C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein

Species:

Leishmania donovani

UniProt:

A0A3S7WVD2_LEIDO

TriTrypDb:

LdBPK_190300.1 , LdCL_190008000 , LDHU3_19.0350

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7WVD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVD2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	14
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.485
CLV_NRD_NRD_1	39	41	PF00675	0.500
CLV_NRD_NRD_1	71	73	PF00675	0.520
CLV_NRD_NRD_1	88	90	PF00675	0.544
CLV_PCSK_KEX2_1	144	146	PF00082	0.425
CLV_PCSK_KEX2_1	39	41	PF00082	0.506
CLV_PCSK_KEX2_1	71	73	PF00082	0.500
CLV_PCSK_KEX2_1	88	90	PF00082	0.518
CLV_PCSK_SKI1_1	164	168	PF00082	0.716
DEG_Nend_UBRbox_3	1	3	PF02207	0.662
DOC_CYCLIN_RxL_1	37	47	PF00134	0.386
DOC_MAPK_MEF2A_6	210	219	PF00069	0.547
DOC_MAPK_MEF2A_6	244	253	PF00069	0.465
DOC_MAPK_MEF2A_6	39	46	PF00069	0.388
DOC_MAPK_NFAT4_5	39	47	PF00069	0.386
DOC_USP7_MATH_1	186	190	PF00917	0.686
DOC_USP7_MATH_1	332	336	PF00917	0.701
DOC_USP7_MATH_1	342	346	PF00917	0.695
DOC_USP7_UBL2_3	119	123	PF12436	0.597
DOC_USP7_UBL2_3	367	371	PF12436	0.674
DOC_WW_Pin1_4	14	19	PF00397	0.551
DOC_WW_Pin1_4	2	7	PF00397	0.574
LIG_14-3-3_CanoR_1	282	292	PF00244	0.542
LIG_14-3-3_CanoR_1	39	43	PF00244	0.591
LIG_FHA_1	14	20	PF00498	0.595
LIG_FHA_1	22	28	PF00498	0.515
LIG_FHA_2	127	133	PF00498	0.436
LIG_FHA_2	284	290	PF00498	0.585
LIG_GBD_Chelix_1	44	52	PF00786	0.441
LIG_LIR_Gen_1	57	64	PF02991	0.554
LIG_LIR_Nem_3	262	268	PF02991	0.409
LIG_LIR_Nem_3	57	62	PF02991	0.555
LIG_LIR_Nem_3	68	73	PF02991	0.557
LIG_LRP6_Inhibitor_1	272	278	PF00058	0.410
LIG_NRBOX	145	151	PF00104	0.506
LIG_PTB_Apo_2	264	271	PF02174	0.428
LIG_PTB_Phospho_1	264	270	PF10480	0.448
LIG_SH2_CRK	234	238	PF00017	0.542
LIG_SH2_CRK	59	63	PF00017	0.456
LIG_SH2_CRK	70	74	PF00017	0.471
LIG_SH2_GRB2like	299	302	PF00017	0.564
LIG_SH2_SRC	90	93	PF00017	0.520
LIG_SH2_STAP1	270	274	PF00017	0.427
LIG_SH2_STAT3	125	128	PF00017	0.553
LIG_SH2_STAT5	103	106	PF00017	0.446
LIG_SH2_STAT5	113	116	PF00017	0.427
LIG_SH3_3	153	159	PF00018	0.651
LIG_SH3_3	171	177	PF00018	0.507
LIG_SH3_3	291	297	PF00018	0.595
LIG_SH3_3	90	96	PF00018	0.390
LIG_TRAF2_1	129	132	PF00917	0.478
MOD_CK1_1	126	132	PF00069	0.490
MOD_CK1_1	315	321	PF00069	0.629
MOD_CK1_1	345	351	PF00069	0.802
MOD_CK1_1	372	378	PF00069	0.667
MOD_CK2_1	126	132	PF00069	0.473
MOD_CK2_1	283	289	PF00069	0.586
MOD_CK2_1	352	358	PF00069	0.749
MOD_CK2_1	44	50	PF00069	0.490
MOD_GlcNHglycan	188	191	PF01048	0.686
MOD_GlcNHglycan	227	231	PF01048	0.638
MOD_GlcNHglycan	314	317	PF01048	0.661
MOD_GlcNHglycan	347	350	PF01048	0.718
MOD_GlcNHglycan	379	382	PF01048	0.758
MOD_GSK3_1	108	115	PF00069	0.442
MOD_GSK3_1	119	126	PF00069	0.507
MOD_GSK3_1	23	30	PF00069	0.587
MOD_GSK3_1	97	104	PF00069	0.434
MOD_N-GLC_1	139	144	PF02516	0.430
MOD_N-GLC_1	332	337	PF02516	0.734
MOD_NEK2_1	27	32	PF00069	0.513
MOD_NEK2_1	283	288	PF00069	0.510
MOD_NEK2_1	44	49	PF00069	0.477
MOD_OFUCOSY	281	287	PF10250	0.574
MOD_PIKK_1	123	129	PF00454	0.421
MOD_PIKK_1	21	27	PF00454	0.591
MOD_PIKK_1	332	338	PF00454	0.592
MOD_PKA_2	345	351	PF00069	0.624
MOD_PKA_2	38	44	PF00069	0.584
MOD_Plk_1	108	114	PF00069	0.463
MOD_Plk_1	139	145	PF00069	0.449
MOD_Plk_1	261	267	PF00069	0.451
MOD_Plk_2-3	101	107	PF00069	0.439
MOD_Plk_4	27	33	PF00069	0.597
MOD_ProDKin_1	14	20	PF00069	0.545
MOD_ProDKin_1	2	8	PF00069	0.577
MOD_SUMO_for_1	389	392	PF00179	0.728
MOD_SUMO_rev_2	111	120	PF00179	0.527
MOD_SUMO_rev_2	75	80	PF00179	0.556
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.450
TRG_ENDOCYTIC_2	59	62	PF00928	0.424
TRG_ENDOCYTIC_2	70	73	PF00928	0.431
TRG_ENDOCYTIC_2	90	93	PF00928	0.396
TRG_ER_diArg_1	143	145	PF00400	0.453
TRG_ER_diArg_1	38	40	PF00400	0.508
TRG_ER_diArg_1	70	72	PF00400	0.560
TRG_ER_diArg_1	87	89	PF00400	0.549
TRG_ER_diLys_1	388	392	PF00400	0.748
TRG_NES_CRM1_1	148	160	PF08389	0.619
TRG_NES_CRM1_1	37	50	PF08389	0.568
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I4	Leptomonas seymouri	70%	99%
A0A0N1PG85	Leptomonas seymouri	32%	100%
A0A0S4KEK3	Bodo saltans	37%	100%
A0A1X0P6E1	Trypanosomatidae	36%	100%
A0A3Q8IA61	Leishmania donovani	30%	100%
A0A3R7RSV6	Trypanosoma rangeli	34%	100%
A0A422P3A2	Trypanosoma rangeli	40%	96%
A4H9Y7	Leishmania braziliensis	32%	100%
A4H9Y8	Leishmania braziliensis	74%	100%
A4HY39	Leishmania infantum	99%	100%
A4HY52	Leishmania infantum	31%	100%
D0A0F3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A0F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	91%
E9ARY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ARY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QDJ1	Leishmania major	30%	100%
V5BSB1	Trypanosoma cruzi	34%	82%
V5BWY8	Trypanosoma cruzi	33%	100%