Histone acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acetyltransferase (GNAT) family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WV24_LEIDO

TriTrypDb:

LdCL_180018200 , LDHU3_18.1640

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0000139	Golgi membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A0A3S7WV24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WV24

Function

Biological processes
Term	Name	Level	Count
GO:0007059	chromosome segregation	2	6
GO:0009987	cellular process	1	6
GO:0006473	protein acetylation	6	1
GO:0006474	N-terminal protein amino acid acetylation	5	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0017196	N-terminal peptidyl-methionine acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0031365	N-terminal protein amino acid modification	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0043966	histone H3 acetylation	7	1
GO:0043967	histone H4 acetylation	7	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004596	peptide alpha-N-acetyltransferase activity	8	7
GO:0008080	N-acetyltransferase activity	6	7
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0034212	peptide N-acetyltransferase activity	7	7
GO:0004402	histone acetyltransferase activity	4	1
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.708
CLV_C14_Caspase3-7	339	343	PF00656	0.688
CLV_C14_Caspase3-7	541	545	PF00656	0.645
CLV_C14_Caspase3-7	607	611	PF00656	0.712
CLV_NRD_NRD_1	25	27	PF00675	0.380
CLV_NRD_NRD_1	302	304	PF00675	0.365
CLV_NRD_NRD_1	316	318	PF00675	0.390
CLV_NRD_NRD_1	415	417	PF00675	0.479
CLV_NRD_NRD_1	435	437	PF00675	0.337
CLV_NRD_NRD_1	439	441	PF00675	0.384
CLV_NRD_NRD_1	570	572	PF00675	0.497
CLV_NRD_NRD_1	655	657	PF00675	0.464
CLV_NRD_NRD_1	93	95	PF00675	0.331
CLV_PCSK_FUR_1	568	572	PF00082	0.535
CLV_PCSK_KEX2_1	25	27	PF00082	0.367
CLV_PCSK_KEX2_1	302	304	PF00082	0.421
CLV_PCSK_KEX2_1	316	318	PF00082	0.324
CLV_PCSK_KEX2_1	415	417	PF00082	0.473
CLV_PCSK_KEX2_1	435	437	PF00082	0.337
CLV_PCSK_KEX2_1	439	441	PF00082	0.384
CLV_PCSK_KEX2_1	568	570	PF00082	0.489
CLV_PCSK_KEX2_1	654	656	PF00082	0.466
CLV_PCSK_KEX2_1	93	95	PF00082	0.331
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.421
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.314
CLV_PCSK_PC7_1	435	441	PF00082	0.353
CLV_PCSK_SKI1_1	281	285	PF00082	0.406
CLV_PCSK_SKI1_1	322	326	PF00082	0.394
CLV_PCSK_SKI1_1	474	478	PF00082	0.335
DEG_SPOP_SBC_1	158	162	PF00917	0.697
DEG_SPOP_SBC_1	41	45	PF00917	0.661
DEG_SPOP_SBC_1	56	60	PF00917	0.688
DEG_SPOP_SBC_1	73	77	PF00917	0.609
DOC_CDC14_PxL_1	383	391	PF14671	0.609
DOC_CKS1_1	602	607	PF01111	0.835
DOC_MAPK_gen_1	302	308	PF00069	0.584
DOC_MAPK_RevD_3	555	571	PF00069	0.681
DOC_PP1_RVXF_1	675	682	PF00149	0.576
DOC_PP1_RVXF_1	80	86	PF00149	0.565
DOC_PP2B_LxvP_1	356	359	PF13499	0.638
DOC_PP2B_LxvP_1	557	560	PF13499	0.692
DOC_SPAK_OSR1_1	440	444	PF12202	0.562
DOC_USP7_MATH_1	158	162	PF00917	0.685
DOC_USP7_MATH_1	209	213	PF00917	0.622
DOC_USP7_MATH_1	359	363	PF00917	0.682
DOC_USP7_MATH_1	365	369	PF00917	0.690
DOC_USP7_MATH_1	374	378	PF00917	0.607
DOC_USP7_MATH_1	50	54	PF00917	0.805
DOC_USP7_MATH_1	505	509	PF00917	0.728
DOC_USP7_MATH_1	56	60	PF00917	0.668
DOC_USP7_MATH_1	560	564	PF00917	0.741
DOC_USP7_MATH_1	609	613	PF00917	0.669
DOC_USP7_MATH_1	659	663	PF00917	0.711
DOC_WW_Pin1_4	1	6	PF00397	0.754
DOC_WW_Pin1_4	144	149	PF00397	0.663
DOC_WW_Pin1_4	161	166	PF00397	0.711
DOC_WW_Pin1_4	501	506	PF00397	0.630
DOC_WW_Pin1_4	52	57	PF00397	0.786
DOC_WW_Pin1_4	571	576	PF00397	0.653
DOC_WW_Pin1_4	598	603	PF00397	0.787
DOC_WW_Pin1_4	614	619	PF00397	0.679
DOC_WW_Pin1_4	628	633	PF00397	0.576
LIG_14-3-3_CanoR_1	281	286	PF00244	0.512
LIG_14-3-3_CanoR_1	345	350	PF00244	0.675
LIG_14-3-3_CanoR_1	594	600	PF00244	0.713
LIG_14-3-3_CanoR_1	654	659	PF00244	0.677
LIG_BIR_III_2	101	105	PF00653	0.527
LIG_BRCT_BRCA1_1	375	379	PF00533	0.659
LIG_CaM_IQ_9	126	141	PF13499	0.528
LIG_deltaCOP1_diTrp_1	135	140	PF00928	0.581
LIG_eIF4E_1	300	306	PF01652	0.552
LIG_FHA_1	215	221	PF00498	0.676
LIG_FHA_1	230	236	PF00498	0.468
LIG_FHA_1	255	261	PF00498	0.468
LIG_FHA_1	269	275	PF00498	0.468
LIG_FHA_1	30	36	PF00498	0.668
LIG_FHA_1	47	53	PF00498	0.677
LIG_FHA_2	130	136	PF00498	0.562
LIG_FHA_2	334	340	PF00498	0.703
LIG_FHA_2	406	412	PF00498	0.671
LIG_FHA_2	425	431	PF00498	0.495
LIG_FHA_2	539	545	PF00498	0.646
LIG_FHA_2	588	594	PF00498	0.701
LIG_FHA_2	605	611	PF00498	0.627
LIG_LIR_Apic_2	626	632	PF02991	0.637
LIG_LIR_Gen_1	110	120	PF02991	0.522
LIG_LIR_Gen_1	376	387	PF02991	0.627
LIG_LIR_Nem_3	110	115	PF02991	0.488
LIG_LIR_Nem_3	22	27	PF02991	0.600
LIG_LIR_Nem_3	296	300	PF02991	0.541
LIG_LIR_Nem_3	376	382	PF02991	0.674
LIG_LIR_Nem_3	634	638	PF02991	0.595
LIG_LYPXL_yS_3	635	638	PF13949	0.599
LIG_NRBOX	304	310	PF00104	0.588
LIG_PCNA_yPIPBox_3	439	451	PF02747	0.541
LIG_Rb_LxCxE_1	665	678	PF01857	0.571
LIG_RPA_C_Fungi	241	253	PF08784	0.363
LIG_RPA_C_Fungi	463	475	PF08784	0.393
LIG_SH2_CRK	487	491	PF00017	0.364
LIG_SH2_CRK	697	701	PF00017	0.363
LIG_SH2_SRC	349	352	PF00017	0.543
LIG_SH2_STAP1	107	111	PF00017	0.400
LIG_SH2_STAP1	112	116	PF00017	0.339
LIG_SH2_STAP1	293	297	PF00017	0.404
LIG_SH2_STAP1	487	491	PF00017	0.352
LIG_SH2_STAT3	285	288	PF00017	0.363
LIG_SH2_STAT5	107	110	PF00017	0.398
LIG_SH2_STAT5	259	262	PF00017	0.302
LIG_SH2_STAT5	285	288	PF00017	0.302
LIG_SH2_STAT5	297	300	PF00017	0.433
LIG_SH2_STAT5	385	388	PF00017	0.500
LIG_SH2_STAT5	494	497	PF00017	0.428
LIG_SH3_3	169	175	PF00018	0.633
LIG_SH3_3	262	268	PF00018	0.352
LIG_SH3_3	30	36	PF00018	0.482
LIG_SH3_3	352	358	PF00018	0.590
LIG_SH3_3	569	575	PF00018	0.544
LIG_SH3_3	599	605	PF00018	0.600
LIG_TRAF2_1	187	190	PF00917	0.492
LIG_TRAF2_1	199	202	PF00917	0.356
LIG_TRAF2_1	408	411	PF00917	0.427
LIG_TRAF2_1	427	430	PF00917	0.608
LIG_TRAF2_1	535	538	PF00917	0.729
LIG_TYR_ITIM	695	700	PF00017	0.363
LIG_WRC_WIRS_1	260	265	PF05994	0.302
MOD_CDC14_SPxK_1	574	577	PF00782	0.562
MOD_CDK_SPK_2	144	149	PF00069	0.575
MOD_CDK_SPK_2	628	633	PF00069	0.516
MOD_CDK_SPxK_1	571	577	PF00069	0.562
MOD_CDK_SPxK_1	614	620	PF00069	0.621
MOD_CK1_1	157	163	PF00069	0.658
MOD_CK1_1	164	170	PF00069	0.627
MOD_CK1_1	17	23	PF00069	0.646
MOD_CK1_1	179	185	PF00069	0.695
MOD_CK1_1	223	229	PF00069	0.570
MOD_CK1_1	254	260	PF00069	0.363
MOD_CK1_1	366	372	PF00069	0.604
MOD_CK1_1	501	507	PF00069	0.617
MOD_CK1_1	55	61	PF00069	0.628
MOD_CK1_1	562	568	PF00069	0.622
MOD_CK1_1	598	604	PF00069	0.634
MOD_CK1_1	623	629	PF00069	0.579
MOD_CK1_1	631	637	PF00069	0.487
MOD_CK2_1	107	113	PF00069	0.436
MOD_CK2_1	129	135	PF00069	0.430
MOD_CK2_1	388	394	PF00069	0.445
MOD_CK2_1	405	411	PF00069	0.520
MOD_CK2_1	424	430	PF00069	0.466
MOD_CK2_1	61	67	PF00069	0.797
MOD_CK2_1	659	665	PF00069	0.602
MOD_DYRK1A_RPxSP_1	571	575	PF00069	0.538
MOD_GlcNHglycan	156	159	PF01048	0.640
MOD_GlcNHglycan	166	169	PF01048	0.631
MOD_GlcNHglycan	227	230	PF01048	0.486
MOD_GlcNHglycan	328	331	PF01048	0.595
MOD_GlcNHglycan	361	364	PF01048	0.649
MOD_GlcNHglycan	499	503	PF01048	0.562
MOD_GlcNHglycan	507	510	PF01048	0.615
MOD_GlcNHglycan	520	523	PF01048	0.597
MOD_GlcNHglycan	597	600	PF01048	0.613
MOD_GlcNHglycan	610	614	PF01048	0.641
MOD_GlcNHglycan	63	66	PF01048	0.720
MOD_GlcNHglycan	661	664	PF01048	0.587
MOD_GSK3_1	1	8	PF00069	0.618
MOD_GSK3_1	10	17	PF00069	0.562
MOD_GSK3_1	140	147	PF00069	0.654
MOD_GSK3_1	150	157	PF00069	0.714
MOD_GSK3_1	159	166	PF00069	0.662
MOD_GSK3_1	210	217	PF00069	0.507
MOD_GSK3_1	225	232	PF00069	0.476
MOD_GSK3_1	341	348	PF00069	0.652
MOD_GSK3_1	359	366	PF00069	0.697
MOD_GSK3_1	37	44	PF00069	0.701
MOD_GSK3_1	46	53	PF00069	0.635
MOD_GSK3_1	501	508	PF00069	0.668
MOD_GSK3_1	510	517	PF00069	0.575
MOD_GSK3_1	57	64	PF00069	0.564
MOD_GSK3_1	73	80	PF00069	0.493
MOD_N-GLC_1	105	110	PF02516	0.317
MOD_NEK2_1	325	330	PF00069	0.658
MOD_NEK2_1	459	464	PF00069	0.539
MOD_NEK2_1	511	516	PF00069	0.675
MOD_NEK2_1	57	62	PF00069	0.613
MOD_NEK2_2	216	221	PF00069	0.506
MOD_NEK2_2	374	379	PF00069	0.588
MOD_PIKK_1	126	132	PF00454	0.470
MOD_PIKK_1	150	156	PF00454	0.633
MOD_PIKK_1	284	290	PF00454	0.363
MOD_PIKK_1	363	369	PF00454	0.686
MOD_PKA_1	654	660	PF00069	0.642
MOD_PKA_2	140	146	PF00069	0.514
MOD_PKA_2	220	226	PF00069	0.519
MOD_PKA_2	654	660	PF00069	0.683
MOD_Plk_1	179	185	PF00069	0.435
MOD_Plk_2-3	388	394	PF00069	0.442
MOD_Plk_2-3	424	430	PF00069	0.466
MOD_Plk_4	107	113	PF00069	0.475
MOD_Plk_4	193	199	PF00069	0.393
MOD_Plk_4	229	235	PF00069	0.465
MOD_Plk_4	281	287	PF00069	0.374
MOD_Plk_4	374	380	PF00069	0.579
MOD_Plk_4	381	387	PF00069	0.477
MOD_Plk_4	388	394	PF00069	0.464
MOD_Plk_4	460	466	PF00069	0.344
MOD_Plk_4	625	631	PF00069	0.504
MOD_ProDKin_1	1	7	PF00069	0.703
MOD_ProDKin_1	144	150	PF00069	0.582
MOD_ProDKin_1	161	167	PF00069	0.643
MOD_ProDKin_1	501	507	PF00069	0.532
MOD_ProDKin_1	52	58	PF00069	0.747
MOD_ProDKin_1	571	577	PF00069	0.562
MOD_ProDKin_1	598	604	PF00069	0.749
MOD_ProDKin_1	614	620	PF00069	0.597
MOD_ProDKin_1	628	634	PF00069	0.446
MOD_SUMO_rev_2	652	662	PF00179	0.590
TRG_DiLeu_BaEn_2	436	442	PF01217	0.468
TRG_ENDOCYTIC_2	112	115	PF00928	0.359
TRG_ENDOCYTIC_2	479	482	PF00928	0.389
TRG_ENDOCYTIC_2	487	490	PF00928	0.352
TRG_ENDOCYTIC_2	635	638	PF00928	0.485
TRG_ENDOCYTIC_2	697	700	PF00928	0.363
TRG_ER_diArg_1	24	26	PF00400	0.488
TRG_ER_diArg_1	399	402	PF00400	0.513
TRG_ER_diArg_1	415	417	PF00400	0.635
TRG_ER_diArg_1	434	436	PF00400	0.384
TRG_ER_diArg_1	439	441	PF00400	0.465
TRG_ER_diArg_1	567	570	PF00400	0.613
TRG_ER_diArg_1	653	656	PF00400	0.573
TRG_ER_diArg_1	81	84	PF00400	0.440
TRG_ER_diArg_1	92	94	PF00400	0.336
TRG_NLS_Bipartite_1	302	320	PF00514	0.408
TRG_NLS_MonoCore_2	314	319	PF00514	0.456
TRG_NLS_MonoExtN_4	315	320	PF00514	0.430
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4M7	Leptomonas seymouri	45%	85%
A4H9N7	Leishmania braziliensis	70%	100%
A4HY02	Leishmania infantum	100%	100%
E9ARR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QDQ8	Leishmania major	89%	100%