WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVD7_LEIDO

TriTrypDb:

LdBPK_190520.1 , LdCL_190010200 , LDHU3_19.0580

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVD7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.556
CLV_C14_Caspase3-7	470	474	PF00656	0.533
CLV_NRD_NRD_1	142	144	PF00675	0.596
CLV_NRD_NRD_1	176	178	PF00675	0.389
CLV_NRD_NRD_1	214	216	PF00675	0.486
CLV_NRD_NRD_1	287	289	PF00675	0.551
CLV_NRD_NRD_1	290	292	PF00675	0.542
CLV_NRD_NRD_1	331	333	PF00675	0.483
CLV_NRD_NRD_1	433	435	PF00675	0.457
CLV_NRD_NRD_1	436	438	PF00675	0.437
CLV_PCSK_FUR_1	136	140	PF00082	0.680
CLV_PCSK_FUR_1	288	292	PF00082	0.664
CLV_PCSK_FUR_1	434	438	PF00082	0.504
CLV_PCSK_KEX2_1	138	140	PF00082	0.675
CLV_PCSK_KEX2_1	142	144	PF00082	0.637
CLV_PCSK_KEX2_1	175	177	PF00082	0.430
CLV_PCSK_KEX2_1	289	291	PF00082	0.589
CLV_PCSK_KEX2_1	433	435	PF00082	0.470
CLV_PCSK_KEX2_1	436	438	PF00082	0.445
CLV_PCSK_KEX2_1	556	558	PF00082	0.568
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.607
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.639
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.626
CLV_PCSK_SKI1_1	114	118	PF00082	0.708
CLV_PCSK_SKI1_1	121	125	PF00082	0.519
CLV_PCSK_SKI1_1	170	174	PF00082	0.448
CLV_PCSK_SKI1_1	220	224	PF00082	0.455
CLV_PCSK_SKI1_1	326	330	PF00082	0.633
CLV_PCSK_SKI1_1	399	403	PF00082	0.447
CLV_PCSK_SKI1_1	408	412	PF00082	0.427
CLV_PCSK_SKI1_1	560	564	PF00082	0.693
DEG_APCC_DBOX_1	204	212	PF00400	0.428
DEG_SCF_TRCP1_1	79	84	PF00400	0.553
DOC_MAPK_gen_1	424	432	PF00069	0.420
DOC_MAPK_gen_1	521	530	PF00069	0.571
DOC_MAPK_gen_1	538	545	PF00069	0.505
DOC_MAPK_MEF2A_6	424	432	PF00069	0.491
DOC_MAPK_RevD_3	543	557	PF00069	0.434
DOC_PP1_RVXF_1	233	240	PF00149	0.624
DOC_PP1_RVXF_1	252	259	PF00149	0.367
DOC_PP2B_LxvP_1	123	126	PF13499	0.541
DOC_PP2B_LxvP_1	364	367	PF13499	0.420
DOC_PP4_FxxP_1	124	127	PF00568	0.641
DOC_USP7_UBL2_3	216	220	PF12436	0.453
DOC_WW_Pin1_4	11	16	PF00397	0.691
LIG_14-3-3_CanoR_1	179	185	PF00244	0.386
LIG_14-3-3_CanoR_1	225	231	PF00244	0.462
LIG_14-3-3_CanoR_1	441	450	PF00244	0.471
LIG_14-3-3_CanoR_1	560	565	PF00244	0.579
LIG_Actin_WH2_2	165	181	PF00022	0.495
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_BIR_III_2	62	66	PF00653	0.536
LIG_BIR_III_4	304	308	PF00653	0.482
LIG_BRCT_BRCA1_1	1	5	PF00533	0.664
LIG_BRCT_BRCA1_1	12	16	PF00533	0.681
LIG_CaM_IQ_9	192	207	PF13499	0.492
LIG_CaM_IQ_9	249	265	PF13499	0.390
LIG_CaM_IQ_9	425	441	PF13499	0.450
LIG_eIF4E_1	118	124	PF01652	0.512
LIG_EVH1_2	105	109	PF00568	0.505
LIG_FHA_1	232	238	PF00498	0.519
LIG_FHA_1	375	381	PF00498	0.604
LIG_FHA_1	405	411	PF00498	0.420
LIG_FHA_1	416	422	PF00498	0.448
LIG_FHA_2	151	157	PF00498	0.430
LIG_FHA_2	181	187	PF00498	0.448
LIG_FHA_2	22	28	PF00498	0.551
LIG_FHA_2	316	322	PF00498	0.631
LIG_FHA_2	340	346	PF00498	0.463
LIG_LIR_Apic_2	122	127	PF02991	0.516
LIG_LIR_Gen_1	497	505	PF02991	0.507
LIG_LIR_Nem_3	108	112	PF02991	0.528
LIG_LIR_Nem_3	166	172	PF02991	0.480
LIG_LIR_Nem_3	497	501	PF02991	0.461
LIG_PCNA_yPIPBox_3	157	169	PF02747	0.447
LIG_PTAP_UEV_1	504	509	PF05743	0.517
LIG_SH2_CRK	498	502	PF00017	0.468
LIG_SH2_CRK	510	514	PF00017	0.469
LIG_SH2_GRB2like	147	150	PF00017	0.550
LIG_SH2_NCK_1	498	502	PF00017	0.573
LIG_SH2_SRC	547	550	PF00017	0.665
LIG_SH2_STAP1	147	151	PF00017	0.512
LIG_SH2_STAT3	266	269	PF00017	0.481
LIG_SH2_STAT5	226	229	PF00017	0.464
LIG_SH2_STAT5	266	269	PF00017	0.420
LIG_SH2_STAT5	414	417	PF00017	0.420
LIG_SH2_STAT5	544	547	PF00017	0.546
LIG_SH3_1	12	18	PF00018	0.554
LIG_SH3_3	12	18	PF00018	0.730
LIG_SH3_3	123	129	PF00018	0.529
LIG_SH3_3	331	337	PF00018	0.550
LIG_SH3_3	35	41	PF00018	0.686
LIG_SH3_3	502	508	PF00018	0.521
LIG_SH3_3	99	105	PF00018	0.608
LIG_WW_3	133	137	PF00397	0.586
MOD_CK1_1	119	125	PF00069	0.513
MOD_CK2_1	150	156	PF00069	0.426
MOD_CK2_1	180	186	PF00069	0.427
MOD_CK2_1	339	345	PF00069	0.454
MOD_CK2_1	368	374	PF00069	0.484
MOD_GlcNHglycan	19	22	PF01048	0.500
MOD_GlcNHglycan	313	318	PF01048	0.492
MOD_GlcNHglycan	361	364	PF01048	0.406
MOD_GlcNHglycan	473	477	PF01048	0.524
MOD_GlcNHglycan	59	62	PF01048	0.711
MOD_GlcNHglycan	79	82	PF01048	0.569
MOD_GSK3_1	17	24	PF00069	0.673
MOD_GSK3_1	220	227	PF00069	0.372
MOD_GSK3_1	395	402	PF00069	0.434
MOD_GSK3_1	404	411	PF00069	0.375
MOD_GSK3_1	77	84	PF00069	0.764
MOD_N-GLC_1	25	30	PF02516	0.576
MOD_N-GLC_2	95	97	PF02516	0.540
MOD_NEK2_1	395	400	PF00069	0.495
MOD_NEK2_1	415	420	PF00069	0.294
MOD_NEK2_1	472	477	PF00069	0.531
MOD_NEK2_1	77	82	PF00069	0.720
MOD_NEK2_1	91	96	PF00069	0.573
MOD_PIKK_1	339	345	PF00454	0.590
MOD_PK_1	34	40	PF00069	0.549
MOD_PKA_2	224	230	PF00069	0.371
MOD_PKA_2	359	365	PF00069	0.377
MOD_PKB_1	406	414	PF00069	0.448
MOD_PKB_1	439	447	PF00069	0.526
MOD_Plk_1	163	169	PF00069	0.510
MOD_Plk_1	25	31	PF00069	0.565
MOD_Plk_4	549	555	PF00069	0.502
MOD_ProDKin_1	11	17	PF00069	0.693
MOD_SUMO_for_1	461	464	PF00179	0.499
MOD_SUMO_rev_2	368	377	PF00179	0.582
MOD_SUMO_rev_2	444	448	PF00179	0.438
TRG_ENDOCYTIC_2	113	116	PF00928	0.588
TRG_ENDOCYTIC_2	498	501	PF00928	0.505
TRG_ENDOCYTIC_2	510	513	PF00928	0.474
TRG_ER_diArg_1	141	143	PF00400	0.667
TRG_ER_diArg_1	175	177	PF00400	0.396
TRG_ER_diArg_1	206	209	PF00400	0.365
TRG_ER_diArg_1	288	291	PF00400	0.548
TRG_ER_diArg_1	432	434	PF00400	0.476
TRG_ER_diArg_1	435	437	PF00400	0.460
TRG_ER_diArg_1	439	442	PF00400	0.433
TRG_NLS_MonoCore_2	287	292	PF00514	0.624
TRG_NLS_MonoExtC_3	287	292	PF00514	0.624
TRG_NLS_MonoExtN_4	285	292	PF00514	0.548
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	408	413	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9S0	Leptomonas seymouri	46%	95%
A0A1X0P7R9	Trypanosomatidae	33%	100%
A0A422P367	Trypanosoma rangeli	34%	100%
A4HA10	Leishmania braziliensis	67%	100%
A4HY74	Leishmania infantum	100%	100%
D0A0J3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AS04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QDG9	Leishmania major	91%	100%
V5BSD1	Trypanosoma cruzi	36%	100%