UTP--glucose-1-phosphate uridylyltransferase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-glucose pyrophosphorylase

Species:

Leishmania donovani

UniProt:

A0A3S7WUZ9_LEIDO

TriTrypDb:

LdBPK_180990.1 , LdCL_180015100 , LDHU3_18.1250

Length:

494

Annotations

Annotations by Jardim et al.

Glycosylation, UDP-glucose pyrophosphorylase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WUZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUZ9

PDB structure(s): 2oef_A , 2oeg_A , 4j18_A , 4m28_A , 4m2a_A , 4m2b_A , 5nzg_A , 5nzh_A , 5nzh_B , 5nzi_A , 5nzj_A , 5nzk_A , 5nzl_A , 5nzm_A

Function

Biological processes
Term	Name	Level	Count
GO:0006011	UDP-glucose metabolic process	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009225	nucleotide-sugar metabolic process	4	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0005975	carbohydrate metabolic process	3	1
GO:0005976	polysaccharide metabolic process	4	1
GO:0005977	glycogen metabolic process	6	1
GO:0006073	obsolete cellular glucan metabolic process	5	1
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006112	energy reserve metabolic process	5	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044042	glucan metabolic process	5	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044264	obsolete cellular polysaccharide metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity	7	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0051748	UTP-monosaccharide-1-phosphate uridylyltransferase activity	6	12
GO:0070569	uridylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.478
CLV_C14_Caspase3-7	267	271	PF00656	0.471
CLV_C14_Caspase3-7	46	50	PF00656	0.548
CLV_C14_Caspase3-7	465	469	PF00656	0.546
CLV_C14_Caspase3-7	56	60	PF00656	0.485
CLV_C14_Caspase3-7	99	103	PF00656	0.539
CLV_NRD_NRD_1	248	250	PF00675	0.319
CLV_PCSK_KEX2_1	229	231	PF00082	0.392
CLV_PCSK_KEX2_1	248	250	PF00082	0.172
CLV_PCSK_KEX2_1	277	279	PF00082	0.282
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.383
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.309
CLV_PCSK_SKI1_1	104	108	PF00082	0.278
CLV_PCSK_SKI1_1	126	130	PF00082	0.288
CLV_PCSK_SKI1_1	140	144	PF00082	0.263
CLV_PCSK_SKI1_1	20	24	PF00082	0.488
CLV_PCSK_SKI1_1	213	217	PF00082	0.278
CLV_PCSK_SKI1_1	229	233	PF00082	0.278
CLV_PCSK_SKI1_1	278	282	PF00082	0.273
CLV_PCSK_SKI1_1	400	404	PF00082	0.278
CLV_PCSK_SKI1_1	442	446	PF00082	0.368
CLV_PCSK_SKI1_1	95	99	PF00082	0.278
DEG_Nend_UBRbox_2	1	3	PF02207	0.724
DOC_CYCLIN_yClb5_NLxxxL_5	305	314	PF00134	0.489
DOC_MAPK_DCC_7	406	416	PF00069	0.493
DOC_MAPK_gen_1	101	109	PF00069	0.494
DOC_MAPK_gen_1	237	246	PF00069	0.538
DOC_MAPK_MEF2A_6	313	320	PF00069	0.562
DOC_PP1_RVXF_1	237	243	PF00149	0.520
DOC_PP2B_LxvP_1	328	331	PF13499	0.478
DOC_PP4_FxxP_1	473	476	PF00568	0.561
DOC_USP7_MATH_1	341	345	PF00917	0.460
DOC_USP7_MATH_1	387	391	PF00917	0.489
DOC_USP7_MATH_1	54	58	PF00917	0.503
DOC_USP7_MATH_1	60	64	PF00917	0.502
DOC_USP7_UBL2_3	140	144	PF12436	0.501
DOC_WW_Pin1_4	343	348	PF00397	0.564
DOC_WW_Pin1_4	484	489	PF00397	0.603
LIG_14-3-3_CanoR_1	118	128	PF00244	0.503
LIG_14-3-3_CanoR_1	261	265	PF00244	0.538
LIG_APCC_ABBAyCdc20_2	261	267	PF00400	0.435
LIG_FHA_1	261	267	PF00498	0.530
LIG_FHA_1	305	311	PF00498	0.478
LIG_FHA_1	325	331	PF00498	0.539
LIG_FHA_1	42	48	PF00498	0.486
LIG_FHA_1	459	465	PF00498	0.540
LIG_FHA_1	74	80	PF00498	0.501
LIG_FHA_2	103	109	PF00498	0.474
LIG_FHA_2	248	254	PF00498	0.478
LIG_FHA_2	379	385	PF00498	0.478
LIG_FHA_2	94	100	PF00498	0.526
LIG_GBD_Chelix_1	77	85	PF00786	0.289
LIG_LIR_Apic_2	185	189	PF02991	0.484
LIG_LIR_Apic_2	471	476	PF02991	0.545
LIG_LIR_Gen_1	105	114	PF02991	0.480
LIG_LIR_Gen_1	193	199	PF02991	0.478
LIG_LIR_Gen_1	294	304	PF02991	0.468
LIG_LIR_Gen_1	425	435	PF02991	0.539
LIG_LIR_Nem_3	105	109	PF02991	0.480
LIG_LIR_Nem_3	193	198	PF02991	0.478
LIG_LIR_Nem_3	294	299	PF02991	0.468
LIG_LIR_Nem_3	374	379	PF02991	0.478
LIG_LIR_Nem_3	396	402	PF02991	0.558
LIG_LIR_Nem_3	425	430	PF02991	0.503
LIG_LYPXL_yS_3	147	150	PF13949	0.503
LIG_MAD2	167	175	PF02301	0.522
LIG_SH2_CRK	195	199	PF00017	0.478
LIG_SH2_CRK	214	218	PF00017	0.478
LIG_SH2_SRC	265	268	PF00017	0.435
LIG_SH2_STAP1	195	199	PF00017	0.488
LIG_SH2_STAT3	116	119	PF00017	0.553
LIG_SH2_STAT5	116	119	PF00017	0.533
LIG_SH2_STAT5	195	198	PF00017	0.488
LIG_SH2_STAT5	265	268	PF00017	0.538
LIG_SH2_STAT5	393	396	PF00017	0.503
LIG_SUMO_SIM_anti_2	155	162	PF11976	0.481
LIG_SUMO_SIM_par_1	314	319	PF11976	0.538
LIG_SUMO_SIM_par_1	384	391	PF11976	0.480
LIG_SUMO_SIM_par_1	412	418	PF11976	0.504
LIG_SUMO_SIM_par_1	96	102	PF11976	0.539
LIG_TRAF2_2	488	493	PF00917	0.533
LIG_UBA3_1	317	322	PF00899	0.508
LIG_WRC_WIRS_1	130	135	PF05994	0.473
LIG_WRC_WIRS_1	29	34	PF05994	0.372
LIG_WRC_WIRS_1	293	298	PF05994	0.558
MOD_CDK_SPK_2	343	348	PF00069	0.564
MOD_CK1_1	132	138	PF00069	0.478
MOD_CK2_1	153	159	PF00069	0.518
MOD_CK2_1	37	43	PF00069	0.517
MOD_CK2_1	422	428	PF00069	0.521
MOD_CK2_1	434	440	PF00069	0.540
MOD_CK2_1	93	99	PF00069	0.529
MOD_GlcNHglycan	135	138	PF01048	0.332
MOD_GlcNHglycan	200	203	PF01048	0.278
MOD_GlcNHglycan	284	287	PF01048	0.265
MOD_GlcNHglycan	343	346	PF01048	0.395
MOD_GlcNHglycan	364	367	PF01048	0.292
MOD_GlcNHglycan	417	420	PF01048	0.338
MOD_GlcNHglycan	424	427	PF01048	0.272
MOD_GlcNHglycan	468	471	PF01048	0.586
MOD_GlcNHglycan	49	52	PF01048	0.347
MOD_GlcNHglycan	8	11	PF01048	0.448
MOD_GSK3_1	129	136	PF00069	0.480
MOD_GSK3_1	300	307	PF00069	0.560
MOD_GSK3_1	335	342	PF00069	0.515
MOD_GSK3_1	37	44	PF00069	0.491
MOD_GSK3_1	484	491	PF00069	0.589
MOD_LATS_1	420	426	PF00433	0.503
MOD_N-GLC_1	133	138	PF02516	0.386
MOD_N-GLC_1	481	486	PF02516	0.563
MOD_NEK2_1	107	112	PF00069	0.501
MOD_NEK2_1	129	134	PF00069	0.492
MOD_NEK2_1	198	203	PF00069	0.478
MOD_NEK2_1	215	220	PF00069	0.478
MOD_NEK2_1	282	287	PF00069	0.465
MOD_NEK2_1	304	309	PF00069	0.483
MOD_NEK2_1	362	367	PF00069	0.510
MOD_NEK2_1	458	463	PF00069	0.538
MOD_NEK2_1	481	486	PF00069	0.581
MOD_NEK2_1	73	78	PF00069	0.520
MOD_NEK2_2	260	265	PF00069	0.558
MOD_PKA_2	247	253	PF00069	0.519
MOD_PKA_2	260	266	PF00069	0.519
MOD_PKA_2	282	288	PF00069	0.465
MOD_Plk_1	107	113	PF00069	0.489
MOD_Plk_1	335	341	PF00069	0.547
MOD_Plk_2-3	102	108	PF00069	0.494
MOD_Plk_2-3	292	298	PF00069	0.529
MOD_Plk_2-3	43	49	PF00069	0.555
MOD_Plk_2-3	62	68	PF00069	0.387
MOD_Plk_2-3	93	99	PF00069	0.537
MOD_Plk_4	102	108	PF00069	0.478
MOD_Plk_4	138	144	PF00069	0.501
MOD_Plk_4	260	266	PF00069	0.558
MOD_Plk_4	300	306	PF00069	0.560
MOD_Plk_4	434	440	PF00069	0.534
MOD_Plk_4	73	79	PF00069	0.507
MOD_Plk_4	93	99	PF00069	0.347
MOD_ProDKin_1	343	349	PF00069	0.564
MOD_ProDKin_1	484	490	PF00069	0.619
MOD_SUMO_for_1	462	465	PF00179	0.426
MOD_SUMO_rev_2	2	8	PF00179	0.644
MOD_SUMO_rev_2	437	444	PF00179	0.538
MOD_SUMO_rev_2	99	106	PF00179	0.507
TRG_DiLeu_BaEn_1	276	281	PF01217	0.558
TRG_DiLeu_BaEn_2	122	128	PF01217	0.561
TRG_DiLeu_BaEn_2	237	243	PF01217	0.509
TRG_ENDOCYTIC_2	147	150	PF00928	0.478
TRG_ENDOCYTIC_2	151	154	PF00928	0.478
TRG_ENDOCYTIC_2	195	198	PF00928	0.468
TRG_ENDOCYTIC_2	212	215	PF00928	0.468
TRG_ENDOCYTIC_2	302	305	PF00928	0.558
TRG_ENDOCYTIC_2	421	424	PF00928	0.479
TRG_ER_diArg_1	372	375	PF00400	0.527
TRG_NES_CRM1_1	56	69	PF08389	0.529
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H7	Leptomonas seymouri	79%	100%
A0A0S4JER9	Bodo saltans	57%	100%
A0A1X0P7U0	Trypanosomatidae	68%	100%
A0A422P1Z6	Trypanosoma rangeli	63%	100%
A4HXX2	Leishmania infantum	100%	100%
C9ZZT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AI58	Leishmania braziliensis	87%	100%
E9ARN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O35156	Cricetulus griseus	36%	97%
O59819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	99%
O64459	Pyrus pyrifolia	37%	100%
P08800	Dictyostelium discoideum	32%	97%
P19595	Solanum tuberosum	36%	100%
P32861	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	99%
P38709	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P57751	Arabidopsis thaliana	36%	100%
P78811	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	98%
P79303	Sus scrofa	35%	97%
Q07130	Bos taurus	36%	97%
Q16851	Homo sapiens	36%	97%
Q43772	Hordeum vulgare	36%	100%
Q4QDU3	Leishmania major	96%	100%
Q54YZ0	Dictyostelium discoideum	36%	98%
Q59KI0	Candida albicans (strain SC5314 / ATCC MYA-2876)	39%	99%
Q8SSC5	Encephalitozoon cuniculi (strain GB-M1)	37%	100%
Q91ZJ5	Mus musculus	36%	97%
Q9LKG7	Astragalus penduliflorus	36%	100%
Q9M9P3	Arabidopsis thaliana	35%	100%
Q9SDX3	Musa acuminata	36%	100%
V5B6M0	Trypanosoma cruzi	60%	100%