Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVI0_LEIDO

TriTrypDb:

LdBPK_191210.1 , LdCL_190017200 , LDHU3_19.1450

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.486
CLV_NRD_NRD_1	11	13	PF00675	0.444
CLV_NRD_NRD_1	118	120	PF00675	0.555
CLV_NRD_NRD_1	199	201	PF00675	0.516
CLV_NRD_NRD_1	95	97	PF00675	0.422
CLV_PCSK_FUR_1	199	203	PF00082	0.523
CLV_PCSK_KEX2_1	10	12	PF00082	0.448
CLV_PCSK_KEX2_1	118	120	PF00082	0.546
CLV_PCSK_KEX2_1	199	201	PF00082	0.516
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.522
CLV_PCSK_PC7_1	195	201	PF00082	0.607
CLV_PCSK_SKI1_1	119	123	PF00082	0.537
DEG_Nend_UBRbox_3	1	3	PF02207	0.453
DEG_SCF_FBW7_1	107	112	PF00400	0.510
DOC_ANK_TNKS_1	147	154	PF00023	0.496
DOC_USP7_MATH_1	109	113	PF00917	0.448
DOC_USP7_MATH_1	175	179	PF00917	0.696
DOC_USP7_UBL2_3	209	213	PF12436	0.549
DOC_WW_Pin1_4	105	110	PF00397	0.525
DOC_WW_Pin1_4	216	221	PF00397	0.665
LIG_14-3-3_CanoR_1	171	175	PF00244	0.589
LIG_BRCT_BRCA1_1	111	115	PF00533	0.432
LIG_FHA_1	27	33	PF00498	0.512
LIG_FHA_2	171	177	PF00498	0.679
LIG_Integrin_RGD_1	45	47	PF01839	0.377
LIG_LIR_Apic_2	225	231	PF02991	0.702
LIG_LIR_Nem_3	129	134	PF02991	0.468
LIG_LIR_Nem_3	184	190	PF02991	0.462
LIG_NRBOX	31	37	PF00104	0.347
LIG_SH2_CRK	131	135	PF00017	0.375
LIG_SH2_SRC	190	193	PF00017	0.494
LIG_SH2_SRC	31	34	PF00017	0.485
LIG_SH2_STAP1	90	94	PF00017	0.392
LIG_SH2_STAT3	212	215	PF00017	0.547
LIG_SH2_STAT3	57	60	PF00017	0.556
LIG_SH2_STAT5	190	193	PF00017	0.627
LIG_SH2_STAT5	31	34	PF00017	0.485
LIG_SH2_STAT5	57	60	PF00017	0.396
LIG_SH2_STAT5	73	76	PF00017	0.251
MOD_CDK_SPxxK_3	216	223	PF00069	0.556
MOD_CK1_1	101	107	PF00069	0.526
MOD_CK1_1	219	225	PF00069	0.626
MOD_CK1_1	67	73	PF00069	0.488
MOD_CK2_1	219	225	PF00069	0.671
MOD_GlcNHglycan	103	106	PF01048	0.508
MOD_GlcNHglycan	115	118	PF01048	0.358
MOD_GlcNHglycan	149	152	PF01048	0.566
MOD_GlcNHglycan	160	163	PF01048	0.648
MOD_GlcNHglycan	49	52	PF01048	0.489
MOD_GSK3_1	101	108	PF00069	0.468
MOD_GSK3_1	109	116	PF00069	0.412
MOD_GSK3_1	158	165	PF00069	0.714
MOD_GSK3_1	215	222	PF00069	0.670
MOD_N-GLC_1	26	31	PF02516	0.551
MOD_NEK2_1	38	43	PF00069	0.361
MOD_NEK2_1	74	79	PF00069	0.382
MOD_PKA_1	25	31	PF00069	0.534
MOD_PKA_2	147	153	PF00069	0.668
MOD_PKA_2	158	164	PF00069	0.629
MOD_PKA_2	167	173	PF00069	0.637
MOD_Plk_1	26	32	PF00069	0.587
MOD_Plk_1	98	104	PF00069	0.583
MOD_Plk_4	109	115	PF00069	0.435
MOD_Plk_4	31	37	PF00069	0.407
MOD_Plk_4	67	73	PF00069	0.399
MOD_ProDKin_1	105	111	PF00069	0.524
MOD_ProDKin_1	216	222	PF00069	0.668
MOD_SUMO_rev_2	18	28	PF00179	0.425
TRG_ENDOCYTIC_2	131	134	PF00928	0.366
TRG_ER_diArg_1	10	12	PF00400	0.448
TRG_ER_diArg_1	199	202	PF00400	0.526
TRG_NLS_MonoExtC_3	121	127	PF00514	0.409
TRG_NLS_MonoExtN_4	119	126	PF00514	0.422
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDU4	Leptomonas seymouri	65%	85%
A0A0S4JKU3	Bodo saltans	34%	100%
A0A1X0P732	Trypanosomatidae	48%	79%
A0A3R7K6K4	Trypanosoma rangeli	48%	86%
A4HA59	Leishmania braziliensis	83%	100%
A4HYE0	Leishmania infantum	100%	100%
D0A0S5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	85%
E9AS73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QD93	Leishmania major	94%	100%
V5BNH1	Trypanosoma cruzi	47%	80%