LeishMANIAdb
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PhoD-like phosphatase, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PhoD-like phosphatase, putative
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WV71_LEIDO
TriTrypDb:
LdBPK_181040.1 * , LdCL_180015600 , LDHU3_18.1330
Length:
825

Annotations

LeishMANIAdb annotations

PhoD domain containing alkaline phosphatase. Based on distant Eukaryotic orthologs, an N-terminal signal peptide is likely.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 3, no: 8
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A0A3S7WV71
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WV71

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 263 267 PF00656 0.409
CLV_NRD_NRD_1 145 147 PF00675 0.579
CLV_NRD_NRD_1 205 207 PF00675 0.659
CLV_NRD_NRD_1 25 27 PF00675 0.448
CLV_NRD_NRD_1 28 30 PF00675 0.457
CLV_NRD_NRD_1 3 5 PF00675 0.488
CLV_NRD_NRD_1 387 389 PF00675 0.503
CLV_NRD_NRD_1 575 577 PF00675 0.469
CLV_NRD_NRD_1 622 624 PF00675 0.554
CLV_NRD_NRD_1 785 787 PF00675 0.373
CLV_PCSK_FUR_1 203 207 PF00082 0.654
CLV_PCSK_FUR_1 23 27 PF00082 0.364
CLV_PCSK_FUR_1 385 389 PF00082 0.519
CLV_PCSK_KEX2_1 145 147 PF00082 0.563
CLV_PCSK_KEX2_1 2 4 PF00082 0.499
CLV_PCSK_KEX2_1 205 207 PF00082 0.659
CLV_PCSK_KEX2_1 25 27 PF00082 0.429
CLV_PCSK_KEX2_1 28 30 PF00082 0.438
CLV_PCSK_KEX2_1 387 389 PF00082 0.503
CLV_PCSK_KEX2_1 575 577 PF00082 0.475
CLV_PCSK_KEX2_1 622 624 PF00082 0.556
CLV_PCSK_KEX2_1 785 787 PF00082 0.415
CLV_PCSK_KEX2_1 814 816 PF00082 0.427
CLV_PCSK_PC1ET2_1 814 816 PF00082 0.427
CLV_PCSK_PC7_1 201 207 PF00082 0.647
CLV_PCSK_PC7_1 810 816 PF00082 0.429
CLV_PCSK_SKI1_1 136 140 PF00082 0.539
CLV_PCSK_SKI1_1 28 32 PF00082 0.272
CLV_PCSK_SKI1_1 371 375 PF00082 0.570
CLV_PCSK_SKI1_1 516 520 PF00082 0.465
CLV_PCSK_SKI1_1 668 672 PF00082 0.535
CLV_PCSK_SKI1_1 712 716 PF00082 0.504
CLV_PCSK_SKI1_1 85 89 PF00082 0.579
DEG_APCC_DBOX_1 370 378 PF00400 0.394
DEG_APCC_DBOX_1 501 509 PF00400 0.298
DEG_APCC_DBOX_1 600 608 PF00400 0.364
DEG_Nend_UBRbox_1 1 4 PF02207 0.718
DEG_SCF_FBW7_1 331 338 PF00400 0.470
DEG_SCF_FBW7_1 733 738 PF00400 0.287
DOC_CKS1_1 332 337 PF01111 0.472
DOC_CKS1_1 409 414 PF01111 0.331
DOC_CYCLIN_yCln2_LP_2 652 658 PF00134 0.266
DOC_CYCLIN_yCln2_LP_2 93 99 PF00134 0.328
DOC_MAPK_DCC_7 205 214 PF00069 0.465
DOC_MAPK_gen_1 203 213 PF00069 0.460
DOC_MAPK_gen_1 25 36 PF00069 0.493
DOC_MAPK_gen_1 468 478 PF00069 0.321
DOC_MAPK_gen_1 500 508 PF00069 0.324
DOC_MAPK_gen_1 575 581 PF00069 0.278
DOC_MAPK_MEF2A_6 205 214 PF00069 0.490
DOC_MAPK_MEF2A_6 759 766 PF00069 0.353
DOC_MAPK_NFAT4_5 759 767 PF00069 0.255
DOC_PP1_RVXF_1 514 520 PF00149 0.259
DOC_PP1_RVXF_1 649 655 PF00149 0.340
DOC_PP2B_LxvP_1 377 380 PF13499 0.322
DOC_PP2B_LxvP_1 93 96 PF13499 0.361
DOC_PP4_FxxP_1 571 574 PF00568 0.305
DOC_PP4_FxxP_1 616 619 PF00568 0.365
DOC_PP4_FxxP_1 640 643 PF00568 0.348
DOC_USP7_MATH_1 149 153 PF00917 0.323
DOC_USP7_MATH_1 161 165 PF00917 0.582
DOC_USP7_MATH_1 187 191 PF00917 0.453
DOC_USP7_MATH_1 335 339 PF00917 0.458
DOC_USP7_MATH_1 549 553 PF00917 0.279
DOC_USP7_MATH_1 56 60 PF00917 0.462
DOC_USP7_MATH_1 787 791 PF00917 0.699
DOC_USP7_MATH_1 803 807 PF00917 0.609
DOC_USP7_UBL2_3 692 696 PF12436 0.462
DOC_WW_Pin1_4 191 196 PF00397 0.424
DOC_WW_Pin1_4 205 210 PF00397 0.479
DOC_WW_Pin1_4 214 219 PF00397 0.515
DOC_WW_Pin1_4 311 316 PF00397 0.517
DOC_WW_Pin1_4 331 336 PF00397 0.501
DOC_WW_Pin1_4 408 413 PF00397 0.358
DOC_WW_Pin1_4 570 575 PF00397 0.317
DOC_WW_Pin1_4 683 688 PF00397 0.487
DOC_WW_Pin1_4 706 711 PF00397 0.472
DOC_WW_Pin1_4 731 736 PF00397 0.299
DOC_WW_Pin1_4 799 804 PF00397 0.676
LIG_14-3-3_CanoR_1 203 209 PF00244 0.505
LIG_14-3-3_CanoR_1 29 35 PF00244 0.520
LIG_14-3-3_CanoR_1 366 374 PF00244 0.378
LIG_14-3-3_CanoR_1 378 384 PF00244 0.414
LIG_14-3-3_CanoR_1 438 448 PF00244 0.403
LIG_14-3-3_CanoR_1 589 593 PF00244 0.342
LIG_14-3-3_CanoR_1 601 611 PF00244 0.410
LIG_14-3-3_CanoR_1 705 710 PF00244 0.532
LIG_14-3-3_CanoR_1 729 733 PF00244 0.328
LIG_14-3-3_CanoR_1 786 796 PF00244 0.667
LIG_Actin_WH2_2 574 591 PF00022 0.303
LIG_AP2alpha_1 63 67 PF02296 0.416
LIG_BIR_III_4 405 409 PF00653 0.354
LIG_BRCT_BRCA1_1 268 272 PF00533 0.411
LIG_Clathr_ClatBox_1 211 215 PF01394 0.469
LIG_deltaCOP1_diTrp_1 451 456 PF00928 0.292
LIG_deltaCOP1_diTrp_1 493 498 PF00928 0.279
LIG_EH1_1 272 280 PF00400 0.337
LIG_FHA_1 519 525 PF00498 0.320
LIG_FHA_1 634 640 PF00498 0.352
LIG_FHA_1 732 738 PF00498 0.293
LIG_FHA_1 755 761 PF00498 0.326
LIG_FHA_1 766 772 PF00498 0.270
LIG_FHA_2 170 176 PF00498 0.478
LIG_FHA_2 223 229 PF00498 0.606
LIG_FHA_2 346 352 PF00498 0.365
LIG_FHA_2 603 609 PF00498 0.315
LIG_LIR_Apic_2 190 195 PF02991 0.416
LIG_LIR_Apic_2 638 643 PF02991 0.342
LIG_LIR_Gen_1 269 279 PF02991 0.431
LIG_LIR_Gen_1 293 302 PF02991 0.342
LIG_LIR_Gen_1 451 460 PF02991 0.357
LIG_LIR_Gen_1 493 499 PF02991 0.318
LIG_LIR_Gen_1 636 643 PF02991 0.313
LIG_LIR_Nem_3 117 123 PF02991 0.317
LIG_LIR_Nem_3 269 275 PF02991 0.476
LIG_LIR_Nem_3 293 297 PF02991 0.351
LIG_LIR_Nem_3 389 395 PF02991 0.335
LIG_LIR_Nem_3 396 402 PF02991 0.349
LIG_LIR_Nem_3 451 456 PF02991 0.301
LIG_LIR_Nem_3 493 498 PF02991 0.294
LIG_LIR_Nem_3 565 569 PF02991 0.351
LIG_LIR_Nem_3 583 588 PF02991 0.298
LIG_LIR_Nem_3 636 640 PF02991 0.303
LIG_LYPXL_yS_3 544 547 PF13949 0.267
LIG_MAD2 329 337 PF02301 0.428
LIG_MYND_1 568 572 PF01753 0.334
LIG_NRBOX 504 510 PF00104 0.301
LIG_NRBOX 759 765 PF00104 0.335
LIG_NRBOX 770 776 PF00104 0.301
LIG_PALB2_WD40_1 451 459 PF16756 0.285
LIG_PCNA_PIPBox_1 278 287 PF02747 0.336
LIG_PCNA_PIPBox_1 777 786 PF02747 0.356
LIG_Pex14_2 372 376 PF04695 0.316
LIG_Pex14_2 562 566 PF04695 0.343
LIG_Pex14_2 63 67 PF04695 0.416
LIG_PTB_Apo_2 631 638 PF02174 0.293
LIG_SH2_CRK 123 127 PF00017 0.290
LIG_SH2_CRK 148 152 PF00017 0.354
LIG_SH2_CRK 192 196 PF00017 0.431
LIG_SH2_CRK 463 467 PF00017 0.346
LIG_SH2_CRK 796 800 PF00017 0.582
LIG_SH2_NCK_1 192 196 PF00017 0.405
LIG_SH2_NCK_1 796 800 PF00017 0.582
LIG_SH2_SRC 421 424 PF00017 0.294
LIG_SH2_SRC 661 664 PF00017 0.355
LIG_SH2_STAP1 257 261 PF00017 0.358
LIG_SH2_STAP1 395 399 PF00017 0.358
LIG_SH2_STAP1 421 425 PF00017 0.268
LIG_SH2_STAP1 796 800 PF00017 0.582
LIG_SH2_STAT5 363 366 PF00017 0.439
LIG_SH2_STAT5 395 398 PF00017 0.344
LIG_SH2_STAT5 463 466 PF00017 0.435
LIG_SH2_STAT5 561 564 PF00017 0.388
LIG_SH2_STAT5 580 583 PF00017 0.281
LIG_SH2_STAT5 603 606 PF00017 0.367
LIG_SH2_STAT5 747 750 PF00017 0.351
LIG_SH2_STAT5 783 786 PF00017 0.564
LIG_SH3_2 687 692 PF14604 0.472
LIG_SH3_3 315 321 PF00018 0.516
LIG_SH3_3 684 690 PF00018 0.498
LIG_SUMO_SIM_anti_2 33 38 PF11976 0.346
LIG_SUMO_SIM_anti_2 47 52 PF11976 0.402
LIG_SUMO_SIM_par_1 207 217 PF11976 0.470
LIG_SUMO_SIM_par_1 33 38 PF11976 0.456
LIG_SUMO_SIM_par_1 426 431 PF11976 0.311
LIG_SUMO_SIM_par_1 772 779 PF11976 0.340
LIG_TRAF2_1 537 540 PF00917 0.260
LIG_TRAF2_1 78 81 PF00917 0.429
LIG_TYR_ITIM 542 547 PF00017 0.256
LIG_UBA3_1 639 644 PF00899 0.297
LIG_UBA3_1 714 718 PF00899 0.319
LIG_WRC_WIRS_1 432 437 PF05994 0.283
LIG_WRC_WIRS_1 563 568 PF05994 0.322
MOD_CDC14_SPxK_1 573 576 PF00782 0.323
MOD_CDC14_SPxK_1 709 712 PF00782 0.382
MOD_CDK_SPK_2 570 575 PF00069 0.302
MOD_CDK_SPxK_1 408 414 PF00069 0.336
MOD_CDK_SPxK_1 570 576 PF00069 0.298
MOD_CDK_SPxK_1 706 712 PF00069 0.370
MOD_CK1_1 18 24 PF00069 0.642
MOD_CK1_1 336 342 PF00069 0.442
MOD_CK1_1 552 558 PF00069 0.332
MOD_CK1_1 602 608 PF00069 0.398
MOD_CK1_1 657 663 PF00069 0.326
MOD_CK1_1 806 812 PF00069 0.629
MOD_CK2_1 222 228 PF00069 0.423
MOD_CK2_1 311 317 PF00069 0.431
MOD_CK2_1 602 608 PF00069 0.310
MOD_CK2_1 75 81 PF00069 0.463
MOD_CK2_1 750 756 PF00069 0.357
MOD_CMANNOS 346 349 PF00535 0.563
MOD_Cter_Amidation 23 26 PF01082 0.379
MOD_GlcNHglycan 15 18 PF01048 0.465
MOD_GlcNHglycan 163 166 PF01048 0.794
MOD_GlcNHglycan 338 341 PF01048 0.700
MOD_GlcNHglycan 41 44 PF01048 0.271
MOD_GlcNHglycan 551 554 PF01048 0.516
MOD_GlcNHglycan 556 559 PF01048 0.568
MOD_GlcNHglycan 739 742 PF01048 0.514
MOD_GlcNHglycan 89 92 PF01048 0.540
MOD_GSK3_1 150 157 PF00069 0.491
MOD_GSK3_1 187 194 PF00069 0.424
MOD_GSK3_1 331 338 PF00069 0.604
MOD_GSK3_1 35 42 PF00069 0.390
MOD_GSK3_1 361 368 PF00069 0.448
MOD_GSK3_1 548 555 PF00069 0.301
MOD_GSK3_1 700 707 PF00069 0.582
MOD_GSK3_1 731 738 PF00069 0.301
MOD_GSK3_1 750 757 PF00069 0.291
MOD_GSK3_1 795 802 PF00069 0.674
MOD_LATS_1 680 686 PF00433 0.442
MOD_N-GLC_1 136 141 PF02516 0.647
MOD_N-GLC_1 366 371 PF02516 0.573
MOD_N-GLC_1 439 444 PF02516 0.515
MOD_N-GLC_1 461 466 PF02516 0.545
MOD_N-GLC_1 633 638 PF02516 0.469
MOD_N-GLC_1 718 723 PF02516 0.586
MOD_N-GLC_1 750 755 PF02516 0.487
MOD_N-GLC_2 789 791 PF02516 0.389
MOD_NEK2_1 107 112 PF00069 0.262
MOD_NEK2_1 154 159 PF00069 0.410
MOD_NEK2_1 297 302 PF00069 0.332
MOD_NEK2_1 308 313 PF00069 0.404
MOD_NEK2_1 35 40 PF00069 0.395
MOD_NEK2_1 44 49 PF00069 0.385
MOD_NEK2_1 554 559 PF00069 0.359
MOD_NEK2_1 599 604 PF00069 0.327
MOD_NEK2_1 764 769 PF00069 0.310
MOD_NEK2_1 775 780 PF00069 0.271
MOD_NEK2_1 794 799 PF00069 0.564
MOD_NEK2_1 87 92 PF00069 0.480
MOD_NEK2_2 187 192 PF00069 0.415
MOD_NEK2_2 635 640 PF00069 0.302
MOD_PIKK_1 114 120 PF00454 0.369
MOD_PIKK_1 366 372 PF00454 0.375
MOD_PIKK_1 439 445 PF00454 0.384
MOD_PKA_1 681 687 PF00069 0.461
MOD_PKA_2 169 175 PF00069 0.462
MOD_PKA_2 204 210 PF00069 0.515
MOD_PKA_2 222 228 PF00069 0.393
MOD_PKA_2 24 30 PF00069 0.631
MOD_PKA_2 365 371 PF00069 0.341
MOD_PKA_2 588 594 PF00069 0.349
MOD_PKA_2 704 710 PF00069 0.505
MOD_PKA_2 728 734 PF00069 0.415
MOD_PKA_2 787 793 PF00069 0.680
MOD_PKA_2 809 815 PF00069 0.629
MOD_Plk_1 114 120 PF00069 0.395
MOD_Plk_1 308 314 PF00069 0.516
MOD_Plk_1 461 467 PF00069 0.408
MOD_Plk_1 57 63 PF00069 0.375
MOD_Plk_1 633 639 PF00069 0.271
MOD_Plk_1 668 674 PF00069 0.352
MOD_Plk_1 750 756 PF00069 0.330
MOD_Plk_2-3 431 437 PF00069 0.339
MOD_Plk_4 150 156 PF00069 0.306
MOD_Plk_4 187 193 PF00069 0.420
MOD_Plk_4 266 272 PF00069 0.424
MOD_Plk_4 274 280 PF00069 0.368
MOD_Plk_4 44 50 PF00069 0.510
MOD_Plk_4 562 568 PF00069 0.367
MOD_Plk_4 58 64 PF00069 0.481
MOD_Plk_4 654 660 PF00069 0.300
MOD_Plk_4 803 809 PF00069 0.630
MOD_ProDKin_1 191 197 PF00069 0.425
MOD_ProDKin_1 205 211 PF00069 0.479
MOD_ProDKin_1 214 220 PF00069 0.516
MOD_ProDKin_1 311 317 PF00069 0.520
MOD_ProDKin_1 331 337 PF00069 0.498
MOD_ProDKin_1 408 414 PF00069 0.357
MOD_ProDKin_1 570 576 PF00069 0.314
MOD_ProDKin_1 683 689 PF00069 0.489
MOD_ProDKin_1 706 712 PF00069 0.465
MOD_ProDKin_1 731 737 PF00069 0.297
MOD_ProDKin_1 799 805 PF00069 0.678
MOD_SUMO_rev_2 602 612 PF00179 0.368
TRG_DiLeu_BaEn_1 756 761 PF01217 0.295
TRG_DiLeu_BaEn_2 292 298 PF01217 0.378
TRG_DiLeu_BaEn_2 514 520 PF01217 0.321
TRG_DiLeu_BaLyEn_6 207 212 PF01217 0.465
TRG_DiLeu_BaLyEn_6 411 416 PF01217 0.332
TRG_DiLeu_BaLyEn_6 501 506 PF01217 0.326
TRG_DiLeu_BaLyEn_6 565 570 PF01217 0.354
TRG_DiLeu_BaLyEn_6 595 600 PF01217 0.309
TRG_DiLeu_LyEn_5 732 737 PF01217 0.323
TRG_ENDOCYTIC_2 123 126 PF00928 0.297
TRG_ENDOCYTIC_2 148 151 PF00928 0.361
TRG_ENDOCYTIC_2 294 297 PF00928 0.327
TRG_ENDOCYTIC_2 463 466 PF00928 0.326
TRG_ENDOCYTIC_2 544 547 PF00928 0.267
TRG_ENDOCYTIC_2 746 749 PF00928 0.347
TRG_ENDOCYTIC_2 796 799 PF00928 0.615
TRG_ER_diArg_1 1 4 PF00400 0.701
TRG_ER_diArg_1 145 147 PF00400 0.363
TRG_ER_diArg_1 201 204 PF00400 0.463
TRG_ER_diArg_1 22 25 PF00400 0.651
TRG_ER_diArg_1 26 29 PF00400 0.574
TRG_ER_diArg_1 386 388 PF00400 0.298
TRG_ER_diArg_1 499 502 PF00400 0.336
TRG_ER_diArg_1 574 576 PF00400 0.286
TRG_ER_diArg_1 621 623 PF00400 0.416
TRG_ER_diArg_1 784 786 PF00400 0.624
TRG_NES_CRM1_1 743 756 PF08389 0.299
TRG_NLS_MonoExtN_4 810 817 PF00514 0.628
TRG_Pf-PMV_PEXEL_1 414 418 PF00026 0.657
TRG_Pf-PMV_PEXEL_1 85 89 PF00026 0.483

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PG58 Leptomonas seymouri 49% 100%
A0A1X0P7Z9 Trypanosomatidae 38% 100%
A0A3S5H7G3 Leishmania donovani 25% 100%
A4H9L0 Leishmania braziliensis 71% 100%
A4HF04 Leishmania braziliensis 24% 100%
A4HXX7 Leishmania infantum 99% 100%
A4I283 Leishmania infantum 25% 100%
C9ZZS6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9ARP0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QDT9 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS