Vps53-like, N-terminal family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVF6_LEIDO

TriTrypDb:

LdBPK_190810.1 , LdCL_190013100 , LDHU3_19.0890

Length:

869

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000938	GARP complex	3	12
GO:0005829	cytosol	2	12
GO:0010008	endosome membrane	5	12
GO:0012506	vesicle membrane	4	12
GO:0016020	membrane	2	12
GO:0030659	cytoplasmic vesicle membrane	5	12
GO:0031090	organelle membrane	3	12
GO:0032991	protein-containing complex	1	12
GO:0098588	bounding membrane of organelle	4	12
GO:0099023	vesicle tethering complex	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3S7WVF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVF6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0009987	cellular process	1	12
GO:0016192	vesicle-mediated transport	4	12
GO:0016197	endosomal transport	4	12
GO:0016482	cytosolic transport	4	12
GO:0042147	retrograde transport, endosome to Golgi	5	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.562
CLV_MEL_PAP_1	93	99	PF00089	0.268
CLV_NRD_NRD_1	155	157	PF00675	0.271
CLV_NRD_NRD_1	267	269	PF00675	0.253
CLV_NRD_NRD_1	352	354	PF00675	0.196
CLV_NRD_NRD_1	449	451	PF00675	0.313
CLV_NRD_NRD_1	474	476	PF00675	0.351
CLV_NRD_NRD_1	58	60	PF00675	0.396
CLV_NRD_NRD_1	617	619	PF00675	0.386
CLV_NRD_NRD_1	662	664	PF00675	0.329
CLV_NRD_NRD_1	713	715	PF00675	0.372
CLV_PCSK_FUR_1	252	256	PF00082	0.287
CLV_PCSK_FUR_1	615	619	PF00082	0.368
CLV_PCSK_KEX2_1	154	156	PF00082	0.287
CLV_PCSK_KEX2_1	254	256	PF00082	0.262
CLV_PCSK_KEX2_1	267	269	PF00082	0.232
CLV_PCSK_KEX2_1	352	354	PF00082	0.329
CLV_PCSK_KEX2_1	430	432	PF00082	0.326
CLV_PCSK_KEX2_1	449	451	PF00082	0.303
CLV_PCSK_KEX2_1	473	475	PF00082	0.356
CLV_PCSK_KEX2_1	617	619	PF00082	0.386
CLV_PCSK_KEX2_1	713	715	PF00082	0.371
CLV_PCSK_KEX2_1	726	728	PF00082	0.397
CLV_PCSK_KEX2_1	734	736	PF00082	0.375
CLV_PCSK_KEX2_1	863	865	PF00082	0.683
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.396
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.268
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.329
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.326
CLV_PCSK_PC1ET2_1	726	728	PF00082	0.421
CLV_PCSK_PC1ET2_1	734	736	PF00082	0.375
CLV_PCSK_PC1ET2_1	863	865	PF00082	0.672
CLV_PCSK_SKI1_1	161	165	PF00082	0.248
CLV_PCSK_SKI1_1	20	24	PF00082	0.577
CLV_PCSK_SKI1_1	268	272	PF00082	0.273
CLV_PCSK_SKI1_1	273	277	PF00082	0.234
CLV_PCSK_SKI1_1	284	288	PF00082	0.202
CLV_PCSK_SKI1_1	337	341	PF00082	0.253
CLV_PCSK_SKI1_1	384	388	PF00082	0.379
CLV_PCSK_SKI1_1	430	434	PF00082	0.429
CLV_PCSK_SKI1_1	514	518	PF00082	0.445
CLV_PCSK_SKI1_1	572	576	PF00082	0.427
CLV_PCSK_SKI1_1	595	599	PF00082	0.301
CLV_PCSK_SKI1_1	636	640	PF00082	0.343
CLV_PCSK_SKI1_1	671	675	PF00082	0.329
CLV_PCSK_SKI1_1	84	88	PF00082	0.307
DEG_APCC_DBOX_1	448	456	PF00400	0.437
DEG_APCC_DBOX_1	594	602	PF00400	0.297
DEG_SPOP_SBC_1	147	151	PF00917	0.287
DOC_CDC14_PxL_1	534	542	PF14671	0.382
DOC_CYCLIN_RxL_1	267	280	PF00134	0.253
DOC_CYCLIN_RxL_1	592	599	PF00134	0.296
DOC_MAPK_gen_1	264	272	PF00069	0.253
DOC_MAPK_gen_1	449	455	PF00069	0.318
DOC_MAPK_gen_1	473	480	PF00069	0.320
DOC_MAPK_MEF2A_6	369	376	PF00069	0.253
DOC_MAPK_NFAT4_5	369	377	PF00069	0.253
DOC_MAPK_RevD_3	461	475	PF00069	0.462
DOC_PP1_RVXF_1	504	511	PF00149	0.435
DOC_PP2B_LxvP_1	639	642	PF13499	0.336
DOC_PP2B_LxvP_1	780	783	PF13499	0.574
DOC_USP7_MATH_1	104	108	PF00917	0.287
DOC_USP7_MATH_1	565	569	PF00917	0.509
DOC_USP7_MATH_1	776	780	PF00917	0.669
DOC_USP7_MATH_1	786	790	PF00917	0.677
DOC_USP7_MATH_1	817	821	PF00917	0.721
DOC_USP7_UBL2_3	178	182	PF12436	0.286
DOC_USP7_UBL2_3	426	430	PF12436	0.331
DOC_WW_Pin1_4	466	471	PF00397	0.429
LIG_14-3-3_CanoR_1	101	111	PF00244	0.243
LIG_14-3-3_CanoR_1	155	164	PF00244	0.256
LIG_14-3-3_CanoR_1	202	206	PF00244	0.313
LIG_14-3-3_CanoR_1	57	66	PF00244	0.246
LIG_14-3-3_CanoR_1	649	659	PF00244	0.470
LIG_14-3-3_CanoR_1	850	859	PF00244	0.549
LIG_Actin_WH2_2	414	432	PF00022	0.311
LIG_Actin_WH2_2	44	61	PF00022	0.304
LIG_APCC_ABBA_1	686	691	PF00400	0.328
LIG_APCC_ABBAyCdc20_2	202	208	PF00400	0.287
LIG_BRCT_BRCA1_1	148	152	PF00533	0.253
LIG_BRCT_BRCA1_1	170	174	PF00533	0.284
LIG_BRCT_BRCA1_1	249	253	PF00533	0.287
LIG_BRCT_BRCA1_1	764	768	PF00533	0.438
LIG_BRCT_BRCA1_1	854	858	PF00533	0.560
LIG_BRCT_BRCA1_2	148	154	PF00533	0.396
LIG_BRCT_BRCA1_2	170	176	PF00533	0.360
LIG_DLG_GKlike_1	739	747	PF00625	0.464
LIG_FHA_1	127	133	PF00498	0.253
LIG_FHA_1	298	304	PF00498	0.253
LIG_FHA_1	324	330	PF00498	0.253
LIG_FHA_1	480	486	PF00498	0.306
LIG_FHA_1	520	526	PF00498	0.485
LIG_FHA_1	573	579	PF00498	0.405
LIG_FHA_1	654	660	PF00498	0.472
LIG_FHA_2	303	309	PF00498	0.253
LIG_FHA_2	342	348	PF00498	0.329
LIG_FHA_2	487	493	PF00498	0.434
LIG_FHA_2	575	581	PF00498	0.454
LIG_FHA_2	731	737	PF00498	0.382
LIG_FHA_2	75	81	PF00498	0.343
LIG_FHA_2	828	834	PF00498	0.566
LIG_Integrin_RGD_1	864	866	PF01839	0.475
LIG_LIR_Gen_1	171	181	PF02991	0.266
LIG_LIR_Gen_1	266	276	PF02991	0.255
LIG_LIR_Gen_1	277	287	PF02991	0.263
LIG_LIR_Gen_1	419	429	PF02991	0.310
LIG_LIR_Gen_1	507	517	PF02991	0.356
LIG_LIR_Gen_1	635	644	PF02991	0.327
LIG_LIR_Gen_1	656	666	PF02991	0.356
LIG_LIR_Gen_1	682	693	PF02991	0.341
LIG_LIR_Gen_1	765	776	PF02991	0.416
LIG_LIR_Gen_1	843	853	PF02991	0.663
LIG_LIR_Nem_3	204	209	PF02991	0.303
LIG_LIR_Nem_3	266	272	PF02991	0.255
LIG_LIR_Nem_3	27	31	PF02991	0.231
LIG_LIR_Nem_3	277	282	PF02991	0.263
LIG_LIR_Nem_3	411	417	PF02991	0.351
LIG_LIR_Nem_3	419	425	PF02991	0.277
LIG_LIR_Nem_3	507	513	PF02991	0.371
LIG_LIR_Nem_3	515	520	PF02991	0.308
LIG_LIR_Nem_3	635	641	PF02991	0.351
LIG_LIR_Nem_3	656	661	PF02991	0.364
LIG_LIR_Nem_3	665	669	PF02991	0.349
LIG_LIR_Nem_3	682	688	PF02991	0.345
LIG_LIR_Nem_3	765	771	PF02991	0.535
LIG_NRBOX	271	277	PF00104	0.379
LIG_NRBOX	593	599	PF00104	0.295
LIG_PCNA_yPIPBox_3	697	710	PF02747	0.385
LIG_Pex14_1	345	349	PF04695	0.253
LIG_Pex14_2	283	287	PF04695	0.252
LIG_Pex14_2	768	772	PF04695	0.535
LIG_PTB_Apo_2	200	207	PF02174	0.396
LIG_PTB_Apo_2	32	39	PF02174	0.253
LIG_PTB_Apo_2	542	549	PF02174	0.363
LIG_PTB_Apo_2	608	615	PF02174	0.448
LIG_PTB_Phospho_1	608	614	PF10480	0.443
LIG_SH2_CRK	279	283	PF00017	0.399
LIG_SH2_GRB2like	33	36	PF00017	0.268
LIG_SH2_NCK_1	279	283	PF00017	0.268
LIG_SH2_NCK_1	644	648	PF00017	0.395
LIG_SH2_PTP2	269	272	PF00017	0.232
LIG_SH2_PTP2	658	661	PF00017	0.345
LIG_SH2_PTP2	94	97	PF00017	0.329
LIG_SH2_SRC	33	36	PF00017	0.312
LIG_SH2_SRC	414	417	PF00017	0.388
LIG_SH2_STAP1	170	174	PF00017	0.268
LIG_SH2_STAP1	249	253	PF00017	0.268
LIG_SH2_STAP1	279	283	PF00017	0.340
LIG_SH2_STAP1	5	9	PF00017	0.591
LIG_SH2_STAP1	521	525	PF00017	0.313
LIG_SH2_STAP1	690	694	PF00017	0.350
LIG_SH2_STAT3	327	330	PF00017	0.253
LIG_SH2_STAT5	200	203	PF00017	0.266
LIG_SH2_STAT5	269	272	PF00017	0.271
LIG_SH2_STAT5	327	330	PF00017	0.253
LIG_SH2_STAT5	33	36	PF00017	0.268
LIG_SH2_STAT5	414	417	PF00017	0.388
LIG_SH2_STAT5	521	524	PF00017	0.390
LIG_SH2_STAT5	658	661	PF00017	0.443
LIG_SH2_STAT5	94	97	PF00017	0.329
LIG_SH3_3	13	19	PF00018	0.498
LIG_SH3_3	585	591	PF00018	0.379
LIG_SH3_3	689	695	PF00018	0.429
LIG_SH3_3	780	786	PF00018	0.706
LIG_Sin3_3	222	229	PF02671	0.329
LIG_SUMO_SIM_anti_2	321	326	PF11976	0.255
LIG_SUMO_SIM_par_1	224	233	PF11976	0.459
LIG_SUMO_SIM_par_1	321	326	PF11976	0.260
LIG_SUMO_SIM_par_1	331	336	PF11976	0.241
LIG_TRAF2_1	163	166	PF00917	0.396
LIG_TRAF2_1	305	308	PF00917	0.396
LIG_TRAF2_1	835	838	PF00917	0.611
LIG_TYR_ITIM	688	693	PF00017	0.464
LIG_UBA3_1	173	182	PF00899	0.287
LIG_UBA3_1	421	430	PF00899	0.305
LIG_WW_3	17	21	PF00397	0.507
LIG_WW_3	503	507	PF00397	0.507
LIG_WW_3	781	785	PF00397	0.579
MOD_CDK_SPxxK_3	466	473	PF00069	0.466
MOD_CK1_1	131	137	PF00069	0.273
MOD_CK1_1	394	400	PF00069	0.472
MOD_CK1_1	524	530	PF00069	0.472
MOD_CK1_1	653	659	PF00069	0.400
MOD_CK1_1	74	80	PF00069	0.374
MOD_CK1_1	759	765	PF00069	0.669
MOD_CK1_1	843	849	PF00069	0.542
MOD_CK1_1	851	857	PF00069	0.535
MOD_CK2_1	102	108	PF00069	0.305
MOD_CK2_1	147	153	PF00069	0.268
MOD_CK2_1	302	308	PF00069	0.268
MOD_CK2_1	401	407	PF00069	0.533
MOD_CK2_1	466	472	PF00069	0.472
MOD_CK2_1	74	80	PF00069	0.374
MOD_GlcNHglycan	170	173	PF01048	0.337
MOD_GlcNHglycan	365	368	PF01048	0.347
MOD_GlcNHglycan	393	396	PF01048	0.532
MOD_GlcNHglycan	410	413	PF01048	0.465
MOD_GlcNHglycan	459	462	PF01048	0.492
MOD_GlcNHglycan	652	655	PF01048	0.514
MOD_GlcNHglycan	750	753	PF01048	0.562
MOD_GlcNHglycan	761	764	PF01048	0.523
MOD_GlcNHglycan	77	80	PF01048	0.324
MOD_GlcNHglycan	775	779	PF01048	0.613
MOD_GlcNHglycan	789	792	PF01048	0.517
MOD_GSK3_1	123	130	PF00069	0.347
MOD_GSK3_1	337	344	PF00069	0.359
MOD_GSK3_1	406	413	PF00069	0.511
MOD_GSK3_1	515	522	PF00069	0.344
MOD_GSK3_1	71	78	PF00069	0.294
MOD_GSK3_1	739	746	PF00069	0.455
MOD_GSK3_1	770	777	PF00069	0.542
MOD_GSK3_1	800	807	PF00069	0.591
MOD_GSK3_1	840	847	PF00069	0.609
MOD_GSK3_1	848	855	PF00069	0.527
MOD_GSK3_1	95	102	PF00069	0.434
MOD_N-GLC_1	126	131	PF02516	0.253
MOD_N-GLC_1	696	701	PF02516	0.405
MOD_N-GLC_1	74	79	PF02516	0.396
MOD_N-GLC_1	786	791	PF02516	0.589
MOD_NEK2_1	128	133	PF00069	0.257
MOD_NEK2_1	168	173	PF00069	0.303
MOD_NEK2_1	214	219	PF00069	0.275
MOD_NEK2_1	297	302	PF00069	0.279
MOD_NEK2_1	363	368	PF00069	0.270
MOD_NEK2_1	485	490	PF00069	0.322
MOD_NEK2_1	601	606	PF00069	0.376
MOD_NEK2_1	634	639	PF00069	0.364
MOD_NEK2_1	743	748	PF00069	0.553
MOD_NEK2_1	800	805	PF00069	0.605
MOD_NEK2_1	848	853	PF00069	0.580
MOD_NEK2_2	516	521	PF00069	0.332
MOD_NEK2_2	609	614	PF00069	0.442
MOD_PIKK_1	155	161	PF00454	0.256
MOD_PIKK_1	188	194	PF00454	0.396
MOD_PIKK_1	337	343	PF00454	0.376
MOD_PIKK_1	487	493	PF00454	0.412
MOD_PIKK_1	99	105	PF00454	0.329
MOD_PK_1	278	284	PF00069	0.281
MOD_PK_1	840	846	PF00069	0.555
MOD_PKA_1	155	161	PF00069	0.256
MOD_PKA_1	254	260	PF00069	0.268
MOD_PKA_1	551	557	PF00069	0.632
MOD_PKA_2	155	161	PF00069	0.256
MOD_PKA_2	201	207	PF00069	0.288
MOD_PKA_2	254	260	PF00069	0.249
MOD_PKA_2	58	64	PF00069	0.269
MOD_PKA_2	849	855	PF00069	0.546
MOD_PKA_2	95	101	PF00069	0.268
MOD_Plk_1	214	220	PF00069	0.267
MOD_Plk_1	337	343	PF00069	0.253
MOD_Plk_1	40	46	PF00069	0.270
MOD_Plk_1	634	640	PF00069	0.341
MOD_Plk_1	696	702	PF00069	0.323
MOD_Plk_1	739	745	PF00069	0.439
MOD_Plk_4	201	207	PF00069	0.288
MOD_Plk_4	278	284	PF00069	0.308
MOD_Plk_4	323	329	PF00069	0.259
MOD_Plk_4	410	416	PF00069	0.451
MOD_Plk_4	516	522	PF00069	0.310
MOD_Plk_4	524	530	PF00069	0.295
MOD_Plk_4	601	607	PF00069	0.356
MOD_Plk_4	609	615	PF00069	0.325
MOD_Plk_4	634	640	PF00069	0.400
MOD_Plk_4	840	846	PF00069	0.724
MOD_ProDKin_1	466	472	PF00069	0.429
MOD_SUMO_for_1	260	263	PF00179	0.287
MOD_SUMO_rev_2	258	262	PF00179	0.271
MOD_SUMO_rev_2	566	571	PF00179	0.526
MOD_SUMO_rev_2	78	86	PF00179	0.363
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.504
TRG_ENDOCYTIC_2	170	173	PF00928	0.268
TRG_ENDOCYTIC_2	269	272	PF00928	0.256
TRG_ENDOCYTIC_2	279	282	PF00928	0.262
TRG_ENDOCYTIC_2	360	363	PF00928	0.253
TRG_ENDOCYTIC_2	414	417	PF00928	0.388
TRG_ENDOCYTIC_2	658	661	PF00928	0.317
TRG_ENDOCYTIC_2	689	692	PF00928	0.330
TRG_ENDOCYTIC_2	94	97	PF00928	0.268
TRG_ER_diArg_1	155	157	PF00400	0.396
TRG_ER_diArg_1	267	269	PF00400	0.253
TRG_ER_diArg_1	448	450	PF00400	0.446
TRG_ER_diArg_1	473	475	PF00400	0.353
TRG_ER_diArg_1	614	617	PF00400	0.399
TRG_ER_diArg_1	712	714	PF00400	0.387
TRG_NES_CRM1_1	667	679	PF08389	0.354
TRG_NLS_MonoExtC_3	233	238	PF00514	0.396
TRG_NLS_MonoExtC_3	351	356	PF00514	0.196
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.254
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	595	599	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	617	621	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSX2	Leptomonas seymouri	79%	98%
A0A0S4J071	Bodo saltans	52%	100%
A0A1X0P670	Trypanosomatidae	59%	95%
A0A3R7KBJ1	Trypanosoma rangeli	58%	98%
A4HA38	Leishmania braziliensis	89%	100%
A4HYA1	Leishmania infantum	100%	100%
D0A0N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AS33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P34561	Caenorhabditis elegans	23%	100%
P87129	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q0WQF4	Arabidopsis thaliana	26%	100%
Q4QDE0	Leishmania major	96%	100%
Q5R5J4	Pongo abelii	23%	100%
Q5VIR6	Homo sapiens	23%	100%
Q5ZLD7	Gallus gallus	23%	100%
Q8CCB4	Mus musculus	23%	100%
V5AZ39	Trypanosoma cruzi	59%	100%