J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WV59_LEIDO

TriTrypDb:

LdBPK_190080.1 , LdCL_190005800 , LDHU3_19.0090

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7WV59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WV59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.302
CLV_C14_Caspase3-7	294	298	PF00656	0.306
CLV_NRD_NRD_1	16	18	PF00675	0.379
CLV_NRD_NRD_1	172	174	PF00675	0.712
CLV_NRD_NRD_1	184	186	PF00675	0.521
CLV_NRD_NRD_1	298	300	PF00675	0.583
CLV_PCSK_KEX2_1	16	18	PF00082	0.379
CLV_PCSK_KEX2_1	183	185	PF00082	0.558
CLV_PCSK_KEX2_1	195	197	PF00082	0.530
CLV_PCSK_KEX2_1	265	267	PF00082	0.588
CLV_PCSK_KEX2_1	393	395	PF00082	0.454
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.626
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.588
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.491
CLV_PCSK_PC7_1	191	197	PF00082	0.622
CLV_PCSK_SKI1_1	16	20	PF00082	0.488
CLV_PCSK_SKI1_1	195	199	PF00082	0.604
CLV_PCSK_SKI1_1	235	239	PF00082	0.580
CLV_PCSK_SKI1_1	88	92	PF00082	0.237
DOC_MAPK_gen_1	333	341	PF00069	0.404
DOC_MAPK_gen_1	85	95	PF00069	0.482
DOC_MAPK_MEF2A_6	335	343	PF00069	0.402
DOC_PP2B_LxvP_1	113	116	PF13499	0.416
DOC_USP7_UBL2_3	261	265	PF12436	0.425
DOC_WW_Pin1_4	251	256	PF00397	0.470
LIG_14-3-3_CanoR_1	151	161	PF00244	0.409
LIG_14-3-3_CanoR_1	251	255	PF00244	0.434
LIG_14-3-3_CanoR_1	314	323	PF00244	0.403
LIG_14-3-3_CanoR_1	65	73	PF00244	0.617
LIG_14-3-3_CanoR_1	9	15	PF00244	0.668
LIG_Actin_WH2_2	357	375	PF00022	0.465
LIG_eIF4E_1	89	95	PF01652	0.417
LIG_FHA_1	143	149	PF00498	0.370
LIG_FHA_1	228	234	PF00498	0.374
LIG_FHA_1	245	251	PF00498	0.298
LIG_FHA_1	352	358	PF00498	0.289
LIG_FHA_2	270	276	PF00498	0.462
LIG_FHA_2	67	73	PF00498	0.607
LIG_IRF3_LxIS_1	99	105	PF10401	0.302
LIG_LIR_Gen_1	140	148	PF02991	0.328
LIG_LIR_Gen_1	223	233	PF02991	0.334
LIG_LIR_Gen_1	288	298	PF02991	0.297
LIG_LIR_Gen_1	72	77	PF02991	0.596
LIG_LIR_Nem_3	140	146	PF02991	0.326
LIG_LIR_Nem_3	203	208	PF02991	0.418
LIG_LIR_Nem_3	223	229	PF02991	0.233
LIG_LIR_Nem_3	236	241	PF02991	0.289
LIG_LIR_Nem_3	288	293	PF02991	0.289
LIG_LIR_Nem_3	331	337	PF02991	0.371
LIG_LIR_Nem_3	72	76	PF02991	0.597
LIG_Pex14_2	87	91	PF04695	0.438
LIG_PTB_Apo_2	45	52	PF02174	0.620
LIG_PTB_Phospho_1	45	51	PF10480	0.619
LIG_SH2_CRK	143	147	PF00017	0.396
LIG_SH2_CRK	205	209	PF00017	0.434
LIG_SH2_CRK	226	230	PF00017	0.321
LIG_SH2_CRK	334	338	PF00017	0.388
LIG_SH2_NCK_1	290	294	PF00017	0.397
LIG_SH2_PTP2	347	350	PF00017	0.289
LIG_SH2_SRC	290	293	PF00017	0.391
LIG_SH2_STAP1	107	111	PF00017	0.415
LIG_SH2_STAT5	302	305	PF00017	0.342
LIG_SH2_STAT5	347	350	PF00017	0.277
LIG_SH2_STAT5	89	92	PF00017	0.417
LIG_SH3_3	124	130	PF00018	0.532
LIG_SUMO_SIM_par_1	98	103	PF11976	0.390
LIG_TRAF2_1	282	285	PF00917	0.322
LIG_TRAF2_1	389	392	PF00917	0.599
LIG_TRAF2_1	396	399	PF00917	0.627
LIG_TYR_ITIM	224	229	PF00017	0.308
LIG_UBA3_1	237	245	PF00899	0.425
LIG_UBA3_1	364	373	PF00899	0.582
LIG_UBA3_1	99	106	PF00899	0.376
LIG_WRC_WIRS_1	329	334	PF05994	0.386
MOD_CK1_1	249	255	PF00069	0.381
MOD_CK2_1	66	72	PF00069	0.610
MOD_DYRK1A_RPxSP_1	251	255	PF00069	0.470
MOD_GlcNHglycan	119	122	PF01048	0.597
MOD_GlcNHglycan	21	25	PF01048	0.362
MOD_GlcNHglycan	316	319	PF01048	0.616
MOD_GlcNHglycan	81	85	PF01048	0.397
MOD_GSK3_1	246	253	PF00069	0.436
MOD_LATS_1	312	318	PF00433	0.386
MOD_N-GLC_1	152	157	PF02516	0.729
MOD_N-GLC_1	168	173	PF02516	0.663
MOD_NEK2_1	100	105	PF00069	0.392
MOD_NEK2_1	152	157	PF00069	0.529
MOD_NEK2_1	20	25	PF00069	0.580
MOD_NEK2_1	250	255	PF00069	0.380
MOD_NEK2_1	363	368	PF00069	0.444
MOD_NEK2_1	372	377	PF00069	0.550
MOD_NEK2_2	328	333	PF00069	0.455
MOD_PIKK_1	228	234	PF00454	0.320
MOD_PIKK_1	372	378	PF00454	0.569
MOD_PIKK_1	66	72	PF00454	0.621
MOD_PKA_2	250	256	PF00069	0.468
MOD_ProDKin_1	251	257	PF00069	0.468
MOD_SUMO_for_1	18	21	PF00179	0.664
MOD_SUMO_for_1	260	263	PF00179	0.388
MOD_SUMO_rev_2	131	139	PF00179	0.401
MOD_SUMO_rev_2	243	250	PF00179	0.369
MOD_SUMO_rev_2	284	289	PF00179	0.327
MOD_SUMO_rev_2	385	395	PF00179	0.663
TRG_DiLeu_BaEn_1	72	77	PF01217	0.610
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.587
TRG_ENDOCYTIC_2	143	146	PF00928	0.322
TRG_ENDOCYTIC_2	205	208	PF00928	0.425
TRG_ENDOCYTIC_2	226	229	PF00928	0.322
TRG_ENDOCYTIC_2	290	293	PF00928	0.289
TRG_ENDOCYTIC_2	301	304	PF00928	0.320
TRG_ENDOCYTIC_2	334	337	PF00928	0.370
TRG_ENDOCYTIC_2	347	350	PF00928	0.227
TRG_ER_diArg_1	16	18	PF00400	0.611
TRG_ER_diArg_1	183	185	PF00400	0.357
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L0	Leptomonas seymouri	75%	100%
A0A0S4IRI9	Bodo saltans	48%	92%
A0A1X0P6G2	Trypanosomatidae	57%	100%
A0A3S5IQZ2	Trypanosoma rangeli	57%	100%
A4H9W6	Leishmania braziliensis	87%	100%
D0A0B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AGR1	Leishmania infantum	100%	100%
E9ARW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QDL2	Leishmania major	95%	100%
V5C1R6	Trypanosoma cruzi	56%	100%