DnaJ domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WV53_LEIDO

TriTrypDb:

LdBPK_181470.1 , LdCL_180020100 , LDHU3_18.1870

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WV53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WV53

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	10
GO:0006448	regulation of translational elongation	7	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009889	regulation of biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0010468	regulation of gene expression	5	10
GO:0010556	regulation of macromolecule biosynthetic process	5	10
GO:0010608	post-transcriptional regulation of gene expression	6	10
GO:0017182	peptidyl-diphthamide metabolic process	7	10
GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	4	10
GO:0018193	peptidyl-amino acid modification	5	10
GO:0018202	peptidyl-histidine modification	6	10
GO:0019222	regulation of metabolic process	3	10
GO:0019538	protein metabolic process	3	10
GO:0031323	regulation of cellular metabolic process	4	10
GO:0031326	regulation of cellular biosynthetic process	5	10
GO:0034248	regulation of amide metabolic process	5	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0050789	regulation of biological process	2	10
GO:0050794	regulation of cellular process	3	10
GO:0051171	regulation of nitrogen compound metabolic process	4	10
GO:0051246	regulation of protein metabolic process	5	10
GO:0060255	regulation of macromolecule metabolic process	4	10
GO:0065007	biological regulation	1	10
GO:0071704	organic substance metabolic process	2	10
GO:0080090	regulation of primary metabolic process	4	10
GO:1900247	regulation of cytoplasmic translational elongation	8	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	10
GO:0002097	tRNA wobble base modification	7	1
GO:0002098	tRNA wobble uridine modification	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0008033	tRNA processing	8	1
GO:0009451	RNA modification	5	1
GO:0016070	RNA metabolic process	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.649
CLV_NRD_NRD_1	53	55	PF00675	0.464
CLV_PCSK_KEX2_1	35	37	PF00082	0.327
CLV_PCSK_KEX2_1	53	55	PF00082	0.429
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.323
CLV_PCSK_PC7_1	31	37	PF00082	0.323
CLV_PCSK_SKI1_1	31	35	PF00082	0.309
CLV_PCSK_SKI1_1	36	40	PF00082	0.309
DOC_PP2B_LxvP_1	19	22	PF13499	0.305
DOC_USP7_MATH_1	151	155	PF00917	0.722
DOC_USP7_MATH_1	4	8	PF00917	0.616
DOC_USP7_MATH_1	91	95	PF00917	0.640
DOC_WW_Pin1_4	11	16	PF00397	0.533
DOC_WW_Pin1_4	58	63	PF00397	0.332
LIG_APCC_ABBA_1	144	149	PF00400	0.639
LIG_BIR_II_1	1	5	PF00653	0.699
LIG_FHA_1	105	111	PF00498	0.596
LIG_FHA_1	96	102	PF00498	0.656
LIG_FHA_2	12	18	PF00498	0.408
LIG_FHA_2	39	45	PF00498	0.306
LIG_LIR_Gen_1	105	115	PF02991	0.643
LIG_LIR_Gen_1	14	22	PF02991	0.352
LIG_LIR_Gen_1	69	76	PF02991	0.330
LIG_LIR_LC3C_4	175	180	PF02991	0.569
LIG_LIR_Nem_3	112	117	PF02991	0.599
LIG_LIR_Nem_3	12	16	PF02991	0.503
LIG_LIR_Nem_3	69	73	PF02991	0.331
LIG_PDZ_Class_2	179	184	PF00595	0.605
LIG_Pex14_2	66	70	PF04695	0.376
LIG_SH2_STAP1	142	146	PF00017	0.629
LIG_SH2_STAT3	164	167	PF00017	0.464
LIG_SH2_STAT5	84	87	PF00017	0.440
LIG_SH3_3	145	151	PF00018	0.693
MOD_CK1_1	165	171	PF00069	0.630
MOD_CK2_1	6	12	PF00069	0.645
MOD_GlcNHglycan	1	4	PF01048	0.702
MOD_GlcNHglycan	153	156	PF01048	0.716
MOD_GlcNHglycan	164	167	PF01048	0.496
MOD_GlcNHglycan	23	26	PF01048	0.352
MOD_GlcNHglycan	50	53	PF01048	0.385
MOD_GlcNHglycan	55	58	PF01048	0.369
MOD_GSK3_1	102	109	PF00069	0.457
MOD_GSK3_1	21	28	PF00069	0.422
MOD_GSK3_1	44	51	PF00069	0.410
MOD_GSK3_1	53	60	PF00069	0.361
MOD_GSK3_1	91	98	PF00069	0.637
MOD_NEK2_1	162	167	PF00069	0.689
MOD_OFUCOSY	171	176	PF10250	0.572
MOD_PIKK_1	91	97	PF00454	0.596
MOD_PKA_1	53	59	PF00069	0.376
MOD_PKA_2	53	59	PF00069	0.376
MOD_Plk_2-3	106	112	PF00069	0.637
MOD_Plk_4	106	112	PF00069	0.657
MOD_Plk_4	174	180	PF00069	0.497
MOD_ProDKin_1	11	17	PF00069	0.532
MOD_ProDKin_1	58	64	PF00069	0.332
TRG_ENDOCYTIC_2	108	111	PF00928	0.615
TRG_ENDOCYTIC_2	16	19	PF00928	0.309
TRG_ER_diArg_1	115	118	PF00400	0.734

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKZ1	Leptomonas seymouri	55%	100%
A0A0S4JNU9	Bodo saltans	39%	100%
A0A1X0P737	Trypanosomatidae	41%	100%
A0A422NIQ2	Trypanosoma rangeli	44%	100%
A4H9Q3	Leishmania braziliensis	67%	100%
A4HY19	Leishmania infantum	99%	100%
D0A566	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ART3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q0VBY7	Bos taurus	26%	100%
Q4QDP0	Leishmania major	92%	100%
Q6P3W2	Homo sapiens	27%	100%