Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVF4_LEIDO

TriTrypDb:

LdBPK_190880.1 , LdCL_190014200 , LDHU3_19.1080

Length:

905

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.509
CLV_C14_Caspase3-7	308	312	PF00656	0.604
CLV_C14_Caspase3-7	548	552	PF00656	0.629
CLV_C14_Caspase3-7	663	667	PF00656	0.594
CLV_C14_Caspase3-7	817	821	PF00656	0.610
CLV_MEL_PAP_1	359	365	PF00089	0.602
CLV_NRD_NRD_1	125	127	PF00675	0.650
CLV_NRD_NRD_1	177	179	PF00675	0.528
CLV_NRD_NRD_1	27	29	PF00675	0.619
CLV_NRD_NRD_1	423	425	PF00675	0.662
CLV_NRD_NRD_1	454	456	PF00675	0.517
CLV_NRD_NRD_1	697	699	PF00675	0.524
CLV_NRD_NRD_1	701	703	PF00675	0.483
CLV_NRD_NRD_1	798	800	PF00675	0.661
CLV_PCSK_FUR_1	123	127	PF00082	0.652
CLV_PCSK_FUR_1	25	29	PF00082	0.617
CLV_PCSK_FUR_1	421	425	PF00082	0.659
CLV_PCSK_FUR_1	698	702	PF00082	0.585
CLV_PCSK_FUR_1	796	800	PF00082	0.548
CLV_PCSK_KEX2_1	125	127	PF00082	0.650
CLV_PCSK_KEX2_1	27	29	PF00082	0.619
CLV_PCSK_KEX2_1	423	425	PF00082	0.687
CLV_PCSK_KEX2_1	429	431	PF00082	0.653
CLV_PCSK_KEX2_1	454	456	PF00082	0.517
CLV_PCSK_KEX2_1	697	699	PF00082	0.520
CLV_PCSK_KEX2_1	700	702	PF00082	0.503
CLV_PCSK_KEX2_1	798	800	PF00082	0.661
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.714
CLV_PCSK_PC7_1	697	703	PF00082	0.494
CLV_PCSK_SKI1_1	145	149	PF00082	0.460
CLV_PCSK_SKI1_1	179	183	PF00082	0.499
CLV_PCSK_SKI1_1	457	461	PF00082	0.520
CLV_PCSK_SKI1_1	56	60	PF00082	0.512
CLV_PCSK_SKI1_1	829	833	PF00082	0.502
CLV_PCSK_SKI1_1	836	840	PF00082	0.538
DEG_APCC_DBOX_1	517	525	PF00400	0.578
DEG_APCC_DBOX_1	534	542	PF00400	0.630
DEG_COP1_1	800	808	PF00400	0.545
DEG_Nend_UBRbox_2	1	3	PF02207	0.616
DEG_SCF_FBW7_1	741	747	PF00400	0.621
DEG_SCF_FBW7_1	890	895	PF00400	0.603
DEG_SPOP_SBC_1	578	582	PF00917	0.729
DEG_SPOP_SBC_1	744	748	PF00917	0.566
DOC_ANK_TNKS_1	124	131	PF00023	0.606
DOC_CDC14_PxL_1	842	850	PF14671	0.587
DOC_CKS1_1	741	746	PF01111	0.624
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.619
DOC_MAPK_gen_1	178	184	PF00069	0.525
DOC_MAPK_gen_1	25	33	PF00069	0.535
DOC_MAPK_gen_1	300	307	PF00069	0.511
DOC_MAPK_gen_1	454	461	PF00069	0.461
DOC_MAPK_gen_1	515	523	PF00069	0.578
DOC_MAPK_MEF2A_6	300	307	PF00069	0.535
DOC_MAPK_MEF2A_6	771	780	PF00069	0.594
DOC_MIT_MIM_1	781	790	PF04212	0.492
DOC_PP2B_LxvP_1	31	34	PF13499	0.641
DOC_PP4_FxxP_1	203	206	PF00568	0.502
DOC_USP7_MATH_1	104	108	PF00917	0.730
DOC_USP7_MATH_1	132	136	PF00917	0.651
DOC_USP7_MATH_1	16	20	PF00917	0.607
DOC_USP7_MATH_1	316	320	PF00917	0.615
DOC_USP7_MATH_1	322	326	PF00917	0.664
DOC_USP7_MATH_1	35	39	PF00917	0.555
DOC_USP7_MATH_1	361	365	PF00917	0.555
DOC_USP7_MATH_1	468	472	PF00917	0.627
DOC_USP7_MATH_1	516	520	PF00917	0.713
DOC_USP7_MATH_1	578	582	PF00917	0.662
DOC_USP7_MATH_1	593	597	PF00917	0.620
DOC_USP7_MATH_1	625	629	PF00917	0.739
DOC_USP7_MATH_1	639	643	PF00917	0.577
DOC_USP7_MATH_1	644	648	PF00917	0.657
DOC_USP7_MATH_1	81	85	PF00917	0.573
DOC_USP7_MATH_1	892	896	PF00917	0.629
DOC_WW_Pin1_4	100	105	PF00397	0.656
DOC_WW_Pin1_4	156	161	PF00397	0.646
DOC_WW_Pin1_4	201	206	PF00397	0.557
DOC_WW_Pin1_4	277	282	PF00397	0.596
DOC_WW_Pin1_4	320	325	PF00397	0.633
DOC_WW_Pin1_4	353	358	PF00397	0.674
DOC_WW_Pin1_4	584	589	PF00397	0.713
DOC_WW_Pin1_4	602	607	PF00397	0.560
DOC_WW_Pin1_4	670	675	PF00397	0.549
DOC_WW_Pin1_4	740	745	PF00397	0.637
DOC_WW_Pin1_4	888	893	PF00397	0.636
DOC_WW_Pin1_4	93	98	PF00397	0.714
LIG_14-3-3_CanoR_1	131	140	PF00244	0.451
LIG_14-3-3_CanoR_1	25	34	PF00244	0.592
LIG_14-3-3_CanoR_1	262	268	PF00244	0.707
LIG_14-3-3_CanoR_1	347	352	PF00244	0.499
LIG_14-3-3_CanoR_1	362	370	PF00244	0.509
LIG_14-3-3_CanoR_1	398	404	PF00244	0.527
LIG_14-3-3_CanoR_1	438	444	PF00244	0.587
LIG_14-3-3_CanoR_1	499	504	PF00244	0.573
LIG_14-3-3_CanoR_1	515	524	PF00244	0.578
LIG_14-3-3_CanoR_1	556	564	PF00244	0.682
LIG_14-3-3_CanoR_1	67	71	PF00244	0.587
LIG_14-3-3_CanoR_1	686	692	PF00244	0.530
LIG_14-3-3_CanoR_1	714	720	PF00244	0.588
LIG_Actin_WH2_2	133	150	PF00022	0.451
LIG_Actin_WH2_2	441	456	PF00022	0.610
LIG_BRCT_BRCA1_1	42	46	PF00533	0.564
LIG_BRCT_BRCA1_1	876	880	PF00533	0.554
LIG_CaM_IQ_9	441	457	PF13499	0.665
LIG_CaM_NSCaTE_8	306	313	PF13499	0.597
LIG_CaM_NSCaTE_8	503	510	PF13499	0.645
LIG_Clathr_ClatBox_1	837	841	PF01394	0.513
LIG_CSL_BTD_1	249	252	PF09270	0.522
LIG_EH_1	877	881	PF12763	0.575
LIG_eIF4E_1	367	373	PF01652	0.543
LIG_eIF4E_1	843	849	PF01652	0.581
LIG_FHA_1	134	140	PF00498	0.595
LIG_FHA_1	157	163	PF00498	0.574
LIG_FHA_1	270	276	PF00498	0.585
LIG_FHA_1	343	349	PF00498	0.552
LIG_FHA_1	354	360	PF00498	0.530
LIG_FHA_1	367	373	PF00498	0.543
LIG_FHA_1	611	617	PF00498	0.600
LIG_FHA_1	636	642	PF00498	0.597
LIG_FHA_1	782	788	PF00498	0.585
LIG_FHA_1	790	796	PF00498	0.692
LIG_FHA_2	175	181	PF00498	0.499
LIG_FHA_2	723	729	PF00498	0.623
LIG_FHA_2	745	751	PF00498	0.517
LIG_LIR_Apic_2	841	846	PF02991	0.509
LIG_LIR_Gen_1	107	117	PF02991	0.495
LIG_LIR_Gen_1	406	414	PF02991	0.512
LIG_LIR_Gen_1	456	465	PF02991	0.502
LIG_LIR_Gen_1	500	509	PF02991	0.624
LIG_LIR_Nem_3	107	112	PF02991	0.511
LIG_LIR_Nem_3	364	370	PF02991	0.541
LIG_LIR_Nem_3	406	410	PF02991	0.506
LIG_LIR_Nem_3	456	461	PF02991	0.495
LIG_LIR_Nem_3	500	504	PF02991	0.523
LIG_NRBOX	186	192	PF00104	0.458
LIG_PDZ_Class_2	900	905	PF00595	0.629
LIG_Pex14_2	488	492	PF04695	0.457
LIG_PTAP_UEV_1	317	322	PF05743	0.689
LIG_SH2_CRK	688	692	PF00017	0.581
LIG_SH2_GRB2like	351	354	PF00017	0.553
LIG_SH2_NCK_1	706	710	PF00017	0.602
LIG_SH2_PTP2	843	846	PF00017	0.504
LIG_SH2_SRC	219	222	PF00017	0.606
LIG_SH2_STAP1	688	692	PF00017	0.505
LIG_SH2_STAP1	833	837	PF00017	0.481
LIG_SH2_STAT3	822	825	PF00017	0.589
LIG_SH2_STAT5	183	186	PF00017	0.481
LIG_SH2_STAT5	351	354	PF00017	0.634
LIG_SH2_STAT5	367	370	PF00017	0.532
LIG_SH2_STAT5	822	825	PF00017	0.589
LIG_SH2_STAT5	843	846	PF00017	0.504
LIG_SH3_3	202	208	PF00018	0.732
LIG_SH3_3	255	261	PF00018	0.497
LIG_SH3_3	278	284	PF00018	0.603
LIG_SH3_3	31	37	PF00018	0.696
LIG_SH3_3	315	321	PF00018	0.675
LIG_SH3_3	368	374	PF00018	0.551
LIG_SH3_3	585	591	PF00018	0.742
LIG_SH3_3	596	602	PF00018	0.655
LIG_SH3_3	640	646	PF00018	0.625
LIG_SH3_3	668	674	PF00018	0.614
LIG_SH3_3	94	100	PF00018	0.779
LIG_SH3_CIN85_PxpxPR_1	589	594	PF14604	0.715
LIG_SH3_CIN85_PxpxPR_1	602	607	PF14604	0.587
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.553
LIG_SUMO_SIM_anti_2	213	218	PF11976	0.505
LIG_SUMO_SIM_anti_2	287	294	PF11976	0.517
LIG_SUMO_SIM_anti_2	369	375	PF11976	0.485
LIG_SUMO_SIM_par_1	207	213	PF11976	0.499
LIG_SUMO_SIM_par_1	369	375	PF11976	0.560
LIG_TRAF2_1	540	543	PF00917	0.628
LIG_TRAF2_1	725	728	PF00917	0.610
LIG_ULM_U2AF65_1	454	459	PF00076	0.521
LIG_WRC_WIRS_1	498	503	PF05994	0.601
MOD_CDK_SPK_2	589	594	PF00069	0.639
MOD_CDK_SPK_2	602	607	PF00069	0.645
MOD_CDK_SPxK_1	888	894	PF00069	0.614
MOD_CK1_1	108	114	PF00069	0.576
MOD_CK1_1	17	23	PF00069	0.683
MOD_CK1_1	204	210	PF00069	0.606
MOD_CK1_1	285	291	PF00069	0.615
MOD_CK1_1	312	318	PF00069	0.625
MOD_CK1_1	323	329	PF00069	0.622
MOD_CK1_1	355	361	PF00069	0.656
MOD_CK1_1	42	48	PF00069	0.657
MOD_CK1_1	580	586	PF00069	0.668
MOD_CK1_1	888	894	PF00069	0.608
MOD_CK1_1	93	99	PF00069	0.664
MOD_CK2_1	277	283	PF00069	0.680
MOD_CK2_1	51	57	PF00069	0.651
MOD_CK2_1	537	543	PF00069	0.672
MOD_CK2_1	687	693	PF00069	0.528
MOD_CK2_1	722	728	PF00069	0.586
MOD_Cter_Amidation	123	126	PF01082	0.657
MOD_DYRK1A_RPxSP_1	201	205	PF00069	0.582
MOD_DYRK1A_RPxSP_1	277	281	PF00069	0.615
MOD_GlcNHglycan	112	115	PF01048	0.678
MOD_GlcNHglycan	16	19	PF01048	0.713
MOD_GlcNHglycan	236	239	PF01048	0.668
MOD_GlcNHglycan	277	280	PF01048	0.629
MOD_GlcNHglycan	283	287	PF01048	0.545
MOD_GlcNHglycan	311	314	PF01048	0.647
MOD_GlcNHglycan	318	321	PF01048	0.656
MOD_GlcNHglycan	363	366	PF01048	0.633
MOD_GlcNHglycan	37	40	PF01048	0.721
MOD_GlcNHglycan	399	402	PF01048	0.537
MOD_GlcNHglycan	410	413	PF01048	0.542
MOD_GlcNHglycan	547	550	PF01048	0.681
MOD_GlcNHglycan	582	585	PF01048	0.689
MOD_GlcNHglycan	595	598	PF01048	0.602
MOD_GlcNHglycan	618	621	PF01048	0.667
MOD_GlcNHglycan	663	666	PF01048	0.714
MOD_GlcNHglycan	733	736	PF01048	0.630
MOD_GlcNHglycan	799	802	PF01048	0.577
MOD_GlcNHglycan	92	95	PF01048	0.669
MOD_GSK3_1	100	107	PF00069	0.716
MOD_GSK3_1	113	120	PF00069	0.517
MOD_GSK3_1	170	177	PF00069	0.519
MOD_GSK3_1	23	30	PF00069	0.601
MOD_GSK3_1	234	241	PF00069	0.753
MOD_GSK3_1	263	270	PF00069	0.640
MOD_GSK3_1	271	278	PF00069	0.628
MOD_GSK3_1	312	319	PF00069	0.592
MOD_GSK3_1	347	354	PF00069	0.570
MOD_GSK3_1	35	42	PF00069	0.565
MOD_GSK3_1	393	400	PF00069	0.571
MOD_GSK3_1	453	460	PF00069	0.669
MOD_GSK3_1	468	475	PF00069	0.681
MOD_GSK3_1	47	54	PF00069	0.580
MOD_GSK3_1	493	500	PF00069	0.557
MOD_GSK3_1	578	585	PF00069	0.664
MOD_GSK3_1	589	596	PF00069	0.623
MOD_GSK3_1	611	618	PF00069	0.829
MOD_GSK3_1	621	628	PF00069	0.564
MOD_GSK3_1	635	642	PF00069	0.541
MOD_GSK3_1	739	746	PF00069	0.629
MOD_GSK3_1	751	758	PF00069	0.493
MOD_GSK3_1	870	877	PF00069	0.613
MOD_GSK3_1	888	895	PF00069	0.484
MOD_N-GLC_1	133	138	PF02516	0.549
MOD_N-GLC_1	352	357	PF02516	0.592
MOD_N-GLC_1	39	44	PF02516	0.587
MOD_N-GLC_1	494	499	PF02516	0.587
MOD_N-GLC_1	616	621	PF02516	0.683
MOD_N-GLC_1	81	86	PF02516	0.607
MOD_N-GLC_2	789	791	PF02516	0.478
MOD_NEK2_1	170	175	PF00069	0.565
MOD_NEK2_1	182	187	PF00069	0.434
MOD_NEK2_1	191	196	PF00069	0.454
MOD_NEK2_1	267	272	PF00069	0.573
MOD_NEK2_1	413	418	PF00069	0.593
MOD_NEK2_1	453	458	PF00069	0.623
MOD_NEK2_1	472	477	PF00069	0.589
MOD_NEK2_1	493	498	PF00069	0.535
MOD_NEK2_1	51	56	PF00069	0.651
MOD_NEK2_1	59	64	PF00069	0.543
MOD_NEK2_1	681	686	PF00069	0.552
MOD_NEK2_2	393	398	PF00069	0.574
MOD_PIKK_1	238	244	PF00454	0.745
MOD_PIKK_1	527	533	PF00454	0.612
MOD_PIKK_1	781	787	PF00454	0.454
MOD_PKA_1	27	33	PF00069	0.621
MOD_PKA_2	130	136	PF00069	0.605
MOD_PKA_2	26	32	PF00069	0.615
MOD_PKA_2	263	269	PF00069	0.601
MOD_PKA_2	361	367	PF00069	0.527
MOD_PKA_2	397	403	PF00069	0.530
MOD_PKA_2	437	443	PF00069	0.705
MOD_PKA_2	453	459	PF00069	0.432
MOD_PKA_2	475	481	PF00069	0.634
MOD_PKA_2	514	520	PF00069	0.577
MOD_PKA_2	593	599	PF00069	0.685
MOD_PKA_2	66	72	PF00069	0.588
MOD_PKA_2	713	719	PF00069	0.656
MOD_PKA_2	797	803	PF00069	0.543
MOD_PKA_2	868	874	PF00069	0.609
MOD_PKB_1	25	33	PF00069	0.620
MOD_PKB_1	347	355	PF00069	0.530
MOD_PKB_1	455	463	PF00069	0.523
MOD_Plk_1	133	139	PF00069	0.544
MOD_Plk_1	212	218	PF00069	0.531
MOD_Plk_1	288	294	PF00069	0.599
MOD_Plk_1	494	500	PF00069	0.586
MOD_Plk_4	105	111	PF00069	0.539
MOD_Plk_4	164	170	PF00069	0.487
MOD_Plk_4	191	197	PF00069	0.596
MOD_Plk_4	212	218	PF00069	0.525
MOD_Plk_4	288	294	PF00069	0.525
MOD_Plk_4	457	463	PF00069	0.516
MOD_Plk_4	468	474	PF00069	0.592
MOD_Plk_4	47	53	PF00069	0.574
MOD_Plk_4	687	693	PF00069	0.682
MOD_Plk_4	844	850	PF00069	0.581
MOD_ProDKin_1	100	106	PF00069	0.654
MOD_ProDKin_1	156	162	PF00069	0.641
MOD_ProDKin_1	201	207	PF00069	0.553
MOD_ProDKin_1	277	283	PF00069	0.595
MOD_ProDKin_1	320	326	PF00069	0.633
MOD_ProDKin_1	353	359	PF00069	0.673
MOD_ProDKin_1	584	590	PF00069	0.710
MOD_ProDKin_1	602	608	PF00069	0.559
MOD_ProDKin_1	670	676	PF00069	0.547
MOD_ProDKin_1	740	746	PF00069	0.639
MOD_ProDKin_1	888	894	PF00069	0.639
MOD_ProDKin_1	93	99	PF00069	0.714
MOD_SUMO_for_1	574	577	PF00179	0.633
TRG_DiLeu_BaEn_4	694	700	PF01217	0.578
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.458
TRG_DiLeu_BaLyEn_6	734	739	PF01217	0.549
TRG_ENDOCYTIC_2	367	370	PF00928	0.532
TRG_ENDOCYTIC_2	688	691	PF00928	0.590
TRG_ER_diArg_1	122	125	PF00400	0.638
TRG_ER_diArg_1	25	28	PF00400	0.616
TRG_ER_diArg_1	261	264	PF00400	0.609
TRG_ER_diArg_1	299	302	PF00400	0.556
TRG_ER_diArg_1	346	349	PF00400	0.552
TRG_ER_diArg_1	421	424	PF00400	0.658
TRG_ER_diArg_1	453	455	PF00400	0.522
TRG_ER_diArg_1	473	476	PF00400	0.597
TRG_ER_diArg_1	696	698	PF00400	0.517
TRG_ER_diArg_1	699	702	PF00400	0.493
TRG_ER_diArg_1	795	798	PF00400	0.582
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	415	419	PF00026	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P316	Leptomonas seymouri	33%	100%
A4HA44	Leishmania braziliensis	66%	98%
A4HYB0	Leishmania infantum	99%	100%
E9AS43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QDC3	Leishmania major	88%	100%