Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WV34_LEIDO

TriTrypDb:

LdBPK_181450.1 , LdCL_180019900 , LDHU3_18.1850

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3S7WV34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WV34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	312	314	PF00675	0.381
CLV_NRD_NRD_1	317	319	PF00675	0.281
CLV_PCSK_FUR_1	315	319	PF00082	0.388
CLV_PCSK_KEX2_1	314	316	PF00082	0.383
CLV_PCSK_KEX2_1	317	319	PF00082	0.269
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.330
CLV_PCSK_PC7_1	313	319	PF00082	0.357
CLV_PCSK_SKI1_1	95	99	PF00082	0.371
DOC_CDC14_PxL_1	80	88	PF14671	0.575
DOC_MAPK_MEF2A_6	104	111	PF00069	0.535
DOC_PP4_FxxP_1	132	135	PF00568	0.553
DOC_PP4_FxxP_1	196	199	PF00568	0.606
DOC_PP4_FxxP_1	232	235	PF00568	0.532
DOC_PP4_FxxP_1	261	264	PF00568	0.475
DOC_USP7_MATH_1	47	51	PF00917	0.733
DOC_USP7_MATH_1	62	66	PF00917	0.776
DOC_USP7_MATH_1	71	75	PF00917	0.697
DOC_USP7_MATH_1	91	95	PF00917	0.446
DOC_USP7_MATH_2	190	196	PF00917	0.662
DOC_WW_Pin1_4	154	159	PF00397	0.642
DOC_WW_Pin1_4	204	209	PF00397	0.608
LIG_14-3-3_CanoR_1	64	73	PF00244	0.760
LIG_14-3-3_CanoR_1	85	91	PF00244	0.593
LIG_14-3-3_CanoR_1	95	102	PF00244	0.521
LIG_APCC_ABBA_1	270	275	PF00400	0.497
LIG_BRCT_BRCA1_1	228	232	PF00533	0.549
LIG_FHA_1	121	127	PF00498	0.552
LIG_FHA_1	294	300	PF00498	0.683
LIG_FHA_1	96	102	PF00498	0.535
LIG_LIR_Apic_2	114	118	PF02991	0.538
LIG_LIR_Apic_2	194	199	PF02991	0.612
LIG_LIR_Apic_2	229	235	PF02991	0.543
LIG_LIR_Apic_2	260	264	PF02991	0.479
LIG_LIR_Gen_1	220	225	PF02991	0.651
LIG_LIR_Gen_1	279	290	PF02991	0.518
LIG_LIR_Nem_3	136	141	PF02991	0.640
LIG_LIR_Nem_3	194	200	PF02991	0.630
LIG_LIR_Nem_3	220	224	PF02991	0.651
LIG_LIR_Nem_3	255	261	PF02991	0.562
LIG_LIR_Nem_3	279	285	PF02991	0.511
LIG_LIR_Nem_3	329	334	PF02991	0.365
LIG_LIR_Nem_3	33	39	PF02991	0.595
LIG_PCNA_yPIPBox_3	284	295	PF02747	0.511
LIG_Pex14_1	331	335	PF04695	0.355
LIG_Pex14_2	196	200	PF04695	0.600
LIG_Pex14_2	261	265	PF04695	0.476
LIG_REV1ctd_RIR_1	135	143	PF16727	0.629
LIG_SH2_CRK	164	168	PF00017	0.621
LIG_SH2_CRK	7	11	PF00017	0.649
LIG_SH2_SRC	321	324	PF00017	0.410
LIG_SH2_STAP1	164	168	PF00017	0.613
LIG_SH2_STAT5	3	6	PF00017	0.573
LIG_SH2_STAT5	321	324	PF00017	0.410
LIG_SH2_STAT5	88	91	PF00017	0.615
LIG_SH3_3	13	19	PF00018	0.645
LIG_SH3_3	164	170	PF00018	0.697
LIG_SH3_3	23	29	PF00018	0.567
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.541
LIG_SUMO_SIM_anti_2	289	294	PF11976	0.532
LIG_TYR_ITIM	333	338	PF00017	0.355
LIG_WRC_WIRS_1	193	198	PF05994	0.652
LIG_WRC_WIRS_1	237	242	PF05994	0.575
LIG_WRC_WIRS_1	258	263	PF05994	0.492
LIG_WW_3	168	172	PF00397	0.616
MOD_CK1_1	24	30	PF00069	0.751
MOD_CK1_1	65	71	PF00069	0.673
MOD_CK2_1	298	304	PF00069	0.550
MOD_GlcNHglycan	159	162	PF01048	0.533
MOD_GlcNHglycan	23	26	PF01048	0.493
MOD_GlcNHglycan	343	346	PF01048	0.640
MOD_GlcNHglycan	49	52	PF01048	0.538
MOD_GlcNHglycan	54	57	PF01048	0.566
MOD_GlcNHglycan	67	70	PF01048	0.502
MOD_GSK3_1	107	114	PF00069	0.530
MOD_GSK3_1	204	211	PF00069	0.616
MOD_GSK3_1	60	67	PF00069	0.747
MOD_GSK3_1	91	98	PF00069	0.576
MOD_N-GLC_1	208	213	PF02516	0.446
MOD_N-GLC_1	293	298	PF02516	0.353
MOD_NEK2_1	257	262	PF00069	0.560
MOD_NEK2_1	30	35	PF00069	0.746
MOD_NEK2_1	86	91	PF00069	0.589
MOD_NEK2_2	226	231	PF00069	0.577
MOD_PKA_2	63	69	PF00069	0.768
MOD_PKA_2	86	92	PF00069	0.624
MOD_PKB_1	93	101	PF00069	0.465
MOD_Plk_1	120	126	PF00069	0.620
MOD_Plk_1	208	214	PF00069	0.644
MOD_Plk_4	122	128	PF00069	0.475
MOD_Plk_4	147	153	PF00069	0.536
MOD_Plk_4	163	169	PF00069	0.616
MOD_Plk_4	192	198	PF00069	0.655
MOD_Plk_4	208	214	PF00069	0.512
MOD_Plk_4	286	292	PF00069	0.510
MOD_Plk_4	326	332	PF00069	0.356
MOD_ProDKin_1	154	160	PF00069	0.645
MOD_ProDKin_1	204	210	PF00069	0.611
TRG_ENDOCYTIC_2	164	167	PF00928	0.631
TRG_ENDOCYTIC_2	221	224	PF00928	0.595
TRG_ENDOCYTIC_2	258	261	PF00928	0.507
TRG_ENDOCYTIC_2	335	338	PF00928	0.530
TRG_ENDOCYTIC_2	7	10	PF00928	0.650
TRG_ER_diArg_1	315	318	PF00400	0.602
TRG_ER_diArg_1	84	87	PF00400	0.546
TRG_ER_diArg_1	92	95	PF00400	0.523
TRG_NLS_MonoExtC_3	312	317	PF00514	0.531
TRG_NLS_MonoExtN_4	313	318	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX40	Leptomonas seymouri	75%	97%
A0A0S4JJX8	Bodo saltans	53%	100%
A0A1X0P7D7	Trypanosomatidae	64%	100%
A4H9Q0	Leishmania braziliensis	80%	100%
A4HY17	Leishmania infantum	100%	100%
D0A568	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ART1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDP2	Leishmania major	94%	100%
V5BJ52	Trypanosoma cruzi	67%	100%