UvrB/uvrC motif containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

centrosomal protein of 104 kDa

Species:

Leishmania donovani

UniProt:

A0A3S7WVF9_LEIDO

TriTrypDb:

LdBPK_190240.1 , LdCL_190007400 , LDHU3_19.0280

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7WVF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVF9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.665
CLV_C14_Caspase3-7	718	722	PF00656	0.675
CLV_C14_Caspase3-7	90	94	PF00656	0.516
CLV_NRD_NRD_1	43	45	PF00675	0.435
CLV_NRD_NRD_1	437	439	PF00675	0.480
CLV_NRD_NRD_1	553	555	PF00675	0.478
CLV_NRD_NRD_1	673	675	PF00675	0.634
CLV_NRD_NRD_1	743	745	PF00675	0.480
CLV_NRD_NRD_1	800	802	PF00675	0.478
CLV_PCSK_KEX2_1	105	107	PF00082	0.446
CLV_PCSK_KEX2_1	400	402	PF00082	0.545
CLV_PCSK_KEX2_1	553	555	PF00082	0.476
CLV_PCSK_KEX2_1	743	745	PF00082	0.471
CLV_PCSK_KEX2_1	799	801	PF00082	0.477
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.509
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.505
CLV_PCSK_PC1ET2_1	799	801	PF00082	0.505
CLV_PCSK_SKI1_1	101	105	PF00082	0.542
CLV_PCSK_SKI1_1	123	127	PF00082	0.361
CLV_PCSK_SKI1_1	138	142	PF00082	0.339
CLV_PCSK_SKI1_1	212	216	PF00082	0.506
CLV_PCSK_SKI1_1	270	274	PF00082	0.472
CLV_PCSK_SKI1_1	631	635	PF00082	0.354
DEG_Nend_Nbox_1	1	3	PF02207	0.551
DEG_SPOP_SBC_1	637	641	PF00917	0.524
DOC_ANK_TNKS_1	593	600	PF00023	0.459
DOC_CDC14_PxL_1	608	616	PF14671	0.520
DOC_CDC14_PxL_1	730	738	PF14671	0.610
DOC_CKS1_1	174	179	PF01111	0.518
DOC_CKS1_1	203	208	PF01111	0.556
DOC_CYCLIN_RxL_1	270	281	PF00134	0.494
DOC_CYCLIN_RxL_1	628	639	PF00134	0.383
DOC_MAPK_gen_1	105	112	PF00069	0.448
DOC_MAPK_gen_1	270	279	PF00069	0.552
DOC_MAPK_gen_1	553	561	PF00069	0.514
DOC_MAPK_gen_1	674	681	PF00069	0.477
DOC_MAPK_MEF2A_6	132	141	PF00069	0.359
DOC_MAPK_MEF2A_6	270	279	PF00069	0.568
DOC_MAPK_MEF2A_6	553	560	PF00069	0.478
DOC_MAPK_MEF2A_6	7	14	PF00069	0.402
DOC_MAPK_MEF2A_6	74	83	PF00069	0.381
DOC_PP1_RVXF_1	629	635	PF00149	0.420
DOC_PP4_FxxP_1	307	310	PF00568	0.697
DOC_PP4_FxxP_1	634	637	PF00568	0.450
DOC_PP4_MxPP_1	193	196	PF00568	0.464
DOC_USP7_MATH_1	320	324	PF00917	0.722
DOC_USP7_MATH_1	450	454	PF00917	0.506
DOC_USP7_MATH_1	458	462	PF00917	0.412
DOC_USP7_MATH_1	505	509	PF00917	0.447
DOC_USP7_MATH_1	575	579	PF00917	0.474
DOC_USP7_MATH_1	668	672	PF00917	0.414
DOC_USP7_MATH_1	685	689	PF00917	0.688
DOC_USP7_MATH_1	701	705	PF00917	0.726
DOC_USP7_UBL2_3	101	105	PF12436	0.501
DOC_USP7_UBL2_3	421	425	PF12436	0.516
DOC_USP7_UBL2_3	565	569	PF12436	0.579
DOC_WW_Pin1_4	173	178	PF00397	0.510
DOC_WW_Pin1_4	199	204	PF00397	0.710
DOC_WW_Pin1_4	306	311	PF00397	0.768
DOC_WW_Pin1_4	312	317	PF00397	0.797
DOC_WW_Pin1_4	407	412	PF00397	0.499
DOC_WW_Pin1_4	545	550	PF00397	0.497
DOC_WW_Pin1_4	690	695	PF00397	0.675
DOC_WW_Pin1_4	855	860	PF00397	0.442
LIG_14-3-3_CanoR_1	132	137	PF00244	0.422
LIG_14-3-3_CanoR_1	216	223	PF00244	0.538
LIG_14-3-3_CanoR_1	401	406	PF00244	0.528
LIG_14-3-3_CanoR_1	44	50	PF00244	0.489
LIG_14-3-3_CanoR_1	674	681	PF00244	0.477
LIG_14-3-3_CanoR_1	703	707	PF00244	0.729
LIG_14-3-3_CanoR_1	723	728	PF00244	0.693
LIG_14-3-3_CanoR_1	814	822	PF00244	0.543
LIG_AP2alpha_1	586	590	PF02296	0.484
LIG_BIR_III_2	305	309	PF00653	0.608
LIG_BIR_III_4	361	365	PF00653	0.696
LIG_Clathr_ClatBox_1	558	562	PF01394	0.508
LIG_Clathr_ClatBox_1	632	636	PF01394	0.479
LIG_eIF4E_1	430	436	PF01652	0.343
LIG_EVH1_1	307	311	PF00568	0.599
LIG_FHA_1	125	131	PF00498	0.374
LIG_FHA_1	185	191	PF00498	0.505
LIG_FHA_1	208	214	PF00498	0.635
LIG_FHA_1	279	285	PF00498	0.499
LIG_FHA_1	361	367	PF00498	0.713
LIG_FHA_1	422	428	PF00498	0.436
LIG_FHA_1	466	472	PF00498	0.392
LIG_FHA_1	495	501	PF00498	0.464
LIG_FHA_1	515	521	PF00498	0.492
LIG_FHA_1	522	528	PF00498	0.526
LIG_FHA_1	600	606	PF00498	0.515
LIG_FHA_1	63	69	PF00498	0.458
LIG_FHA_1	681	687	PF00498	0.736
LIG_FHA_1	724	730	PF00498	0.720
LIG_FHA_1	831	837	PF00498	0.392
LIG_FHA_2	195	201	PF00498	0.561
LIG_FHA_2	387	393	PF00498	0.270
LIG_FHA_2	583	589	PF00498	0.444
LIG_FHA_2	793	799	PF00498	0.470
LIG_FHA_2	85	91	PF00498	0.429
LIG_LIR_Apic_2	304	310	PF02991	0.701
LIG_LIR_Gen_1	135	144	PF02991	0.416
LIG_LIR_Nem_3	135	139	PF02991	0.398
LIG_LIR_Nem_3	741	745	PF02991	0.576
LIG_MYND_1	772	776	PF01753	0.365
LIG_NRBOX	628	634	PF00104	0.427
LIG_Pex14_2	586	590	PF04695	0.484
LIG_SH2_CRK	163	167	PF00017	0.467
LIG_SH2_CRK	473	477	PF00017	0.421
LIG_SH2_CRK	742	746	PF00017	0.541
LIG_SH2_NCK_1	99	103	PF00017	0.472
LIG_SH2_STAP1	423	427	PF00017	0.469
LIG_SH2_STAP1	99	103	PF00017	0.550
LIG_SH2_STAT5	136	139	PF00017	0.345
LIG_SH2_STAT5	15	18	PF00017	0.439
LIG_SH2_STAT5	201	204	PF00017	0.663
LIG_SH2_STAT5	423	426	PF00017	0.405
LIG_SH2_STAT5	430	433	PF00017	0.311
LIG_SH2_STAT5	643	646	PF00017	0.518
LIG_SH2_STAT5	767	770	PF00017	0.495
LIG_SH2_STAT5	82	85	PF00017	0.471
LIG_SH3_1	691	697	PF00018	0.682
LIG_SH3_2	203	208	PF14604	0.663
LIG_SH3_3	200	206	PF00018	0.735
LIG_SH3_3	305	311	PF00018	0.771
LIG_SH3_3	403	409	PF00018	0.518
LIG_SH3_3	606	612	PF00018	0.454
LIG_SH3_3	691	697	PF00018	0.747
LIG_SH3_3	80	86	PF00018	0.432
LIG_SH3_3	856	862	PF00018	0.413
LIG_SH3_3	92	98	PF00018	0.429
LIG_SH3_4	421	428	PF00018	0.476
LIG_SH3_4	648	655	PF00018	0.468
LIG_SUMO_SIM_anti_2	557	562	PF11976	0.495
LIG_SUMO_SIM_par_1	242	247	PF11976	0.523
LIG_SUMO_SIM_par_1	557	562	PF11976	0.478
LIG_SUMO_SIM_par_1	607	613	PF11976	0.521
LIG_SUMO_SIM_par_1	682	688	PF11976	0.527
LIG_TRAF2_1	227	230	PF00917	0.555
LIG_TRAF2_1	325	328	PF00917	0.724
LIG_TRAF2_1	716	719	PF00917	0.759
LIG_TRAF2_1	87	90	PF00917	0.450
LIG_TYR_ITIM	471	476	PF00017	0.399
LIG_TYR_ITIM	740	745	PF00017	0.552
LIG_WRC_WIRS_1	583	588	PF05994	0.470
MOD_CDK_SPxK_1	202	208	PF00069	0.625
MOD_CK1_1	360	366	PF00069	0.749
MOD_CK1_1	410	416	PF00069	0.569
MOD_CK1_1	604	610	PF00069	0.507
MOD_CK1_1	638	644	PF00069	0.503
MOD_CK1_1	693	699	PF00069	0.713
MOD_CK2_1	18	24	PF00069	0.479
MOD_CK2_1	194	200	PF00069	0.540
MOD_CK2_1	386	392	PF00069	0.451
MOD_CK2_1	754	760	PF00069	0.471
MOD_CK2_1	792	798	PF00069	0.434
MOD_CK2_1	84	90	PF00069	0.438
MOD_CK2_1	844	850	PF00069	0.509
MOD_GlcNHglycan	298	301	PF01048	0.714
MOD_GlcNHglycan	320	323	PF01048	0.733
MOD_GlcNHglycan	371	374	PF01048	0.728
MOD_GlcNHglycan	384	387	PF01048	0.568
MOD_GlcNHglycan	507	510	PF01048	0.470
MOD_GlcNHglycan	640	643	PF01048	0.491
MOD_GlcNHglycan	704	707	PF01048	0.720
MOD_GlcNHglycan	711	715	PF01048	0.671
MOD_GlcNHglycan	768	771	PF01048	0.508
MOD_GlcNHglycan	869	873	PF01048	0.507
MOD_GSK3_1	314	321	PF00069	0.704
MOD_GSK3_1	360	367	PF00069	0.658
MOD_GSK3_1	382	389	PF00069	0.380
MOD_GSK3_1	534	541	PF00069	0.396
MOD_GSK3_1	719	726	PF00069	0.556
MOD_N-GLC_1	330	335	PF02516	0.777
MOD_N-GLC_1	754	759	PF02516	0.492
MOD_NEK2_1	472	477	PF00069	0.437
MOD_NEK2_1	527	532	PF00069	0.469
MOD_NEK2_1	62	67	PF00069	0.483
MOD_PIKK_1	465	471	PF00454	0.436
MOD_PIKK_1	662	668	PF00454	0.495
MOD_PK_1	569	575	PF00069	0.562
MOD_PKA_1	400	406	PF00069	0.534
MOD_PKA_1	674	680	PF00069	0.636
MOD_PKA_2	207	213	PF00069	0.659
MOD_PKA_2	215	221	PF00069	0.360
MOD_PKA_2	400	406	PF00069	0.534
MOD_PKA_2	702	708	PF00069	0.738
MOD_PKA_2	813	819	PF00069	0.536
MOD_PKB_1	708	716	PF00069	0.551
MOD_Plk_1	538	544	PF00069	0.422
MOD_Plk_1	754	760	PF00069	0.504
MOD_Plk_4	132	138	PF00069	0.462
MOD_Plk_4	538	544	PF00069	0.396
MOD_Plk_4	582	588	PF00069	0.375
MOD_Plk_4	604	610	PF00069	0.418
MOD_ProDKin_1	173	179	PF00069	0.509
MOD_ProDKin_1	199	205	PF00069	0.708
MOD_ProDKin_1	306	312	PF00069	0.769
MOD_ProDKin_1	407	413	PF00069	0.505
MOD_ProDKin_1	545	551	PF00069	0.495
MOD_ProDKin_1	690	696	PF00069	0.677
MOD_ProDKin_1	855	861	PF00069	0.434
MOD_SUMO_rev_2	118	128	PF00179	0.459
MOD_SUMO_rev_2	641	650	PF00179	0.522
TRG_DiLeu_BaEn_1	798	803	PF01217	0.436
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.615
TRG_ENDOCYTIC_2	136	139	PF00928	0.345
TRG_ENDOCYTIC_2	149	152	PF00928	0.439
TRG_ENDOCYTIC_2	163	166	PF00928	0.356
TRG_ENDOCYTIC_2	356	359	PF00928	0.608
TRG_ENDOCYTIC_2	473	476	PF00928	0.381
TRG_ENDOCYTIC_2	742	745	PF00928	0.553
TRG_ER_diArg_1	553	555	PF00400	0.516
TRG_ER_diArg_1	707	710	PF00400	0.691
TRG_ER_diArg_1	742	744	PF00400	0.535
TRG_ER_diArg_1	800	802	PF00400	0.478
TRG_NES_CRM1_1	274	287	PF08389	0.498
TRG_Pf-PMV_PEXEL_1	518	522	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	553	557	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	800	805	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U7	Leptomonas seymouri	24%	100%
A0A0N0P8K1	Leptomonas seymouri	63%	99%
A0A0S4ILQ6	Bodo saltans	28%	88%
A0A1X0P6E5	Trypanosomatidae	39%	100%
A0A3R7MW28	Trypanosoma rangeli	38%	100%
A0A3S7X6A2	Leishmania donovani	24%	100%
A4H9Y2	Leishmania braziliensis	76%	100%
A4HL43	Leishmania braziliensis	26%	100%
A4HY47	Leishmania infantum	99%	100%
A4I8M3	Leishmania infantum	24%	100%
D0A0E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
D3Z8X7	Rattus norvegicus	26%	95%
E9ARX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B3I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	99%
O60308	Homo sapiens	26%	95%
Q4QDJ6	Leishmania major	94%	100%
Q80V31	Mus musculus	26%	94%
V5DTJ3	Trypanosoma cruzi	38%	100%