CYTH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVE7_LEIDO

TriTrypDb:

LdBPK_190620.1 , LdCL_190011200 , LDHU3_19.0700

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVE7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.631
CLV_C14_Caspase3-7	255	259	PF00656	0.689
CLV_NRD_NRD_1	318	320	PF00675	0.406
CLV_NRD_NRD_1	438	440	PF00675	0.518
CLV_NRD_NRD_1	459	461	PF00675	0.739
CLV_NRD_NRD_1	507	509	PF00675	0.572
CLV_NRD_NRD_1	515	517	PF00675	0.420
CLV_PCSK_KEX2_1	438	440	PF00082	0.518
CLV_PCSK_KEX2_1	459	461	PF00082	0.687
CLV_PCSK_KEX2_1	507	509	PF00082	0.572
CLV_PCSK_SKI1_1	145	149	PF00082	0.488
CLV_PCSK_SKI1_1	319	323	PF00082	0.533
CLV_PCSK_SKI1_1	510	514	PF00082	0.519
CLV_PCSK_SKI1_1	523	527	PF00082	0.511
CLV_PCSK_SKI1_1	588	592	PF00082	0.464
DEG_APCC_DBOX_1	437	445	PF00400	0.533
DEG_Nend_UBRbox_3	1	3	PF02207	0.487
DEG_SPOP_SBC_1	106	110	PF00917	0.746
DEG_SPOP_SBC_1	446	450	PF00917	0.454
DOC_CDC14_PxL_1	654	662	PF14671	0.570
DOC_CYCLIN_yClb5_NLxxxL_5	438	445	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	392	398	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	597	603	PF00134	0.559
DOC_MAPK_DCC_7	653	662	PF00069	0.592
DOC_MAPK_FxFP_2	37	40	PF00069	0.487
DOC_MAPK_gen_1	345	355	PF00069	0.488
DOC_MAPK_gen_1	438	446	PF00069	0.561
DOC_MAPK_gen_1	507	515	PF00069	0.530
DOC_MAPK_MEF2A_6	128	137	PF00069	0.549
DOC_MAPK_MEF2A_6	348	355	PF00069	0.471
DOC_MAPK_MEF2A_6	419	428	PF00069	0.520
DOC_MAPK_MEF2A_6	47	55	PF00069	0.448
DOC_MAPK_MEF2A_6	653	662	PF00069	0.660
DOC_PP2B_LxvP_1	133	136	PF13499	0.611
DOC_PP2B_LxvP_1	369	372	PF13499	0.389
DOC_PP2B_LxvP_1	392	395	PF13499	0.522
DOC_PP2B_LxvP_1	53	56	PF13499	0.430
DOC_PP2B_LxvP_1	597	600	PF13499	0.485
DOC_PP4_FxxP_1	37	40	PF00568	0.487
DOC_PP4_FxxP_1	499	502	PF00568	0.521
DOC_SPAK_OSR1_1	570	574	PF12202	0.392
DOC_USP7_MATH_1	105	109	PF00917	0.767
DOC_USP7_MATH_1	222	226	PF00917	0.661
DOC_USP7_MATH_1	247	251	PF00917	0.742
DOC_USP7_MATH_1	254	258	PF00917	0.773
DOC_USP7_MATH_1	453	457	PF00917	0.724
DOC_USP7_MATH_1	606	610	PF00917	0.609
DOC_USP7_MATH_1	624	628	PF00917	0.670
DOC_USP7_MATH_1	71	75	PF00917	0.722
DOC_USP7_UBL2_3	145	149	PF12436	0.443
DOC_USP7_UBL2_3	289	293	PF12436	0.802
DOC_USP7_UBL2_3	575	579	PF12436	0.603
DOC_WW_Pin1_4	498	503	PF00397	0.527
LIG_14-3-3_CanoR_1	17	23	PF00244	0.527
LIG_14-3-3_CanoR_1	229	237	PF00244	0.479
LIG_14-3-3_CanoR_1	319	325	PF00244	0.429
LIG_14-3-3_CanoR_1	47	51	PF00244	0.587
LIG_14-3-3_CanoR_1	507	513	PF00244	0.522
LIG_14-3-3_CanoR_1	588	593	PF00244	0.474
LIG_14-3-3_CanoR_1	596	600	PF00244	0.424
LIG_14-3-3_CanoR_1	65	71	PF00244	0.567
LIG_Actin_WH2_2	305	321	PF00022	0.495
LIG_APCC_ABBA_1	660	665	PF00400	0.483
LIG_BRCT_BRCA1_1	107	111	PF00533	0.547
LIG_BRCT_BRCA1_1	201	205	PF00533	0.636
LIG_DLG_GKlike_1	508	515	PF00625	0.602
LIG_EVH1_1	654	658	PF00568	0.633
LIG_FHA_1	185	191	PF00498	0.530
LIG_FHA_1	406	412	PF00498	0.517
LIG_FHA_1	559	565	PF00498	0.510
LIG_FHA_1	592	598	PF00498	0.451
LIG_FHA_1	693	699	PF00498	0.503
LIG_FHA_1	715	721	PF00498	0.482
LIG_FHA_1	726	732	PF00498	0.487
LIG_FHA_2	193	199	PF00498	0.629
LIG_FHA_2	334	340	PF00498	0.683
LIG_FHA_2	363	369	PF00498	0.571
LIG_FHA_2	491	497	PF00498	0.519
LIG_FXI_DFP_1	36	40	PF00024	0.480
LIG_GBD_Chelix_1	712	720	PF00786	0.588
LIG_Integrin_RGD_1	688	690	PF01839	0.524
LIG_LIR_Apic_2	34	40	PF02991	0.471
LIG_LIR_Apic_2	356	362	PF02991	0.479
LIG_LIR_Apic_2	496	502	PF02991	0.510
LIG_LIR_Apic_2	667	672	PF02991	0.516
LIG_LIR_Gen_1	202	212	PF02991	0.599
LIG_LIR_Gen_1	258	269	PF02991	0.685
LIG_LIR_Gen_1	30	41	PF02991	0.464
LIG_LIR_Gen_1	511	519	PF02991	0.569
LIG_LIR_Gen_1	569	577	PF02991	0.546
LIG_LIR_Gen_1	736	744	PF02991	0.500
LIG_LIR_Gen_1	84	93	PF02991	0.598
LIG_LIR_Nem_3	202	208	PF02991	0.602
LIG_LIR_Nem_3	258	264	PF02991	0.689
LIG_LIR_Nem_3	29	35	PF02991	0.458
LIG_LIR_Nem_3	323	327	PF02991	0.524
LIG_LIR_Nem_3	38	44	PF02991	0.437
LIG_LIR_Nem_3	401	407	PF02991	0.462
LIG_LIR_Nem_3	511	515	PF02991	0.494
LIG_LIR_Nem_3	569	574	PF02991	0.552
LIG_LIR_Nem_3	576	581	PF02991	0.493
LIG_LIR_Nem_3	736	741	PF02991	0.471
LIG_LIR_Nem_3	84	90	PF02991	0.609
LIG_LYPXL_yS_3	41	44	PF13949	0.504
LIG_MYND_3	306	310	PF01753	0.613
LIG_NRBOX	440	446	PF00104	0.569
LIG_PAM2_1	232	244	PF00658	0.625
LIG_PCNA_TLS_4	732	739	PF02747	0.497
LIG_SH2_CRK	324	328	PF00017	0.499
LIG_SH2_CRK	669	673	PF00017	0.546
LIG_SH2_SRC	241	244	PF00017	0.614
LIG_SH2_SRC	434	437	PF00017	0.514
LIG_SH2_STAP1	33	37	PF00017	0.531
LIG_SH2_STAP1	367	371	PF00017	0.411
LIG_SH2_STAP1	407	411	PF00017	0.570
LIG_SH2_STAP1	567	571	PF00017	0.609
LIG_SH2_STAP1	63	67	PF00017	0.698
LIG_SH2_STAP1	696	700	PF00017	0.449
LIG_SH2_STAP1	87	91	PF00017	0.589
LIG_SH2_STAT3	211	214	PF00017	0.626
LIG_SH2_STAT3	275	278	PF00017	0.688
LIG_SH2_STAT3	637	640	PF00017	0.666
LIG_SH2_STAT5	275	278	PF00017	0.629
LIG_SH2_STAT5	359	362	PF00017	0.566
LIG_SH2_STAT5	407	410	PF00017	0.518
LIG_SH2_STAT5	489	492	PF00017	0.577
LIG_SH2_STAT5	524	527	PF00017	0.452
LIG_SH2_STAT5	631	634	PF00017	0.704
LIG_SH2_STAT5	637	640	PF00017	0.637
LIG_SH2_STAT5	738	741	PF00017	0.501
LIG_SH3_1	653	659	PF00018	0.633
LIG_SH3_3	53	59	PF00018	0.568
LIG_SH3_3	652	658	PF00018	0.630
LIG_SH3_3	675	681	PF00018	0.631
LIG_SH3_3	703	709	PF00018	0.594
LIG_TRAF2_1	43	46	PF00917	0.519
LIG_TRAF2_1	639	642	PF00917	0.736
LIG_UBA3_1	525	529	PF00899	0.563
MOD_CK1_1	126	132	PF00069	0.628
MOD_CK1_1	184	190	PF00069	0.593
MOD_CK1_1	194	200	PF00069	0.579
MOD_CK1_1	232	238	PF00069	0.500
MOD_CK1_1	283	289	PF00069	0.746
MOD_CK1_1	402	408	PF00069	0.478
MOD_CK1_1	447	453	PF00069	0.576
MOD_CK1_1	541	547	PF00069	0.569
MOD_CK1_1	627	633	PF00069	0.615
MOD_CK1_1	66	72	PF00069	0.733
MOD_CK2_1	333	339	PF00069	0.643
MOD_CK2_1	340	346	PF00069	0.599
MOD_CK2_1	362	368	PF00069	0.580
MOD_CK2_1	460	466	PF00069	0.704
MOD_CK2_1	636	642	PF00069	0.757
MOD_CK2_1	730	736	PF00069	0.479
MOD_GlcNHglycan	125	128	PF01048	0.665
MOD_GlcNHglycan	208	211	PF01048	0.453
MOD_GlcNHglycan	224	227	PF01048	0.478
MOD_GlcNHglycan	234	237	PF01048	0.410
MOD_GlcNHglycan	249	252	PF01048	0.508
MOD_GlcNHglycan	534	537	PF01048	0.607
MOD_GlcNHglycan	620	623	PF01048	0.747
MOD_GlcNHglycan	65	68	PF01048	0.630
MOD_GlcNHglycan	71	74	PF01048	0.720
MOD_GSK3_1	11	18	PF00069	0.570
MOD_GSK3_1	181	188	PF00069	0.518
MOD_GSK3_1	199	206	PF00069	0.557
MOD_GSK3_1	279	286	PF00069	0.733
MOD_GSK3_1	445	452	PF00069	0.542
MOD_GSK3_1	477	484	PF00069	0.645
MOD_GSK3_1	498	505	PF00069	0.537
MOD_GSK3_1	586	593	PF00069	0.466
MOD_GSK3_1	607	614	PF00069	0.625
MOD_GSK3_1	627	634	PF00069	0.681
MOD_GSK3_1	680	687	PF00069	0.671
MOD_NEK2_1	185	190	PF00069	0.445
MOD_NEK2_1	280	285	PF00069	0.765
MOD_NEK2_1	426	431	PF00069	0.469
MOD_NEK2_1	444	449	PF00069	0.590
MOD_NEK2_1	586	591	PF00069	0.489
MOD_NEK2_1	611	616	PF00069	0.700
MOD_NEK2_1	664	669	PF00069	0.436
MOD_NEK2_2	314	319	PF00069	0.451
MOD_NEK2_2	362	367	PF00069	0.588
MOD_NEK2_2	502	507	PF00069	0.555
MOD_NEK2_2	524	529	PF00069	0.346
MOD_PIKK_1	259	265	PF00454	0.672
MOD_PIKK_1	273	279	PF00454	0.712
MOD_PIKK_1	280	286	PF00454	0.711
MOD_PIKK_1	405	411	PF00454	0.568
MOD_PIKK_1	453	459	PF00454	0.640
MOD_PIKK_1	558	564	PF00454	0.470
MOD_PIKK_1	624	630	PF00454	0.699
MOD_PIKK_1	636	642	PF00454	0.674
MOD_PIKK_1	680	686	PF00454	0.670
MOD_PKA_2	405	411	PF00069	0.586
MOD_PKA_2	426	432	PF00069	0.535
MOD_PKA_2	46	52	PF00069	0.468
MOD_PKA_2	595	601	PF00069	0.513
MOD_Plk_1	355	361	PF00069	0.417
MOD_Plk_1	45	51	PF00069	0.558
MOD_Plk_1	477	483	PF00069	0.647
MOD_Plk_1	502	508	PF00069	0.562
MOD_Plk_1	664	670	PF00069	0.441
MOD_Plk_1	714	720	PF00069	0.561
MOD_Plk_1	725	731	PF00069	0.468
MOD_Plk_4	115	121	PF00069	0.566
MOD_Plk_4	158	164	PF00069	0.513
MOD_Plk_4	181	187	PF00069	0.591
MOD_Plk_4	355	361	PF00069	0.417
MOD_Plk_4	362	368	PF00069	0.454
MOD_Plk_4	46	52	PF00069	0.486
MOD_Plk_4	477	483	PF00069	0.638
MOD_Plk_4	508	514	PF00069	0.499
MOD_Plk_4	573	579	PF00069	0.520
MOD_Plk_4	58	64	PF00069	0.553
MOD_Plk_4	632	638	PF00069	0.628
MOD_Plk_4	715	721	PF00069	0.546
MOD_ProDKin_1	498	504	PF00069	0.533
MOD_SUMO_for_1	27	30	PF00179	0.489
MOD_SUMO_rev_2	400	405	PF00179	0.473
MOD_SUMO_rev_2	418	426	PF00179	0.530
TRG_DiLeu_BaEn_1	86	91	PF01217	0.665
TRG_DiLeu_BaEn_2	383	389	PF01217	0.563
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.518
TRG_DiLeu_BaLyEn_6	656	661	PF01217	0.558
TRG_ENDOCYTIC_2	32	35	PF00928	0.439
TRG_ENDOCYTIC_2	324	327	PF00928	0.488
TRG_ENDOCYTIC_2	41	44	PF00928	0.510
TRG_ENDOCYTIC_2	434	437	PF00928	0.514
TRG_ENDOCYTIC_2	738	741	PF00928	0.447
TRG_ENDOCYTIC_2	87	90	PF00928	0.593
TRG_ER_diArg_1	351	354	PF00400	0.444
TRG_ER_diArg_1	437	439	PF00400	0.507
TRG_ER_diArg_1	506	508	PF00400	0.467
TRG_ER_diArg_1	51	54	PF00400	0.428
TRG_ER_diArg_1	513	516	PF00400	0.378
TRG_NES_CRM1_1	715	726	PF08389	0.539
TRG_Pf-PMV_PEXEL_1	285	290	PF00026	0.710
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	554	558	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD6	Leptomonas seymouri	55%	93%
A0A1X0P6B2	Trypanosomatidae	26%	100%
A4HA20	Leishmania braziliensis	79%	99%
A4HY83	Leishmania infantum	99%	100%
E9AS14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDF9	Leishmania major	93%	100%