Uracil-DNA glycosylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

uracil-DNA-glycosylase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUW8_LEIDO

TriTrypDb:

LdBPK_180480.1 , LdCL_180009700 , LDHU3_18.0600

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0005739	mitochondrion	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7WUW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUW8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006284	base-excision repair	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004844	uracil DNA N-glycosylase activity	6	7
GO:0016787	hydrolase activity	2	7
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	7
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	7
GO:0019104	DNA N-glycosylase activity	4	7
GO:0097506	deaminated base DNA N-glycosylase activity	5	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	60	62	PF00675	0.707
CLV_NRD_NRD_1	9	11	PF00675	0.673
CLV_PCSK_KEX2_1	60	62	PF00082	0.705
CLV_PCSK_SKI1_1	167	171	PF00082	0.394
CLV_PCSK_SKI1_1	198	202	PF00082	0.464
CLV_PCSK_SKI1_1	220	224	PF00082	0.273
CLV_PCSK_SKI1_1	257	261	PF00082	0.315
CLV_PCSK_SKI1_1	3	7	PF00082	0.653
CLV_PCSK_SKI1_1	323	327	PF00082	0.298
CLV_PCSK_SKI1_1	55	59	PF00082	0.777
DEG_APCC_DBOX_1	166	174	PF00400	0.510
DEG_Kelch_Keap1_1	38	43	PF01344	0.673
DEG_Nend_UBRbox_3	1	3	PF02207	0.669
DEG_SPOP_SBC_1	150	154	PF00917	0.500
DOC_CYCLIN_yClb1_LxF_4	321	326	PF00134	0.565
DOC_MAPK_gen_1	194	201	PF00069	0.427
DOC_MAPK_gen_1	30	39	PF00069	0.530
DOC_PP1_RVXF_1	321	327	PF00149	0.515
DOC_PP4_FxxP_1	169	172	PF00568	0.387
DOC_PP4_FxxP_1	266	269	PF00568	0.477
DOC_USP7_MATH_1	125	129	PF00917	0.738
DOC_USP7_MATH_1	133	137	PF00917	0.660
DOC_USP7_MATH_1	150	154	PF00917	0.373
DOC_USP7_MATH_1	20	24	PF00917	0.668
DOC_USP7_MATH_1	210	214	PF00917	0.374
DOC_USP7_MATH_1	374	378	PF00917	0.423
DOC_USP7_MATH_1	91	95	PF00917	0.738
DOC_USP7_UBL2_3	54	58	PF12436	0.708
DOC_WW_Pin1_4	351	356	PF00397	0.477
DOC_WW_Pin1_4	43	48	PF00397	0.767
LIG_14-3-3_CanoR_1	34	40	PF00244	0.599
LIG_BRCT_BRCA1_1	179	183	PF00533	0.368
LIG_BRCT_BRCA1_1	212	216	PF00533	0.384
LIG_CtBP_PxDLS_1	249	253	PF00389	0.515
LIG_deltaCOP1_diTrp_1	165	169	PF00928	0.399
LIG_deltaCOP1_diTrp_1	176	183	PF00928	0.416
LIG_FHA_1	258	264	PF00498	0.515
LIG_FHA_1	286	292	PF00498	0.477
LIG_FHA_1	307	313	PF00498	0.466
LIG_FHA_2	160	166	PF00498	0.443
LIG_FHA_2	2	8	PF00498	0.679
LIG_FHA_2	57	63	PF00498	0.721
LIG_LIR_Apic_2	168	172	PF02991	0.395
LIG_LIR_Gen_1	180	190	PF02991	0.412
LIG_LIR_Gen_1	205	216	PF02991	0.386
LIG_LIR_Gen_1	227	235	PF02991	0.557
LIG_LIR_Gen_1	302	313	PF02991	0.515
LIG_LIR_Nem_3	165	169	PF02991	0.404
LIG_LIR_Nem_3	180	186	PF02991	0.449
LIG_LIR_Nem_3	205	211	PF02991	0.356
LIG_LIR_Nem_3	213	219	PF02991	0.311
LIG_LIR_Nem_3	227	232	PF02991	0.494
LIG_LIR_Nem_3	302	308	PF02991	0.515
LIG_LIR_Nem_3	4	9	PF02991	0.668
LIG_MAD2	220	228	PF02301	0.477
LIG_MYND_1	145	149	PF01753	0.603
LIG_NRBOX	323	329	PF00104	0.565
LIG_PCNA_yPIPBox_3	2	11	PF02747	0.752
LIG_SH2_STAT3	332	335	PF00017	0.565
LIG_SH2_STAT5	273	276	PF00017	0.477
LIG_SH3_3	196	202	PF00018	0.468
LIG_SH3_3	243	249	PF00018	0.476
LIG_SUMO_SIM_anti_2	94	101	PF11976	0.659
LIG_SUMO_SIM_par_1	287	292	PF11976	0.476
MOD_CDC14_SPxK_1	51	54	PF00782	0.790
MOD_CDK_SPK_2	43	48	PF00069	0.701
MOD_CDK_SPxK_1	48	54	PF00069	0.795
MOD_CDK_SPxxK_3	48	55	PF00069	0.796
MOD_CK1_1	118	124	PF00069	0.742
MOD_CK1_1	136	142	PF00069	0.678
MOD_CK1_1	177	183	PF00069	0.420
MOD_CK1_1	300	306	PF00069	0.508
MOD_CK1_1	354	360	PF00069	0.477
MOD_CK2_1	159	165	PF00069	0.456
MOD_CK2_1	273	279	PF00069	0.515
MOD_CK2_1	37	43	PF00069	0.675
MOD_CK2_1	56	62	PF00069	0.559
MOD_GlcNHglycan	118	121	PF01048	0.693
MOD_GlcNHglycan	127	130	PF01048	0.593
MOD_GlcNHglycan	136	139	PF01048	0.757
MOD_GlcNHglycan	14	17	PF01048	0.690
MOD_GlcNHglycan	179	182	PF01048	0.428
MOD_GlcNHglycan	302	305	PF01048	0.277
MOD_GlcNHglycan	356	359	PF01048	0.277
MOD_GlcNHglycan	368	371	PF01048	0.277
MOD_GSK3_1	295	302	PF00069	0.467
MOD_GSK3_1	347	354	PF00069	0.499
MOD_GSK3_1	42	49	PF00069	0.796
MOD_GSK3_1	63	70	PF00069	0.754
MOD_GSK3_1	98	105	PF00069	0.668
MOD_N-GLC_1	20	25	PF02516	0.531
MOD_N-GLC_1	285	290	PF02516	0.277
MOD_N-GLC_1	389	394	PF02516	0.510
MOD_N-GLC_2	212	214	PF02516	0.415
MOD_NEK2_1	1	6	PF00069	0.673
MOD_NEK2_1	238	243	PF00069	0.477
MOD_NEK2_1	285	290	PF00069	0.471
MOD_NEK2_1	356	361	PF00069	0.491
MOD_NEK2_1	37	42	PF00069	0.672
MOD_NEK2_1	389	394	PF00069	0.596
MOD_NEK2_1	89	94	PF00069	0.655
MOD_NEK2_1	97	102	PF00069	0.666
MOD_PIKK_1	314	320	PF00454	0.515
MOD_PKA_1	10	16	PF00069	0.659
MOD_Plk_1	20	26	PF00069	0.631
MOD_Plk_1	285	291	PF00069	0.477
MOD_Plk_1	89	95	PF00069	0.656
MOD_Plk_1	98	104	PF00069	0.662
MOD_Plk_4	1	7	PF00069	0.745
MOD_ProDKin_1	351	357	PF00069	0.477
MOD_ProDKin_1	43	49	PF00069	0.768
TRG_DiLeu_BaEn_1	279	284	PF01217	0.515
TRG_DiLeu_BaEn_2	164	170	PF01217	0.393
TRG_ENDOCYTIC_2	229	232	PF00928	0.500
TRG_ENDOCYTIC_2	256	259	PF00928	0.477
TRG_NES_CRM1_1	280	292	PF08389	0.477
TRG_NLS_MonoExtC_3	335	341	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	188	193	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK50	Leptomonas seymouri	56%	94%
A0A0S4JHG4	Bodo saltans	55%	100%
A4H9F6	Leishmania braziliensis	75%	95%
A4HXS3	Leishmania infantum	100%	100%
E9ARI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	95%
O74834	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
P12887	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P13158	Human herpesvirus 2 (strain 333)	35%	100%