Sarcalumenin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sarcalumenin, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WV81_LEIDO

TriTrypDb:

LdBPK_190270.1 , LdCL_190007700 , LDHU3_19.0310

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	21
GO:0016020	membrane	2	21
GO:0110165	cellular anatomical entity	1	21
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A0A3S7WV81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WV81

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	21
GO:0005488	binding	1	21
GO:0005525	GTP binding	5	21
GO:0017076	purine nucleotide binding	4	21
GO:0019001	guanyl nucleotide binding	5	21
GO:0032553	ribonucleotide binding	3	21
GO:0032555	purine ribonucleotide binding	4	21
GO:0032561	guanyl ribonucleotide binding	5	21
GO:0035639	purine ribonucleoside triphosphate binding	4	21
GO:0036094	small molecule binding	2	21
GO:0043167	ion binding	2	21
GO:0043168	anion binding	3	21
GO:0097159	organic cyclic compound binding	2	21
GO:0097367	carbohydrate derivative binding	2	21
GO:1901265	nucleoside phosphate binding	3	21
GO:1901363	heterocyclic compound binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.493
CLV_NRD_NRD_1	171	173	PF00675	0.414
CLV_NRD_NRD_1	306	308	PF00675	0.417
CLV_NRD_NRD_1	344	346	PF00675	0.452
CLV_PCSK_KEX2_1	306	308	PF00082	0.420
CLV_PCSK_KEX2_1	344	346	PF00082	0.452
CLV_PCSK_SKI1_1	128	132	PF00082	0.413
CLV_PCSK_SKI1_1	206	210	PF00082	0.478
CLV_PCSK_SKI1_1	221	225	PF00082	0.417
CLV_PCSK_SKI1_1	306	310	PF00082	0.402
CLV_PCSK_SKI1_1	367	371	PF00082	0.424
CLV_Separin_Metazoa	234	238	PF03568	0.462
CLV_Separin_Metazoa	254	258	PF03568	0.296
DEG_APCC_DBOX_1	185	193	PF00400	0.393
DEG_APCC_DBOX_1	321	329	PF00400	0.430
DEG_SCF_FBW7_1	586	593	PF00400	0.830
DEG_SPOP_SBC_1	506	510	PF00917	0.710
DEG_SPOP_SBC_1	525	529	PF00917	0.561
DOC_CKS1_1	157	162	PF01111	0.392
DOC_CKS1_1	587	592	PF01111	0.751
DOC_CYCLIN_RxL_1	123	135	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	70	76	PF00134	0.380
DOC_MAPK_gen_1	172	179	PF00069	0.427
DOC_MAPK_gen_1	306	313	PF00069	0.420
DOC_MAPK_MEF2A_6	186	194	PF00069	0.364
DOC_MAPK_MEF2A_6	322	329	PF00069	0.413
DOC_PP4_FxxP_1	144	147	PF00568	0.445
DOC_PP4_FxxP_1	193	196	PF00568	0.380
DOC_SPAK_OSR1_1	372	376	PF12202	0.485
DOC_USP7_MATH_1	184	188	PF00917	0.393
DOC_USP7_MATH_1	365	369	PF00917	0.495
DOC_USP7_MATH_1	493	497	PF00917	0.760
DOC_USP7_MATH_1	506	510	PF00917	0.820
DOC_USP7_MATH_1	525	529	PF00917	0.678
DOC_USP7_MATH_1	575	579	PF00917	0.852
DOC_USP7_MATH_1	581	585	PF00917	0.829
DOC_USP7_MATH_1	590	594	PF00917	0.834
DOC_USP7_UBL2_3	333	337	PF12436	0.417
DOC_WW_Pin1_4	156	161	PF00397	0.385
DOC_WW_Pin1_4	266	271	PF00397	0.421
DOC_WW_Pin1_4	491	496	PF00397	0.816
DOC_WW_Pin1_4	497	502	PF00397	0.814
DOC_WW_Pin1_4	513	518	PF00397	0.835
DOC_WW_Pin1_4	526	531	PF00397	0.709
DOC_WW_Pin1_4	571	576	PF00397	0.840
DOC_WW_Pin1_4	586	591	PF00397	0.688
LIG_14-3-3_CanoR_1	153	157	PF00244	0.467
LIG_14-3-3_CanoR_1	555	561	PF00244	0.646
LIG_14-3-3_CanoR_1	65	71	PF00244	0.454
LIG_Actin_WH2_2	209	227	PF00022	0.417
LIG_Actin_WH2_2	390	408	PF00022	0.469
LIG_APCC_ABBA_1	190	195	PF00400	0.380
LIG_APCC_ABBA_1	426	431	PF00400	0.639
LIG_BIR_II_1	1	5	PF00653	0.706
LIG_BIR_III_4	200	204	PF00653	0.441
LIG_BRCT_BRCA1_1	273	277	PF00533	0.450
LIG_BRCT_BRCA1_1	493	497	PF00533	0.663
LIG_EH_1	414	418	PF12763	0.761
LIG_FHA_1	157	163	PF00498	0.392
LIG_FHA_1	230	236	PF00498	0.472
LIG_FHA_1	35	41	PF00498	0.522
LIG_FHA_1	421	427	PF00498	0.659
LIG_FHA_1	445	451	PF00498	0.683
LIG_FHA_1	461	467	PF00498	0.674
LIG_FHA_1	77	83	PF00498	0.493
LIG_FHA_2	153	159	PF00498	0.384
LIG_FHA_2	451	457	PF00498	0.799
LIG_FHA_2	587	593	PF00498	0.662
LIG_FHA_2	96	102	PF00498	0.378
LIG_FXI_DFP_1	357	361	PF00024	0.378
LIG_LIR_Apic_2	262	267	PF02991	0.462
LIG_LIR_Gen_1	175	184	PF02991	0.413
LIG_LIR_Gen_1	188	199	PF02991	0.391
LIG_LIR_Gen_1	272	278	PF02991	0.513
LIG_LIR_Gen_1	48	57	PF02991	0.530
LIG_LIR_Gen_1	64	73	PF02991	0.541
LIG_LIR_Gen_1	99	107	PF02991	0.393
LIG_LIR_Nem_3	175	179	PF02991	0.405
LIG_LIR_Nem_3	188	194	PF02991	0.351
LIG_LIR_Nem_3	211	216	PF02991	0.573
LIG_LIR_Nem_3	241	246	PF02991	0.496
LIG_LIR_Nem_3	272	276	PF02991	0.512
LIG_LIR_Nem_3	359	363	PF02991	0.429
LIG_LIR_Nem_3	48	52	PF02991	0.543
LIG_LIR_Nem_3	64	70	PF02991	0.421
LIG_LIR_Nem_3	79	84	PF02991	0.388
LIG_LIR_Nem_3	99	105	PF02991	0.382
LIG_NRBOX	284	290	PF00104	0.547
LIG_PCNA_yPIPBox_3	421	429	PF02747	0.657
LIG_Pex14_1	264	268	PF04695	0.467
LIG_Pex14_2	133	137	PF04695	0.385
LIG_Pex14_2	209	213	PF04695	0.434
LIG_Pex14_2	273	277	PF04695	0.455
LIG_Pex14_2	369	373	PF04695	0.382
LIG_Pex14_2	52	56	PF04695	0.411
LIG_Pex14_2	67	71	PF04695	0.359
LIG_SH2_CRK	174	178	PF00017	0.393
LIG_SH2_CRK	239	243	PF00017	0.454
LIG_SH2_GRB2like	176	179	PF00017	0.322
LIG_SH2_NCK_1	346	350	PF00017	0.437
LIG_SH2_PTP2	176	179	PF00017	0.424
LIG_SH2_SRC	174	177	PF00017	0.453
LIG_SH2_STAP1	36	40	PF00017	0.522
LIG_SH2_STAP1	47	51	PF00017	0.462
LIG_SH2_STAP1	57	61	PF00017	0.477
LIG_SH2_STAT3	546	549	PF00017	0.567
LIG_SH2_STAT3	84	87	PF00017	0.424
LIG_SH2_STAT5	176	179	PF00017	0.413
LIG_SH2_STAT5	259	262	PF00017	0.437
LIG_SH2_STAT5	36	39	PF00017	0.412
LIG_SH2_STAT5	84	87	PF00017	0.403
LIG_SH3_3	264	270	PF00018	0.499
LIG_SH3_3	48	54	PF00018	0.454
LIG_SH3_3	485	491	PF00018	0.745
LIG_SH3_3	5	11	PF00018	0.635
LIG_SH3_3	512	518	PF00018	0.676
LIG_SH3_3	584	590	PF00018	0.790
LIG_SH3_3	596	602	PF00018	0.759
LIG_SUMO_SIM_anti_2	152	159	PF11976	0.397
LIG_SUMO_SIM_anti_2	279	287	PF11976	0.538
LIG_TRAF2_1	231	234	PF00917	0.604
LIG_TRAF2_1	416	419	PF00917	0.578
LIG_TRAF2_1	42	45	PF00917	0.508
LIG_TRAF2_1	589	592	PF00917	0.700
LIG_TRAF2_2	293	298	PF00917	0.465
LIG_WRC_WIRS_1	260	265	PF05994	0.447
LIG_WRC_WIRS_1	366	371	PF05994	0.355
LIG_WRC_WIRS_1	46	51	PF05994	0.342
LIG_WW_3	254	258	PF00397	0.474
MOD_CK1_1	136	142	PF00069	0.273
MOD_CK1_1	269	275	PF00069	0.606
MOD_CK1_1	461	467	PF00069	0.709
MOD_CK1_1	476	482	PF00069	0.754
MOD_CK1_1	566	572	PF00069	0.699
MOD_CK1_1	574	580	PF00069	0.635
MOD_CK2_1	228	234	PF00069	0.582
MOD_CK2_1	365	371	PF00069	0.357
MOD_CK2_1	450	456	PF00069	0.827
MOD_CK2_1	493	499	PF00069	0.843
MOD_CK2_1	52	58	PF00069	0.406
MOD_CK2_1	586	592	PF00069	0.834
MOD_CK2_1	95	101	PF00069	0.378
MOD_GlcNHglycan	16	19	PF01048	0.623
MOD_GlcNHglycan	3	6	PF01048	0.680
MOD_GlcNHglycan	440	443	PF01048	0.672
MOD_GlcNHglycan	460	463	PF01048	0.723
MOD_GlcNHglycan	475	478	PF01048	0.755
MOD_GlcNHglycan	491	494	PF01048	0.784
MOD_GlcNHglycan	522	525	PF01048	0.821
MOD_GlcNHglycan	558	561	PF01048	0.822
MOD_GlcNHglycan	577	580	PF01048	0.833
MOD_GlcNHglycan	74	77	PF01048	0.393
MOD_GSK3_1	152	159	PF00069	0.412
MOD_GSK3_1	396	403	PF00069	0.500
MOD_GSK3_1	420	427	PF00069	0.625
MOD_GSK3_1	460	467	PF00069	0.732
MOD_GSK3_1	473	480	PF00069	0.687
MOD_GSK3_1	489	496	PF00069	0.627
MOD_GSK3_1	520	527	PF00069	0.838
MOD_GSK3_1	556	563	PF00069	0.839
MOD_GSK3_1	566	573	PF00069	0.819
MOD_GSK3_1	582	589	PF00069	0.724
MOD_GSK3_1	590	597	PF00069	0.741
MOD_GSK3_1	72	79	PF00069	0.387
MOD_GSK3_1	96	103	PF00069	0.393
MOD_N-GLC_1	244	249	PF02516	0.472
MOD_N-GLC_1	250	255	PF02516	0.497
MOD_N-GLC_2	178	180	PF02516	0.322
MOD_N-GLC_2	612	614	PF02516	0.635
MOD_NEK2_1	1	6	PF00069	0.639
MOD_NEK2_1	119	124	PF00069	0.440
MOD_NEK2_1	133	138	PF00069	0.364
MOD_NEK2_1	208	213	PF00069	0.493
MOD_NEK2_1	329	334	PF00069	0.519
MOD_NEK2_1	396	401	PF00069	0.549
MOD_NEK2_1	458	463	PF00069	0.723
MOD_NEK2_1	466	471	PF00069	0.743
MOD_NEK2_1	505	510	PF00069	0.860
MOD_NEK2_1	570	575	PF00069	0.655
MOD_NEK2_1	85	90	PF00069	0.428
MOD_NEK2_2	424	429	PF00069	0.571
MOD_NEK2_2	66	71	PF00069	0.393
MOD_PIKK_1	229	235	PF00454	0.472
MOD_PIKK_1	34	40	PF00454	0.380
MOD_PIKK_1	613	619	PF00454	0.656
MOD_PKA_2	14	20	PF00069	0.815
MOD_PKA_2	152	158	PF00069	0.437
MOD_PKA_2	458	464	PF00069	0.628
MOD_PKA_2	52	58	PF00069	0.402
MOD_PKA_2	554	560	PF00069	0.633
MOD_Plk_1	100	106	PF00069	0.378
MOD_Plk_1	57	63	PF00069	0.464
MOD_Plk_1	582	588	PF00069	0.826
MOD_Plk_2-3	152	158	PF00069	0.486
MOD_Plk_2-3	45	51	PF00069	0.495
MOD_Plk_4	133	139	PF00069	0.412
MOD_Plk_4	152	158	PF00069	0.394
MOD_Plk_4	238	244	PF00069	0.491
MOD_Plk_4	259	265	PF00069	0.458
MOD_Plk_4	300	306	PF00069	0.402
MOD_Plk_4	396	402	PF00069	0.436
MOD_Plk_4	424	430	PF00069	0.617
MOD_Plk_4	477	483	PF00069	0.687
MOD_Plk_4	52	58	PF00069	0.408
MOD_Plk_4	600	606	PF00069	0.836
MOD_Plk_4	77	83	PF00069	0.394
MOD_ProDKin_1	156	162	PF00069	0.385
MOD_ProDKin_1	266	272	PF00069	0.416
MOD_ProDKin_1	491	497	PF00069	0.819
MOD_ProDKin_1	513	519	PF00069	0.859
MOD_ProDKin_1	526	532	PF00069	0.703
MOD_ProDKin_1	571	577	PF00069	0.840
MOD_ProDKin_1	586	592	PF00069	0.687
MOD_SUMO_rev_2	274	282	PF00179	0.502
MOD_SUMO_rev_2	418	423	PF00179	0.652
TRG_DiLeu_BaEn_1	152	157	PF01217	0.505
TRG_DiLeu_BaEn_1	185	190	PF01217	0.402
TRG_DiLeu_BaEn_1	280	285	PF01217	0.435
TRG_DiLeu_BaEn_1	385	390	PF01217	0.549
TRG_ENDOCYTIC_2	174	177	PF00928	0.398
TRG_ENDOCYTIC_2	239	242	PF00928	0.456
TRG_ENDOCYTIC_2	346	349	PF00928	0.417
TRG_ENDOCYTIC_2	366	369	PF00928	0.215
TRG_ER_diArg_1	219	222	PF00400	0.547
TRG_ER_diArg_1	305	307	PF00400	0.438
TRG_ER_diArg_1	343	345	PF00400	0.532
TRG_NES_CRM1_1	280	295	PF08389	0.532
TRG_NLS_MonoExtC_3	334	340	PF00514	0.413
TRG_NLS_MonoExtN_4	333	339	PF00514	0.393
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K7	Leptomonas seymouri	78%	100%
A0A0N0P9A4	Leptomonas seymouri	44%	100%
A0A0S4KGM0	Bodo saltans	63%	100%
A0A1X0P6D7	Trypanosomatidae	63%	100%
A0A1X0P9Q8	Trypanosomatidae	45%	100%
A0A3R7LDF3	Trypanosoma rangeli	60%	100%
A0A3S7X801	Leishmania donovani	46%	100%
A0A422P0G8	Trypanosoma rangeli	45%	100%
A4H9Y5	Leishmania braziliensis	75%	100%
A4HAT9	Leishmania braziliensis	46%	100%
A4HY50	Leishmania infantum	100%	100%
A4IA07	Leishmania infantum	46%	100%
D0A0F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ARX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B513	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q4Q2X3	Leishmania major	46%	100%
Q4QDJ3	Leishmania major	92%	100%
Q4V8H8	Rattus norvegicus	34%	100%
Q8BH64	Mus musculus	34%	100%
Q9NZN4	Homo sapiens	34%	100%
V5BSA9	Trypanosoma cruzi	60%	100%
V5DGT0	Trypanosoma cruzi	44%	100%