Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUY5_LEIDO

TriTrypDb:

LdBPK_180930.1 , LdCL_180014500 , LDHU3_18.1180

Length:

899

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUY5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.646
CLV_C14_Caspase3-7	174	178	PF00656	0.533
CLV_C14_Caspase3-7	228	232	PF00656	0.489
CLV_C14_Caspase3-7	471	475	PF00656	0.685
CLV_C14_Caspase3-7	599	603	PF00656	0.463
CLV_C14_Caspase3-7	879	883	PF00656	0.618
CLV_NRD_NRD_1	142	144	PF00675	0.546
CLV_NRD_NRD_1	239	241	PF00675	0.467
CLV_NRD_NRD_1	293	295	PF00675	0.627
CLV_NRD_NRD_1	347	349	PF00675	0.680
CLV_NRD_NRD_1	422	424	PF00675	0.695
CLV_NRD_NRD_1	525	527	PF00675	0.764
CLV_NRD_NRD_1	639	641	PF00675	0.511
CLV_NRD_NRD_1	654	656	PF00675	0.507
CLV_NRD_NRD_1	697	699	PF00675	0.480
CLV_NRD_NRD_1	721	723	PF00675	0.503
CLV_NRD_NRD_1	739	741	PF00675	0.458
CLV_NRD_NRD_1	78	80	PF00675	0.549
CLV_NRD_NRD_1	780	782	PF00675	0.706
CLV_NRD_NRD_1	858	860	PF00675	0.639
CLV_NRD_NRD_1	895	897	PF00675	0.700
CLV_PCSK_FUR_1	345	349	PF00082	0.624
CLV_PCSK_FUR_1	652	656	PF00082	0.600
CLV_PCSK_FUR_1	695	699	PF00082	0.461
CLV_PCSK_KEX2_1	142	144	PF00082	0.559
CLV_PCSK_KEX2_1	283	285	PF00082	0.708
CLV_PCSK_KEX2_1	347	349	PF00082	0.636
CLV_PCSK_KEX2_1	525	527	PF00082	0.763
CLV_PCSK_KEX2_1	639	641	PF00082	0.468
CLV_PCSK_KEX2_1	654	656	PF00082	0.550
CLV_PCSK_KEX2_1	697	699	PF00082	0.589
CLV_PCSK_KEX2_1	721	723	PF00082	0.532
CLV_PCSK_KEX2_1	738	740	PF00082	0.450
CLV_PCSK_KEX2_1	78	80	PF00082	0.549
CLV_PCSK_KEX2_1	780	782	PF00082	0.706
CLV_PCSK_KEX2_1	858	860	PF00082	0.639
CLV_PCSK_KEX2_1	895	897	PF00082	0.700
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.708
CLV_PCSK_SKI1_1	133	137	PF00082	0.631
CLV_PCSK_SKI1_1	207	211	PF00082	0.516
CLV_PCSK_SKI1_1	280	284	PF00082	0.686
CLV_PCSK_SKI1_1	39	43	PF00082	0.489
CLV_PCSK_SKI1_1	490	494	PF00082	0.559
CLV_PCSK_SKI1_1	526	530	PF00082	0.813
CLV_PCSK_SKI1_1	552	556	PF00082	0.638
CLV_PCSK_SKI1_1	697	701	PF00082	0.520
DEG_APCC_DBOX_1	697	705	PF00400	0.508
DEG_SPOP_SBC_1	172	176	PF00917	0.594
DEG_SPOP_SBC_1	26	30	PF00917	0.546
DEG_SPOP_SBC_1	514	518	PF00917	0.574
DOC_CKS1_1	411	416	PF01111	0.677
DOC_CYCLIN_RxL_1	129	138	PF00134	0.554
DOC_CYCLIN_RxL_1	523	532	PF00134	0.632
DOC_MAPK_gen_1	38	44	PF00069	0.447
DOC_MAPK_gen_1	695	704	PF00069	0.454
DOC_MAPK_gen_1	78	85	PF00069	0.524
DOC_MAPK_MEF2A_6	207	216	PF00069	0.503
DOC_MAPK_MEF2A_6	38	46	PF00069	0.492
DOC_MAPK_MEF2A_6	695	704	PF00069	0.463
DOC_MAPK_NFAT4_5	39	47	PF00069	0.496
DOC_MAPK_NFAT4_5	697	705	PF00069	0.464
DOC_PP1_RVXF_1	488	494	PF00149	0.555
DOC_PP1_SILK_1	635	640	PF00149	0.389
DOC_PP2B_LxvP_1	152	155	PF13499	0.633
DOC_PP2B_LxvP_1	267	270	PF13499	0.527
DOC_PP2B_LxvP_1	309	312	PF13499	0.707
DOC_PP2B_LxvP_1	439	442	PF13499	0.666
DOC_PP2B_LxvP_1	809	812	PF13499	0.586
DOC_PP2B_LxvP_1	868	871	PF13499	0.632
DOC_PP4_FxxP_1	251	254	PF00568	0.532
DOC_USP7_MATH_1	105	109	PF00917	0.625
DOC_USP7_MATH_1	155	159	PF00917	0.705
DOC_USP7_MATH_1	172	176	PF00917	0.530
DOC_USP7_MATH_1	180	184	PF00917	0.630
DOC_USP7_MATH_1	358	362	PF00917	0.597
DOC_USP7_MATH_1	468	472	PF00917	0.723
DOC_USP7_MATH_1	494	498	PF00917	0.623
DOC_USP7_MATH_1	524	528	PF00917	0.650
DOC_USP7_MATH_1	541	545	PF00917	0.643
DOC_USP7_MATH_1	577	581	PF00917	0.497
DOC_USP7_MATH_1	592	596	PF00917	0.369
DOC_USP7_MATH_1	626	630	PF00917	0.443
DOC_USP7_MATH_1	673	677	PF00917	0.496
DOC_USP7_MATH_1	771	775	PF00917	0.649
DOC_USP7_MATH_1	782	786	PF00917	0.582
DOC_USP7_MATH_1	804	808	PF00917	0.645
DOC_USP7_UBL2_3	39	43	PF12436	0.489
DOC_WW_Pin1_4	176	181	PF00397	0.601
DOC_WW_Pin1_4	27	32	PF00397	0.608
DOC_WW_Pin1_4	307	312	PF00397	0.708
DOC_WW_Pin1_4	314	319	PF00397	0.666
DOC_WW_Pin1_4	374	379	PF00397	0.654
DOC_WW_Pin1_4	389	394	PF00397	0.617
DOC_WW_Pin1_4	404	409	PF00397	0.574
DOC_WW_Pin1_4	410	415	PF00397	0.672
DOC_WW_Pin1_4	767	772	PF00397	0.691
DOC_WW_Pin1_4	800	805	PF00397	0.677
DOC_WW_Pin1_4	807	812	PF00397	0.632
DOC_WW_Pin1_4	821	826	PF00397	0.611
DOC_WW_Pin1_4	832	837	PF00397	0.574
DOC_WW_Pin1_4	889	894	PF00397	0.605
LIG_14-3-3_CanoR_1	399	409	PF00244	0.676
LIG_14-3-3_CanoR_1	464	472	PF00244	0.671
LIG_14-3-3_CanoR_1	481	489	PF00244	0.596
LIG_14-3-3_CanoR_1	525	529	PF00244	0.654
LIG_14-3-3_CanoR_1	585	591	PF00244	0.462
LIG_14-3-3_CanoR_1	674	682	PF00244	0.461
LIG_14-3-3_CanoR_1	756	764	PF00244	0.683
LIG_14-3-3_CanoR_1	781	791	PF00244	0.656
LIG_14-3-3_CanoR_1	82	86	PF00244	0.463
LIG_14-3-3_CanoR_1	895	899	PF00244	0.700
LIG_APCC_ABBAyCdc20_2	525	531	PF00400	0.631
LIG_BIR_II_1	1	5	PF00653	0.599
LIG_BIR_III_2	177	181	PF00653	0.593
LIG_BIR_III_4	166	170	PF00653	0.634
LIG_BIR_III_4	261	265	PF00653	0.475
LIG_FHA_1	211	217	PF00498	0.428
LIG_FHA_1	467	473	PF00498	0.680
LIG_FHA_1	533	539	PF00498	0.659
LIG_FHA_1	70	76	PF00498	0.569
LIG_FHA_1	851	857	PF00498	0.706
LIG_FHA_2	3	9	PF00498	0.599
LIG_FHA_2	382	388	PF00498	0.588
LIG_FHA_2	516	522	PF00498	0.692
LIG_FHA_2	611	617	PF00498	0.510
LIG_Integrin_RGD_1	143	145	PF01839	0.566
LIG_LIR_Apic_2	387	393	PF02991	0.660
LIG_LIR_Gen_1	134	140	PF02991	0.630
LIG_LIR_Gen_1	2	8	PF02991	0.542
LIG_LIR_Gen_1	60	71	PF02991	0.527
LIG_LIR_Nem_3	134	139	PF02991	0.631
LIG_LIR_Nem_3	275	281	PF02991	0.507
LIG_LIR_Nem_3	60	66	PF02991	0.477
LIG_MYND_1	328	332	PF01753	0.645
LIG_NBox_RRM_1	235	245	PF00076	0.458
LIG_PDZ_Class_1	894	899	PF00595	0.701
LIG_PTAP_UEV_1	317	322	PF05743	0.721
LIG_RPA_C_Fungi	599	611	PF08784	0.404
LIG_SH2_NCK_1	227	231	PF00017	0.449
LIG_SH2_PTP2	63	66	PF00017	0.479
LIG_SH2_STAP1	671	675	PF00017	0.490
LIG_SH2_STAT3	734	737	PF00017	0.560
LIG_SH2_STAT5	36	39	PF00017	0.503
LIG_SH2_STAT5	4	7	PF00017	0.597
LIG_SH2_STAT5	63	66	PF00017	0.479
LIG_SH2_STAT5	863	866	PF00017	0.693
LIG_SH2_STAT5	891	894	PF00017	0.658
LIG_SH3_1	423	429	PF00018	0.723
LIG_SH3_2	394	399	PF14604	0.593
LIG_SH3_2	811	816	PF14604	0.582
LIG_SH3_3	117	123	PF00018	0.681
LIG_SH3_3	273	279	PF00018	0.555
LIG_SH3_3	309	315	PF00018	0.717
LIG_SH3_3	318	324	PF00018	0.636
LIG_SH3_3	370	376	PF00018	0.666
LIG_SH3_3	377	383	PF00018	0.615
LIG_SH3_3	391	397	PF00018	0.561
LIG_SH3_3	422	428	PF00018	0.727
LIG_SH3_3	503	509	PF00018	0.671
LIG_SH3_3	535	541	PF00018	0.617
LIG_SH3_3	61	67	PF00018	0.486
LIG_SH3_3	738	744	PF00018	0.541
LIG_SH3_3	765	771	PF00018	0.682
LIG_SH3_3	798	804	PF00018	0.632
LIG_SH3_3	808	814	PF00018	0.581
LIG_SH3_3	869	875	PF00018	0.653
LIG_SH3_CIN85_PxpxPR_1	811	816	PF14604	0.582
LIG_SUMO_SIM_par_1	53	60	PF11976	0.415
LIG_SUMO_SIM_par_1	594	602	PF11976	0.456
LIG_TRAF2_1	254	257	PF00917	0.599
LIG_TRAF2_1	303	306	PF00917	0.666
LIG_TRAF2_1	384	387	PF00917	0.695
LIG_TRAF2_1	667	670	PF00917	0.491
LIG_WW_1	871	874	PF00397	0.654
LIG_WW_3	310	314	PF00397	0.717
LIG_WW_3	813	817	PF00397	0.644
MOD_CDC14_SPxK_1	310	313	PF00782	0.715
MOD_CDC14_SPxK_1	415	418	PF00782	0.708
MOD_CDK_SPK_2	311	316	PF00069	0.725
MOD_CDK_SPK_2	767	772	PF00069	0.691
MOD_CDK_SPxK_1	307	313	PF00069	0.712
MOD_CDK_SPxK_1	412	418	PF00069	0.711
MOD_CDK_SPxK_1	889	895	PF00069	0.606
MOD_CDK_SPxxK_3	889	896	PF00069	0.606
MOD_CK1_1	138	144	PF00069	0.622
MOD_CK1_1	2	8	PF00069	0.596
MOD_CK1_1	243	249	PF00069	0.507
MOD_CK1_1	314	320	PF00069	0.731
MOD_CK1_1	338	344	PF00069	0.708
MOD_CK1_1	351	357	PF00069	0.585
MOD_CK1_1	431	437	PF00069	0.600
MOD_CK1_1	466	472	PF00069	0.679
MOD_CK1_1	544	550	PF00069	0.641
MOD_CK1_1	774	780	PF00069	0.666
MOD_CK1_1	807	813	PF00069	0.645
MOD_CK1_1	820	826	PF00069	0.578
MOD_CK2_1	2	8	PF00069	0.596
MOD_CK2_1	347	353	PF00069	0.616
MOD_CK2_1	381	387	PF00069	0.591
MOD_CK2_1	515	521	PF00069	0.603
MOD_CK2_1	610	616	PF00069	0.512
MOD_CK2_1	626	632	PF00069	0.350
MOD_CK2_1	782	788	PF00069	0.661
MOD_Cter_Amidation	345	348	PF01082	0.679
MOD_GlcNHglycan	105	108	PF01048	0.668
MOD_GlcNHglycan	116	119	PF01048	0.618
MOD_GlcNHglycan	12	15	PF01048	0.633
MOD_GlcNHglycan	123	126	PF01048	0.546
MOD_GlcNHglycan	161	164	PF01048	0.646
MOD_GlcNHglycan	189	192	PF01048	0.627
MOD_GlcNHglycan	227	230	PF01048	0.511
MOD_GlcNHglycan	245	248	PF01048	0.386
MOD_GlcNHglycan	261	265	PF01048	0.431
MOD_GlcNHglycan	334	338	PF01048	0.704
MOD_GlcNHglycan	439	442	PF01048	0.675
MOD_GlcNHglycan	466	469	PF01048	0.670
MOD_GlcNHglycan	498	501	PF01048	0.666
MOD_GlcNHglycan	546	549	PF01048	0.760
MOD_GlcNHglycan	579	582	PF01048	0.512
MOD_GlcNHglycan	67	70	PF01048	0.552
MOD_GlcNHglycan	675	678	PF01048	0.501
MOD_GlcNHglycan	750	753	PF01048	0.613
MOD_GlcNHglycan	760	763	PF01048	0.690
MOD_GlcNHglycan	773	776	PF01048	0.577
MOD_GlcNHglycan	785	788	PF01048	0.607
MOD_GlcNHglycan	792	795	PF01048	0.565
MOD_GlcNHglycan	826	829	PF01048	0.694
MOD_GSK3_1	114	121	PF00069	0.680
MOD_GSK3_1	131	138	PF00069	0.542
MOD_GSK3_1	155	162	PF00069	0.686
MOD_GSK3_1	172	179	PF00069	0.544
MOD_GSK3_1	25	32	PF00069	0.602
MOD_GSK3_1	307	314	PF00069	0.714
MOD_GSK3_1	322	329	PF00069	0.581
MOD_GSK3_1	347	354	PF00069	0.651
MOD_GSK3_1	381	388	PF00069	0.659
MOD_GSK3_1	400	407	PF00069	0.595
MOD_GSK3_1	412	419	PF00069	0.589
MOD_GSK3_1	464	471	PF00069	0.693
MOD_GSK3_1	477	484	PF00069	0.610
MOD_GSK3_1	492	499	PF00069	0.557
MOD_GSK3_1	65	72	PF00069	0.567
MOD_GSK3_1	767	774	PF00069	0.637
MOD_GSK3_1	800	807	PF00069	0.656
MOD_GSK3_1	817	824	PF00069	0.562
MOD_GSK3_1	850	857	PF00069	0.673
MOD_GSK3_1	887	894	PF00069	0.661
MOD_LATS_1	157	163	PF00433	0.549
MOD_LATS_1	333	339	PF00433	0.665
MOD_LATS_1	462	468	PF00433	0.656
MOD_N-GLC_1	10	15	PF02516	0.640
MOD_N-GLC_1	832	837	PF02516	0.592
MOD_NEK2_1	135	140	PF00069	0.674
MOD_NEK2_1	171	176	PF00069	0.570
MOD_NEK2_1	437	442	PF00069	0.691
MOD_NEK2_1	46	51	PF00069	0.527
MOD_NEK2_1	586	591	PF00069	0.502
MOD_NEK2_1	610	615	PF00069	0.516
MOD_NEK2_1	7	12	PF00069	0.543
MOD_NEK2_2	444	449	PF00069	0.644
MOD_NEK2_2	468	473	PF00069	0.724
MOD_NEK2_2	524	529	PF00069	0.631
MOD_OFUCOSY	502	508	PF10250	0.609
MOD_PIKK_1	358	364	PF00454	0.598
MOD_PIKK_1	431	437	PF00454	0.677
MOD_PIKK_1	466	472	PF00454	0.649
MOD_PIKK_1	481	487	PF00454	0.645
MOD_PIKK_1	626	632	PF00454	0.499
MOD_PK_1	876	882	PF00069	0.614
MOD_PKA_1	240	246	PF00069	0.484
MOD_PKA_1	347	353	PF00069	0.633
MOD_PKA_2	347	353	PF00069	0.663
MOD_PKA_2	463	469	PF00069	0.678
MOD_PKA_2	480	486	PF00069	0.546
MOD_PKA_2	524	530	PF00069	0.634
MOD_PKA_2	633	639	PF00069	0.464
MOD_PKA_2	673	679	PF00069	0.456
MOD_PKA_2	748	754	PF00069	0.614
MOD_PKA_2	757	763	PF00069	0.687
MOD_PKA_2	771	777	PF00069	0.567
MOD_PKA_2	81	87	PF00069	0.481
MOD_PKB_1	345	353	PF00069	0.674
MOD_PKB_1	756	764	PF00069	0.644
MOD_Plk_1	385	391	PF00069	0.674
MOD_Plk_4	131	137	PF00069	0.653
MOD_Plk_4	2	8	PF00069	0.542
MOD_Plk_4	207	213	PF00069	0.516
MOD_Plk_4	326	332	PF00069	0.604
MOD_Plk_4	592	598	PF00069	0.497
MOD_Plk_4	633	639	PF00069	0.464
MOD_Plk_4	804	810	PF00069	0.647
MOD_ProDKin_1	176	182	PF00069	0.604
MOD_ProDKin_1	27	33	PF00069	0.597
MOD_ProDKin_1	307	313	PF00069	0.712
MOD_ProDKin_1	314	320	PF00069	0.666
MOD_ProDKin_1	374	380	PF00069	0.656
MOD_ProDKin_1	389	395	PF00069	0.622
MOD_ProDKin_1	404	410	PF00069	0.575
MOD_ProDKin_1	412	418	PF00069	0.649
MOD_ProDKin_1	767	773	PF00069	0.691
MOD_ProDKin_1	800	806	PF00069	0.680
MOD_ProDKin_1	807	813	PF00069	0.631
MOD_ProDKin_1	821	827	PF00069	0.610
MOD_ProDKin_1	832	838	PF00069	0.575
MOD_ProDKin_1	889	895	PF00069	0.606
MOD_SUMO_for_1	282	285	PF00179	0.650
TRG_DiLeu_BaEn_1	696	701	PF01217	0.594
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.638
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.366
TRG_ENDOCYTIC_2	227	230	PF00928	0.511
TRG_ENDOCYTIC_2	4	7	PF00928	0.542
TRG_ENDOCYTIC_2	63	66	PF00928	0.479
TRG_ER_diArg_1	345	348	PF00400	0.636
TRG_ER_diArg_1	524	526	PF00400	0.752
TRG_ER_diArg_1	638	640	PF00400	0.495
TRG_ER_diArg_1	652	655	PF00400	0.565
TRG_ER_diArg_1	697	699	PF00400	0.384
TRG_ER_diArg_1	721	724	PF00400	0.503
TRG_ER_diArg_1	738	740	PF00400	0.450
TRG_ER_diArg_1	77	79	PF00400	0.553
TRG_ER_diArg_1	780	782	PF00400	0.661
TRG_ER_diArg_1	858	860	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	526	531	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	644	648	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	698	703	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H9K1	Leishmania braziliensis	54%	97%
A4HXW6	Leishmania infantum	100%	100%
E9ARN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	95%
Q4QDU9	Leishmania major	82%	97%