FYVE zinc finger containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FYVE zinc finger, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WVE0_LEIDO

TriTrypDb:

LdBPK_190930.1 , LdCL_190014700 , LDHU3_19.1140

Length:

832

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVE0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.692
CLV_C14_Caspase3-7	178	182	PF00656	0.741
CLV_NRD_NRD_1	124	126	PF00675	0.750
CLV_NRD_NRD_1	214	216	PF00675	0.750
CLV_NRD_NRD_1	282	284	PF00675	0.710
CLV_NRD_NRD_1	422	424	PF00675	0.515
CLV_NRD_NRD_1	426	428	PF00675	0.491
CLV_NRD_NRD_1	434	436	PF00675	0.473
CLV_NRD_NRD_1	462	464	PF00675	0.364
CLV_NRD_NRD_1	469	471	PF00675	0.371
CLV_NRD_NRD_1	477	479	PF00675	0.411
CLV_NRD_NRD_1	482	484	PF00675	0.318
CLV_NRD_NRD_1	552	554	PF00675	0.372
CLV_NRD_NRD_1	624	626	PF00675	0.566
CLV_NRD_NRD_1	93	95	PF00675	0.541
CLV_PCSK_FUR_1	467	471	PF00082	0.411
CLV_PCSK_FUR_1	622	626	PF00082	0.552
CLV_PCSK_KEX2_1	124	126	PF00082	0.750
CLV_PCSK_KEX2_1	214	216	PF00082	0.750
CLV_PCSK_KEX2_1	282	284	PF00082	0.710
CLV_PCSK_KEX2_1	422	424	PF00082	0.526
CLV_PCSK_KEX2_1	426	428	PF00082	0.502
CLV_PCSK_KEX2_1	434	436	PF00082	0.468
CLV_PCSK_KEX2_1	462	464	PF00082	0.364
CLV_PCSK_KEX2_1	469	471	PF00082	0.371
CLV_PCSK_KEX2_1	477	479	PF00082	0.411
CLV_PCSK_KEX2_1	482	484	PF00082	0.318
CLV_PCSK_KEX2_1	552	554	PF00082	0.375
CLV_PCSK_KEX2_1	624	626	PF00082	0.507
CLV_PCSK_KEX2_1	92	94	PF00082	0.557
CLV_PCSK_PC7_1	422	428	PF00082	0.547
CLV_PCSK_PC7_1	478	484	PF00082	0.393
CLV_PCSK_PC7_1	89	95	PF00082	0.629
CLV_PCSK_SKI1_1	400	404	PF00082	0.730
CLV_PCSK_SKI1_1	435	439	PF00082	0.531
CLV_PCSK_SKI1_1	469	473	PF00082	0.355
CLV_PCSK_SKI1_1	739	743	PF00082	0.698
DEG_SPOP_SBC_1	14	18	PF00917	0.547
DEG_SPOP_SBC_1	324	328	PF00917	0.697
DOC_CKS1_1	1	6	PF01111	0.676
DOC_CKS1_1	243	248	PF01111	0.737
DOC_CKS1_1	299	304	PF01111	0.734
DOC_CKS1_1	703	708	PF01111	0.644
DOC_CYCLIN_RxL_1	463	476	PF00134	0.411
DOC_MAPK_gen_1	603	612	PF00069	0.411
DOC_MAPK_gen_1	92	100	PF00069	0.587
DOC_MAPK_RevD_3	610	625	PF00069	0.411
DOC_MAPK_RevD_3	80	94	PF00069	0.649
DOC_PP2B_LxvP_1	252	255	PF13499	0.714
DOC_PP2B_LxvP_1	321	324	PF13499	0.728
DOC_USP7_MATH_1	134	138	PF00917	0.777
DOC_USP7_MATH_1	14	18	PF00917	0.722
DOC_USP7_MATH_1	159	163	PF00917	0.767
DOC_USP7_MATH_1	281	285	PF00917	0.811
DOC_USP7_MATH_1	325	329	PF00917	0.816
DOC_USP7_MATH_1	354	358	PF00917	0.773
DOC_USP7_MATH_1	490	494	PF00917	0.411
DOC_USP7_MATH_1	719	723	PF00917	0.581
DOC_WW_Pin1_4	116	121	PF00397	0.707
DOC_WW_Pin1_4	124	129	PF00397	0.720
DOC_WW_Pin1_4	130	135	PF00397	0.712
DOC_WW_Pin1_4	198	203	PF00397	0.781
DOC_WW_Pin1_4	242	247	PF00397	0.734
DOC_WW_Pin1_4	291	296	PF00397	0.752
DOC_WW_Pin1_4	298	303	PF00397	0.725
DOC_WW_Pin1_4	357	362	PF00397	0.735
DOC_WW_Pin1_4	369	374	PF00397	0.607
DOC_WW_Pin1_4	383	388	PF00397	0.821
DOC_WW_Pin1_4	558	563	PF00397	0.400
DOC_WW_Pin1_4	702	707	PF00397	0.648
LIG_14-3-3_CanoR_1	209	216	PF00244	0.825
LIG_14-3-3_CanoR_1	238	246	PF00244	0.832
LIG_14-3-3_CanoR_1	270	274	PF00244	0.776
LIG_14-3-3_CanoR_1	282	291	PF00244	0.649
LIG_14-3-3_CanoR_1	332	336	PF00244	0.826
LIG_14-3-3_CanoR_1	400	410	PF00244	0.708
LIG_14-3-3_CanoR_1	469	475	PF00244	0.513
LIG_14-3-3_CanoR_1	513	517	PF00244	0.497
LIG_14-3-3_CanoR_1	657	665	PF00244	0.729
LIG_14-3-3_CanoR_1	724	731	PF00244	0.636
LIG_14-3-3_CanoR_1	83	91	PF00244	0.644
LIG_BIR_II_1	1	5	PF00653	0.583
LIG_BIR_III_1	1	5	PF00653	0.583
LIG_BIR_III_3	1	5	PF00653	0.583
LIG_BIR_III_4	174	178	PF00653	0.723
LIG_BRCT_BRCA1_1	255	259	PF00533	0.827
LIG_Clathr_ClatBox_1	23	27	PF01394	0.674
LIG_Clathr_ClatBox_1	58	62	PF01394	0.738
LIG_Clathr_ClatBox_1	780	784	PF01394	0.814
LIG_CtBP_PxDLS_1	379	384	PF00389	0.624
LIG_deltaCOP1_diTrp_1	225	234	PF00928	0.701
LIG_eIF4E_1	432	438	PF01652	0.551
LIG_eIF4E_1	466	472	PF01652	0.411
LIG_FHA_1	168	174	PF00498	0.746
LIG_FHA_1	243	249	PF00498	0.736
LIG_FHA_1	325	331	PF00498	0.723
LIG_FHA_1	357	363	PF00498	0.759
LIG_FHA_1	500	506	PF00498	0.411
LIG_FHA_1	527	533	PF00498	0.513
LIG_FHA_1	535	541	PF00498	0.381
LIG_FHA_1	573	579	PF00498	0.416
LIG_FHA_1	650	656	PF00498	0.634
LIG_FHA_1	69	75	PF00498	0.611
LIG_FHA_1	703	709	PF00498	0.645
LIG_FHA_1	83	89	PF00498	0.579
LIG_FHA_2	14	20	PF00498	0.587
LIG_FHA_2	162	168	PF00498	0.788
LIG_FHA_2	176	182	PF00498	0.638
LIG_FHA_2	387	393	PF00498	0.739
LIG_FHA_2	4	10	PF00498	0.739
LIG_FHA_2	412	418	PF00498	0.662
LIG_FHA_2	531	537	PF00498	0.389
LIG_FHA_2	649	655	PF00498	0.536
LIG_FHA_2	724	730	PF00498	0.634
LIG_FHA_2	811	817	PF00498	0.692
LIG_HCF-1_HBM_1	547	550	PF13415	0.411
LIG_KLC1_Yacidic_2	57	62	PF13176	0.739
LIG_LIR_Gen_1	57	65	PF02991	0.666
LIG_LIR_Nem_3	57	63	PF02991	0.671
LIG_LIR_Nem_3	641	647	PF02991	0.521
LIG_MYND_1	246	250	PF01753	0.730
LIG_MYND_1	369	373	PF01753	0.694
LIG_MYND_1	562	566	PF01753	0.416
LIG_SH2_CRK	308	312	PF00017	0.611
LIG_SH2_GRB2like	617	620	PF00017	0.411
LIG_SH2_NCK_1	308	312	PF00017	0.611
LIG_SH2_PTP2	60	63	PF00017	0.658
LIG_SH2_STAP1	285	289	PF00017	0.835
LIG_SH2_STAP1	528	532	PF00017	0.411
LIG_SH2_STAT3	216	219	PF00017	0.815
LIG_SH2_STAT5	216	219	PF00017	0.776
LIG_SH2_STAT5	285	288	PF00017	0.708
LIG_SH2_STAT5	474	477	PF00017	0.513
LIG_SH2_STAT5	495	498	PF00017	0.411
LIG_SH2_STAT5	504	507	PF00017	0.411
LIG_SH2_STAT5	528	531	PF00017	0.411
LIG_SH2_STAT5	60	63	PF00017	0.658
LIG_SH2_STAT5	686	689	PF00017	0.763
LIG_SH2_STAT5	730	733	PF00017	0.645
LIG_SH2_STAT5	734	737	PF00017	0.666
LIG_SH3_2	120	125	PF14604	0.749
LIG_SH3_3	114	120	PF00018	0.786
LIG_SH3_3	247	253	PF00018	0.826
LIG_SH3_3	370	376	PF00018	0.704
LIG_SH3_3	502	508	PF00018	0.513
LIG_SH3_3	609	615	PF00018	0.513
LIG_SUMO_SIM_anti_2	574	582	PF11976	0.397
LIG_SUMO_SIM_anti_2	776	782	PF11976	0.745
LIG_SUMO_SIM_par_1	22	28	PF11976	0.573
LIG_SUMO_SIM_par_1	409	417	PF11976	0.574
LIG_SUMO_SIM_par_1	574	582	PF11976	0.397
LIG_SUMO_SIM_par_1	824	832	PF11976	0.797
LIG_TRAF2_1	414	417	PF00917	0.594
LIG_TRAF2_1	651	654	PF00917	0.646
LIG_TYR_ITIM	58	63	PF00017	0.669
MOD_CDK_SPK_2	198	203	PF00069	0.666
MOD_CK1_1	148	154	PF00069	0.763
MOD_CK1_1	236	242	PF00069	0.728
MOD_CK1_1	244	250	PF00069	0.725
MOD_CK1_1	272	278	PF00069	0.713
MOD_CK1_1	297	303	PF00069	0.753
MOD_CK1_1	357	363	PF00069	0.703
MOD_CK1_1	378	384	PF00069	0.835
MOD_CK1_1	473	479	PF00069	0.411
MOD_CK1_1	526	532	PF00069	0.411
MOD_CK1_1	694	700	PF00069	0.650
MOD_CK1_1	776	782	PF00069	0.733
MOD_CK2_1	161	167	PF00069	0.703
MOD_CK2_1	3	9	PF00069	0.740
MOD_CK2_1	357	363	PF00069	0.704
MOD_CK2_1	411	417	PF00069	0.572
MOD_CK2_1	648	654	PF00069	0.525
MOD_Cter_Amidation	496	499	PF01082	0.411
MOD_GlcNHglycan	107	110	PF01048	0.618
MOD_GlcNHglycan	136	139	PF01048	0.754
MOD_GlcNHglycan	178	181	PF01048	0.776
MOD_GlcNHglycan	211	214	PF01048	0.826
MOD_GlcNHglycan	308	311	PF01048	0.658
MOD_GlcNHglycan	327	330	PF01048	0.641
MOD_GlcNHglycan	343	346	PF01048	0.492
MOD_GlcNHglycan	348	351	PF01048	0.691
MOD_GlcNHglycan	356	359	PF01048	0.692
MOD_GlcNHglycan	363	367	PF01048	0.500
MOD_GlcNHglycan	377	380	PF01048	0.716
MOD_GlcNHglycan	403	406	PF01048	0.713
MOD_GlcNHglycan	633	636	PF01048	0.697
MOD_GlcNHglycan	681	685	PF01048	0.670
MOD_GlcNHglycan	693	696	PF01048	0.610
MOD_GlcNHglycan	715	718	PF01048	0.573
MOD_GlcNHglycan	721	724	PF01048	0.576
MOD_GlcNHglycan	756	759	PF01048	0.783
MOD_GSK3_1	124	131	PF00069	0.761
MOD_GSK3_1	145	152	PF00069	0.759
MOD_GSK3_1	182	189	PF00069	0.767
MOD_GSK3_1	205	212	PF00069	0.720
MOD_GSK3_1	230	237	PF00069	0.725
MOD_GSK3_1	238	245	PF00069	0.731
MOD_GSK3_1	290	297	PF00069	0.740
MOD_GSK3_1	319	326	PF00069	0.814
MOD_GSK3_1	346	353	PF00069	0.662
MOD_GSK3_1	508	515	PF00069	0.510
MOD_GSK3_1	526	533	PF00069	0.227
MOD_GSK3_1	586	593	PF00069	0.513
MOD_GSK3_1	64	71	PF00069	0.745
MOD_GSK3_1	719	726	PF00069	0.572
MOD_N-GLC_1	148	153	PF02516	0.793
MOD_N-GLC_1	223	228	PF02516	0.807
MOD_N-GLC_2	636	638	PF02516	0.549
MOD_NEK2_1	234	239	PF00069	0.730
MOD_NEK2_1	274	279	PF00069	0.811
MOD_NEK2_1	341	346	PF00069	0.691
MOD_NEK2_1	362	367	PF00069	0.742
MOD_NEK2_1	380	385	PF00069	0.797
MOD_NEK2_1	735	740	PF00069	0.671
MOD_NEK2_2	150	155	PF00069	0.598
MOD_PIKK_1	182	188	PF00454	0.629
MOD_PIKK_1	214	220	PF00454	0.779
MOD_PIKK_1	391	397	PF00454	0.709
MOD_PIKK_1	82	88	PF00454	0.653
MOD_PKA_1	214	220	PF00069	0.702
MOD_PKA_1	422	428	PF00069	0.625
MOD_PKA_2	105	111	PF00069	0.619
MOD_PKA_2	142	148	PF00069	0.740
MOD_PKA_2	186	192	PF00069	0.763
MOD_PKA_2	214	220	PF00069	0.728
MOD_PKA_2	234	240	PF00069	0.612
MOD_PKA_2	269	275	PF00069	0.713
MOD_PKA_2	281	287	PF00069	0.712
MOD_PKA_2	331	337	PF00069	0.822
MOD_PKA_2	422	428	PF00069	0.577
MOD_PKA_2	512	518	PF00069	0.510
MOD_PKA_2	656	662	PF00069	0.710
MOD_PKA_2	723	729	PF00069	0.632
MOD_PKA_2	82	88	PF00069	0.599
MOD_PKB_1	288	296	PF00069	0.742
MOD_Plk_1	490	496	PF00069	0.411
MOD_Plk_1	500	506	PF00069	0.411
MOD_Plk_1	546	552	PF00069	0.524
MOD_Plk_1	776	782	PF00069	0.721
MOD_Plk_2-3	810	816	PF00069	0.809
MOD_Plk_4	269	275	PF00069	0.815
MOD_Plk_4	386	392	PF00069	0.742
MOD_Plk_4	500	506	PF00069	0.400
MOD_Plk_4	572	578	PF00069	0.397
MOD_Plk_4	776	782	PF00069	0.823
MOD_ProDKin_1	116	122	PF00069	0.710
MOD_ProDKin_1	124	130	PF00069	0.722
MOD_ProDKin_1	198	204	PF00069	0.782
MOD_ProDKin_1	242	248	PF00069	0.736
MOD_ProDKin_1	291	297	PF00069	0.752
MOD_ProDKin_1	298	304	PF00069	0.725
MOD_ProDKin_1	357	363	PF00069	0.738
MOD_ProDKin_1	369	375	PF00069	0.608
MOD_ProDKin_1	383	389	PF00069	0.824
MOD_ProDKin_1	558	564	PF00069	0.400
MOD_ProDKin_1	702	708	PF00069	0.646
MOD_SUMO_for_1	524	527	PF00179	0.411
MOD_SUMO_rev_2	415	421	PF00179	0.647
TRG_DiLeu_BaEn_4	416	422	PF01217	0.534
TRG_DiLeu_BaEn_4	653	659	PF01217	0.689
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.812
TRG_DiLeu_BaLyEn_6	441	446	PF01217	0.654
TRG_ENDOCYTIC_2	60	63	PF00928	0.658
TRG_ENDOCYTIC_2	646	649	PF00928	0.486
TRG_ER_diArg_1	104	107	PF00400	0.589
TRG_ER_diArg_1	123	125	PF00400	0.759
TRG_ER_diArg_1	214	216	PF00400	0.750
TRG_ER_diArg_1	421	423	PF00400	0.521
TRG_ER_diArg_1	426	428	PF00400	0.489
TRG_ER_diArg_1	466	469	PF00400	0.378
TRG_ER_diArg_1	551	553	PF00400	0.355
TRG_ER_diArg_1	621	624	PF00400	0.518
TRG_ER_diArg_1	91	94	PF00400	0.543
TRG_Pf-PMV_PEXEL_1	435	440	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R7	Leptomonas seymouri	53%	99%
A4HA51	Leishmania braziliensis	80%	100%
A4HYB5	Leishmania infantum	100%	100%
E9AS48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QDB8	Leishmania major	94%	100%