Peroxisomal_enoyl-coa_hydratase_putative/GeneDB:L mjF.18.0580

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisomal enoyl-coa hydratase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUX8_LEIDO

TriTrypDb:

LdBPK_180580.1 , LdCL_180010700 , LDHU3_18.0730

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WUX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUX8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	9
GO:0006629	lipid metabolic process	3	9
GO:0006631	fatty acid metabolic process	4	9
GO:0006635	fatty acid beta-oxidation	6	9
GO:0008152	metabolic process	1	9
GO:0009056	catabolic process	2	9
GO:0009062	fatty acid catabolic process	5	9
GO:0009987	cellular process	1	9
GO:0016042	lipid catabolic process	4	9
GO:0016054	organic acid catabolic process	4	9
GO:0019395	fatty acid oxidation	5	9
GO:0019752	carboxylic acid metabolic process	5	9
GO:0030258	lipid modification	4	9
GO:0032787	monocarboxylic acid metabolic process	6	9
GO:0034440	lipid oxidation	5	9
GO:0043436	oxoacid metabolic process	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044242	cellular lipid catabolic process	4	9
GO:0044248	cellular catabolic process	3	9
GO:0044255	cellular lipid metabolic process	3	9
GO:0044281	small molecule metabolic process	2	9
GO:0044282	small molecule catabolic process	3	9
GO:0046395	carboxylic acid catabolic process	5	9
GO:0071704	organic substance metabolic process	2	9
GO:0072329	monocarboxylic acid catabolic process	6	9
GO:1901575	organic substance catabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004300	enoyl-CoA hydratase activity	5	6
GO:0016829	lyase activity	2	6
GO:0016835	carbon-oxygen lyase activity	3	6
GO:0016836	hydro-lyase activity	4	6
GO:0016853	isomerase activity	2	1
GO:0016860	intramolecular oxidoreductase activity	3	1
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4	1
GO:0051750	delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	16	22	PF00089	0.410
CLV_NRD_NRD_1	18	20	PF00675	0.493
CLV_NRD_NRD_1	241	243	PF00675	0.387
CLV_PCSK_KEX2_1	18	20	PF00082	0.453
CLV_PCSK_KEX2_1	2	4	PF00082	0.694
CLV_PCSK_KEX2_1	243	245	PF00082	0.447
CLV_PCSK_KEX2_1	301	303	PF00082	0.453
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.730
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.402
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.424
CLV_PCSK_SKI1_1	260	264	PF00082	0.471
DEG_Nend_UBRbox_1	1	4	PF02207	0.659
DOC_CYCLIN_RxL_1	204	215	PF00134	0.394
DOC_MAPK_gen_1	46	53	PF00069	0.634
DOC_PP1_RVXF_1	205	212	PF00149	0.394
DOC_PP4_MxPP_1	99	102	PF00568	0.546
DOC_USP7_MATH_1	102	106	PF00917	0.674
DOC_USP7_MATH_1	111	115	PF00917	0.581
DOC_USP7_MATH_1	271	275	PF00917	0.381
DOC_WW_Pin1_4	249	254	PF00397	0.360
LIG_14-3-3_CanoR_1	170	178	PF00244	0.360
LIG_14-3-3_CanoR_1	269	277	PF00244	0.477
LIG_14-3-3_CterR_2	321	323	PF00244	0.663
LIG_APCC_ABBAyCdc20_2	302	308	PF00400	0.424
LIG_CaM_IQ_9	121	137	PF13499	0.453
LIG_FHA_1	175	181	PF00498	0.541
LIG_FHA_1	204	210	PF00498	0.453
LIG_FHA_1	257	263	PF00498	0.424
LIG_FHA_1	28	34	PF00498	0.532
LIG_FHA_2	210	216	PF00498	0.453
LIG_FHA_2	271	277	PF00498	0.481
LIG_LIR_Nem_3	215	219	PF02991	0.476
LIG_LIR_Nem_3	232	237	PF02991	0.413
LIG_LYPXL_SIV_4	54	62	PF13949	0.401
LIG_LYPXL_yS_3	234	237	PF13949	0.381
LIG_NRBOX	61	67	PF00104	0.478
LIG_RPA_C_Fungi	237	249	PF08784	0.394
LIG_SH2_STAP1	55	59	PF00017	0.406
LIG_SH2_STAT5	171	174	PF00017	0.549
LIG_SH3_2	41	46	PF14604	0.568
LIG_SH3_3	38	44	PF00018	0.555
LIG_SUMO_SIM_par_1	32	38	PF11976	0.514
MOD_CK1_1	114	120	PF00069	0.326
MOD_CK1_1	162	168	PF00069	0.360
MOD_CK2_1	176	182	PF00069	0.394
MOD_CK2_1	214	220	PF00069	0.435
MOD_CK2_1	270	276	PF00069	0.424
MOD_CK2_1	6	12	PF00069	0.567
MOD_GlcNHglycan	102	105	PF01048	0.624
MOD_GlcNHglycan	114	117	PF01048	0.545
MOD_GlcNHglycan	215	219	PF01048	0.452
MOD_GlcNHglycan	37	40	PF01048	0.502
MOD_GlcNHglycan	8	11	PF01048	0.587
MOD_GlcNHglycan	87	90	PF01048	0.390
MOD_GlcNHglycan	95	99	PF01048	0.553
MOD_GSK3_1	107	114	PF00069	0.817
MOD_GSK3_1	158	165	PF00069	0.397
MOD_GSK3_1	170	177	PF00069	0.394
MOD_GSK3_1	60	67	PF00069	0.508
MOD_NEK2_1	209	214	PF00069	0.360
MOD_NEK2_2	176	181	PF00069	0.453
MOD_PKA_2	169	175	PF00069	0.424
MOD_Plk_2-3	64	70	PF00069	0.445
MOD_Plk_4	12	18	PF00069	0.557
MOD_ProDKin_1	249	255	PF00069	0.360
MOD_SUMO_rev_2	215	224	PF00179	0.362
MOD_SUMO_rev_2	86	96	PF00179	0.416
TRG_DiLeu_BaEn_1	12	17	PF01217	0.536
TRG_DiLeu_BaEn_1	61	66	PF01217	0.473
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.644
TRG_ENDOCYTIC_2	234	237	PF00928	0.465
TRG_ER_diArg_1	143	146	PF00400	0.394
TRG_ER_diArg_1	17	19	PF00400	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVP1	Leptomonas seymouri	72%	100%
A0A0S4J4R9	Bodo saltans	42%	97%
A0A0S4JCT1	Bodo saltans	26%	100%
A0A0S4JWH0	Bodo saltans	27%	100%
A0A1X0NJ83	Trypanosomatidae	27%	100%
A0A3Q8IIZ5	Leishmania donovani	31%	100%
A0A3Q8IV04	Leishmania donovani	29%	100%
A0A3R7KI60	Trypanosoma rangeli	26%	100%
A0PJR5	Danio rerio	26%	100%
A4H9G6	Leishmania braziliensis	85%	100%
A4HHN0	Leishmania braziliensis	32%	100%
A4HXT3	Leishmania infantum	100%	100%
A4I4U5	Leishmania infantum	31%	100%
A4YI89	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	30%	100%
A8ALR7	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	29%	100%
A9MR28	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	29%	100%
A9MYJ5	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	28%	100%
B1IRE0	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	28%	100%
B1LFW9	Escherichia coli (strain SMS-3-5 / SECEC)	28%	100%
B4T6J5	Salmonella newport (strain SL254)	29%	100%
B4TIG9	Salmonella heidelberg (strain SL476)	28%	100%
B4TWR3	Salmonella schwarzengrund (strain CVM19633)	28%	100%
B5BL54	Salmonella paratyphi A (strain AKU_12601)	28%	100%
B5F749	Salmonella agona (strain SL483)	28%	100%
B5FHG4	Salmonella dublin (strain CT_02021853)	28%	100%
B5R1Q9	Salmonella enteritidis PT4 (strain P125109)	29%	100%
B5RGA4	Salmonella gallinarum (strain 287/91 / NCTC 13346)	29%	100%
C0Q4L2	Salmonella paratyphi C (strain RKS4594)	28%	100%
D0A2C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AE93	Leishmania major	31%	100%
E9AEL3	Leishmania major	29%	100%
E9AHU0	Leishmania infantum	29%	100%
E9ALJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ARJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B5S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
F4JML5	Arabidopsis thaliana	29%	100%
F9XMX6	Zymoseptoria tritici (strain CBS 115943 / IPO323)	24%	100%
G4V4T7	Amycolatopsis orientalis	26%	100%
O34893	Bacillus subtilis (strain 168)	30%	100%
O35459	Mus musculus	36%	99%
O53561	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	100%
P31551	Escherichia coli (strain K12)	28%	100%
P34559	Caenorhabditis elegans	29%	100%
P52046	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	27%	100%
P59395	Shigella flexneri	28%	100%
P94549	Bacillus subtilis (strain 168)	28%	100%
Q0S7P8	Rhodococcus jostii (strain RHA1)	25%	100%
Q0TLV3	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	28%	100%
Q13011	Homo sapiens	34%	98%
Q1ZXF1	Dictyostelium discoideum	28%	100%
Q2TBT3	Bos taurus	29%	100%
Q3MIE0	Rattus norvegicus	23%	100%
Q3TLP5	Mus musculus	28%	100%
Q4PEN0	Ustilago maydis (strain 521 / FGSC 9021)	28%	100%
Q4QDY4	Leishmania major	95%	100%
Q4WF54	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	30%	100%
Q52995	Rhizobium meliloti (strain 1021)	26%	100%
Q54HG7	Dictyostelium discoideum	25%	100%
Q54SS0	Dictyostelium discoideum	33%	100%
Q57TJ1	Salmonella choleraesuis (strain SC-B67)	28%	100%
Q589W8	Alternaria alternata	26%	100%
Q5PIL1	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	28%	100%
Q5R646	Pongo abelii	27%	100%
Q5RFG0	Pongo abelii	33%	98%
Q62651	Rattus norvegicus	36%	99%
Q86YB7	Homo sapiens	29%	100%
Q8FLA6	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	28%	100%
Q8XA35	Escherichia coli O157:H7	28%	100%
Q8Z9L5	Salmonella typhi	29%	100%
Q8ZRX5	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	28%	100%
Q96DC8	Homo sapiens	24%	100%
Q96VB3	Alternaria alternata	26%	100%
Q9D7J9	Mus musculus	23%	100%
Q9FHR8	Arabidopsis thaliana	35%	100%
Q9P4U7	Alternaria alternata	26%	100%
Q9P4U9	Alternaria alternata	26%	100%
V5BNA5	Trypanosoma cruzi	26%	100%
V5BWB9	Trypanosoma cruzi	46%	88%
V5DTT7	Trypanosoma cruzi	29%	100%