Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WV70_LEIDO

TriTrypDb:

LdBPK_181670.1 , LdCL_180022100 , LDHU3_18.2150

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WV70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WV70

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.682
CLV_NRD_NRD_1	138	140	PF00675	0.614
CLV_NRD_NRD_1	18	20	PF00675	0.601
CLV_NRD_NRD_1	258	260	PF00675	0.621
CLV_NRD_NRD_1	452	454	PF00675	0.632
CLV_NRD_NRD_1	468	470	PF00675	0.489
CLV_NRD_NRD_1	616	618	PF00675	0.506
CLV_NRD_NRD_1	76	78	PF00675	0.742
CLV_PCSK_KEX2_1	138	140	PF00082	0.614
CLV_PCSK_KEX2_1	258	260	PF00082	0.629
CLV_PCSK_KEX2_1	452	454	PF00082	0.632
CLV_PCSK_KEX2_1	468	470	PF00082	0.489
CLV_PCSK_KEX2_1	616	618	PF00082	0.506
CLV_PCSK_KEX2_1	76	78	PF00082	0.622
CLV_PCSK_SKI1_1	116	120	PF00082	0.593
CLV_PCSK_SKI1_1	355	359	PF00082	0.665
CLV_PCSK_SKI1_1	573	577	PF00082	0.558
CLV_PCSK_SKI1_1	86	90	PF00082	0.622
DEG_APCC_DBOX_1	350	358	PF00400	0.645
DEG_APCC_DBOX_1	5	13	PF00400	0.644
DEG_SCF_FBW7_1	304	311	PF00400	0.627
DOC_CKS1_1	108	113	PF01111	0.565
DOC_CKS1_1	305	310	PF01111	0.625
DOC_CKS1_1	497	502	PF01111	0.568
DOC_CYCLIN_yCln2_LP_2	497	503	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	599	605	PF00134	0.618
DOC_MAPK_gen_1	138	144	PF00069	0.664
DOC_MAPK_gen_1	452	458	PF00069	0.628
DOC_MAPK_gen_1	570	580	PF00069	0.558
DOC_PP2B_LxvP_1	427	430	PF13499	0.610
DOC_PP2B_LxvP_1	599	602	PF13499	0.628
DOC_PP4_FxxP_1	207	210	PF00568	0.660
DOC_PP4_FxxP_1	403	406	PF00568	0.534
DOC_PP4_FxxP_1	581	584	PF00568	0.599
DOC_USP7_MATH_1	103	107	PF00917	0.628
DOC_USP7_MATH_1	242	246	PF00917	0.612
DOC_USP7_MATH_1	308	312	PF00917	0.654
DOC_USP7_MATH_1	325	329	PF00917	0.527
DOC_USP7_MATH_1	414	418	PF00917	0.624
DOC_USP7_MATH_1	474	478	PF00917	0.614
DOC_USP7_MATH_1	516	520	PF00917	0.648
DOC_USP7_MATH_1	82	86	PF00917	0.715
DOC_WW_Pin1_4	107	112	PF00397	0.599
DOC_WW_Pin1_4	205	210	PF00397	0.659
DOC_WW_Pin1_4	244	249	PF00397	0.596
DOC_WW_Pin1_4	304	309	PF00397	0.611
DOC_WW_Pin1_4	441	446	PF00397	0.630
DOC_WW_Pin1_4	496	501	PF00397	0.624
DOC_WW_Pin1_4	579	584	PF00397	0.552
DOC_WW_Pin1_4	597	602	PF00397	0.513
LIG_14-3-3_CanoR_1	120	126	PF00244	0.576
LIG_14-3-3_CanoR_1	19	27	PF00244	0.558
LIG_14-3-3_CanoR_1	34	38	PF00244	0.568
LIG_14-3-3_CanoR_1	351	355	PF00244	0.601
LIG_14-3-3_CanoR_1	402	406	PF00244	0.533
LIG_14-3-3_CanoR_1	41	49	PF00244	0.576
LIG_14-3-3_CanoR_1	523	532	PF00244	0.647
LIG_14-3-3_CanoR_1	587	592	PF00244	0.567
LIG_14-3-3_CanoR_1	86	93	PF00244	0.537
LIG_Actin_WH2_2	571	589	PF00022	0.558
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_BRCT_BRCA1_1	476	480	PF00533	0.610
LIG_Clathr_ClatBox_1	370	374	PF01394	0.607
LIG_FHA_1	160	166	PF00498	0.627
LIG_FHA_1	245	251	PF00498	0.629
LIG_FHA_1	376	382	PF00498	0.605
LIG_FHA_1	422	428	PF00498	0.700
LIG_FHA_1	44	50	PF00498	0.529
LIG_FHA_1	445	451	PF00498	0.642
LIG_FHA_1	496	502	PF00498	0.569
LIG_FHA_1	550	556	PF00498	0.614
LIG_FHA_1	587	593	PF00498	0.566
LIG_FHA_2	122	128	PF00498	0.578
LIG_FHA_2	506	512	PF00498	0.676
LIG_FHA_2	574	580	PF00498	0.572
LIG_FHA_2	87	93	PF00498	0.567
LIG_LIR_Apic_2	106	111	PF02991	0.623
LIG_LIR_Apic_2	206	210	PF02991	0.651
LIG_LIR_Apic_2	319	325	PF02991	0.614
LIG_LIR_Apic_2	579	584	PF02991	0.599
LIG_LIR_Gen_1	187	194	PF02991	0.547
LIG_LIR_Gen_1	477	488	PF02991	0.572
LIG_LIR_Gen_1	635	646	PF02991	0.527
LIG_LIR_Gen_1	651	661	PF02991	0.477
LIG_LIR_Nem_3	334	338	PF02991	0.603
LIG_LIR_Nem_3	477	483	PF02991	0.568
LIG_LIR_Nem_3	635	641	PF02991	0.530
LIG_LIR_Nem_3	651	657	PF02991	0.478
LIG_LIR_Nem_3	658	663	PF02991	0.509
LIG_LYPXL_S_1	337	341	PF13949	0.609
LIG_LYPXL_yS_3	338	341	PF13949	0.610
LIG_MYND_1	602	606	PF01753	0.560
LIG_PTAP_UEV_1	54	59	PF05743	0.621
LIG_RPA_C_Fungi	537	549	PF08784	0.551
LIG_SH2_CRK	108	112	PF00017	0.532
LIG_SH2_NCK_1	322	326	PF00017	0.609
LIG_SH2_NCK_1	510	514	PF00017	0.579
LIG_SH2_NCK_1	638	642	PF00017	0.525
LIG_SH2_SRC	53	56	PF00017	0.616
LIG_SH2_SRC	638	641	PF00017	0.525
LIG_SH2_STAP1	410	414	PF00017	0.563
LIG_SH2_STAP1	43	47	PF00017	0.620
LIG_SH2_STAP1	510	514	PF00017	0.579
LIG_SH2_STAT5	322	325	PF00017	0.613
LIG_SH2_STAT5	43	46	PF00017	0.646
LIG_SH3_2	171	176	PF14604	0.610
LIG_SH3_2	55	60	PF14604	0.628
LIG_SH3_3	168	174	PF00018	0.662
LIG_SH3_3	175	181	PF00018	0.592
LIG_SH3_3	206	212	PF00018	0.658
LIG_SH3_3	265	271	PF00018	0.675
LIG_SH3_3	302	308	PF00018	0.631
LIG_SH3_3	423	429	PF00018	0.605
LIG_SH3_3	501	507	PF00018	0.571
LIG_SH3_3	518	524	PF00018	0.576
LIG_SH3_3	52	58	PF00018	0.556
LIG_TRAF2_1	124	127	PF00917	0.573
LIG_TRAF2_1	434	437	PF00917	0.680
LIG_TRAF2_1	528	531	PF00917	0.537
LIG_TRFH_1	99	103	PF08558	0.597
LIG_WW_3	300	304	PF00397	0.581
LIG_WW_3	520	524	PF00397	0.643
MOD_CDK_SPK_2	208	213	PF00069	0.662
MOD_CK1_1	107	113	PF00069	0.574
MOD_CK1_1	128	134	PF00069	0.642
MOD_CK1_1	159	165	PF00069	0.622
MOD_CK1_1	187	193	PF00069	0.594
MOD_CK1_1	208	214	PF00069	0.613
MOD_CK1_1	21	27	PF00069	0.541
MOD_CK1_1	350	356	PF00069	0.654
MOD_CK1_1	45	51	PF00069	0.531
MOD_CK1_1	478	484	PF00069	0.571
MOD_CK1_1	526	532	PF00069	0.597
MOD_CK1_1	547	553	PF00069	0.572
MOD_CK2_1	121	127	PF00069	0.576
MOD_CK2_1	190	196	PF00069	0.614
MOD_CK2_1	505	511	PF00069	0.676
MOD_CK2_1	587	593	PF00069	0.610
MOD_Cter_Amidation	74	77	PF01082	0.628
MOD_GlcNHglycan	233	236	PF01048	0.659
MOD_GlcNHglycan	244	247	PF01048	0.557
MOD_GlcNHglycan	359	362	PF01048	0.692
MOD_GlcNHglycan	417	420	PF01048	0.580
MOD_GlcNHglycan	525	528	PF01048	0.609
MOD_GlcNHglycan	55	58	PF01048	0.638
MOD_GlcNHglycan	566	569	PF01048	0.648
MOD_GSK3_1	103	110	PF00069	0.589
MOD_GSK3_1	121	128	PF00069	0.461
MOD_GSK3_1	18	25	PF00069	0.593
MOD_GSK3_1	190	197	PF00069	0.662
MOD_GSK3_1	237	244	PF00069	0.625
MOD_GSK3_1	304	311	PF00069	0.646
MOD_GSK3_1	316	323	PF00069	0.588
MOD_GSK3_1	349	356	PF00069	0.662
MOD_GSK3_1	41	48	PF00069	0.542
MOD_GSK3_1	474	481	PF00069	0.610
MOD_GSK3_1	522	529	PF00069	0.582
MOD_GSK3_1	540	547	PF00069	0.478
MOD_GSK3_1	623	630	PF00069	0.564
MOD_GSK3_1	82	89	PF00069	0.541
MOD_LATS_1	236	242	PF00433	0.575
MOD_N-GLC_1	231	236	PF02516	0.631
MOD_N-GLC_1	647	652	PF02516	0.531
MOD_NEK2_1	104	109	PF00069	0.634
MOD_NEK2_1	316	321	PF00069	0.635
MOD_NEK2_1	333	338	PF00069	0.497
MOD_NEK2_1	357	362	PF00069	0.598
MOD_NEK2_1	42	47	PF00069	0.634
MOD_NEK2_1	475	480	PF00069	0.612
MOD_NEK2_1	538	543	PF00069	0.565
MOD_NEK2_1	549	554	PF00069	0.540
MOD_NEK2_1	586	591	PF00069	0.565
MOD_NEK2_1	623	628	PF00069	0.557
MOD_NEK2_2	372	377	PF00069	0.581
MOD_PIKK_1	125	131	PF00454	0.630
MOD_PIKK_1	625	631	PF00454	0.570
MOD_PIKK_1	65	71	PF00454	0.596
MOD_PKA_2	159	165	PF00069	0.617
MOD_PKA_2	18	24	PF00069	0.569
MOD_PKA_2	237	243	PF00069	0.604
MOD_PKA_2	33	39	PF00069	0.610
MOD_PKA_2	350	356	PF00069	0.596
MOD_PKA_2	401	407	PF00069	0.534
MOD_PKA_2	522	528	PF00069	0.651
MOD_PKA_2	586	592	PF00069	0.565
MOD_PKA_2	59	65	PF00069	0.691
MOD_Plk_1	21	27	PF00069	0.541
MOD_Plk_1	333	339	PF00069	0.547
MOD_Plk_4	366	372	PF00069	0.559
MOD_Plk_4	544	550	PF00069	0.601
MOD_Plk_4	587	593	PF00069	0.587
MOD_Plk_4	655	661	PF00069	0.533
MOD_ProDKin_1	107	113	PF00069	0.588
MOD_ProDKin_1	205	211	PF00069	0.660
MOD_ProDKin_1	244	250	PF00069	0.598
MOD_ProDKin_1	304	310	PF00069	0.610
MOD_ProDKin_1	441	447	PF00069	0.627
MOD_ProDKin_1	496	502	PF00069	0.624
MOD_ProDKin_1	579	585	PF00069	0.552
MOD_ProDKin_1	597	603	PF00069	0.513
MOD_SUMO_for_1	133	136	PF00179	0.637
MOD_SUMO_rev_2	190	199	PF00179	0.622
MOD_SUMO_rev_2	567	575	PF00179	0.561
TRG_DiLeu_BaEn_1	471	476	PF01217	0.613
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.556
TRG_DiLeu_BaLyEn_6	581	586	PF01217	0.553
TRG_ENDOCYTIC_2	188	191	PF00928	0.654
TRG_ENDOCYTIC_2	338	341	PF00928	0.610
TRG_ENDOCYTIC_2	638	641	PF00928	0.525
TRG_ENDOCYTIC_2	99	102	PF00928	0.599
TRG_ER_diArg_1	138	141	PF00400	0.601
TRG_ER_diArg_1	258	260	PF00400	0.621
TRG_ER_diArg_1	451	453	PF00400	0.633
TRG_ER_diArg_1	467	469	PF00400	0.490
TRG_ER_diArg_1	615	617	PF00400	0.511
TRG_ER_diArg_1	76	78	PF00400	0.622
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.705
TRG_Pf-PMV_PEXEL_1	617	622	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H9R9	Leishmania braziliensis	44%	95%
A4HY38	Leishmania infantum	99%	100%
Q4QDM1	Leishmania major	77%	100%