RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WV37_LEIDO

TriTrypDb:

LdBPK_181160.1 , LdCL_180016800 , LDHU3_18.1470

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WV37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WV37

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0061630	ubiquitin protein ligase activity	5	12
GO:0061659	ubiquitin-like protein ligase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.704
CLV_NRD_NRD_1	178	180	PF00675	0.638
CLV_NRD_NRD_1	253	255	PF00675	0.555
CLV_PCSK_KEX2_1	220	222	PF00082	0.637
CLV_PCSK_KEX2_1	252	254	PF00082	0.508
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.637
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.522
CLV_PCSK_SKI1_1	179	183	PF00082	0.565
DEG_APCC_DBOX_1	161	169	PF00400	0.703
DOC_MAPK_gen_1	179	187	PF00069	0.621
DOC_MAPK_MEF2A_6	179	187	PF00069	0.539
DOC_MAPK_MEF2A_6	203	210	PF00069	0.459
DOC_MAPK_NFAT4_5	180	188	PF00069	0.624
DOC_PP2B_LxvP_1	351	354	PF13499	0.457
DOC_USP7_MATH_1	360	364	PF00917	0.711
DOC_USP7_MATH_1	93	97	PF00917	0.818
DOC_USP7_UBL2_3	180	184	PF12436	0.522
DOC_USP7_UBL2_3	195	199	PF12436	0.566
DOC_WW_Pin1_4	57	62	PF00397	0.752
LIG_14-3-3_CanoR_1	179	184	PF00244	0.546
LIG_14-3-3_CanoR_1	344	354	PF00244	0.353
LIG_FHA_1	123	129	PF00498	0.479
LIG_FHA_1	138	144	PF00498	0.434
LIG_FHA_1	180	186	PF00498	0.540
LIG_FHA_1	213	219	PF00498	0.579
LIG_FHA_2	229	235	PF00498	0.637
LIG_FHA_2	241	247	PF00498	0.409
LIG_FHA_2	294	300	PF00498	0.760
LIG_MYND_1	163	167	PF01753	0.667
LIG_PDZ_Class_1	360	365	PF00595	0.715
LIG_SH2_GRB2like	41	44	PF00017	0.781
LIG_SH2_SRC	141	144	PF00017	0.455
LIG_SH2_STAT3	201	204	PF00017	0.472
LIG_SH2_STAT5	131	134	PF00017	0.609
LIG_SH2_STAT5	267	270	PF00017	0.494
LIG_SH3_1	335	341	PF00018	0.367
LIG_SH3_3	157	163	PF00018	0.496
LIG_SH3_3	335	341	PF00018	0.353
LIG_SH3_3	64	70	PF00018	0.800
LIG_TRAF2_1	189	192	PF00917	0.582
LIG_TRAF2_1	231	234	PF00917	0.605
LIG_WRC_WIRS_1	127	132	PF05994	0.502
MOD_CK1_1	117	123	PF00069	0.565
MOD_CK2_1	131	137	PF00069	0.537
MOD_CK2_1	186	192	PF00069	0.597
MOD_CK2_1	228	234	PF00069	0.764
MOD_CK2_1	292	298	PF00069	0.764
MOD_GlcNHglycan	283	286	PF01048	0.738
MOD_GlcNHglycan	83	86	PF01048	0.825
MOD_GSK3_1	110	117	PF00069	0.486
MOD_GSK3_1	122	129	PF00069	0.488
MOD_GSK3_1	131	138	PF00069	0.455
MOD_GSK3_1	237	244	PF00069	0.520
MOD_GSK3_1	254	261	PF00069	0.460
MOD_GSK3_1	277	284	PF00069	0.848
MOD_N-GLC_1	152	157	PF02516	0.514
MOD_N-GLC_1	228	233	PF02516	0.723
MOD_N-GLC_1	4	9	PF02516	0.818
MOD_N-GLC_1	42	47	PF02516	0.800
MOD_N-GLC_1	56	61	PF02516	0.841
MOD_N-GLC_1	81	86	PF02516	0.908
MOD_N-GLC_1	93	98	PF02516	0.712
MOD_NEK2_1	130	135	PF00069	0.440
MOD_NEK2_1	292	297	PF00069	0.654
MOD_NMyristoyl	1	7	PF02799	0.674
MOD_PIKK_1	122	128	PF00454	0.598
MOD_PIKK_1	254	260	PF00454	0.468
MOD_PIKK_1	4	10	PF00454	0.782
MOD_PKA_1	179	185	PF00069	0.621
MOD_Plk_1	114	120	PF00069	0.499
MOD_Plk_1	193	199	PF00069	0.487
MOD_Plk_1	240	246	PF00069	0.438
MOD_Plk_2-3	137	143	PF00069	0.552
MOD_Plk_2-3	186	192	PF00069	0.624
MOD_Plk_2-3	241	247	PF00069	0.498
MOD_Plk_4	117	123	PF00069	0.606
MOD_Plk_4	126	132	PF00069	0.558
MOD_Plk_4	346	352	PF00069	0.387
MOD_ProDKin_1	57	63	PF00069	0.754
MOD_SUMO_for_1	163	166	PF00179	0.563
MOD_SUMO_for_1	168	171	PF00179	0.536
TRG_ER_diArg_1	253	255	PF00400	0.521
TRG_NLS_MonoExtN_4	250	256	PF00514	0.522
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI8	Leptomonas seymouri	73%	99%
A0A0S4JNW6	Bodo saltans	32%	96%
A0A1X0P805	Trypanosomatidae	50%	98%
A0A422P0Q0	Trypanosoma rangeli	53%	100%
A4H9M5	Leishmania braziliensis	79%	97%
A4HXY9	Leishmania infantum	99%	100%
D0A5B8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ARQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	99%
Q4QDS7	Leishmania major	93%	99%
V5BNN3	Trypanosoma cruzi	56%	100%