Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVB3_LEIDO

TriTrypDb:

LdBPK_190490.1 , LdCL_190009900 , LDHU3_19.0540

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0020016	ciliary pocket	2	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WVB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVB3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.228
CLV_NRD_NRD_1	201	203	PF00675	0.411
CLV_NRD_NRD_1	39	41	PF00675	0.407
CLV_NRD_NRD_1	78	80	PF00675	0.422
CLV_PCSK_KEX2_1	179	181	PF00082	0.228
CLV_PCSK_KEX2_1	201	203	PF00082	0.317
CLV_PCSK_KEX2_1	39	41	PF00082	0.444
CLV_PCSK_PC7_1	197	203	PF00082	0.410
CLV_PCSK_PC7_1	35	41	PF00082	0.482
CLV_PCSK_SKI1_1	193	197	PF00082	0.234
CLV_PCSK_SKI1_1	40	44	PF00082	0.487
CLV_PCSK_SKI1_1	9	13	PF00082	0.394
DEG_APCC_DBOX_1	3	11	PF00400	0.704
DEG_Nend_Nbox_1	1	3	PF02207	0.651
DOC_CKS1_1	10	15	PF01111	0.613
DOC_MAPK_gen_1	201	209	PF00069	0.520
DOC_MAPK_gen_1	21	28	PF00069	0.606
DOC_MAPK_gen_1	83	91	PF00069	0.588
DOC_PP1_RVXF_1	177	184	PF00149	0.262
DOC_PP4_FxxP_1	101	104	PF00568	0.545
DOC_USP7_MATH_1	15	19	PF00917	0.700
DOC_USP7_MATH_1	22	26	PF00917	0.667
DOC_USP7_MATH_1	30	34	PF00917	0.597
DOC_USP7_MATH_1	45	49	PF00917	0.653
DOC_USP7_MATH_1	96	100	PF00917	0.638
DOC_USP7_UBL2_3	46	50	PF12436	0.761
DOC_WW_Pin1_4	9	14	PF00397	0.614
LIG_14-3-3_CanoR_1	180	186	PF00244	0.428
LIG_14-3-3_CanoR_1	21	27	PF00244	0.711
LIG_deltaCOP1_diTrp_1	143	152	PF00928	0.238
LIG_FHA_2	47	53	PF00498	0.737
LIG_FHA_2	82	88	PF00498	0.595
LIG_GBD_Chelix_1	105	113	PF00786	0.240
LIG_LIR_Apic_2	99	104	PF02991	0.547
LIG_LIR_Gen_1	165	173	PF02991	0.320
LIG_LIR_Nem_3	165	169	PF02991	0.343
LIG_NRBOX	202	208	PF00104	0.616
LIG_SH2_CRK	158	162	PF00017	0.279
LIG_SH2_CRK	166	170	PF00017	0.295
LIG_SH2_STAP1	166	170	PF00017	0.262
LIG_SH2_STAT5	124	127	PF00017	0.304
LIG_SH2_STAT5	132	135	PF00017	0.243
LIG_SH2_STAT5	158	161	PF00017	0.303
LIG_SH2_STAT5	90	93	PF00017	0.567
LIG_TYR_ITIM	156	161	PF00017	0.383
MOD_CK1_1	24	30	PF00069	0.706
MOD_CK2_1	46	52	PF00069	0.724
MOD_CK2_1	81	87	PF00069	0.612
MOD_Cter_Amidation	177	180	PF01082	0.262
MOD_GlcNHglycan	119	122	PF01048	0.331
MOD_GlcNHglycan	13	16	PF01048	0.447
MOD_GlcNHglycan	28	31	PF01048	0.392
MOD_GlcNHglycan	56	59	PF01048	0.514
MOD_GSK3_1	11	18	PF00069	0.715
MOD_GSK3_1	113	120	PF00069	0.301
MOD_GSK3_1	189	196	PF00069	0.463
MOD_GSK3_1	22	29	PF00069	0.714
MOD_N-GLC_1	197	202	PF02516	0.364
MOD_NEK2_1	113	118	PF00069	0.333
MOD_NEK2_1	26	31	PF00069	0.756
MOD_NEK2_2	30	35	PF00069	0.750
MOD_NEK2_2	96	101	PF00069	0.640
MOD_PIKK_1	66	72	PF00454	0.800
MOD_PKA_2	22	28	PF00069	0.654
MOD_Plk_4	164	170	PF00069	0.266
MOD_Plk_4	96	102	PF00069	0.569
MOD_ProDKin_1	9	15	PF00069	0.614
MOD_SUMO_rev_2	59	68	PF00179	0.618
TRG_ENDOCYTIC_2	154	157	PF00928	0.249
TRG_ENDOCYTIC_2	158	161	PF00928	0.306
TRG_ENDOCYTIC_2	166	169	PF00928	0.343
TRG_ER_diArg_1	179	181	PF00400	0.428
TRG_ER_diArg_1	201	203	PF00400	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE20	Leptomonas seymouri	74%	100%
A0A0S4IUQ3	Bodo saltans	47%	100%
A0A1X0P6B8	Trypanosomatidae	60%	100%
A0A3R7KYF8	Trypanosoma rangeli	60%	100%
A4HA07	Leishmania braziliensis	88%	100%
A4HY71	Leishmania infantum	100%	100%
D0A0J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AS01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QDH2	Leishmania major	94%	100%
V5DTP2	Trypanosoma cruzi	59%	100%