GPI mannosyltransferase 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

gpi mannosyltransferase 2

Species:

Leishmania donovani

UniProt:

A0A3S7WV16_LEIDO

TriTrypDb:

LdBPK_180960.1 , LdCL_180014800 , LDHU3_18.1210

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	7
GO:0016020	membrane	2	7
GO:0031090	organelle membrane	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0031501	mannosyltransferase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3S7WV16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WV16

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	7
GO:0006505	GPI anchor metabolic process	6	7
GO:0006506	GPI anchor biosynthetic process	6	7
GO:0006629	lipid metabolic process	3	7
GO:0006643	membrane lipid metabolic process	4	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006661	phosphatidylinositol biosynthetic process	6	7
GO:0006664	glycolipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	7
GO:0008654	phospholipid biosynthetic process	5	7
GO:0009058	biosynthetic process	2	7
GO:0009247	glycolipid biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	7
GO:0019637	organophosphate metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0045017	glycerolipid biosynthetic process	4	7
GO:0046467	membrane lipid biosynthetic process	4	7
GO:0046474	glycerophospholipid biosynthetic process	5	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046488	phosphatidylinositol metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1903509	liposaccharide metabolic process	4	7

Molecular functions
Term	Name	Level	Count
GO:0000009	alpha-1,6-mannosyltransferase activity	6	7
GO:0000030	mannosyltransferase activity	5	7
GO:0003824	catalytic activity	1	7
GO:0004376	glycolipid mannosyltransferase activity	6	7
GO:0016740	transferase activity	2	7
GO:0016757	glycosyltransferase activity	3	7
GO:0016758	hexosyltransferase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.505
CLV_C14_Caspase3-7	373	377	PF00656	0.637
CLV_NRD_NRD_1	151	153	PF00675	0.453
CLV_NRD_NRD_1	183	185	PF00675	0.262
CLV_NRD_NRD_1	217	219	PF00675	0.513
CLV_NRD_NRD_1	278	280	PF00675	0.262
CLV_NRD_NRD_1	3	5	PF00675	0.394
CLV_NRD_NRD_1	529	531	PF00675	0.453
CLV_NRD_NRD_1	613	615	PF00675	0.266
CLV_PCSK_KEX2_1	151	153	PF00082	0.453
CLV_PCSK_KEX2_1	183	185	PF00082	0.262
CLV_PCSK_KEX2_1	2	4	PF00082	0.397
CLV_PCSK_KEX2_1	277	279	PF00082	0.307
CLV_PCSK_KEX2_1	475	477	PF00082	0.378
CLV_PCSK_KEX2_1	529	531	PF00082	0.476
CLV_PCSK_KEX2_1	613	615	PF00082	0.266
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.378
CLV_PCSK_SKI1_1	183	187	PF00082	0.298
CLV_PCSK_SKI1_1	26	30	PF00082	0.236
CLV_PCSK_SKI1_1	400	404	PF00082	0.382
CLV_PCSK_SKI1_1	530	534	PF00082	0.462
CLV_PCSK_SKI1_1	603	607	PF00082	0.247
CLV_PCSK_SKI1_1	69	73	PF00082	0.344
DEG_APCC_DBOX_1	3	11	PF00400	0.622
DEG_APCC_DBOX_1	493	501	PF00400	0.552
DEG_APCC_DBOX_1	68	76	PF00400	0.293
DEG_Nend_UBRbox_1	1	4	PF02207	0.630
DEG_SCF_FBW7_1	392	399	PF00400	0.558
DEG_SCF_FBW7_2	209	215	PF00400	0.689
DOC_AGCK_PIF_1	565	570	PF00069	0.266
DOC_CDC14_PxL_1	136	144	PF14671	0.293
DOC_CKS1_1	209	214	PF01111	0.678
DOC_CKS1_1	289	294	PF01111	0.293
DOC_CYCLIN_yCln2_LP_2	357	360	PF00134	0.654
DOC_CYCLIN_yCln2_LP_2	439	445	PF00134	0.344
DOC_CYCLIN_yCln2_LP_2	578	584	PF00134	0.293
DOC_MAPK_gen_1	183	190	PF00069	0.462
DOC_MAPK_gen_1	2	11	PF00069	0.622
DOC_MAPK_gen_1	557	564	PF00069	0.285
DOC_MAPK_gen_1	613	622	PF00069	0.466
DOC_MAPK_MEF2A_6	2	11	PF00069	0.590
DOC_MAPK_RevD_3	514	530	PF00069	0.236
DOC_PP1_RVXF_1	31	38	PF00149	0.299
DOC_PP2B_LxvP_1	254	257	PF13499	0.602
DOC_PP2B_LxvP_1	357	360	PF13499	0.686
DOC_PP2B_LxvP_1	493	496	PF13499	0.552
DOC_PP2B_LxvP_1	578	581	PF13499	0.351
DOC_PP4_FxxP_1	190	193	PF00568	0.462
DOC_PP4_FxxP_1	87	90	PF00568	0.520
DOC_USP7_MATH_1	379	383	PF00917	0.628
DOC_USP7_MATH_1	396	400	PF00917	0.575
DOC_USP7_MATH_1	43	47	PF00917	0.362
DOC_USP7_MATH_1	455	459	PF00917	0.540
DOC_USP7_MATH_1	462	466	PF00917	0.501
DOC_USP7_MATH_1	468	472	PF00917	0.488
DOC_USP7_MATH_1	479	483	PF00917	0.565
DOC_USP7_MATH_1	626	630	PF00917	0.260
DOC_WW_Pin1_4	205	210	PF00397	0.691
DOC_WW_Pin1_4	288	293	PF00397	0.311
DOC_WW_Pin1_4	336	341	PF00397	0.594
DOC_WW_Pin1_4	392	397	PF00397	0.601
DOC_WW_Pin1_4	570	575	PF00397	0.221
DOC_WW_Pin1_4	656	661	PF00397	0.270
LIG_14-3-3_CanoR_1	107	111	PF00244	0.498
LIG_14-3-3_CanoR_1	197	204	PF00244	0.636
LIG_14-3-3_CanoR_1	231	241	PF00244	0.496
LIG_14-3-3_CanoR_1	26	35	PF00244	0.266
LIG_14-3-3_CanoR_1	330	335	PF00244	0.560
LIG_14-3-3_CanoR_1	400	405	PF00244	0.563
LIG_14-3-3_CanoR_1	409	419	PF00244	0.425
LIG_14-3-3_CanoR_1	654	660	PF00244	0.272
LIG_14-3-3_CanoR_1	673	681	PF00244	0.433
LIG_APCC_ABBA_1	298	303	PF00400	0.310
LIG_APCC_ABBA_1	39	44	PF00400	0.473
LIG_BRCT_BRCA1_1	429	433	PF00533	0.262
LIG_CaM_NSCaTE_8	560	567	PF13499	0.298
LIG_eIF4E_1	559	565	PF01652	0.266
LIG_FHA_1	148	154	PF00498	0.262
LIG_FHA_1	209	215	PF00498	0.676
LIG_FHA_1	248	254	PF00498	0.592
LIG_FHA_1	300	306	PF00498	0.326
LIG_FHA_1	57	63	PF00498	0.298
LIG_FHA_2	250	256	PF00498	0.513
LIG_FHA_2	264	270	PF00498	0.620
LIG_FHA_2	53	59	PF00498	0.337
LIG_FHA_2	96	102	PF00498	0.546
LIG_GBD_Chelix_1	416	424	PF00786	0.344
LIG_GBD_Chelix_1	67	75	PF00786	0.344
LIG_LIR_Apic_2	189	193	PF02991	0.462
LIG_LIR_Gen_1	105	115	PF02991	0.462
LIG_LIR_Gen_1	44	53	PF02991	0.335
LIG_LIR_Gen_1	5	16	PF02991	0.586
LIG_LIR_Gen_1	615	625	PF02991	0.416
LIG_LIR_Gen_1	682	692	PF02991	0.297
LIG_LIR_Nem_3	105	111	PF02991	0.462
LIG_LIR_Nem_3	12	16	PF02991	0.601
LIG_LIR_Nem_3	44	50	PF02991	0.348
LIG_LIR_Nem_3	5	11	PF02991	0.610
LIG_LIR_Nem_3	563	568	PF02991	0.395
LIG_LIR_Nem_3	615	620	PF02991	0.425
LIG_LIR_Nem_3	682	688	PF02991	0.297
LIG_LYPXL_S_1	551	555	PF13949	0.462
LIG_LYPXL_yS_3	552	555	PF13949	0.262
LIG_MYND_1	491	495	PF01753	0.554
LIG_NRBOX	635	641	PF00104	0.270
LIG_NRBOX	661	667	PF00104	0.293
LIG_PCNA_PIPBox_1	328	337	PF02747	0.567
LIG_Pex14_1	406	410	PF04695	0.523
LIG_RPA_C_Fungi	273	285	PF08784	0.344
LIG_SH2_CRK	125	129	PF00017	0.242
LIG_SH2_NCK_1	42	46	PF00017	0.496
LIG_SH2_PTP2	166	169	PF00017	0.344
LIG_SH2_SRC	103	106	PF00017	0.454
LIG_SH2_SRC	42	45	PF00017	0.444
LIG_SH2_STAP1	129	133	PF00017	0.268
LIG_SH2_STAP1	301	305	PF00017	0.293
LIG_SH2_STAT3	129	132	PF00017	0.270
LIG_SH2_STAT5	127	130	PF00017	0.293
LIG_SH2_STAT5	166	169	PF00017	0.465
LIG_SH2_STAT5	301	304	PF00017	0.311
LIG_SH2_STAT5	315	318	PF00017	0.354
LIG_SH2_STAT5	334	337	PF00017	0.541
LIG_SH2_STAT5	52	55	PF00017	0.334
LIG_SH2_STAT5	520	523	PF00017	0.293
LIG_SH2_STAT5	525	528	PF00017	0.293
LIG_SH2_STAT5	568	571	PF00017	0.293
LIG_SH2_STAT5	594	597	PF00017	0.284
LIG_SH3_1	206	212	PF00018	0.578
LIG_SH3_1	356	362	PF00018	0.607
LIG_SH3_3	131	137	PF00018	0.293
LIG_SH3_3	206	212	PF00018	0.586
LIG_SH3_3	35	41	PF00018	0.344
LIG_SH3_3	356	362	PF00018	0.607
LIG_SH3_3	444	450	PF00018	0.299
LIG_SH3_3	485	491	PF00018	0.438
LIG_SH3_3	513	519	PF00018	0.506
LIG_SUMO_SIM_anti_2	679	685	PF11976	0.284
LIG_SUMO_SIM_par_1	507	512	PF11976	0.293
LIG_SUMO_SIM_par_1	580	586	PF11976	0.344
LIG_SxIP_EBH_1	381	390	PF03271	0.501
LIG_TRAF2_1	98	101	PF00917	0.400
LIG_TRFH_1	13	17	PF08558	0.489
LIG_TRFH_1	37	41	PF08558	0.299
LIG_ULM_U2AF65_1	613	618	PF00076	0.299
LIG_WRC_WIRS_1	187	192	PF05994	0.293
MOD_CK1_1	205	211	PF00069	0.577
MOD_CK1_1	304	310	PF00069	0.299
MOD_CK1_1	563	569	PF00069	0.344
MOD_CK1_1	672	678	PF00069	0.306
MOD_CK1_1	679	685	PF00069	0.279
MOD_CK2_1	207	213	PF00069	0.625
MOD_CK2_1	232	238	PF00069	0.455
MOD_CK2_1	263	269	PF00069	0.557
MOD_CK2_1	409	415	PF00069	0.351
MOD_CK2_1	95	101	PF00069	0.406
MOD_GlcNHglycan	17	20	PF01048	0.466
MOD_GlcNHglycan	336	339	PF01048	0.430
MOD_GlcNHglycan	342	345	PF01048	0.667
MOD_GlcNHglycan	351	354	PF01048	0.576
MOD_GlcNHglycan	457	460	PF01048	0.450
MOD_GlcNHglycan	464	467	PF01048	0.362
MOD_GlcNHglycan	470	473	PF01048	0.336
MOD_GlcNHglycan	481	484	PF01048	0.432
MOD_GlcNHglycan	565	568	PF01048	0.344
MOD_GSK3_1	229	236	PF00069	0.612
MOD_GSK3_1	330	337	PF00069	0.486
MOD_GSK3_1	386	393	PF00069	0.472
MOD_GSK3_1	396	403	PF00069	0.442
MOD_GSK3_1	420	427	PF00069	0.274
MOD_GSK3_1	52	59	PF00069	0.402
MOD_GSK3_1	566	573	PF00069	0.275
MOD_GSK3_1	669	676	PF00069	0.319
MOD_NEK2_1	128	133	PF00069	0.282
MOD_NEK2_1	169	174	PF00069	0.245
MOD_NEK2_1	249	254	PF00069	0.342
MOD_NEK2_1	420	425	PF00069	0.306
MOD_NEK2_1	627	632	PF00069	0.410
MOD_NEK2_1	642	647	PF00069	0.219
MOD_NEK2_1	655	660	PF00069	0.293
MOD_NEK2_1	76	81	PF00069	0.346
MOD_NEK2_2	301	306	PF00069	0.293
MOD_NEK2_2	560	565	PF00069	0.426
MOD_PIKK_1	128	134	PF00454	0.480
MOD_PKA_1	183	189	PF00069	0.344
MOD_PKA_2	106	112	PF00069	0.344
MOD_PKA_2	183	189	PF00069	0.352
MOD_PKA_2	196	202	PF00069	0.362
MOD_PKA_2	247	253	PF00069	0.368
MOD_PKA_2	479	485	PF00069	0.479
MOD_PKA_2	612	618	PF00069	0.290
MOD_PKA_2	672	678	PF00069	0.293
MOD_PKA_2	679	685	PF00069	0.293
MOD_PKB_1	24	32	PF00069	0.236
MOD_Plk_1	229	235	PF00069	0.486
MOD_Plk_1	237	243	PF00069	0.303
MOD_Plk_4	183	189	PF00069	0.306
MOD_Plk_4	249	255	PF00069	0.393
MOD_Plk_4	301	307	PF00069	0.321
MOD_Plk_4	330	336	PF00069	0.473
MOD_Plk_4	386	392	PF00069	0.532
MOD_Plk_4	560	566	PF00069	0.326
MOD_Plk_4	583	589	PF00069	0.306
MOD_Plk_4	642	648	PF00069	0.344
MOD_Plk_4	679	685	PF00069	0.370
MOD_Plk_4	90	96	PF00069	0.389
MOD_ProDKin_1	205	211	PF00069	0.615
MOD_ProDKin_1	288	294	PF00069	0.311
MOD_ProDKin_1	336	342	PF00069	0.487
MOD_ProDKin_1	392	398	PF00069	0.486
MOD_ProDKin_1	570	576	PF00069	0.236
MOD_ProDKin_1	656	662	PF00069	0.270
MOD_SUMO_for_1	404	407	PF00179	0.475
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.299
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.344
TRG_ENDOCYTIC_2	125	128	PF00928	0.242
TRG_ENDOCYTIC_2	166	169	PF00928	0.293
TRG_ENDOCYTIC_2	243	246	PF00928	0.335
TRG_ENDOCYTIC_2	520	523	PF00928	0.293
TRG_ENDOCYTIC_2	528	531	PF00928	0.293
TRG_ENDOCYTIC_2	552	555	PF00928	0.307
TRG_ENDOCYTIC_2	559	562	PF00928	0.344
TRG_ENDOCYTIC_2	663	666	PF00928	0.293
TRG_ER_diArg_1	1	4	PF00400	0.529
TRG_ER_diArg_1	151	153	PF00400	0.282
TRG_ER_diArg_1	182	184	PF00400	0.293
TRG_ER_diArg_1	23	26	PF00400	0.446
TRG_ER_diArg_1	276	279	PF00400	0.359
TRG_ER_diArg_1	381	384	PF00400	0.485
TRG_ER_diArg_1	528	530	PF00400	0.282
TRG_ER_diArg_1	613	616	PF00400	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL0	Leptomonas seymouri	52%	100%
A4H9K3	Leishmania braziliensis	75%	100%
A4HXW9	Leishmania infantum	99%	100%
E9ARN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QDU6	Leishmania major	91%	100%