Histone_H3_variant_putative/GeneDB:LmjF.19.0630

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone H3 variant V

Species:

Leishmania donovani

UniProt:

A0A3S7WVC7_LEIDO

TriTrypDb:

LdBPK_190630.1 , LdCL_190011300 , LDHU3_19.0710

Length:

145

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000781	chromosome, telomeric region	3	1
GO:0000786	nucleosome	3	12
GO:0005634	nucleus	5	3
GO:0032991	protein-containing complex	1	12
GO:0032993	protein-DNA complex	2	12
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0044815	DNA packaging complex	2	12

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Expansion

Sequence features

A0A3S7WVC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVC7

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006353	DNA-templated transcription termination	6	1
GO:0006369	termination of RNA polymerase II transcription	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030527	structural constituent of chromatin	2	12
GO:0046982	protein heterodimerization activity	4	12
GO:0046983	protein dimerization activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.324
CLV_NRD_NRD_1	48	50	PF00675	0.388
CLV_NRD_NRD_1	61	63	PF00675	0.326
CLV_NRD_NRD_1	78	80	PF00675	0.305
CLV_PCSK_KEX2_1	125	127	PF00082	0.355
CLV_PCSK_KEX2_1	46	48	PF00082	0.343
CLV_PCSK_KEX2_1	78	80	PF00082	0.303
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.381
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.257
CLV_PCSK_PC7_1	74	80	PF00082	0.303

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE44	Leptomonas seymouri	73%	100%
A0A0S4IWA8	Bodo saltans	57%	100%
A0A0S4J721	Bodo saltans	62%	100%
A0A1X0P6L2	Trypanosomatidae	54%	94%
A0A3Q8IC67	Leishmania donovani	55%	100%
A0A3R7KFK4	Trypanosoma rangeli	52%	96%
A0A422MY47	Trypanosoma rangeli	56%	100%
A1CP80	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	53%	100%
A1D240	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	53%	100%
A2QRR5	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	53%	100%

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