Variant SH3 domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxin 13, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WV91_LEIDO

TriTrypDb:

LdBPK_190060.1 , LdCL_190005600 , LDHU3_19.0070

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	1
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0046860	glycosome membrane	7	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7WV91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WV91

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007031	peroxisome organization	5	1
GO:0009987	cellular process	1	1
GO:0015919	peroxisomal membrane transport	5	1
GO:0016043	cellular component organization	3	1
GO:0043574	peroxisomal transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.538
CLV_NRD_NRD_1	127	129	PF00675	0.647
CLV_NRD_NRD_1	274	276	PF00675	0.510
CLV_NRD_NRD_1	348	350	PF00675	0.426
CLV_NRD_NRD_1	401	403	PF00675	0.297
CLV_PCSK_FUR_1	125	129	PF00082	0.643
CLV_PCSK_KEX2_1	127	129	PF00082	0.647
CLV_PCSK_KEX2_1	274	276	PF00082	0.506
CLV_PCSK_KEX2_1	348	350	PF00082	0.388
CLV_PCSK_KEX2_1	401	403	PF00082	0.314
DEG_APCC_DBOX_1	244	252	PF00400	0.346
DEG_Nend_Nbox_1	1	3	PF02207	0.462
DOC_MAPK_gen_1	148	158	PF00069	0.460
DOC_MAPK_gen_1	243	251	PF00069	0.301
DOC_MAPK_MEF2A_6	245	253	PF00069	0.321
DOC_PP1_RVXF_1	364	370	PF00149	0.423
DOC_USP7_MATH_1	362	366	PF00917	0.523
DOC_USP7_MATH_1	381	385	PF00917	0.557
DOC_USP7_MATH_1	61	65	PF00917	0.521
DOC_WW_Pin1_4	103	108	PF00397	0.561
DOC_WW_Pin1_4	118	123	PF00397	0.523
DOC_WW_Pin1_4	277	282	PF00397	0.752
LIG_14-3-3_CanoR_1	275	281	PF00244	0.700
LIG_14-3-3_CanoR_1	300	308	PF00244	0.762
LIG_14-3-3_CanoR_1	366	370	PF00244	0.423
LIG_Actin_WH2_2	158	173	PF00022	0.426
LIG_BIR_III_4	284	288	PF00653	0.739
LIG_eIF4E_1	36	42	PF01652	0.579
LIG_FHA_1	161	167	PF00498	0.400
LIG_FHA_1	218	224	PF00498	0.522
LIG_FHA_2	307	313	PF00498	0.763
LIG_FHA_2	316	322	PF00498	0.756
LIG_GBD_Chelix_1	158	166	PF00786	0.672
LIG_IBAR_NPY_1	60	62	PF08397	0.486
LIG_LIR_Apic_2	356	360	PF02991	0.466
LIG_LIR_Gen_1	407	416	PF02991	0.652
LIG_LIR_Nem_3	283	289	PF02991	0.770
LIG_LIR_Nem_3	407	412	PF02991	0.631
LIG_PDZ_Class_1	414	419	PF00595	0.648
LIG_Pex14_1	323	327	PF04695	0.747
LIG_Pex14_2	177	181	PF04695	0.366
LIG_SH2_CRK	286	290	PF00017	0.771
LIG_SH2_CRK	357	361	PF00017	0.512
LIG_SH2_SRC	380	383	PF00017	0.534
LIG_SH2_STAP1	185	189	PF00017	0.357
LIG_SH2_STAP1	295	299	PF00017	0.748
LIG_SH2_STAP1	355	359	PF00017	0.526
LIG_SH2_STAP1	396	400	PF00017	0.423
LIG_SH2_STAT3	355	358	PF00017	0.562
LIG_TRAF2_1	121	124	PF00917	0.505
LIG_WRC_WIRS_1	53	58	PF05994	0.736
MOD_CDK_SPxxK_3	118	125	PF00069	0.654
MOD_CK1_1	298	304	PF00069	0.718
MOD_CK1_1	306	312	PF00069	0.728
MOD_CK1_1	342	348	PF00069	0.480
MOD_CK1_1	365	371	PF00069	0.432
MOD_CK1_1	395	401	PF00069	0.456
MOD_CK1_1	66	72	PF00069	0.757
MOD_CK1_1	75	81	PF00069	0.623
MOD_CK1_1	90	96	PF00069	0.602
MOD_CK2_1	118	124	PF00069	0.606
MOD_CK2_1	169	175	PF00069	0.475
MOD_CK2_1	277	283	PF00069	0.637
MOD_CK2_1	288	294	PF00069	0.643
MOD_CK2_1	299	305	PF00069	0.690
MOD_CK2_1	315	321	PF00069	0.519
MOD_CK2_1	381	387	PF00069	0.440
MOD_CMANNOS	244	247	PF00535	0.496
MOD_GlcNHglycan	10	13	PF01048	0.679
MOD_GlcNHglycan	171	174	PF01048	0.466
MOD_GlcNHglycan	227	230	PF01048	0.636
MOD_GlcNHglycan	237	240	PF01048	0.583
MOD_GlcNHglycan	341	344	PF01048	0.694
MOD_GlcNHglycan	38	41	PF01048	0.659
MOD_GlcNHglycan	49	52	PF01048	0.658
MOD_GSK3_1	235	242	PF00069	0.591
MOD_GSK3_1	295	302	PF00069	0.660
MOD_GSK3_1	43	50	PF00069	0.677
MOD_N-GLC_1	118	123	PF02516	0.673
MOD_N-GLC_1	66	71	PF02516	0.675
MOD_NEK2_1	13	18	PF00069	0.605
MOD_NEK2_1	207	212	PF00069	0.631
MOD_NEK2_1	26	31	PF00069	0.533
MOD_NEK2_1	42	47	PF00069	0.687
MOD_NEK2_1	88	93	PF00069	0.778
MOD_NEK2_2	14	19	PF00069	0.499
MOD_NEK2_2	295	300	PF00069	0.710
MOD_PIKK_1	217	223	PF00454	0.724
MOD_PIKK_1	288	294	PF00454	0.731
MOD_PIKK_1	333	339	PF00454	0.758
MOD_PIKK_1	80	86	PF00454	0.781
MOD_PKA_2	276	282	PF00069	0.635
MOD_PKA_2	299	305	PF00069	0.698
MOD_PKA_2	306	312	PF00069	0.752
MOD_PKA_2	339	345	PF00069	0.749
MOD_PKA_2	365	371	PF00069	0.252
MOD_Plk_1	295	301	PF00069	0.663
MOD_Plk_1	315	321	PF00069	0.687
MOD_Plk_1	66	72	PF00069	0.675
MOD_Plk_2-3	315	321	PF00069	0.643
MOD_Plk_4	14	20	PF00069	0.523
MOD_Plk_4	180	186	PF00069	0.472
MOD_Plk_4	26	32	PF00069	0.525
MOD_ProDKin_1	103	109	PF00069	0.725
MOD_ProDKin_1	118	124	PF00069	0.670
MOD_ProDKin_1	277	283	PF00069	0.712
TRG_ENDOCYTIC_2	184	187	PF00928	0.445
TRG_ENDOCYTIC_2	286	289	PF00928	0.740
TRG_ENDOCYTIC_2	351	354	PF00928	0.466
TRG_ER_diArg_1	125	128	PF00400	0.556
TRG_ER_diArg_1	274	277	PF00400	0.691
TRG_ER_diArg_1	348	350	PF00400	0.577
TRG_NES_CRM1_1	157	168	PF08389	0.614
TRG_Pf-PMV_PEXEL_1	137	142	PF00026	0.659
TRG_PTS1	416	419	PF00515	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9X6	Leptomonas seymouri	69%	99%
A0A0S4J170	Bodo saltans	25%	92%
A0A1X0P6F7	Trypanosomatidae	35%	100%
A0A422NCY3	Trypanosoma rangeli	33%	100%
A4H9W4	Leishmania braziliensis	78%	100%
D0A0C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AGQ9	Leishmania infantum	100%	100%
E9ARV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QDL4	Leishmania major	88%	100%