Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WV76_LEIDO

TriTrypDb:

LdBPK_181550.1 , LdCL_180020800 , LDHU3_18.1960

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WV76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WV76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.510
CLV_NRD_NRD_1	177	179	PF00675	0.546
CLV_NRD_NRD_1	298	300	PF00675	0.577
CLV_NRD_NRD_1	31	33	PF00675	0.449
CLV_NRD_NRD_1	385	387	PF00675	0.419
CLV_NRD_NRD_1	464	466	PF00675	0.466
CLV_NRD_NRD_1	474	476	PF00675	0.526
CLV_NRD_NRD_1	499	501	PF00675	0.557
CLV_NRD_NRD_1	561	563	PF00675	0.691
CLV_PCSK_FUR_1	559	563	PF00082	0.666
CLV_PCSK_KEX2_1	150	152	PF00082	0.510
CLV_PCSK_KEX2_1	176	178	PF00082	0.559
CLV_PCSK_KEX2_1	23	25	PF00082	0.452
CLV_PCSK_KEX2_1	298	300	PF00082	0.584
CLV_PCSK_KEX2_1	31	33	PF00082	0.561
CLV_PCSK_KEX2_1	385	387	PF00082	0.419
CLV_PCSK_KEX2_1	474	476	PF00082	0.536
CLV_PCSK_KEX2_1	499	501	PF00082	0.557
CLV_PCSK_KEX2_1	561	563	PF00082	0.691
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.452
CLV_PCSK_PC7_1	470	476	PF00082	0.361
CLV_PCSK_SKI1_1	178	182	PF00082	0.592
CLV_PCSK_SKI1_1	209	213	PF00082	0.394
CLV_PCSK_SKI1_1	317	321	PF00082	0.420
CLV_PCSK_SKI1_1	386	390	PF00082	0.579
CLV_PCSK_SKI1_1	39	43	PF00082	0.505
CLV_PCSK_SKI1_1	465	469	PF00082	0.347
CLV_PCSK_SKI1_1	506	510	PF00082	0.535
DEG_APCC_DBOX_1	444	452	PF00400	0.355
DEG_MDM2_SWIB_1	526	533	PF02201	0.286
DOC_ANK_TNKS_1	31	38	PF00023	0.471
DOC_CYCLIN_RxL_1	460	472	PF00134	0.338
DOC_CYCLIN_RxL_1	85	96	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.469
DOC_CYCLIN_yCln2_LP_2	452	458	PF00134	0.473
DOC_MAPK_DCC_7	298	306	PF00069	0.313
DOC_MAPK_gen_1	120	129	PF00069	0.487
DOC_MAPK_gen_1	298	306	PF00069	0.475
DOC_MAPK_gen_1	439	448	PF00069	0.347
DOC_MAPK_HePTP_8	438	450	PF00069	0.446
DOC_MAPK_MEF2A_6	123	131	PF00069	0.480
DOC_MAPK_MEF2A_6	298	306	PF00069	0.505
DOC_MAPK_MEF2A_6	362	370	PF00069	0.459
DOC_MAPK_MEF2A_6	441	450	PF00069	0.397
DOC_MAPK_MEF2A_6	81	89	PF00069	0.366
DOC_MAPK_NFAT4_5	445	453	PF00069	0.446
DOC_USP7_MATH_1	294	298	PF00917	0.589
DOC_USP7_MATH_1	410	414	PF00917	0.334
DOC_USP7_MATH_1	7	11	PF00917	0.445
DOC_USP7_UBL2_3	412	416	PF12436	0.346
DOC_WW_Pin1_4	157	162	PF00397	0.438
DOC_WW_Pin1_4	312	317	PF00397	0.402
DOC_WW_Pin1_4	439	444	PF00397	0.512
DOC_WW_Pin1_4	451	456	PF00397	0.465
LIG_14-3-3_CanoR_1	114	119	PF00244	0.580
LIG_14-3-3_CanoR_1	150	154	PF00244	0.522
LIG_14-3-3_CterR_2	559	563	PF00244	0.574
LIG_APCC_ABBA_1	159	164	PF00400	0.525
LIG_deltaCOP1_diTrp_1	189	196	PF00928	0.384
LIG_FHA_1	126	132	PF00498	0.501
LIG_FHA_1	137	143	PF00498	0.411
LIG_FHA_1	198	204	PF00498	0.417
LIG_FHA_1	264	270	PF00498	0.461
LIG_FHA_1	275	281	PF00498	0.357
LIG_FHA_1	459	465	PF00498	0.361
LIG_FHA_1	478	484	PF00498	0.340
LIG_FHA_1	542	548	PF00498	0.331
LIG_FHA_1	73	79	PF00498	0.397
LIG_FHA_2	193	199	PF00498	0.324
LIG_FHA_2	442	448	PF00498	0.413
LIG_FHA_2	65	71	PF00498	0.514
LIG_FHA_2	77	83	PF00498	0.431
LIG_LIR_Gen_1	189	197	PF02991	0.428
LIG_LIR_Gen_1	434	443	PF02991	0.305
LIG_LIR_Gen_1	44	53	PF02991	0.393
LIG_LIR_Gen_1	520	531	PF02991	0.335
LIG_LIR_Nem_3	189	194	PF02991	0.589
LIG_LIR_Nem_3	254	258	PF02991	0.377
LIG_LIR_Nem_3	336	342	PF02991	0.481
LIG_LIR_Nem_3	434	440	PF02991	0.299
LIG_LIR_Nem_3	44	48	PF02991	0.386
LIG_LIR_Nem_3	520	526	PF02991	0.335
LIG_LYPXL_yS_3	255	258	PF13949	0.393
LIG_NBox_RRM_1	543	553	PF00076	0.355
LIG_NRBOX	239	245	PF00104	0.369
LIG_PCNA_yPIPBox_3	377	389	PF02747	0.396
LIG_Pex14_2	526	530	PF04695	0.284
LIG_Rb_pABgroove_1	462	470	PF01858	0.356
LIG_SH2_CRK	22	26	PF00017	0.336
LIG_SH2_CRK	27	31	PF00017	0.363
LIG_SH2_CRK	398	402	PF00017	0.464
LIG_SH2_SRC	52	55	PF00017	0.439
LIG_SH2_STAP1	512	516	PF00017	0.360
LIG_SH2_STAP1	523	527	PF00017	0.328
LIG_SH2_STAT5	214	217	PF00017	0.398
LIG_SH2_STAT5	232	235	PF00017	0.401
LIG_SH2_STAT5	321	324	PF00017	0.386
LIG_SH2_STAT5	341	344	PF00017	0.308
LIG_SH2_STAT5	364	367	PF00017	0.450
LIG_SH2_STAT5	528	531	PF00017	0.290
LIG_SH3_2	455	460	PF14604	0.409
LIG_SH3_3	155	161	PF00018	0.451
LIG_SH3_3	27	33	PF00018	0.389
LIG_SH3_3	452	458	PF00018	0.405
LIG_SH3_3	68	74	PF00018	0.487
LIG_SUMO_SIM_anti_2	279	284	PF11976	0.297
LIG_SUMO_SIM_anti_2	444	450	PF11976	0.445
LIG_SUMO_SIM_par_1	126	133	PF11976	0.391
LIG_SUMO_SIM_par_1	163	171	PF11976	0.482
LIG_SUMO_SIM_par_1	264	273	PF11976	0.503
LIG_SUMO_SIM_par_1	277	284	PF11976	0.258
LIG_SUMO_SIM_par_1	428	434	PF11976	0.434
LIG_SUMO_SIM_par_1	447	454	PF11976	0.238
LIG_TRAF2_1	161	164	PF00917	0.483
LIG_TRAF2_1	216	219	PF00917	0.543
LIG_TRAF2_1	91	94	PF00917	0.454
LIG_TYR_ITIM	25	30	PF00017	0.448
LIG_UBA3_1	16	23	PF00899	0.364
LIG_WRC_WIRS_1	411	416	PF05994	0.329
LIG_WRC_WIRS_1	42	47	PF05994	0.419
MOD_CDC14_SPxK_1	442	445	PF00782	0.337
MOD_CDK_SPK_2	312	317	PF00069	0.455
MOD_CDK_SPxK_1	439	445	PF00069	0.355
MOD_CK1_1	205	211	PF00069	0.467
MOD_CK1_1	44	50	PF00069	0.418
MOD_CK1_1	76	82	PF00069	0.390
MOD_CK1_1	97	103	PF00069	0.579
MOD_CK2_1	157	163	PF00069	0.512
MOD_CK2_1	192	198	PF00069	0.385
MOD_CK2_1	201	207	PF00069	0.339
MOD_CK2_1	281	287	PF00069	0.473
MOD_CK2_1	64	70	PF00069	0.433
MOD_CK2_1	76	82	PF00069	0.322
MOD_GlcNHglycan	155	158	PF01048	0.563
MOD_GlcNHglycan	398	401	PF01048	0.461
MOD_GlcNHglycan	427	430	PF01048	0.538
MOD_GlcNHglycan	533	536	PF01048	0.299
MOD_GlcNHglycan	9	12	PF01048	0.522
MOD_GlcNHglycan	93	99	PF01048	0.538
MOD_GSK3_1	136	143	PF00069	0.479
MOD_GSK3_1	145	152	PF00069	0.480
MOD_GSK3_1	153	160	PF00069	0.530
MOD_GSK3_1	197	204	PF00069	0.356
MOD_GSK3_1	281	288	PF00069	0.443
MOD_GSK3_1	321	328	PF00069	0.396
MOD_GSK3_1	364	371	PF00069	0.411
MOD_GSK3_1	72	79	PF00069	0.391
MOD_N-GLC_2	199	201	PF02516	0.396
MOD_NEK2_1	197	202	PF00069	0.393
MOD_PIKK_1	140	146	PF00454	0.400
MOD_PK_1	114	120	PF00069	0.510
MOD_PK_1	123	129	PF00069	0.319
MOD_PKA_2	113	119	PF00069	0.588
MOD_PKA_2	149	155	PF00069	0.522
MOD_PKA_2	345	351	PF00069	0.533
MOD_PKB_1	112	120	PF00069	0.587
MOD_Plk_1	263	269	PF00069	0.413
MOD_Plk_2-3	192	198	PF00069	0.407
MOD_Plk_2-3	345	351	PF00069	0.466
MOD_Plk_4	192	198	PF00069	0.377
MOD_Plk_4	228	234	PF00069	0.487
MOD_Plk_4	281	287	PF00069	0.502
MOD_Plk_4	305	311	PF00069	0.445
MOD_Plk_4	368	374	PF00069	0.344
MOD_Plk_4	41	47	PF00069	0.437
MOD_Plk_4	410	416	PF00069	0.355
MOD_Plk_4	73	79	PF00069	0.427
MOD_ProDKin_1	157	163	PF00069	0.430
MOD_ProDKin_1	312	318	PF00069	0.401
MOD_ProDKin_1	439	445	PF00069	0.509
MOD_ProDKin_1	451	457	PF00069	0.465
TRG_DiLeu_BaEn_1	207	212	PF01217	0.419
TRG_DiLeu_BaEn_1	254	259	PF01217	0.447
TRG_DiLeu_BaEn_1	82	87	PF01217	0.404
TRG_DiLeu_BaEn_2	191	197	PF01217	0.421
TRG_DiLeu_BaEn_4	333	339	PF01217	0.395
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.357
TRG_ENDOCYTIC_2	22	25	PF00928	0.339
TRG_ENDOCYTIC_2	255	258	PF00928	0.457
TRG_ENDOCYTIC_2	27	30	PF00928	0.341
TRG_ENDOCYTIC_2	339	342	PF00928	0.483
TRG_ENDOCYTIC_2	398	401	PF00928	0.401
TRG_ENDOCYTIC_2	523	526	PF00928	0.335
TRG_ER_diArg_1	149	151	PF00400	0.474
TRG_ER_diArg_1	176	178	PF00400	0.559
TRG_ER_diArg_1	298	300	PF00400	0.585
TRG_ER_diArg_1	30	32	PF00400	0.405
TRG_ER_diArg_1	384	386	PF00400	0.355
TRG_ER_diArg_1	474	476	PF00400	0.595
TRG_ER_diArg_1	498	500	PF00400	0.551
TRG_ER_diArg_1	559	562	PF00400	0.665
TRG_NES_CRM1_1	425	436	PF08389	0.377
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRD6	Leptomonas seymouri	57%	100%
A0A1X0P7Z6	Trypanosomatidae	30%	100%
A0A3R7M1T0	Trypanosoma rangeli	30%	100%
D0A560	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AGQ6	Leishmania infantum	100%	100%
E9AI61	Leishmania braziliensis	79%	100%
E9ARU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QDN3	Leishmania major	94%	100%
V5BDF3	Trypanosoma cruzi	31%	100%