Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WV44_LEIDO

TriTrypDb:

LdBPK_181480.1 , LdCL_180020200 , LDHU3_18.1880

Length:

1048

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WV44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WV44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	376	380	PF00656	0.727
CLV_C14_Caspase3-7	652	656	PF00656	0.754
CLV_C14_Caspase3-7	719	723	PF00656	0.596
CLV_NRD_NRD_1	1041	1043	PF00675	0.480
CLV_NRD_NRD_1	234	236	PF00675	0.698
CLV_NRD_NRD_1	684	686	PF00675	0.572
CLV_NRD_NRD_1	842	844	PF00675	0.454
CLV_NRD_NRD_1	900	902	PF00675	0.500
CLV_NRD_NRD_1	934	936	PF00675	0.423
CLV_PCSK_FUR_1	231	235	PF00082	0.734
CLV_PCSK_FUR_1	682	686	PF00082	0.727
CLV_PCSK_KEX2_1	1040	1042	PF00082	0.466
CLV_PCSK_KEX2_1	230	232	PF00082	0.747
CLV_PCSK_KEX2_1	233	235	PF00082	0.695
CLV_PCSK_KEX2_1	684	686	PF00082	0.572
CLV_PCSK_KEX2_1	842	844	PF00082	0.404
CLV_PCSK_KEX2_1	900	902	PF00082	0.500
CLV_PCSK_KEX2_1	934	936	PF00082	0.410
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.747
CLV_PCSK_SKI1_1	1009	1013	PF00082	0.548
CLV_PCSK_SKI1_1	1042	1046	PF00082	0.526
CLV_PCSK_SKI1_1	234	238	PF00082	0.668
CLV_PCSK_SKI1_1	308	312	PF00082	0.580
CLV_PCSK_SKI1_1	457	461	PF00082	0.728
CLV_PCSK_SKI1_1	685	689	PF00082	0.601
CLV_PCSK_SKI1_1	694	698	PF00082	0.620
CLV_PCSK_SKI1_1	977	981	PF00082	0.496
DEG_SPOP_SBC_1	731	735	PF00917	0.650
DEG_SPOP_SBC_1	819	823	PF00917	0.667
DEG_SPOP_SBC_1	837	841	PF00917	0.526
DOC_CDC14_PxL_1	593	601	PF14671	0.435
DOC_CKS1_1	260	265	PF01111	0.609
DOC_CKS1_1	513	518	PF01111	0.524
DOC_CKS1_1	532	537	PF01111	0.559
DOC_CKS1_1	826	831	PF01111	0.500
DOC_CYCLIN_RxL_1	682	695	PF00134	0.719
DOC_CYCLIN_RxL_1	971	983	PF00134	0.567
DOC_CYCLIN_yCln2_LP_2	498	504	PF00134	0.772
DOC_MAPK_DCC_7	960	969	PF00069	0.434
DOC_MAPK_gen_1	1040	1048	PF00069	0.524
DOC_MAPK_gen_1	684	693	PF00069	0.676
DOC_MAPK_gen_1	825	832	PF00069	0.532
DOC_MAPK_gen_1	870	879	PF00069	0.421
DOC_MAPK_JIP1_4	873	879	PF00069	0.550
DOC_MAPK_MEF2A_6	188	196	PF00069	0.676
DOC_MAPK_MEF2A_6	586	595	PF00069	0.601
DOC_MAPK_MEF2A_6	870	879	PF00069	0.493
DOC_MAPK_MEF2A_6	891	899	PF00069	0.532
DOC_MAPK_MEF2A_6	960	969	PF00069	0.434
DOC_PP2B_LxvP_1	835	838	PF13499	0.451
DOC_PP4_FxxP_1	549	552	PF00568	0.421
DOC_PP4_FxxP_1	80	83	PF00568	0.668
DOC_USP7_MATH_1	103	107	PF00917	0.473
DOC_USP7_MATH_1	1044	1048	PF00917	0.557
DOC_USP7_MATH_1	224	228	PF00917	0.752
DOC_USP7_MATH_1	315	319	PF00917	0.623
DOC_USP7_MATH_1	342	346	PF00917	0.762
DOC_USP7_MATH_1	369	373	PF00917	0.726
DOC_USP7_MATH_1	511	515	PF00917	0.494
DOC_USP7_MATH_1	568	572	PF00917	0.494
DOC_USP7_MATH_1	629	633	PF00917	0.784
DOC_USP7_MATH_1	657	661	PF00917	0.647
DOC_USP7_MATH_1	686	690	PF00917	0.613
DOC_USP7_MATH_1	725	729	PF00917	0.687
DOC_USP7_MATH_1	731	735	PF00917	0.649
DOC_USP7_MATH_1	748	752	PF00917	0.582
DOC_USP7_MATH_1	76	80	PF00917	0.623
DOC_USP7_MATH_1	813	817	PF00917	0.618
DOC_USP7_MATH_1	819	823	PF00917	0.637
DOC_USP7_MATH_1	838	842	PF00917	0.621
DOC_USP7_MATH_1	937	941	PF00917	0.614
DOC_WW_Pin1_4	158	163	PF00397	0.654
DOC_WW_Pin1_4	234	239	PF00397	0.681
DOC_WW_Pin1_4	259	264	PF00397	0.716
DOC_WW_Pin1_4	277	282	PF00397	0.423
DOC_WW_Pin1_4	347	352	PF00397	0.773
DOC_WW_Pin1_4	512	517	PF00397	0.535
DOC_WW_Pin1_4	531	536	PF00397	0.570
DOC_WW_Pin1_4	627	632	PF00397	0.702
DOC_WW_Pin1_4	705	710	PF00397	0.637
DOC_WW_Pin1_4	717	722	PF00397	0.646
DOC_WW_Pin1_4	733	738	PF00397	0.781
DOC_WW_Pin1_4	79	84	PF00397	0.637
DOC_WW_Pin1_4	825	830	PF00397	0.690
DOC_WW_Pin1_4	849	854	PF00397	0.436
DOC_WW_Pin1_4	884	889	PF00397	0.586
DOC_WW_Pin1_4	987	992	PF00397	0.516
LIG_14-3-3_CanoR_1	10	17	PF00244	0.635
LIG_14-3-3_CanoR_1	155	163	PF00244	0.701
LIG_14-3-3_CanoR_1	288	292	PF00244	0.565
LIG_14-3-3_CanoR_1	337	346	PF00244	0.633
LIG_14-3-3_CanoR_1	569	573	PF00244	0.552
LIG_14-3-3_CanoR_1	685	691	PF00244	0.608
LIG_14-3-3_CanoR_1	717	721	PF00244	0.746
LIG_14-3-3_CanoR_1	836	846	PF00244	0.499
LIG_14-3-3_CanoR_1	971	979	PF00244	0.531
LIG_Actin_WH2_2	549	566	PF00022	0.464
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BIR_III_2	394	398	PF00653	0.749
LIG_BIR_III_2	49	53	PF00653	0.670
LIG_BIR_III_2	628	632	PF00653	0.783
LIG_BRCT_BRCA1_1	122	126	PF00533	0.432
LIG_CSL_BTD_1	266	269	PF09270	0.549
LIG_CSL_BTD_1	348	351	PF09270	0.615
LIG_CSL_BTD_1	875	878	PF09270	0.492
LIG_DLG_GKlike_1	891	899	PF00625	0.585
LIG_FHA_1	105	111	PF00498	0.487
LIG_FHA_1	112	118	PF00498	0.420
LIG_FHA_1	158	164	PF00498	0.672
LIG_FHA_1	311	317	PF00498	0.483
LIG_FHA_1	326	332	PF00498	0.688
LIG_FHA_1	399	405	PF00498	0.770
LIG_FHA_1	483	489	PF00498	0.807
LIG_FHA_1	546	552	PF00498	0.419
LIG_FHA_1	752	758	PF00498	0.663
LIG_FHA_1	764	770	PF00498	0.459
LIG_FHA_1	854	860	PF00498	0.467
LIG_FHA_1	991	997	PF00498	0.604
LIG_FHA_2	1027	1033	PF00498	0.593
LIG_FHA_2	259	265	PF00498	0.698
LIG_FHA_2	513	519	PF00498	0.500
LIG_FHA_2	55	61	PF00498	0.686
LIG_FHA_2	628	634	PF00498	0.651
LIG_FHA_2	819	825	PF00498	0.755
LIG_FHA_2	885	891	PF00498	0.527
LIG_LIR_Apic_2	379	385	PF02991	0.747
LIG_LIR_Apic_2	475	481	PF02991	0.764
LIG_LIR_Apic_2	548	552	PF02991	0.422
LIG_LIR_Apic_2	79	83	PF02991	0.592
LIG_LIR_Gen_1	131	140	PF02991	0.571
LIG_LIR_Gen_1	518	527	PF02991	0.455
LIG_LIR_Nem_3	123	129	PF02991	0.458
LIG_LIR_Nem_3	131	135	PF02991	0.430
LIG_LIR_Nem_3	445	451	PF02991	0.634
LIG_LIR_Nem_3	518	522	PF02991	0.477
LIG_LIR_Nem_3	548	553	PF02991	0.423
LIG_LIR_Nem_3	74	80	PF02991	0.711
LIG_LIR_Nem_3	756	762	PF02991	0.513
LIG_LIR_Nem_3	785	790	PF02991	0.433
LIG_LYPXL_yS_3	759	762	PF13949	0.517
LIG_MYND_1	799	803	PF01753	0.578
LIG_NRBOX	912	918	PF00104	0.375
LIG_PDZ_Class_2	1043	1048	PF00595	0.677
LIG_PTB_Apo_2	240	247	PF02174	0.588
LIG_Rb_pABgroove_1	472	480	PF01858	0.729
LIG_RPA_C_Fungi	207	219	PF08784	0.572
LIG_RPA_C_Fungi	930	942	PF08784	0.494
LIG_SH2_CRK	448	452	PF00017	0.713
LIG_SH2_CRK	478	482	PF00017	0.748
LIG_SH2_NCK_1	314	318	PF00017	0.583
LIG_SH2_NCK_1	478	482	PF00017	0.724
LIG_SH2_PTP2	382	385	PF00017	0.713
LIG_SH2_PTP2	787	790	PF00017	0.410
LIG_SH2_SRC	314	317	PF00017	0.409
LIG_SH2_SRC	382	385	PF00017	0.576
LIG_SH2_STAP1	12	16	PF00017	0.621
LIG_SH2_STAP1	34	38	PF00017	0.455
LIG_SH2_STAT3	12	15	PF00017	0.618
LIG_SH2_STAT3	213	216	PF00017	0.581
LIG_SH2_STAT5	30	33	PF00017	0.642
LIG_SH2_STAT5	382	385	PF00017	0.649
LIG_SH2_STAT5	541	544	PF00017	0.413
LIG_SH2_STAT5	582	585	PF00017	0.438
LIG_SH2_STAT5	787	790	PF00017	0.424
LIG_SH2_STAT5	797	800	PF00017	0.463
LIG_SH3_1	478	484	PF00018	0.622
LIG_SH3_3	238	244	PF00018	0.726
LIG_SH3_3	380	386	PF00018	0.622
LIG_SH3_3	478	484	PF00018	0.633
LIG_SH3_3	505	511	PF00018	0.665
LIG_SH3_3	680	686	PF00018	0.537
LIG_SH3_3	823	829	PF00018	0.497
LIG_SH3_3	83	89	PF00018	0.653
LIG_SH3_3	872	878	PF00018	0.495
LIG_SH3_3	896	902	PF00018	0.507
LIG_SH3_3	958	964	PF00018	0.446
LIG_SH3_5	385	389	PF00018	0.765
LIG_SUMO_SIM_anti_2	949	954	PF11976	0.544
LIG_SUMO_SIM_par_1	106	112	PF11976	0.493
LIG_SUMO_SIM_par_1	190	195	PF11976	0.555
LIG_SUMO_SIM_par_1	398	403	PF11976	0.772
LIG_SUMO_SIM_par_1	689	695	PF11976	0.703
LIG_SUMO_SIM_par_1	965	970	PF11976	0.425
LIG_SxIP_EBH_1	825	836	PF03271	0.591
LIG_TRAF2_1	18	21	PF00917	0.627
LIG_TRAF2_1	33	36	PF00917	0.486
LIG_TRAF2_1	552	555	PF00917	0.585
LIG_TRAF2_1	887	890	PF00917	0.578
LIG_TRAF2_2	535	540	PF00917	0.555
LIG_TRFH_1	849	853	PF08558	0.427
LIG_TYR_ITIM	446	451	PF00017	0.634
LIG_TYR_ITIM	757	762	PF00017	0.515
LIG_WRC_WIRS_1	129	134	PF05994	0.421
LIG_WRC_WIRS_1	370	375	PF05994	0.585
LIG_WRC_WIRS_1	546	551	PF05994	0.408
LIG_WRC_WIRS_1	693	698	PF05994	0.657
LIG_WRC_WIRS_1	77	82	PF05994	0.620
LIG_WW_3	509	513	PF00397	0.570
MOD_CDK_SPxxK_3	884	891	PF00069	0.581
MOD_CK1_1	128	134	PF00069	0.422
MOD_CK1_1	158	164	PF00069	0.634
MOD_CK1_1	211	217	PF00069	0.729
MOD_CK1_1	259	265	PF00069	0.561
MOD_CK1_1	347	353	PF00069	0.636
MOD_CK1_1	452	458	PF00069	0.657
MOD_CK1_1	490	496	PF00069	0.674
MOD_CK1_1	571	577	PF00069	0.434
MOD_CK1_1	664	670	PF00069	0.706
MOD_CK1_1	671	677	PF00069	0.608
MOD_CK1_1	689	695	PF00069	0.671
MOD_CK1_1	733	739	PF00069	0.740
MOD_CK1_1	751	757	PF00069	0.651
MOD_CK1_1	79	85	PF00069	0.677
MOD_CK1_1	884	890	PF00069	0.528
MOD_CK1_1	990	996	PF00069	0.627
MOD_CK2_1	1026	1032	PF00069	0.602
MOD_CK2_1	258	264	PF00069	0.662
MOD_CK2_1	512	518	PF00069	0.518
MOD_CK2_1	54	60	PF00069	0.644
MOD_CK2_1	627	633	PF00069	0.649
MOD_CK2_1	818	824	PF00069	0.733
MOD_CK2_1	884	890	PF00069	0.572
MOD_CK2_1	905	911	PF00069	0.470
MOD_CMANNOS	772	775	PF00535	0.422
MOD_DYRK1A_RPxSP_1	512	516	PF00069	0.536
MOD_GlcNHglycan	1	4	PF01048	0.635
MOD_GlcNHglycan	12	15	PF01048	0.705
MOD_GlcNHglycan	176	179	PF01048	0.728
MOD_GlcNHglycan	226	229	PF01048	0.714
MOD_GlcNHglycan	248	251	PF01048	0.600
MOD_GlcNHglycan	418	421	PF01048	0.774
MOD_GlcNHglycan	429	432	PF01048	0.612
MOD_GlcNHglycan	451	454	PF01048	0.668
MOD_GlcNHglycan	655	658	PF01048	0.738
MOD_GlcNHglycan	659	662	PF01048	0.701
MOD_GlcNHglycan	663	666	PF01048	0.648
MOD_GlcNHglycan	902	905	PF01048	0.518
MOD_GlcNHglycan	907	910	PF01048	0.485
MOD_GlcNHglycan	939	942	PF01048	0.639
MOD_GlcNHglycan	957	960	PF01048	0.342
MOD_GSK3_1	104	111	PF00069	0.451
MOD_GSK3_1	208	215	PF00069	0.632
MOD_GSK3_1	321	328	PF00069	0.559
MOD_GSK3_1	487	494	PF00069	0.724
MOD_GSK3_1	567	574	PF00069	0.489
MOD_GSK3_1	635	642	PF00069	0.647
MOD_GSK3_1	653	660	PF00069	0.800
MOD_GSK3_1	664	671	PF00069	0.613
MOD_GSK3_1	726	733	PF00069	0.674
MOD_GSK3_1	747	754	PF00069	0.539
MOD_GSK3_1	813	820	PF00069	0.545
MOD_GSK3_1	849	856	PF00069	0.402
MOD_GSK3_1	877	884	PF00069	0.495
MOD_N-GLC_2	339	341	PF02516	0.669
MOD_N-GLC_2	620	622	PF02516	0.553
MOD_NEK2_1	125	130	PF00069	0.536
MOD_NEK2_1	208	213	PF00069	0.604
MOD_NEK2_1	287	292	PF00069	0.613
MOD_NEK2_1	310	315	PF00069	0.575
MOD_NEK2_1	716	721	PF00069	0.679
MOD_NEK2_1	859	864	PF00069	0.609
MOD_NEK2_1	946	951	PF00069	0.430
MOD_NEK2_1	980	985	PF00069	0.627
MOD_NEK2_2	504	509	PF00069	0.637
MOD_NEK2_2	568	573	PF00069	0.489
MOD_PIKK_1	140	146	PF00454	0.552
MOD_PIKK_1	212	218	PF00454	0.620
MOD_PIKK_1	389	395	PF00454	0.699
MOD_PIKK_1	457	463	PF00454	0.782
MOD_PIKK_1	493	499	PF00454	0.714
MOD_PIKK_1	763	769	PF00454	0.468
MOD_PIKK_1	980	986	PF00454	0.633
MOD_PK_1	363	369	PF00069	0.725
MOD_PKA_1	900	906	PF00069	0.584
MOD_PKA_2	1026	1032	PF00069	0.673
MOD_PKA_2	156	162	PF00069	0.739
MOD_PKA_2	211	217	PF00069	0.612
MOD_PKA_2	287	293	PF00069	0.600
MOD_PKA_2	511	517	PF00069	0.539
MOD_PKA_2	556	562	PF00069	0.469
MOD_PKA_2	568	574	PF00069	0.483
MOD_PKA_2	716	722	PF00069	0.725
MOD_PKA_2	900	906	PF00069	0.584
MOD_PKA_2	970	976	PF00069	0.518
MOD_PKB_1	155	163	PF00069	0.505
MOD_Plk_1	325	331	PF00069	0.682
MOD_Plk_1	363	369	PF00069	0.725
MOD_Plk_1	813	819	PF00069	0.649
MOD_Plk_1	859	865	PF00069	0.598
MOD_Plk_1	891	897	PF00069	0.588
MOD_Plk_1	94	100	PF00069	0.549
MOD_Plk_4	104	110	PF00069	0.538
MOD_Plk_4	125	131	PF00069	0.380
MOD_Plk_4	270	276	PF00069	0.474
MOD_Plk_4	344	350	PF00069	0.754
MOD_Plk_4	369	375	PF00069	0.669
MOD_Plk_4	378	384	PF00069	0.782
MOD_Plk_4	545	551	PF00069	0.416
MOD_Plk_4	664	670	PF00069	0.751
MOD_Plk_4	686	692	PF00069	0.650
MOD_Plk_4	783	789	PF00069	0.515
MOD_Plk_4	813	819	PF00069	0.672
MOD_Plk_4	859	865	PF00069	0.605
MOD_Plk_4	948	954	PF00069	0.419
MOD_ProDKin_1	158	164	PF00069	0.657
MOD_ProDKin_1	234	240	PF00069	0.681
MOD_ProDKin_1	259	265	PF00069	0.709
MOD_ProDKin_1	277	283	PF00069	0.419
MOD_ProDKin_1	347	353	PF00069	0.774
MOD_ProDKin_1	512	518	PF00069	0.531
MOD_ProDKin_1	531	537	PF00069	0.571
MOD_ProDKin_1	627	633	PF00069	0.704
MOD_ProDKin_1	705	711	PF00069	0.638
MOD_ProDKin_1	717	723	PF00069	0.647
MOD_ProDKin_1	733	739	PF00069	0.779
MOD_ProDKin_1	79	85	PF00069	0.635
MOD_ProDKin_1	825	831	PF00069	0.645
MOD_ProDKin_1	849	855	PF00069	0.433
MOD_ProDKin_1	884	890	PF00069	0.580
MOD_ProDKin_1	987	993	PF00069	0.518
MOD_SUMO_rev_2	183	190	PF00179	0.610
MOD_SUMO_rev_2	585	591	PF00179	0.610
TRG_DiLeu_BaEn_4	203	209	PF01217	0.526
TRG_DiLeu_BaEn_4	892	898	PF01217	0.581
TRG_DiLeu_BaLyEn_6	1033	1038	PF01217	0.579
TRG_DiLeu_BaLyEn_6	774	779	PF01217	0.378
TRG_DiLeu_BaLyEn_6	878	883	PF01217	0.492
TRG_ENDOCYTIC_2	34	37	PF00928	0.462
TRG_ENDOCYTIC_2	448	451	PF00928	0.640
TRG_ENDOCYTIC_2	580	583	PF00928	0.550
TRG_ENDOCYTIC_2	759	762	PF00928	0.517
TRG_ENDOCYTIC_2	787	790	PF00928	0.416
TRG_ER_diArg_1	1039	1042	PF00400	0.452
TRG_ER_diArg_1	231	234	PF00400	0.769
TRG_ER_diArg_1	299	302	PF00400	0.567
TRG_ER_diArg_1	681	684	PF00400	0.527
TRG_ER_diArg_1	842	845	PF00400	0.449
TRG_ER_diArg_1	899	901	PF00400	0.483
TRG_ER_diArg_1	933	935	PF00400	0.401
TRG_NLS_MonoExtC_3	229	234	PF00514	0.737
TRG_Pf-PMV_PEXEL_1	115	120	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U0	Leptomonas seymouri	43%	95%
A4H9Q4	Leishmania braziliensis	77%	100%
A4HY20	Leishmania infantum	100%	100%
E9ART4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QDN9	Leishmania major	92%	100%