LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WVB1_LEIDO
TriTrypDb:
LdBPK_190260.1 , LdCL_190007600 , LDHU3_19.0300
Length:
960

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVB1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVB1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 299 303 PF00656 0.663
CLV_C14_Caspase3-7 446 450 PF00656 0.834
CLV_C14_Caspase3-7 805 809 PF00656 0.556
CLV_NRD_NRD_1 15 17 PF00675 0.720
CLV_NRD_NRD_1 157 159 PF00675 0.719
CLV_NRD_NRD_1 423 425 PF00675 0.677
CLV_NRD_NRD_1 55 57 PF00675 0.755
CLV_NRD_NRD_1 729 731 PF00675 0.746
CLV_NRD_NRD_1 780 782 PF00675 0.579
CLV_NRD_NRD_1 895 897 PF00675 0.623
CLV_PCSK_FUR_1 421 425 PF00082 0.677
CLV_PCSK_KEX2_1 15 17 PF00082 0.720
CLV_PCSK_KEX2_1 157 159 PF00082 0.719
CLV_PCSK_KEX2_1 423 425 PF00082 0.677
CLV_PCSK_KEX2_1 54 56 PF00082 0.741
CLV_PCSK_KEX2_1 779 781 PF00082 0.677
CLV_PCSK_KEX2_1 895 897 PF00082 0.605
CLV_PCSK_PC1ET2_1 54 56 PF00082 0.843
CLV_PCSK_SKI1_1 205 209 PF00082 0.740
CLV_PCSK_SKI1_1 290 294 PF00082 0.786
CLV_PCSK_SKI1_1 424 428 PF00082 0.691
CLV_PCSK_SKI1_1 436 440 PF00082 0.675
CLV_PCSK_SKI1_1 599 603 PF00082 0.642
CLV_PCSK_SKI1_1 816 820 PF00082 0.550
CLV_PCSK_SKI1_1 823 827 PF00082 0.441
CLV_PCSK_SKI1_1 952 956 PF00082 0.563
DEG_APCC_DBOX_1 435 443 PF00400 0.773
DEG_Nend_UBRbox_2 1 3 PF02207 0.758
DEG_SCF_FBW7_1 564 569 PF00400 0.606
DEG_SCF_FBW7_1 744 750 PF00400 0.768
DEG_SPOP_SBC_1 324 328 PF00917 0.718
DEG_SPOP_SBC_1 541 545 PF00917 0.752
DEG_SPOP_SBC_1 632 636 PF00917 0.777
DOC_CKS1_1 724 729 PF01111 0.782
DOC_CKS1_1 733 738 PF01111 0.685
DOC_CKS1_1 744 749 PF01111 0.508
DOC_CYCLIN_yCln2_LP_2 506 512 PF00134 0.808
DOC_MAPK_gen_1 676 685 PF00069 0.763
DOC_MAPK_gen_1 820 830 PF00069 0.474
DOC_MAPK_MEF2A_6 551 560 PF00069 0.735
DOC_PP2B_LxvP_1 286 289 PF13499 0.734
DOC_PP2B_LxvP_1 629 632 PF13499 0.771
DOC_PP2B_LxvP_1 757 760 PF13499 0.600
DOC_PP4_FxxP_1 498 501 PF00568 0.646
DOC_PP4_FxxP_1 799 802 PF00568 0.559
DOC_SPAK_OSR1_1 101 105 PF12202 0.743
DOC_USP7_MATH_1 194 198 PF00917 0.825
DOC_USP7_MATH_1 209 213 PF00917 0.737
DOC_USP7_MATH_1 230 234 PF00917 0.750
DOC_USP7_MATH_1 296 300 PF00917 0.756
DOC_USP7_MATH_1 34 38 PF00917 0.858
DOC_USP7_MATH_1 348 352 PF00917 0.721
DOC_USP7_MATH_1 353 357 PF00917 0.708
DOC_USP7_MATH_1 364 368 PF00917 0.539
DOC_USP7_MATH_1 477 481 PF00917 0.731
DOC_USP7_MATH_1 566 570 PF00917 0.671
DOC_USP7_MATH_1 711 715 PF00917 0.803
DOC_USP7_MATH_1 747 751 PF00917 0.737
DOC_USP7_MATH_1 956 960 PF00917 0.797
DOC_USP7_MATH_2 566 572 PF00917 0.829
DOC_WW_Pin1_4 221 226 PF00397 0.836
DOC_WW_Pin1_4 237 242 PF00397 0.602
DOC_WW_Pin1_4 251 256 PF00397 0.636
DOC_WW_Pin1_4 263 268 PF00397 0.730
DOC_WW_Pin1_4 290 295 PF00397 0.696
DOC_WW_Pin1_4 360 365 PF00397 0.683
DOC_WW_Pin1_4 505 510 PF00397 0.690
DOC_WW_Pin1_4 537 542 PF00397 0.715
DOC_WW_Pin1_4 544 549 PF00397 0.741
DOC_WW_Pin1_4 552 557 PF00397 0.725
DOC_WW_Pin1_4 562 567 PF00397 0.660
DOC_WW_Pin1_4 633 638 PF00397 0.697
DOC_WW_Pin1_4 666 671 PF00397 0.855
DOC_WW_Pin1_4 702 707 PF00397 0.754
DOC_WW_Pin1_4 723 728 PF00397 0.835
DOC_WW_Pin1_4 732 737 PF00397 0.733
DOC_WW_Pin1_4 743 748 PF00397 0.513
DOC_WW_Pin1_4 771 776 PF00397 0.589
DOC_WW_Pin1_4 83 88 PF00397 0.763
DOC_WW_Pin1_4 879 884 PF00397 0.605
LIG_14-3-3_CanoR_1 15 19 PF00244 0.717
LIG_14-3-3_CanoR_1 35 43 PF00244 0.524
LIG_14-3-3_CanoR_1 423 431 PF00244 0.687
LIG_14-3-3_CanoR_1 5 13 PF00244 0.741
LIG_14-3-3_CanoR_1 524 532 PF00244 0.701
LIG_14-3-3_CanoR_1 599 609 PF00244 0.852
LIG_14-3-3_CanoR_1 668 677 PF00244 0.771
LIG_14-3-3_CanoR_1 754 760 PF00244 0.639
LIG_14-3-3_CanoR_1 895 903 PF00244 0.564
LIG_BRCT_BRCA1_1 196 200 PF00533 0.825
LIG_BRCT_BRCA1_1 522 526 PF00533 0.798
LIG_BRCT_BRCA1_1 533 537 PF00533 0.642
LIG_BRCT_BRCA1_1 619 623 PF00533 0.693
LIG_BRCT_BRCA1_1 87 91 PF00533 0.787
LIG_CtBP_PxDLS_1 573 577 PF00389 0.823
LIG_eIF4E_1 903 909 PF01652 0.478
LIG_FHA_1 134 140 PF00498 0.781
LIG_FHA_1 242 248 PF00498 0.660
LIG_FHA_1 324 330 PF00498 0.710
LIG_FHA_1 353 359 PF00498 0.628
LIG_FHA_1 659 665 PF00498 0.732
LIG_FHA_1 724 730 PF00498 0.843
LIG_FHA_1 817 823 PF00498 0.601
LIG_FHA_2 121 127 PF00498 0.753
LIG_FHA_2 194 200 PF00498 0.722
LIG_FHA_2 467 473 PF00498 0.714
LIG_FHA_2 563 569 PF00498 0.725
LIG_FHA_2 929 935 PF00498 0.558
LIG_FHA_2 937 943 PF00498 0.490
LIG_FXI_DFP_1 487 491 PF00024 0.692
LIG_GSK3_LRP6_1 552 557 PF00069 0.749
LIG_IBAR_NPY_1 585 587 PF08397 0.625
LIG_Integrin_isoDGR_2 877 879 PF01839 0.531
LIG_LIR_Apic_2 497 501 PF02991 0.645
LIG_LIR_Apic_2 798 802 PF02991 0.551
LIG_LIR_Gen_1 278 288 PF02991 0.789
LIG_LIR_Gen_1 900 909 PF02991 0.448
LIG_LIR_Nem_3 278 283 PF02991 0.780
LIG_LIR_Nem_3 620 626 PF02991 0.764
LIG_LIR_Nem_3 854 860 PF02991 0.465
LIG_LIR_Nem_3 900 906 PF02991 0.470
LIG_MLH1_MIPbox_1 620 624 PF16413 0.601
LIG_NRBOX 282 288 PF00104 0.721
LIG_NRP_CendR_1 958 960 PF00754 0.828
LIG_Pex14_2 490 494 PF04695 0.691
LIG_PTAP_UEV_1 86 91 PF05743 0.754
LIG_Rb_pABgroove_1 836 844 PF01858 0.501
LIG_SH2_CRK 587 591 PF00017 0.848
LIG_SH2_CRK 627 631 PF00017 0.714
LIG_SH2_CRK 926 930 PF00017 0.479
LIG_SH2_NCK_1 274 278 PF00017 0.722
LIG_SH2_NCK_1 587 591 PF00017 0.770
LIG_SH2_NCK_1 627 631 PF00017 0.714
LIG_SH2_SRC 903 906 PF00017 0.499
LIG_SH2_STAT5 274 277 PF00017 0.727
LIG_SH2_STAT5 587 590 PF00017 0.845
LIG_SH2_STAT5 627 630 PF00017 0.723
LIG_SH2_STAT5 745 748 PF00017 0.844
LIG_SH2_STAT5 861 864 PF00017 0.463
LIG_SH3_1 741 747 PF00018 0.843
LIG_SH3_2 953 958 PF14604 0.681
LIG_SH3_3 169 175 PF00018 0.751
LIG_SH3_3 222 228 PF00018 0.829
LIG_SH3_3 229 235 PF00018 0.711
LIG_SH3_3 264 270 PF00018 0.829
LIG_SH3_3 550 556 PF00018 0.765
LIG_SH3_3 592 598 PF00018 0.743
LIG_SH3_3 646 652 PF00018 0.755
LIG_SH3_3 721 727 PF00018 0.741
LIG_SH3_3 741 747 PF00018 0.513
LIG_SH3_3 749 755 PF00018 0.825
LIG_SH3_3 84 90 PF00018 0.834
LIG_SH3_3 950 956 PF00018 0.611
LIG_SUMO_SIM_anti_2 939 948 PF11976 0.507
LIG_TRFH_1 627 631 PF08558 0.792
LIG_UBA3_1 871 875 PF00899 0.481
LIG_UBA3_1 946 955 PF00899 0.637
LIG_WRC_WIRS_1 349 354 PF05994 0.615
LIG_WRC_WIRS_1 365 370 PF05994 0.688
LIG_WRC_WIRS_1 827 832 PF05994 0.567
LIG_WW_3 176 180 PF00397 0.741
LIG_WW_3 596 600 PF00397 0.754
MOD_CDK_SPK_2 253 258 PF00069 0.733
MOD_CDK_SPK_2 666 671 PF00069 0.855
MOD_CDK_SPxxK_3 241 248 PF00069 0.762
MOD_CDK_SPxxK_3 251 258 PF00069 0.648
MOD_CDK_SPxxK_3 544 551 PF00069 0.749
MOD_CDK_SPxxK_3 552 559 PF00069 0.725
MOD_CDK_SPxxK_3 723 730 PF00069 0.741
MOD_CK1_1 120 126 PF00069 0.826
MOD_CK1_1 14 20 PF00069 0.718
MOD_CK1_1 211 217 PF00069 0.752
MOD_CK1_1 240 246 PF00069 0.740
MOD_CK1_1 335 341 PF00069 0.612
MOD_CK1_1 384 390 PF00069 0.800
MOD_CK1_1 402 408 PF00069 0.517
MOD_CK1_1 536 542 PF00069 0.712
MOD_CK1_1 600 606 PF00069 0.816
MOD_CK1_1 669 675 PF00069 0.857
MOD_CK1_1 689 695 PF00069 0.512
MOD_CK1_1 702 708 PF00069 0.739
MOD_CK1_1 714 720 PF00069 0.782
MOD_CK2_1 120 126 PF00069 0.754
MOD_CK2_1 387 393 PF00069 0.696
MOD_CK2_1 416 422 PF00069 0.708
MOD_CK2_1 494 500 PF00069 0.695
MOD_CK2_1 562 568 PF00069 0.725
MOD_CK2_1 928 934 PF00069 0.509
MOD_GlcNHglycan 104 107 PF01048 0.655
MOD_GlcNHglycan 211 214 PF01048 0.816
MOD_GlcNHglycan 258 261 PF01048 0.845
MOD_GlcNHglycan 290 293 PF01048 0.770
MOD_GlcNHglycan 298 301 PF01048 0.707
MOD_GlcNHglycan 355 358 PF01048 0.660
MOD_GlcNHglycan 378 381 PF01048 0.803
MOD_GlcNHglycan 400 404 PF01048 0.695
MOD_GlcNHglycan 44 47 PF01048 0.850
MOD_GlcNHglycan 456 459 PF01048 0.755
MOD_GlcNHglycan 469 472 PF01048 0.647
MOD_GlcNHglycan 479 482 PF01048 0.772
MOD_GlcNHglycan 483 486 PF01048 0.576
MOD_GlcNHglycan 599 602 PF01048 0.725
MOD_GlcNHglycan 604 608 PF01048 0.797
MOD_GlcNHglycan 640 643 PF01048 0.842
MOD_GlcNHglycan 645 648 PF01048 0.754
MOD_GlcNHglycan 71 74 PF01048 0.835
MOD_GlcNHglycan 721 724 PF01048 0.740
MOD_GlcNHglycan 737 740 PF01048 0.741
MOD_GlcNHglycan 757 760 PF01048 0.372
MOD_GlcNHglycan 835 838 PF01048 0.587
MOD_GlcNHglycan 87 90 PF01048 0.623
MOD_GSK3_1 208 215 PF00069 0.850
MOD_GSK3_1 217 224 PF00069 0.695
MOD_GSK3_1 235 242 PF00069 0.720
MOD_GSK3_1 288 295 PF00069 0.718
MOD_GSK3_1 324 331 PF00069 0.704
MOD_GSK3_1 332 339 PF00069 0.682
MOD_GSK3_1 348 355 PF00069 0.791
MOD_GSK3_1 360 367 PF00069 0.649
MOD_GSK3_1 372 379 PF00069 0.593
MOD_GSK3_1 387 394 PF00069 0.700
MOD_GSK3_1 477 484 PF00069 0.759
MOD_GSK3_1 490 497 PF00069 0.685
MOD_GSK3_1 501 508 PF00069 0.755
MOD_GSK3_1 520 527 PF00069 0.732
MOD_GSK3_1 531 538 PF00069 0.637
MOD_GSK3_1 540 547 PF00069 0.503
MOD_GSK3_1 562 569 PF00069 0.831
MOD_GSK3_1 633 640 PF00069 0.770
MOD_GSK3_1 654 661 PF00069 0.775
MOD_GSK3_1 666 673 PF00069 0.780
MOD_GSK3_1 695 702 PF00069 0.793
MOD_GSK3_1 711 718 PF00069 0.685
MOD_GSK3_1 719 726 PF00069 0.716
MOD_GSK3_1 731 738 PF00069 0.507
MOD_GSK3_1 739 746 PF00069 0.513
MOD_LATS_1 206 212 PF00433 0.842
MOD_N-GLC_1 209 214 PF02516 0.764
MOD_N-GLC_1 251 256 PF02516 0.739
MOD_N-GLC_1 332 337 PF02516 0.590
MOD_N-GLC_1 372 377 PF02516 0.711
MOD_N-GLC_1 454 459 PF02516 0.822
MOD_N-GLC_1 520 525 PF02516 0.813
MOD_N-GLC_1 653 658 PF02516 0.764
MOD_N-GLC_1 816 821 PF02516 0.611
MOD_NEK2_1 102 107 PF00069 0.718
MOD_NEK2_1 272 277 PF00069 0.741
MOD_NEK2_1 323 328 PF00069 0.721
MOD_NEK2_1 336 341 PF00069 0.569
MOD_NEK2_1 352 357 PF00069 0.515
MOD_NEK2_1 376 381 PF00069 0.792
MOD_NEK2_1 494 499 PF00069 0.694
MOD_NEK2_1 696 701 PF00069 0.857
MOD_NEK2_1 737 742 PF00069 0.844
MOD_NEK2_1 841 846 PF00069 0.493
MOD_NEK2_2 364 369 PF00069 0.707
MOD_NEK2_2 897 902 PF00069 0.574
MOD_PIKK_1 17 23 PF00454 0.715
MOD_PIKK_1 384 390 PF00454 0.703
MOD_PIKK_1 590 596 PF00454 0.699
MOD_PIKK_1 739 745 PF00454 0.845
MOD_PKA_2 14 20 PF00069 0.766
MOD_PKA_2 34 40 PF00069 0.527
MOD_PKA_2 422 428 PF00069 0.672
MOD_PKA_2 654 660 PF00069 0.721
MOD_PKA_2 670 676 PF00069 0.784
MOD_PKA_2 69 75 PF00069 0.836
MOD_PKA_2 711 717 PF00069 0.743
MOD_PKA_2 753 759 PF00069 0.662
MOD_PKA_2 763 769 PF00069 0.552
MOD_PKB_1 814 822 PF00069 0.518
MOD_Plk_1 306 312 PF00069 0.703
MOD_Plk_1 332 338 PF00069 0.591
MOD_Plk_1 372 378 PF00069 0.713
MOD_Plk_2-3 422 428 PF00069 0.694
MOD_Plk_4 391 397 PF00069 0.799
MOD_Plk_4 501 507 PF00069 0.727
MOD_Plk_4 823 829 PF00069 0.473
MOD_Plk_4 942 948 PF00069 0.498
MOD_ProDKin_1 221 227 PF00069 0.831
MOD_ProDKin_1 237 243 PF00069 0.601
MOD_ProDKin_1 251 257 PF00069 0.631
MOD_ProDKin_1 263 269 PF00069 0.728
MOD_ProDKin_1 290 296 PF00069 0.696
MOD_ProDKin_1 360 366 PF00069 0.682
MOD_ProDKin_1 505 511 PF00069 0.692
MOD_ProDKin_1 537 543 PF00069 0.718
MOD_ProDKin_1 544 550 PF00069 0.744
MOD_ProDKin_1 552 558 PF00069 0.730
MOD_ProDKin_1 562 568 PF00069 0.662
MOD_ProDKin_1 633 639 PF00069 0.702
MOD_ProDKin_1 666 672 PF00069 0.855
MOD_ProDKin_1 702 708 PF00069 0.756
MOD_ProDKin_1 723 729 PF00069 0.836
MOD_ProDKin_1 732 738 PF00069 0.735
MOD_ProDKin_1 743 749 PF00069 0.510
MOD_ProDKin_1 771 777 PF00069 0.583
MOD_ProDKin_1 83 89 PF00069 0.763
MOD_ProDKin_1 879 885 PF00069 0.616
MOD_SUMO_for_1 601 604 PF00179 0.642
TRG_DiLeu_BaEn_1 391 396 PF01217 0.698
TRG_ENDOCYTIC_2 861 864 PF00928 0.455
TRG_ENDOCYTIC_2 903 906 PF00928 0.447
TRG_ENDOCYTIC_2 926 929 PF00928 0.482
TRG_ER_diArg_1 55 57 PF00400 0.642
TRG_ER_diArg_1 778 781 PF00400 0.685
TRG_ER_diArg_1 895 897 PF00400 0.623
TRG_NES_CRM1_1 927 942 PF08389 0.491
TRG_Pf-PMV_PEXEL_1 16 21 PF00026 0.714

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PF30 Leptomonas seymouri 50% 98%
A4H9Y4 Leishmania braziliensis 79% 99%
A4HY49 Leishmania infantum 100% 100%
E9ARX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QDJ4 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS