LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved (fragment)
Species:
Leishmania donovani
UniProt:
A0A3S7WVB2_LEIDO
TriTrypDb:
LdBPK_190570.1 , LdCL_190010700 , LDHU3_19.0630
Length:
529

Annotations

LeishMANIAdb annotations

Belongs to a poorly known protein family found in basal Eukaryota (also containing A0A0A1U905_ENTIV, A0A0A1U245_ENTIV). Very distantly related to animal prominins.. The first TM segment can equally be a signal peptide, with no change in overall topology. If related to prominins, this massively expanded family could play a role in vesicular processes.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 19, no: 1
NetGPI no yes: 0, no: 20
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19

Expansion

Sequence features

A0A3S7WVB2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVB2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 3 7 PF00082 0.600
CLV_PCSK_SKI1_1 367 371 PF00082 0.598
CLV_PCSK_SKI1_1 496 500 PF00082 0.257
DEG_APCC_KENBOX_2 504 508 PF00400 0.486
DOC_CKS1_1 171 176 PF01111 0.308
DOC_MAPK_gen_1 202 211 PF00069 0.411
DOC_MAPK_gen_1 95 104 PF00069 0.669
DOC_MAPK_MEF2A_6 106 115 PF00069 0.519
DOC_USP7_MATH_1 25 29 PF00917 0.443
DOC_USP7_MATH_1 421 425 PF00917 0.425
DOC_WW_Pin1_4 170 175 PF00397 0.391
DOC_WW_Pin1_4 513 518 PF00397 0.595
DOC_WW_Pin1_4 521 526 PF00397 0.589
LIG_14-3-3_CanoR_1 157 163 PF00244 0.417
LIG_14-3-3_CanoR_1 464 471 PF00244 0.257
LIG_14-3-3_CanoR_1 53 62 PF00244 0.404
LIG_BIR_II_1 1 5 PF00653 0.536
LIG_EH1_1 219 227 PF00400 0.486
LIG_EH1_1 479 487 PF00400 0.336
LIG_FHA_1 159 165 PF00498 0.405
LIG_FHA_1 188 194 PF00498 0.398
LIG_FHA_1 2 8 PF00498 0.571
LIG_FHA_1 258 264 PF00498 0.448
LIG_FHA_1 369 375 PF00498 0.364
LIG_FHA_1 406 412 PF00498 0.374
LIG_FHA_1 49 55 PF00498 0.376
LIG_FHA_2 377 383 PF00498 0.468
LIG_FHA_2 456 462 PF00498 0.449
LIG_GBD_Chelix_1 250 258 PF00786 0.338
LIG_LIR_Apic_2 363 368 PF02991 0.348
LIG_LIR_Apic_2 398 402 PF02991 0.416
LIG_LIR_Apic_2 428 432 PF02991 0.349
LIG_LIR_Apic_2 91 96 PF02991 0.562
LIG_LIR_Gen_1 180 189 PF02991 0.318
LIG_LIR_Gen_1 190 200 PF02991 0.341
LIG_LIR_Gen_1 297 305 PF02991 0.384
LIG_LIR_Nem_3 144 150 PF02991 0.314
LIG_LIR_Nem_3 180 185 PF02991 0.312
LIG_LIR_Nem_3 190 195 PF02991 0.312
LIG_LIR_Nem_3 242 248 PF02991 0.300
LIG_LIR_Nem_3 297 301 PF02991 0.390
LIG_LIR_Nem_3 398 404 PF02991 0.465
LIG_LIR_Nem_3 428 434 PF02991 0.452
LIG_LIR_Nem_3 56 61 PF02991 0.338
LIG_LYPXL_S_1 62 66 PF13949 0.515
LIG_Pex14_1 241 245 PF04695 0.452
LIG_Pex14_2 248 252 PF04695 0.356
LIG_SH2_CRK 129 133 PF00017 0.408
LIG_SH2_CRK 399 403 PF00017 0.295
LIG_SH2_GRB2like 152 155 PF00017 0.350
LIG_SH2_PTP2 192 195 PF00017 0.442
LIG_SH2_PTP2 365 368 PF00017 0.350
LIG_SH2_PTP2 429 432 PF00017 0.406
LIG_SH2_PTP2 93 96 PF00017 0.555
LIG_SH2_SRC 61 64 PF00017 0.392
LIG_SH2_STAT5 152 155 PF00017 0.320
LIG_SH2_STAT5 192 195 PF00017 0.349
LIG_SH2_STAT5 200 203 PF00017 0.332
LIG_SH2_STAT5 245 248 PF00017 0.315
LIG_SH2_STAT5 264 267 PF00017 0.266
LIG_SH2_STAT5 287 290 PF00017 0.291
LIG_SH2_STAT5 365 368 PF00017 0.405
LIG_SH2_STAT5 383 386 PF00017 0.259
LIG_SH2_STAT5 429 432 PF00017 0.408
LIG_SH2_STAT5 462 465 PF00017 0.396
LIG_SH2_STAT5 61 64 PF00017 0.323
LIG_SH2_STAT5 93 96 PF00017 0.555
LIG_SH3_3 168 174 PF00018 0.435
LIG_SH3_3 512 518 PF00018 0.601
LIG_SH3_3 519 525 PF00018 0.612
LIG_SUMO_SIM_anti_2 355 364 PF11976 0.412
LIG_TRFH_1 60 64 PF08558 0.358
LIG_TYR_ITIM 127 132 PF00017 0.467
LIG_Vh1_VBS_1 1 19 PF01044 0.371
MOD_CDC14_SPxK_1 524 527 PF00782 0.583
MOD_CDK_SPxK_1 521 527 PF00069 0.577
MOD_CK1_1 391 397 PF00069 0.350
MOD_CK1_1 40 46 PF00069 0.381
MOD_CK1_1 454 460 PF00069 0.548
MOD_CK2_1 376 382 PF00069 0.438
MOD_CK2_1 40 46 PF00069 0.437
MOD_CK2_1 85 91 PF00069 0.694
MOD_GlcNHglycan 167 170 PF01048 0.608
MOD_GlcNHglycan 178 182 PF01048 0.503
MOD_GlcNHglycan 23 26 PF01048 0.594
MOD_GlcNHglycan 233 236 PF01048 0.445
MOD_GlcNHglycan 266 269 PF01048 0.585
MOD_GlcNHglycan 314 317 PF01048 0.569
MOD_GlcNHglycan 466 469 PF01048 0.614
MOD_GSK3_1 142 149 PF00069 0.422
MOD_GSK3_1 158 165 PF00069 0.302
MOD_GSK3_1 173 180 PF00069 0.381
MOD_GSK3_1 21 28 PF00069 0.475
MOD_GSK3_1 346 353 PF00069 0.354
MOD_GSK3_1 36 43 PF00069 0.284
MOD_GSK3_1 421 428 PF00069 0.345
MOD_GSK3_1 451 458 PF00069 0.507
MOD_GSK3_1 521 528 PF00069 0.618
MOD_N-GLC_1 153 158 PF02516 0.534
MOD_N-GLC_1 165 170 PF02516 0.553
MOD_N-GLC_1 187 192 PF02516 0.550
MOD_N-GLC_1 328 333 PF02516 0.593
MOD_N-GLC_1 376 381 PF02516 0.681
MOD_N-GLC_1 40 45 PF02516 0.624
MOD_N-GLC_1 421 426 PF02516 0.525
MOD_N-GLC_1 452 457 PF02516 0.665
MOD_N-GLC_2 322 324 PF02516 0.598
MOD_NEK2_1 1 6 PF00069 0.631
MOD_NEK2_1 153 158 PF00069 0.388
MOD_NEK2_1 162 167 PF00069 0.374
MOD_NEK2_1 18 23 PF00069 0.499
MOD_NEK2_1 370 375 PF00069 0.396
MOD_NEK2_1 475 480 PF00069 0.339
MOD_NEK2_1 71 76 PF00069 0.417
MOD_OFUCOSY 237 243 PF10250 0.323
MOD_OFUCOSY 387 392 PF10250 0.529
MOD_OFUCOSY 83 89 PF10250 0.535
MOD_PIKK_1 304 310 PF00454 0.426
MOD_PIKK_1 346 352 PF00454 0.398
MOD_PIKK_1 455 461 PF00454 0.428
MOD_PIKK_1 53 59 PF00454 0.405
MOD_PK_1 470 476 PF00069 0.309
MOD_PKA_2 231 237 PF00069 0.576
MOD_PKA_2 469 475 PF00069 0.377
MOD_Plk_1 158 164 PF00069 0.383
MOD_Plk_1 177 183 PF00069 0.314
MOD_Plk_1 187 193 PF00069 0.358
MOD_Plk_1 328 334 PF00069 0.379
MOD_Plk_1 40 46 PF00069 0.427
MOD_Plk_1 452 458 PF00069 0.489
MOD_Plk_2-3 146 152 PF00069 0.449
MOD_Plk_4 128 134 PF00069 0.423
MOD_Plk_4 187 193 PF00069 0.355
MOD_Plk_4 361 367 PF00069 0.323
MOD_Plk_4 385 391 PF00069 0.336
MOD_Plk_4 40 46 PF00069 0.441
MOD_Plk_4 425 431 PF00069 0.390
MOD_Plk_4 470 476 PF00069 0.272
MOD_ProDKin_1 170 176 PF00069 0.394
MOD_ProDKin_1 513 519 PF00069 0.595
MOD_ProDKin_1 521 527 PF00069 0.590
MOD_SUMO_for_1 96 99 PF00179 0.573
TRG_DiLeu_BaEn_1 385 390 PF01217 0.282
TRG_DiLeu_BaLyEn_6 429 434 PF01217 0.342
TRG_ENDOCYTIC_2 129 132 PF00928 0.380
TRG_ENDOCYTIC_2 147 150 PF00928 0.449
TRG_ENDOCYTIC_2 192 195 PF00928 0.407
TRG_ENDOCYTIC_2 245 248 PF00928 0.283
TRG_ENDOCYTIC_2 63 66 PF00928 0.272
TRG_Pf-PMV_PEXEL_1 27 32 PF00026 0.592

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8Y8 Leptomonas seymouri 55% 100%
A0A0S4ITY9 Bodo saltans 25% 100%
A0A0S4IXB1 Bodo saltans 28% 100%
A0A0S4IXU4 Bodo saltans 28% 100%
A0A1X0NVP9 Trypanosomatidae 39% 100%
A0A1X0NWC8 Trypanosomatidae 37% 100%
A0A1X0P6A6 Trypanosomatidae 30% 100%
A0A3Q8IB78 Leishmania donovani 95% 100%
A0A422N059 Trypanosoma rangeli 38% 100%
A4HA16 Leishmania braziliensis 74% 100%
A4HY78 Leishmania infantum 95% 100%
A4HY79 Leishmania infantum 99% 100%
C9ZWF5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 97%
D0A5X9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 93%
E9AS08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
E9AS09 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4QDG4 Leishmania major 90% 100%
Q4QDG5 Leishmania major 89% 100%
V5C1U9 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS