Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVC5_LEIDO

TriTrypDb:

LdBPK_190450.1 , LdCL_190009500 , LDHU3_19.0500

Length:

949

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WVC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.676
CLV_C14_Caspase3-7	64	68	PF00656	0.599
CLV_C14_Caspase3-7	810	814	PF00656	0.483
CLV_C14_Caspase3-7	830	834	PF00656	0.661
CLV_C14_Caspase3-7	938	942	PF00656	0.533
CLV_NRD_NRD_1	146	148	PF00675	0.680
CLV_NRD_NRD_1	171	173	PF00675	0.778
CLV_NRD_NRD_1	176	178	PF00675	0.611
CLV_NRD_NRD_1	223	225	PF00675	0.701
CLV_NRD_NRD_1	248	250	PF00675	0.684
CLV_NRD_NRD_1	275	277	PF00675	0.702
CLV_NRD_NRD_1	412	414	PF00675	0.662
CLV_NRD_NRD_1	97	99	PF00675	0.737
CLV_PCSK_KEX2_1	146	148	PF00082	0.643
CLV_PCSK_KEX2_1	169	171	PF00082	0.745
CLV_PCSK_KEX2_1	176	178	PF00082	0.608
CLV_PCSK_KEX2_1	223	225	PF00082	0.701
CLV_PCSK_KEX2_1	248	250	PF00082	0.684
CLV_PCSK_KEX2_1	275	277	PF00082	0.702
CLV_PCSK_KEX2_1	97	99	PF00082	0.737
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.645
CLV_PCSK_PC7_1	165	171	PF00082	0.623
CLV_PCSK_PC7_1	172	178	PF00082	0.559
CLV_PCSK_SKI1_1	497	501	PF00082	0.623
CLV_PCSK_SKI1_1	638	642	PF00082	0.607
DEG_APCC_DBOX_1	19	27	PF00400	0.457
DEG_APCC_DBOX_1	544	552	PF00400	0.587
DEG_SPOP_SBC_1	599	603	PF00917	0.689
DEG_SPOP_SBC_1	855	859	PF00917	0.804
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.655
DOC_MAPK_gen_1	611	620	PF00069	0.724
DOC_MAPK_MEF2A_6	414	423	PF00069	0.611
DOC_MIT_MIM_1	14	24	PF04212	0.545
DOC_PP2B_LxvP_1	469	472	PF13499	0.660
DOC_PP4_FxxP_1	115	118	PF00568	0.617
DOC_PP4_FxxP_1	355	358	PF00568	0.637
DOC_USP7_MATH_1	141	145	PF00917	0.706
DOC_USP7_MATH_1	219	223	PF00917	0.588
DOC_USP7_MATH_1	264	268	PF00917	0.594
DOC_USP7_MATH_1	309	313	PF00917	0.720
DOC_USP7_MATH_1	359	363	PF00917	0.701
DOC_USP7_MATH_1	367	371	PF00917	0.642
DOC_USP7_MATH_1	510	514	PF00917	0.663
DOC_USP7_MATH_1	577	581	PF00917	0.610
DOC_USP7_MATH_1	600	604	PF00917	0.662
DOC_USP7_MATH_1	652	656	PF00917	0.665
DOC_USP7_MATH_1	7	11	PF00917	0.621
DOC_USP7_MATH_1	721	725	PF00917	0.841
DOC_USP7_MATH_1	829	833	PF00917	0.637
DOC_USP7_MATH_1	855	859	PF00917	0.811
DOC_USP7_MATH_1	92	96	PF00917	0.680
DOC_USP7_UBL2_3	534	538	PF12436	0.630
DOC_WW_Pin1_4	106	111	PF00397	0.639
DOC_WW_Pin1_4	266	271	PF00397	0.564
DOC_WW_Pin1_4	299	304	PF00397	0.631
DOC_WW_Pin1_4	330	335	PF00397	0.634
DOC_WW_Pin1_4	354	359	PF00397	0.652
DOC_WW_Pin1_4	392	397	PF00397	0.708
DOC_WW_Pin1_4	412	417	PF00397	0.749
DOC_WW_Pin1_4	428	433	PF00397	0.638
DOC_WW_Pin1_4	521	526	PF00397	0.605
DOC_WW_Pin1_4	564	569	PF00397	0.634
DOC_WW_Pin1_4	582	587	PF00397	0.713
DOC_WW_Pin1_4	595	600	PF00397	0.595
DOC_WW_Pin1_4	609	614	PF00397	0.811
DOC_WW_Pin1_4	638	643	PF00397	0.675
DOC_WW_Pin1_4	648	653	PF00397	0.596
DOC_WW_Pin1_4	664	669	PF00397	0.601
DOC_WW_Pin1_4	717	722	PF00397	0.639
DOC_WW_Pin1_4	77	82	PF00397	0.587
DOC_WW_Pin1_4	841	846	PF00397	0.653
DOC_WW_Pin1_4	90	95	PF00397	0.683
LIG_14-3-3_CanoR_1	146	154	PF00244	0.680
LIG_14-3-3_CanoR_1	165	173	PF00244	0.625
LIG_14-3-3_CanoR_1	176	182	PF00244	0.568
LIG_14-3-3_CanoR_1	184	193	PF00244	0.564
LIG_14-3-3_CanoR_1	275	280	PF00244	0.550
LIG_14-3-3_CanoR_1	337	344	PF00244	0.692
LIG_14-3-3_CanoR_1	377	382	PF00244	0.664
LIG_14-3-3_CanoR_1	497	506	PF00244	0.738
LIG_14-3-3_CanoR_1	614	619	PF00244	0.623
LIG_14-3-3_CanoR_1	900	910	PF00244	0.496
LIG_14-3-3_CanoR_1	97	107	PF00244	0.685
LIG_Actin_WH2_2	684	702	PF00022	0.549
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_BIR_III_2	313	317	PF00653	0.579
LIG_BRCT_BRCA1_1	10	14	PF00533	0.598
LIG_BRCT_BRCA1_1	379	383	PF00533	0.588
LIG_BRCT_BRCA1_1	560	564	PF00533	0.631
LIG_BRCT_BRCA1_1	742	746	PF00533	0.595
LIG_FHA_1	176	182	PF00498	0.574
LIG_FHA_1	333	339	PF00498	0.726
LIG_FHA_1	39	45	PF00498	0.534
LIG_FHA_1	445	451	PF00498	0.742
LIG_FHA_1	516	522	PF00498	0.767
LIG_FHA_1	583	589	PF00498	0.575
LIG_FHA_1	615	621	PF00498	0.660
LIG_FHA_1	779	785	PF00498	0.660
LIG_FHA_1	858	864	PF00498	0.646
LIG_FHA_1	902	908	PF00498	0.611
LIG_FHA_1	915	921	PF00498	0.383
LIG_FHA_1	94	100	PF00498	0.679
LIG_FHA_2	344	350	PF00498	0.665
LIG_FHA_2	432	438	PF00498	0.649
LIG_FHA_2	499	505	PF00498	0.619
LIG_FHA_2	622	628	PF00498	0.675
LIG_FHA_2	808	814	PF00498	0.562
LIG_Integrin_RGD_1	224	226	PF01839	0.696
LIG_LIR_Apic_2	631	637	PF02991	0.708
LIG_LIR_Gen_1	11	21	PF02991	0.562
LIG_LIR_Gen_1	190	199	PF02991	0.567
LIG_LIR_Gen_1	380	391	PF02991	0.625
LIG_LIR_Gen_1	480	487	PF02991	0.630
LIG_LIR_Gen_1	680	688	PF02991	0.548
LIG_LIR_Nem_3	11	17	PF02991	0.574
LIG_LIR_Nem_3	190	196	PF02991	0.559
LIG_LIR_Nem_3	380	386	PF02991	0.620
LIG_LIR_Nem_3	480	485	PF02991	0.656
LIG_LIR_Nem_3	576	581	PF02991	0.633
LIG_LIR_Nem_3	680	684	PF02991	0.649
LIG_LIR_Nem_3	922	928	PF02991	0.458
LIG_MAD2	73	81	PF02301	0.651
LIG_MYND_1	851	855	PF01753	0.640
LIG_PCNA_yPIPBox_3	696	704	PF02747	0.488
LIG_PTAP_UEV_1	415	420	PF05743	0.630
LIG_PTB_Apo_2	888	895	PF02174	0.530
LIG_PTB_Phospho_1	888	894	PF10480	0.534
LIG_Rb_LxCxE_1	208	228	PF01857	0.641
LIG_REV1ctd_RIR_1	190	198	PF16727	0.564
LIG_SH2_CRK	294	298	PF00017	0.677
LIG_SH2_CRK	634	638	PF00017	0.702
LIG_SH2_CRK	802	806	PF00017	0.488
LIG_SH2_NCK_1	581	585	PF00017	0.560
LIG_SH2_SRC	282	285	PF00017	0.603
LIG_SH2_SRC	763	766	PF00017	0.555
LIG_SH2_SRC	939	942	PF00017	0.451
LIG_SH2_STAP1	327	331	PF00017	0.667
LIG_SH2_STAT3	284	287	PF00017	0.535
LIG_SH2_STAT5	173	176	PF00017	0.588
LIG_SH2_STAT5	802	805	PF00017	0.491
LIG_SH2_STAT5	894	897	PF00017	0.534
LIG_SH2_STAT5	939	942	PF00017	0.451
LIG_SH3_1	293	299	PF00018	0.649
LIG_SH3_1	413	419	PF00018	0.641
LIG_SH3_2	107	112	PF14604	0.577
LIG_SH3_3	104	110	PF00018	0.635
LIG_SH3_3	293	299	PF00018	0.787
LIG_SH3_3	413	419	PF00018	0.641
LIG_SH3_3	426	432	PF00018	0.528
LIG_SH3_3	445	451	PF00018	0.612
LIG_SH3_3	461	467	PF00018	0.627
LIG_SH3_3	607	613	PF00018	0.755
LIG_SH3_3	860	866	PF00018	0.669
LIG_TRAF2_1	680	683	PF00917	0.513
LIG_TYR_ITIM	800	805	PF00017	0.494
LIG_WRC_WIRS_1	438	443	PF05994	0.615
LIG_WW_3	109	113	PF00397	0.651
MOD_CDC14_SPxK_1	109	112	PF00782	0.601
MOD_CDC14_SPxK_1	269	272	PF00782	0.565
MOD_CDK_SPK_2	521	526	PF00069	0.605
MOD_CDK_SPK_2	609	614	PF00069	0.637
MOD_CDK_SPK_2	77	82	PF00069	0.562
MOD_CDK_SPxK_1	106	112	PF00069	0.650
MOD_CDK_SPxK_1	266	272	PF00069	0.568
MOD_CDK_SPxxK_3	330	337	PF00069	0.595
MOD_CDK_SPxxK_3	354	361	PF00069	0.569
MOD_CDK_SPxxK_3	77	84	PF00069	0.571
MOD_CDK_SPxxK_3	841	848	PF00069	0.656
MOD_CDK_SPxxK_3	90	97	PF00069	0.590
MOD_CK1_1	101	107	PF00069	0.700
MOD_CK1_1	148	154	PF00069	0.657
MOD_CK1_1	431	437	PF00069	0.689
MOD_CK1_1	453	459	PF00069	0.707
MOD_CK1_1	491	497	PF00069	0.620
MOD_CK1_1	513	519	PF00069	0.647
MOD_CK1_1	674	680	PF00069	0.588
MOD_CK1_1	724	730	PF00069	0.663
MOD_CK1_1	740	746	PF00069	0.684
MOD_CK1_1	856	862	PF00069	0.633
MOD_CK1_1	905	911	PF00069	0.484
MOD_CK1_1	93	99	PF00069	0.807
MOD_CK2_1	130	136	PF00069	0.580
MOD_CK2_1	182	188	PF00069	0.641
MOD_CK2_1	317	323	PF00069	0.596
MOD_CK2_1	392	398	PF00069	0.666
MOD_CK2_1	498	504	PF00069	0.620
MOD_CK2_1	56	62	PF00069	0.636
MOD_CK2_1	677	683	PF00069	0.578
MOD_CK2_1	7	13	PF00069	0.530
MOD_CK2_1	741	747	PF00069	0.665
MOD_DYRK1A_RPxSP_1	106	110	PF00069	0.637
MOD_GlcNHglycan	10	13	PF01048	0.601
MOD_GlcNHglycan	119	122	PF01048	0.635
MOD_GlcNHglycan	132	135	PF01048	0.574
MOD_GlcNHglycan	139	142	PF01048	0.615
MOD_GlcNHglycan	266	269	PF01048	0.798
MOD_GlcNHglycan	299	302	PF01048	0.682
MOD_GlcNHglycan	318	322	PF01048	0.663
MOD_GlcNHglycan	416	419	PF01048	0.614
MOD_GlcNHglycan	452	455	PF01048	0.694
MOD_GlcNHglycan	490	493	PF01048	0.711
MOD_GlcNHglycan	494	497	PF01048	0.788
MOD_GlcNHglycan	512	515	PF01048	0.583
MOD_GlcNHglycan	554	557	PF01048	0.545
MOD_GlcNHglycan	560	563	PF01048	0.546
MOD_GlcNHglycan	575	578	PF01048	0.691
MOD_GlcNHglycan	58	61	PF01048	0.634
MOD_GlcNHglycan	593	596	PF01048	0.642
MOD_GlcNHglycan	602	605	PF01048	0.696
MOD_GlcNHglycan	658	661	PF01048	0.701
MOD_GlcNHglycan	673	676	PF01048	0.521
MOD_GlcNHglycan	685	688	PF01048	0.334
MOD_GlcNHglycan	791	794	PF01048	0.582
MOD_GSK3_1	137	144	PF00069	0.722
MOD_GSK3_1	184	191	PF00069	0.666
MOD_GSK3_1	437	444	PF00069	0.724
MOD_GSK3_1	488	495	PF00069	0.646
MOD_GSK3_1	498	505	PF00069	0.596
MOD_GSK3_1	510	517	PF00069	0.719
MOD_GSK3_1	552	559	PF00069	0.739
MOD_GSK3_1	560	567	PF00069	0.637
MOD_GSK3_1	569	576	PF00069	0.561
MOD_GSK3_1	591	598	PF00069	0.631
MOD_GSK3_1	641	648	PF00069	0.634
MOD_GSK3_1	652	659	PF00069	0.558
MOD_GSK3_1	662	669	PF00069	0.800
MOD_GSK3_1	703	710	PF00069	0.648
MOD_GSK3_1	717	724	PF00069	0.660
MOD_GSK3_1	733	740	PF00069	0.702
MOD_GSK3_1	774	781	PF00069	0.695
MOD_GSK3_1	829	836	PF00069	0.643
MOD_GSK3_1	853	860	PF00069	0.704
MOD_GSK3_1	901	908	PF00069	0.494
MOD_GSK3_1	914	921	PF00069	0.465
MOD_GSK3_1	93	100	PF00069	0.815
MOD_N-GLC_1	238	243	PF02516	0.642
MOD_N-GLC_1	342	347	PF02516	0.674
MOD_N-GLC_1	902	907	PF02516	0.503
MOD_NEK2_1	182	187	PF00069	0.621
MOD_NEK2_1	38	43	PF00069	0.510
MOD_NEK2_1	441	446	PF00069	0.737
MOD_NEK2_1	558	563	PF00069	0.664
MOD_NEK2_1	800	805	PF00069	0.530
MOD_NEK2_1	85	90	PF00069	0.664
MOD_NEK2_1	901	906	PF00069	0.500
MOD_NEK2_2	141	146	PF00069	0.710
MOD_PIKK_1	337	343	PF00454	0.647
MOD_PIKK_1	516	522	PF00454	0.751
MOD_PIKK_1	800	806	PF00454	0.492
MOD_PIKK_1	807	813	PF00454	0.482
MOD_PIKK_1	905	911	PF00454	0.484
MOD_PKA_1	275	281	PF00069	0.645
MOD_PKA_1	97	103	PF00069	0.682
MOD_PKA_2	145	151	PF00069	0.649
MOD_PKA_2	164	170	PF00069	0.547
MOD_PKA_2	175	181	PF00069	0.554
MOD_PKA_2	188	194	PF00069	0.580
MOD_PKA_2	275	281	PF00069	0.593
MOD_PKA_2	724	730	PF00069	0.663
MOD_PKA_2	914	920	PF00069	0.452
MOD_PKA_2	97	103	PF00069	0.749
MOD_Plk_1	327	333	PF00069	0.665
MOD_Plk_1	66	72	PF00069	0.698
MOD_Plk_1	767	773	PF00069	0.697
MOD_Plk_1	784	790	PF00069	0.469
MOD_Plk_1	902	908	PF00069	0.524
MOD_Plk_2-3	931	937	PF00069	0.520
MOD_Plk_4	188	194	PF00069	0.577
MOD_Plk_4	641	647	PF00069	0.699
MOD_Plk_4	931	937	PF00069	0.520
MOD_ProDKin_1	106	112	PF00069	0.640
MOD_ProDKin_1	266	272	PF00069	0.565
MOD_ProDKin_1	299	305	PF00069	0.635
MOD_ProDKin_1	330	336	PF00069	0.634
MOD_ProDKin_1	354	360	PF00069	0.654
MOD_ProDKin_1	392	398	PF00069	0.712
MOD_ProDKin_1	412	418	PF00069	0.747
MOD_ProDKin_1	428	434	PF00069	0.637
MOD_ProDKin_1	521	527	PF00069	0.605
MOD_ProDKin_1	564	570	PF00069	0.636
MOD_ProDKin_1	582	588	PF00069	0.645
MOD_ProDKin_1	595	601	PF00069	0.596
MOD_ProDKin_1	609	615	PF00069	0.810
MOD_ProDKin_1	638	644	PF00069	0.676
MOD_ProDKin_1	648	654	PF00069	0.596
MOD_ProDKin_1	664	670	PF00069	0.598
MOD_ProDKin_1	717	723	PF00069	0.640
MOD_ProDKin_1	77	83	PF00069	0.591
MOD_ProDKin_1	841	847	PF00069	0.653
MOD_ProDKin_1	90	96	PF00069	0.684
MOD_SUMO_rev_2	431	441	PF00179	0.682
MOD_SUMO_rev_2	65	75	PF00179	0.653
TRG_DiLeu_BaEn_1	13	18	PF01217	0.477
TRG_DiLeu_BaEn_1	796	801	PF01217	0.542
TRG_ENDOCYTIC_2	294	297	PF00928	0.793
TRG_ENDOCYTIC_2	802	805	PF00928	0.491
TRG_ER_diArg_1	145	147	PF00400	0.649
TRG_ER_diArg_1	170	172	PF00400	0.786
TRG_ER_diArg_1	175	177	PF00400	0.616
TRG_ER_diArg_1	199	202	PF00400	0.674
TRG_ER_diArg_1	248	251	PF00400	0.647
TRG_ER_diArg_1	360	363	PF00400	0.578
TRG_ER_diArg_1	97	99	PF00400	0.745
TRG_NES_CRM1_1	682	694	PF08389	0.541
TRG_NES_CRM1_1	811	822	PF08389	0.591
TRG_NLS_MonoCore_2	168	173	PF00514	0.643
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K8	Leptomonas seymouri	35%	95%
A4HA03	Leishmania braziliensis	58%	100%
A4HY67	Leishmania infantum	100%	100%
E9ARZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QDH6	Leishmania major	87%	100%