BTB/POZ domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WV66_LEIDO

TriTrypDb:

LdBPK_181540.1 , LdCL_180020700 , LDHU3_18.1950

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WV66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WV66

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.530
CLV_NRD_NRD_1	175	177	PF00675	0.436
CLV_NRD_NRD_1	201	203	PF00675	0.432
CLV_NRD_NRD_1	204	206	PF00675	0.427
CLV_NRD_NRD_1	247	249	PF00675	0.641
CLV_NRD_NRD_1	388	390	PF00675	0.549
CLV_PCSK_FUR_1	202	206	PF00082	0.420
CLV_PCSK_KEX2_1	175	177	PF00082	0.436
CLV_PCSK_KEX2_1	201	203	PF00082	0.432
CLV_PCSK_KEX2_1	204	206	PF00082	0.427
CLV_PCSK_KEX2_1	247	249	PF00082	0.643
CLV_PCSK_KEX2_1	40	42	PF00082	0.400
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.388
CLV_PCSK_SKI1_1	165	169	PF00082	0.524
CLV_PCSK_SKI1_1	247	251	PF00082	0.648
CLV_PCSK_SKI1_1	376	380	PF00082	0.537
CLV_PCSK_SKI1_1	40	44	PF00082	0.400
CLV_PCSK_SKI1_1	77	81	PF00082	0.291
DEG_SPOP_SBC_1	361	365	PF00917	0.524
DOC_CDC14_PxL_1	207	215	PF14671	0.498
DOC_CYCLIN_RxL_1	245	252	PF00134	0.586
DOC_MAPK_gen_1	175	182	PF00069	0.383
DOC_MAPK_MEF2A_6	175	184	PF00069	0.374
DOC_PP1_RVXF_1	33	39	PF00149	0.283
DOC_USP7_MATH_1	218	222	PF00917	0.441
DOC_USP7_MATH_1	225	229	PF00917	0.516
DOC_USP7_MATH_1	260	264	PF00917	0.644
DOC_USP7_MATH_1	360	364	PF00917	0.647
DOC_USP7_MATH_1	367	371	PF00917	0.494
DOC_USP7_MATH_1	4	8	PF00917	0.652
DOC_USP7_MATH_1	62	66	PF00917	0.294
DOC_USP7_MATH_1	94	98	PF00917	0.490
DOC_WW_Pin1_4	239	244	PF00397	0.635
DOC_WW_Pin1_4	249	254	PF00397	0.545
LIG_14-3-3_CanoR_1	165	171	PF00244	0.411
LIG_14-3-3_CanoR_1	283	290	PF00244	0.555
LIG_14-3-3_CanoR_1	295	300	PF00244	0.425
LIG_14-3-3_CanoR_1	51	61	PF00244	0.280
LIG_Actin_WH2_2	400	417	PF00022	0.545
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_BIR_III_1	1	5	PF00653	0.631
LIG_BIR_III_3	1	5	PF00653	0.631
LIG_Clathr_ClatBox_1	396	400	PF01394	0.447
LIG_FHA_1	166	172	PF00498	0.394
LIG_FHA_1	283	289	PF00498	0.509
LIG_FHA_1	70	76	PF00498	0.315
LIG_FHA_2	12	18	PF00498	0.556
LIG_FHA_2	153	159	PF00498	0.391
LIG_FHA_2	369	375	PF00498	0.560
LIG_LIR_Gen_1	155	164	PF02991	0.450
LIG_LIR_Nem_3	155	160	PF02991	0.446
LIG_LIR_Nem_3	200	206	PF02991	0.431
LIG_LIR_Nem_3	208	213	PF02991	0.420
LIG_LIR_Nem_3	99	105	PF02991	0.386
LIG_LYPXL_yS_3	210	213	PF13949	0.483
LIG_NRBOX	100	106	PF00104	0.326
LIG_NRBOX	179	185	PF00104	0.432
LIG_PDZ_Class_2	414	419	PF00595	0.568
LIG_Pex14_1	203	207	PF04695	0.492
LIG_Pex14_2	50	54	PF04695	0.312
LIG_REV1ctd_RIR_1	47	55	PF16727	0.312
LIG_SH2_CRK	157	161	PF00017	0.457
LIG_SH2_SRC	137	140	PF00017	0.326
LIG_SH2_STAP1	128	132	PF00017	0.377
LIG_SH2_STAP1	166	170	PF00017	0.399
LIG_SH2_STAT5	330	333	PF00017	0.449
LIG_SH2_STAT5	337	340	PF00017	0.441
LIG_SH2_STAT5	37	40	PF00017	0.312
LIG_SH2_STAT5	53	56	PF00017	0.312
MOD_CDC14_SPxK_1	244	247	PF00782	0.586
MOD_CDC14_SPxK_1	252	255	PF00782	0.577
MOD_CDK_SPxK_1	241	247	PF00069	0.595
MOD_CDK_SPxK_1	249	255	PF00069	0.567
MOD_CDK_SPxxK_3	241	248	PF00069	0.632
MOD_CK1_1	221	227	PF00069	0.503
MOD_CK1_1	233	239	PF00069	0.531
MOD_CK1_1	262	268	PF00069	0.632
MOD_CK1_1	69	75	PF00069	0.329
MOD_CK2_1	368	374	PF00069	0.559
MOD_GlcNHglycan	143	146	PF01048	0.454
MOD_GlcNHglycan	193	196	PF01048	0.498
MOD_GlcNHglycan	220	223	PF01048	0.509
MOD_GlcNHglycan	227	230	PF01048	0.505
MOD_GlcNHglycan	232	236	PF01048	0.499
MOD_GlcNHglycan	262	265	PF01048	0.648
MOD_GlcNHglycan	269	272	PF01048	0.591
MOD_GlcNHglycan	299	302	PF01048	0.547
MOD_GlcNHglycan	364	367	PF01048	0.567
MOD_GlcNHglycan	382	385	PF01048	0.369
MOD_GlcNHglycan	64	67	PF01048	0.388
MOD_GlcNHglycan	68	71	PF01048	0.306
MOD_GlcNHglycan	82	85	PF01048	0.278
MOD_GlcNHglycan	92	95	PF01048	0.297
MOD_GSK3_1	221	228	PF00069	0.570
MOD_GSK3_1	256	263	PF00069	0.643
MOD_GSK3_1	297	304	PF00069	0.468
MOD_GSK3_1	4	11	PF00069	0.578
MOD_GSK3_1	62	69	PF00069	0.378
MOD_GSK3_1	90	97	PF00069	0.291
MOD_LATS_1	139	145	PF00433	0.426
MOD_LATS_1	78	84	PF00433	0.378
MOD_NEK2_1	190	195	PF00069	0.463
MOD_NEK2_1	306	311	PF00069	0.554
MOD_NEK2_1	313	318	PF00069	0.506
MOD_NEK2_1	36	41	PF00069	0.321
MOD_NEK2_1	90	95	PF00069	0.312
MOD_NEK2_2	123	128	PF00069	0.415
MOD_NEK2_2	368	373	PF00069	0.461
MOD_PKA_2	191	197	PF00069	0.411
MOD_PKA_2	282	288	PF00069	0.556
MOD_PKA_2	306	312	PF00069	0.539
MOD_PKA_2	380	386	PF00069	0.496
MOD_PKB_1	295	303	PF00069	0.545
MOD_Plk_1	301	307	PF00069	0.475
MOD_Plk_1	4	10	PF00069	0.635
MOD_Plk_2-3	13	19	PF00069	0.555
MOD_Plk_4	123	129	PF00069	0.339
MOD_Plk_4	152	158	PF00069	0.378
MOD_Plk_4	166	172	PF00069	0.390
MOD_Plk_4	262	268	PF00069	0.605
MOD_Plk_4	70	76	PF00069	0.312
MOD_ProDKin_1	239	245	PF00069	0.632
MOD_ProDKin_1	249	255	PF00069	0.547
MOD_SUMO_for_1	132	135	PF00179	0.373
MOD_SUMO_rev_2	383	392	PF00179	0.542
TRG_ENDOCYTIC_2	157	160	PF00928	0.447
TRG_ENDOCYTIC_2	188	191	PF00928	0.429
TRG_ENDOCYTIC_2	210	213	PF00928	0.483
TRG_ER_diArg_1	201	203	PF00400	0.432
TRG_ER_diArg_1	204	206	PF00400	0.427
TRG_ER_diArg_1	246	248	PF00400	0.665
TRG_ER_diArg_1	294	297	PF00400	0.470
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZP2	Leptomonas seymouri	46%	99%
A4H9Q7	Leishmania braziliensis	68%	99%
A4HY26	Leishmania infantum	100%	100%
E9ART9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QDN4	Leishmania major	91%	100%