Multiprotein-bridging_factor_1_putative/GeneDB:Lm jF.19.0190

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

multiprotein-bridging factor 1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WV69_LEIDO

TriTrypDb:

LdBPK_190180.1 , LdCL_190006800 , LDHU3_19.0190

Length:

163

Annotations

Annotations by Jardim et al.

Transcription, Multi-bridging factor 1 Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WV69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WV69

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.584
CLV_MEL_PAP_1	110	116	PF00089	0.394
CLV_NRD_NRD_1	30	32	PF00675	0.372
CLV_NRD_NRD_1	51	53	PF00675	0.329
CLV_PCSK_SKI1_1	144	148	PF00082	0.575
CLV_PCSK_SKI1_1	31	35	PF00082	0.335
CLV_PCSK_SKI1_1	91	95	PF00082	0.377
CLV_PCSK_SKI1_1	96	100	PF00082	0.345
DOC_MAPK_gen_1	134	143	PF00069	0.337
DOC_MAPK_gen_1	80	90	PF00069	0.600
DOC_MAPK_HePTP_8	131	143	PF00069	0.437
DOC_MAPK_MEF2A_6	134	143	PF00069	0.437
DOC_MAPK_MEF2A_6	82	90	PF00069	0.593
DOC_USP7_MATH_1	41	45	PF00917	0.554
DOC_WW_Pin1_4	155	160	PF00397	0.561
LIG_14-3-3_CanoR_1	109	117	PF00244	0.478
LIG_Actin_WH2_2	128	146	PF00022	0.337
LIG_deltaCOP1_diTrp_1	11	19	PF00928	0.483
LIG_FHA_1	76	82	PF00498	0.492
LIG_FHA_2	32	38	PF00498	0.558
LIG_FHA_2	6	12	PF00498	0.597
LIG_SUMO_SIM_anti_2	111	119	PF11976	0.478
LIG_TRAF2_1	125	128	PF00917	0.478
MOD_CDK_SPK_2	155	160	PF00069	0.616
MOD_GlcNHglycan	121	124	PF01048	0.401
MOD_GlcNHglycan	26	29	PF01048	0.305
MOD_GlcNHglycan	43	46	PF01048	0.354
MOD_GlcNHglycan	63	66	PF01048	0.354
MOD_GSK3_1	108	115	PF00069	0.450
MOD_N-GLC_1	75	80	PF02516	0.344
MOD_N-GLC_1	99	104	PF02516	0.437
MOD_NEK2_1	152	157	PF00069	0.720
MOD_NEK2_1	99	104	PF00069	0.437
MOD_PIKK_1	99	105	PF00454	0.337
MOD_PKA_1	31	37	PF00069	0.572
MOD_PKA_2	108	114	PF00069	0.478
MOD_Plk_1	75	81	PF00069	0.544
MOD_Plk_4	112	118	PF00069	0.437
MOD_ProDKin_1	155	161	PF00069	0.565
MOD_SUMO_for_1	133	136	PF00179	0.337
TRG_ER_diArg_1	88	91	PF00400	0.525
TRG_NES_CRM1_1	104	119	PF08389	0.394
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.283

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K7	Leptomonas seymouri	83%	100%
A0A1X0P7A2	Trypanosomatidae	64%	100%
A0A422NCU0	Trypanosoma rangeli	59%	98%
A4H9X6	Leishmania braziliensis	93%	100%
D0A0D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AGS1	Leishmania infantum	100%	100%
E9ARX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O14467	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
O60869	Homo sapiens	36%	100%
O94700	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
P69736	Rattus norvegicus	36%	100%
Q3T0V7	Bos taurus	36%	100%
Q4QDK2	Leishmania major	97%	100%
Q4WX89	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	27%	100%
Q53IP3	Gibberella fujikuroi	27%	100%
Q5A940	Candida albicans (strain SC5314 / ATCC MYA-2876)	33%	100%
Q6BXQ8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	35%	100%
Q6CIP4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	37%	100%
Q6FJN0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	100%
Q6GPQ6	Xenopus laevis	35%	100%
Q6PBY3	Danio rerio	32%	100%
Q752P7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	100%
Q871W6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	100%
Q8TG23	Yarrowia lipolytica (strain CLIB 122 / E 150)	33%	100%
Q9JMG1	Mus musculus	36%	100%
Q9LV58	Arabidopsis thaliana	38%	100%
Q9LXT3	Arabidopsis thaliana	37%	100%
Q9SJI8	Arabidopsis thaliana	37%	100%