tRNA pseudouridine synthase A-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA pseudouridine synthase A-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WVG1_LEIDO

TriTrypDb:

LdBPK_190990.1 , LdCL_190015200 , LDHU3_19.1230

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVG1

Function

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Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	6
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	6

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0004730	pseudouridylate synthase activity	5	6
GO:0005488	binding	1	11
GO:0009982	pseudouridine synthase activity	4	11
GO:0016829	lyase activity	2	6
GO:0016835	carbon-oxygen lyase activity	3	6
GO:0016836	hydro-lyase activity	4	6
GO:0016853	isomerase activity	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.583
CLV_NRD_NRD_1	20	22	PF00675	0.605
CLV_NRD_NRD_1	213	215	PF00675	0.377
CLV_NRD_NRD_1	243	245	PF00675	0.532
CLV_NRD_NRD_1	268	270	PF00675	0.331
CLV_NRD_NRD_1	327	329	PF00675	0.379
CLV_NRD_NRD_1	360	362	PF00675	0.689
CLV_NRD_NRD_1	475	477	PF00675	0.344
CLV_PCSK_KEX2_1	20	22	PF00082	0.601
CLV_PCSK_KEX2_1	213	215	PF00082	0.377

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I702	Leptomonas seymouri	72%	79%
A0A1X0P663	Trypanosomatidae	61%	84%
A0A422NHE5	Trypanosoma rangeli	62%	86%
A4HA54	Leishmania braziliensis	85%	100%
A4HYB9	Leishmania infantum	100%	100%
D0A0P7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	89%
E9AS53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QDB3	Leishmania major	96%	100%
V5BNI6	Trypanosoma cruzi	65%	86%

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