_LIR_Apic_2	39	43	PF02991	0.484
LIG_LIR_Nem_3	127	132	PF02991	0.357
LIG_RPA_C_Fungi	13	25	PF08784	0.537
LIG_SH2_STAP1	159	163	PF00017	0.364
LIG_SH2_STAT5	159	162	PF00017	0.361
LIG_SUMO_SIM_par_1	140	148	PF11976	0.411
LIG_WRC_WIRS_1	11	16	PF05994	0.446
MOD_CDK_SPK_2	90	95	PF00069	0.584
MOD_CDK_SPxxK_3	88	95	PF00069	0.545
MOD_CK1_1	97	103	PF00069	0.574
MOD_CK2_1	162	168	PF00069	0.496
MOD_Cter_Amidation	123	126	PF01082	0.470
MOD_DYRK1A_RPxSP_1	90	94	PF00069	0.634
MOD_GlcNHglycan	139	142	PF01048	0.499
MOD_GlcNHglycan	96	99	PF01048	0.631
MOD_GSK3_1	16	23	PF00069	0.573
MOD_GSK3_1	56	63	PF00069	0.611
MOD_GSK3_1	80	87	PF00069	0.494
MOD_GSK3_1	90	97	PF00069	0.594
MOD_NEK2_1	16	21	PF00069	0.553
MOD_NEK2_1	86	91	PF00069	0.564
MOD_NEK2_2	20	25	PF00069	0.469
MOD_PKA_1	113	119	PF00069	0.438
MOD_PKA_1	125	131	PF00069	0.314
MOD_PKA_1	36	42	PF00069	0.545
MOD_PKA_2	113	119	PF00069	0.307
MOD_PKA_2	125	131	PF00069	0.314
MOD_PKA_2	16	22	PF00069	0.585
MOD_PKA_2	36	42	PF00069	0.556
MOD_PKA_2	80	86	PF00069	0.509
MOD_PKA_2	94	100	PF00069	0.669
MOD_Plk_1	84	90	PF00069	0.491
MOD_Plk_4	10	16	PF00069	0.450
MOD_Plk_4	125	131	PF00069	0.334
MOD_ProDKin_1	58	64	PF00069	0.478
MOD_ProDKin_1	88	94	PF00069	0.667
TRG_ENDOCYTIC_2	71	74	PF00928	0.552
TRG_ER_diArg_1	101	104	PF00400	0.537
TRG_ER_diArg_1	16	18	PF00400	0.458
TRG_ER_diArg_1	51	53	PF00400	0.403
TRG_ER_diArg_1	79	82	PF00400	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JUD0	Bodo saltans	52%	100%
A0A1X0P6W6	Trypanosomatidae	68%	100%
A0A422NUM9	Trypanosoma rangeli	68%	100%
A4HA72	Leishmania braziliensis	95%	100%
A4HYE4	Leishmania infantum	100%	100%
D0A0S9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AS77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QD89	Leishmania major	98%	100%