LeishMANIAdb
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Diacylglycerol kinase catalytic domain containing protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Diacylglycerol kinase catalytic domain containing protein, putative
Gene product:
Diacylglycerol kinase catalytic domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WVF1_LEIDO
TriTrypDb:
LdBPK_191040.1 * , LdCL_190015700 , LDHU3_19.1290
Length:
966

Annotations

LeishMANIAdb annotations

Could be a sphingosine kinase. Membrane-associated without any TM segments.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 1
GO:0042721 TIM22 mitochondrial import inner membrane insertion complex 4 1
GO:0098796 membrane protein complex 2 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0098800 inner mitochondrial membrane protein complex 3 1
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7WVF1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVF1

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 2
GO:0006796 phosphate-containing compound metabolic process 4 2
GO:0008152 metabolic process 1 2
GO:0009987 cellular process 1 3
GO:0016310 phosphorylation 5 2
GO:0044237 cellular metabolic process 2 2
GO:0006810 transport 3 1
GO:0006839 mitochondrial transport 4 1
GO:0006886 intracellular protein transport 4 1
GO:0006996 organelle organization 4 1
GO:0007005 mitochondrion organization 5 1
GO:0007006 mitochondrial membrane organization 5 1
GO:0007007 inner mitochondrial membrane organization 6 1
GO:0008104 protein localization 4 1
GO:0015031 protein transport 4 1
GO:0016043 cellular component organization 3 1
GO:0033036 macromolecule localization 2 1
GO:0033365 protein localization to organelle 5 1
GO:0045039 protein insertion into mitochondrial inner membrane 6 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051204 protein insertion into mitochondrial membrane 5 1
GO:0051205 protein insertion into membrane 5 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051668 localization within membrane 3 1
GO:0061024 membrane organization 4 1
GO:0070585 protein localization to mitochondrion 6 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0072594 establishment of protein localization to organelle 4 1
GO:0072655 establishment of protein localization to mitochondrion 5 1
GO:0072657 protein localization to membrane 4 1
GO:0090150 establishment of protein localization to membrane 4 1
GO:0090151 establishment of protein localization to mitochondrial membrane 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016301 kinase activity 4 6
GO:0016740 transferase activity 2 6
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 6
GO:0017050 D-erythro-sphingosine kinase activity 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 494 498 PF00656 0.607
CLV_C14_Caspase3-7 852 856 PF00656 0.605
CLV_NRD_NRD_1 569 571 PF00675 0.724
CLV_NRD_NRD_1 7 9 PF00675 0.478
CLV_NRD_NRD_1 709 711 PF00675 0.746
CLV_NRD_NRD_1 937 939 PF00675 0.516
CLV_NRD_NRD_1 951 953 PF00675 0.519
CLV_NRD_NRD_1 964 966 PF00675 0.479
CLV_PCSK_FUR_1 567 571 PF00082 0.705
CLV_PCSK_KEX2_1 232 234 PF00082 0.505
CLV_PCSK_KEX2_1 569 571 PF00082 0.724
CLV_PCSK_KEX2_1 711 713 PF00082 0.741
CLV_PCSK_KEX2_1 937 939 PF00082 0.516
CLV_PCSK_KEX2_1 951 953 PF00082 0.547
CLV_PCSK_KEX2_1 964 966 PF00082 0.462
CLV_PCSK_PC1ET2_1 232 234 PF00082 0.505
CLV_PCSK_PC1ET2_1 711 713 PF00082 0.709
CLV_PCSK_PC7_1 565 571 PF00082 0.572
CLV_PCSK_PC7_1 960 966 PF00082 0.469
CLV_PCSK_SKI1_1 35 39 PF00082 0.347
CLV_PCSK_SKI1_1 412 416 PF00082 0.324
CLV_PCSK_SKI1_1 685 689 PF00082 0.838
CLV_PCSK_SKI1_1 844 848 PF00082 0.287
CLV_PCSK_SKI1_1 885 889 PF00082 0.398
DEG_SPOP_SBC_1 536 540 PF00917 0.503
DEG_SPOP_SBC_1 667 671 PF00917 0.640
DEG_SPOP_SBC_1 694 698 PF00917 0.641
DEG_SPOP_SBC_1 92 96 PF00917 0.781
DOC_ANK_TNKS_1 576 583 PF00023 0.647
DOC_CKS1_1 142 147 PF01111 0.693
DOC_CKS1_1 633 638 PF01111 0.469
DOC_CYCLIN_yCln2_LP_2 311 317 PF00134 0.612
DOC_CYCLIN_yCln2_LP_2 599 605 PF00134 0.587
DOC_MAPK_gen_1 168 177 PF00069 0.571
DOC_MAPK_MEF2A_6 35 42 PF00069 0.661
DOC_MAPK_MEF2A_6 469 476 PF00069 0.510
DOC_PP1_RVXF_1 401 407 PF00149 0.565
DOC_PP1_RVXF_1 883 889 PF00149 0.564
DOC_PP2B_LxvP_1 316 319 PF13499 0.532
DOC_PP2B_LxvP_1 599 602 PF13499 0.569
DOC_PP2B_LxvP_1 782 785 PF13499 0.412
DOC_PP2B_LxvP_1 932 935 PF13499 0.772
DOC_PP4_FxxP_1 888 891 PF00568 0.557
DOC_SPAK_OSR1_1 831 835 PF12202 0.542
DOC_USP7_MATH_1 108 112 PF00917 0.813
DOC_USP7_MATH_1 125 129 PF00917 0.608
DOC_USP7_MATH_1 149 153 PF00917 0.766
DOC_USP7_MATH_1 211 215 PF00917 0.835
DOC_USP7_MATH_1 241 245 PF00917 0.792
DOC_USP7_MATH_1 294 298 PF00917 0.612
DOC_USP7_MATH_1 353 357 PF00917 0.778
DOC_USP7_MATH_1 4 8 PF00917 0.764
DOC_USP7_MATH_1 421 425 PF00917 0.611
DOC_USP7_MATH_1 450 454 PF00917 0.504
DOC_USP7_MATH_1 536 540 PF00917 0.484
DOC_USP7_MATH_1 667 671 PF00917 0.573
DOC_USP7_MATH_1 694 698 PF00917 0.575
DOC_USP7_MATH_1 76 80 PF00917 0.631
DOC_USP7_MATH_1 92 96 PF00917 0.675
DOC_WW_Pin1_4 141 146 PF00397 0.733
DOC_WW_Pin1_4 204 209 PF00397 0.810
DOC_WW_Pin1_4 223 228 PF00397 0.633
DOC_WW_Pin1_4 332 337 PF00397 0.542
DOC_WW_Pin1_4 375 380 PF00397 0.819
DOC_WW_Pin1_4 528 533 PF00397 0.626
DOC_WW_Pin1_4 537 542 PF00397 0.551
DOC_WW_Pin1_4 616 621 PF00397 0.560
DOC_WW_Pin1_4 632 637 PF00397 0.373
DOC_WW_Pin1_4 644 649 PF00397 0.510
DOC_WW_Pin1_4 835 840 PF00397 0.487
LIG_14-3-3_CanoR_1 233 239 PF00244 0.832
LIG_14-3-3_CanoR_1 382 388 PF00244 0.803
LIG_14-3-3_CanoR_1 390 397 PF00244 0.591
LIG_14-3-3_CanoR_1 438 443 PF00244 0.612
LIG_14-3-3_CanoR_1 567 576 PF00244 0.605
LIG_14-3-3_CanoR_1 630 634 PF00244 0.536
LIG_14-3-3_CanoR_1 820 827 PF00244 0.527
LIG_14-3-3_CanoR_1 922 930 PF00244 0.803
LIG_14-3-3_CanoR_1 951 961 PF00244 0.564
LIG_14-3-3_CterR_2 964 966 PF00244 0.687
LIG_Actin_WH2_2 554 571 PF00022 0.458
LIG_BIR_II_1 1 5 PF00653 0.783
LIG_BIR_III_2 737 741 PF00653 0.566
LIG_BIR_III_2 745 749 PF00653 0.587
LIG_BIR_III_3 1 5 PF00653 0.770
LIG_BIR_III_4 579 583 PF00653 0.611
LIG_BRCT_BRCA1_1 670 674 PF00533 0.602
LIG_CaM_IQ_9 425 440 PF13499 0.625
LIG_DLG_GKlike_1 438 446 PF00625 0.612
LIG_EH1_1 637 645 PF00400 0.482
LIG_eIF4E_1 777 783 PF01652 0.412
LIG_FHA_1 162 168 PF00498 0.651
LIG_FHA_1 249 255 PF00498 0.536
LIG_FHA_1 266 272 PF00498 0.574
LIG_FHA_1 28 34 PF00498 0.702
LIG_FHA_1 528 534 PF00498 0.625
LIG_FHA_1 788 794 PF00498 0.365
LIG_FHA_1 795 801 PF00498 0.316
LIG_FHA_1 845 851 PF00498 0.612
LIG_FHA_1 891 897 PF00498 0.675
LIG_FHA_2 142 148 PF00498 0.697
LIG_FHA_2 261 267 PF00498 0.542
LIG_FHA_2 320 326 PF00498 0.534
LIG_FHA_2 333 339 PF00498 0.470
LIG_FHA_2 492 498 PF00498 0.587
LIG_FHA_2 758 764 PF00498 0.372
LIG_FHA_2 903 909 PF00498 0.730
LIG_Integrin_isoDGR_2 773 775 PF01839 0.542
LIG_IRF3_LxIS_1 640 647 PF10401 0.453
LIG_LIR_Gen_1 324 331 PF02991 0.520
LIG_LIR_Gen_1 36 46 PF02991 0.653
LIG_LIR_Gen_1 452 462 PF02991 0.504
LIG_LIR_Gen_1 758 769 PF02991 0.397
LIG_LIR_Nem_3 324 329 PF02991 0.520
LIG_LIR_Nem_3 36 42 PF02991 0.651
LIG_LIR_Nem_3 452 457 PF02991 0.504
LIG_LIR_Nem_3 758 764 PF02991 0.398
LIG_LIR_Nem_3 809 814 PF02991 0.329
LIG_NRBOX 938 944 PF00104 0.622
LIG_NRBOX 945 951 PF00104 0.709
LIG_Pex14_2 64 68 PF04695 0.615
LIG_SH2_PTP2 39 42 PF00017 0.574
LIG_SH2_SRC 317 320 PF00017 0.487
LIG_SH2_SRC 735 738 PF00017 0.620
LIG_SH2_STAP1 126 130 PF00017 0.718
LIG_SH2_STAP1 397 401 PF00017 0.611
LIG_SH2_STAP1 613 617 PF00017 0.513
LIG_SH2_STAT3 595 598 PF00017 0.506
LIG_SH2_STAT5 317 320 PF00017 0.513
LIG_SH2_STAT5 39 42 PF00017 0.574
LIG_SH2_STAT5 466 469 PF00017 0.379
LIG_SH2_STAT5 595 598 PF00017 0.551
LIG_SH2_STAT5 613 616 PF00017 0.576
LIG_SH2_STAT5 735 738 PF00017 0.620
LIG_SH2_STAT5 814 817 PF00017 0.407
LIG_SH3_1 243 249 PF00018 0.669
LIG_SH3_1 469 475 PF00018 0.505
LIG_SH3_2 602 607 PF14604 0.585
LIG_SH3_3 139 145 PF00018 0.758
LIG_SH3_3 196 202 PF00018 0.788
LIG_SH3_3 20 26 PF00018 0.787
LIG_SH3_3 243 249 PF00018 0.794
LIG_SH3_3 40 46 PF00018 0.510
LIG_SH3_3 469 475 PF00018 0.505
LIG_SH3_3 550 556 PF00018 0.379
LIG_SH3_3 599 605 PF00018 0.626
LIG_SH3_3 617 623 PF00018 0.414
LIG_SH3_3 759 765 PF00018 0.464
LIG_SUMO_SIM_anti_2 452 459 PF11976 0.504
LIG_SUMO_SIM_par_1 163 169 PF11976 0.581
LIG_SUMO_SIM_par_1 642 647 PF11976 0.463
LIG_TRAF2_1 498 501 PF00917 0.604
LIG_TYR_ITIM 37 42 PF00017 0.380
LIG_UBA3_1 949 958 PF00899 0.644
LIG_WW_3 470 474 PF00397 0.629
MOD_CDK_SPxxK_3 375 382 PF00069 0.787
MOD_CK1_1 111 117 PF00069 0.791
MOD_CK1_1 128 134 PF00069 0.572
MOD_CK1_1 152 158 PF00069 0.612
MOD_CK1_1 24 30 PF00069 0.716
MOD_CK1_1 265 271 PF00069 0.504
MOD_CK1_1 289 295 PF00069 0.389
MOD_CK1_1 370 376 PF00069 0.717
MOD_CK1_1 386 392 PF00069 0.609
MOD_CK1_1 453 459 PF00069 0.465
MOD_CK1_1 477 483 PF00069 0.778
MOD_CK1_1 504 510 PF00069 0.814
MOD_CK1_1 520 526 PF00069 0.533
MOD_CK1_1 527 533 PF00069 0.734
MOD_CK1_1 547 553 PF00069 0.332
MOD_CK1_1 585 591 PF00069 0.712
MOD_CK1_1 689 695 PF00069 0.770
MOD_CK1_1 809 815 PF00069 0.413
MOD_CK1_1 849 855 PF00069 0.454
MOD_CK1_1 892 898 PF00069 0.604
MOD_CK1_1 925 931 PF00069 0.795
MOD_CK2_1 241 247 PF00069 0.812
MOD_CK2_1 260 266 PF00069 0.332
MOD_CK2_1 45 51 PF00069 0.596
MOD_CK2_1 644 650 PF00069 0.571
MOD_CK2_1 694 700 PF00069 0.804
MOD_CK2_1 757 763 PF00069 0.489
MOD_CK2_1 902 908 PF00069 0.657
MOD_CK2_1 91 97 PF00069 0.791
MOD_Cter_Amidation 935 938 PF01082 0.655
MOD_GlcNHglycan 100 103 PF01048 0.735
MOD_GlcNHglycan 111 114 PF01048 0.755
MOD_GlcNHglycan 121 124 PF01048 0.654
MOD_GlcNHglycan 127 130 PF01048 0.572
MOD_GlcNHglycan 157 160 PF01048 0.502
MOD_GlcNHglycan 209 212 PF01048 0.822
MOD_GlcNHglycan 213 216 PF01048 0.755
MOD_GlcNHglycan 234 237 PF01048 0.775
MOD_GlcNHglycan 288 291 PF01048 0.469
MOD_GlcNHglycan 385 388 PF01048 0.761
MOD_GlcNHglycan 391 394 PF01048 0.523
MOD_GlcNHglycan 418 422 PF01048 0.488
MOD_GlcNHglycan 47 50 PF01048 0.637
MOD_GlcNHglycan 476 479 PF01048 0.730
MOD_GlcNHglycan 570 573 PF01048 0.783
MOD_GlcNHglycan 590 594 PF01048 0.470
MOD_GlcNHglycan 697 700 PF01048 0.829
MOD_GlcNHglycan 730 733 PF01048 0.743
MOD_GlcNHglycan 808 811 PF01048 0.345
MOD_GlcNHglycan 840 843 PF01048 0.506
MOD_GlcNHglycan 899 902 PF01048 0.587
MOD_GlcNHglycan 924 927 PF01048 0.753
MOD_GSK3_1 124 131 PF00069 0.653
MOD_GSK3_1 148 155 PF00069 0.725
MOD_GSK3_1 176 183 PF00069 0.466
MOD_GSK3_1 203 210 PF00069 0.752
MOD_GSK3_1 24 31 PF00069 0.690
MOD_GSK3_1 285 292 PF00069 0.478
MOD_GSK3_1 370 377 PF00069 0.650
MOD_GSK3_1 417 424 PF00069 0.444
MOD_GSK3_1 449 456 PF00069 0.488
MOD_GSK3_1 504 511 PF00069 0.754
MOD_GSK3_1 520 527 PF00069 0.616
MOD_GSK3_1 531 538 PF00069 0.640
MOD_GSK3_1 585 592 PF00069 0.715
MOD_GSK3_1 669 676 PF00069 0.768
MOD_GSK3_1 685 692 PF00069 0.602
MOD_GSK3_1 72 79 PF00069 0.524
MOD_LATS_1 174 180 PF00433 0.480
MOD_LATS_1 436 442 PF00433 0.504
MOD_LATS_1 726 732 PF00433 0.667
MOD_LATS_1 818 824 PF00433 0.499
MOD_N-GLC_1 134 139 PF02516 0.621
MOD_N-GLC_2 170 172 PF02516 0.672
MOD_N-GLC_2 417 419 PF02516 0.529
MOD_N-GLC_2 594 596 PF02516 0.635
MOD_NEK2_1 178 183 PF00069 0.374
MOD_NEK2_1 203 208 PF00069 0.738
MOD_NEK2_1 3 8 PF00069 0.724
MOD_NEK2_1 374 379 PF00069 0.705
MOD_NEK2_1 406 411 PF00069 0.493
MOD_NEK2_1 449 454 PF00069 0.488
MOD_NEK2_1 542 547 PF00069 0.535
MOD_NEK2_1 568 573 PF00069 0.752
MOD_NEK2_1 64 69 PF00069 0.558
MOD_NEK2_1 757 762 PF00069 0.521
MOD_NEK2_1 794 799 PF00069 0.395
MOD_NEK2_1 806 811 PF00069 0.317
MOD_NEK2_1 832 837 PF00069 0.411
MOD_NEK2_1 846 851 PF00069 0.394
MOD_NEK2_2 69 74 PF00069 0.605
MOD_OFUCOSY 419 425 PF10250 0.546
MOD_PIKK_1 176 182 PF00454 0.511
MOD_PIKK_1 496 502 PF00454 0.777
MOD_PK_1 822 828 PF00069 0.504
MOD_PKA_1 232 238 PF00069 0.636
MOD_PKA_2 232 238 PF00069 0.811
MOD_PKA_2 239 245 PF00069 0.706
MOD_PKA_2 381 387 PF00069 0.777
MOD_PKA_2 389 395 PF00069 0.512
MOD_PKA_2 518 524 PF00069 0.617
MOD_PKA_2 568 574 PF00069 0.671
MOD_PKA_2 588 594 PF00069 0.573
MOD_PKA_2 629 635 PF00069 0.668
MOD_PKA_2 660 666 PF00069 0.811
MOD_PKA_2 69 75 PF00069 0.534
MOD_PKA_2 821 827 PF00069 0.415
MOD_PKB_1 820 828 PF00069 0.454
MOD_Plk_1 523 529 PF00069 0.759
MOD_Plk_4 450 456 PF00069 0.439
MOD_Plk_4 59 65 PF00069 0.396
MOD_Plk_4 757 763 PF00069 0.505
MOD_Plk_4 764 770 PF00069 0.421
MOD_Plk_4 799 805 PF00069 0.366
MOD_Plk_4 822 828 PF00069 0.469
MOD_Plk_4 945 951 PF00069 0.584
MOD_ProDKin_1 141 147 PF00069 0.676
MOD_ProDKin_1 204 210 PF00069 0.779
MOD_ProDKin_1 223 229 PF00069 0.538
MOD_ProDKin_1 332 338 PF00069 0.407
MOD_ProDKin_1 375 381 PF00069 0.794
MOD_ProDKin_1 528 534 PF00069 0.803
MOD_ProDKin_1 537 543 PF00069 0.690
MOD_ProDKin_1 616 622 PF00069 0.702
MOD_ProDKin_1 632 638 PF00069 0.452
MOD_ProDKin_1 644 650 PF00069 0.646
MOD_ProDKin_1 835 841 PF00069 0.329
TRG_DiLeu_BaLyEn_6 919 924 PF01217 0.659
TRG_ENDOCYTIC_2 39 42 PF00928 0.452
TRG_ER_diArg_1 195 198 PF00400 0.575
TRG_ER_diArg_1 243 246 PF00400 0.624
TRG_ER_diArg_1 564 567 PF00400 0.655
TRG_ER_diArg_1 568 570 PF00400 0.691
TRG_ER_diArg_1 937 939 PF00400 0.712
TRG_ER_diArg_1 950 952 PF00400 0.644
TRG_Pf-PMV_PEXEL_1 922 927 PF00026 0.678

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM78 Leptomonas seymouri 40% 100%
A4HYC4 Leishmania infantum 99% 100%
E9AS58 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4QDA8 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS