CYTH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVE7_LEIDO

TriTrypDb:

LdBPK_190620.1 , LdCL_190011200 , LDHU3_19.0700

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVE7

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.631
CLV_C14_Caspase3-7	255	259	PF00656	0.689
CLV_NRD_NRD_1	318	320	PF00675	0.406
CLV_NRD_NRD_1	438	440	PF00675	0.518
CLV_NRD_NRD_1	459	461	PF00675	0.739
CLV_NRD_NRD_1	507	509	PF00675	0.572
CLV_NRD_NRD_1	515	517	PF00675	0.420
CLV_PCSK_KEX2_1	438	440	PF00082	0.518
CLV_PCSK_KEX2_1	459	461	PF00082	0.687
CLV_PCSK_KEX2_1	507	509	PF00082	0.572

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD6	Leptomonas seymouri	55%	93%
A0A1X0P6B2	Trypanosomatidae	26%	100%
A4HA20	Leishmania braziliensis	79%	99%
A4HY83	Leishmania infantum	99%	100%
E9AS14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDF9	Leishmania major	93%	100%

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