Dynein light chain Tctex-type, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein light chain Tctex-type, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUW6_LEIDO

TriTrypDb:

LdBPK_180730.1 , LdCL_180012400 , LDHU3_18.0980

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3S7WUW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUW6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.690
CLV_C14_Caspase3-7	17	21	PF00656	0.701
CLV_C14_Caspase3-7	83	87	PF00656	0.726
CLV_NRD_NRD_1	207	209	PF00675	0.412
CLV_PCSK_SKI1_1	196	200	PF00082	0.514
CLV_PCSK_SKI1_1	42	46	PF00082	0.853
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.514
DOC_MAPK_gen_1	208	216	PF00069	0.412
DOC_USP7_MATH_1	146	150	PF00917	0.704
DOC_USP7_MATH_1	2	6	PF00917	0.759
DOC_USP7_MATH_1	71	75	PF00917	0.816
DOC_WW_Pin1_4	122	127	PF00397	0.662
DOC_WW_Pin1_4	151	156	PF00397	0.629
LIG_14-3-3_CanoR_1	110	120	PF00244	0.641
LIG_APCC_ABBA_1	124	129	PF00400	0.663
LIG_BIR_II_1	1	5	PF00653	0.844
LIG_BRCT_BRCA1_1	124	128	PF00533	0.640
LIG_EH1_1	199	207	PF00400	0.412
LIG_FHA_1	58	64	PF00498	0.737
LIG_FHA_2	8	14	PF00498	0.753
LIG_FHA_2	81	87	PF00498	0.661
LIG_LIR_Apic_2	218	224	PF02991	0.514
LIG_LIR_Gen_1	177	187	PF02991	0.514
LIG_LIR_Gen_1	244	250	PF02991	0.477
LIG_LIR_Nem_3	177	182	PF02991	0.416
LIG_LIR_Nem_3	244	250	PF02991	0.477
LIG_MLH1_MIPbox_1	124	128	PF16413	0.640
LIG_SH2_CRK	240	244	PF00017	0.385
LIG_SH2_NCK_1	240	244	PF00017	0.509
LIG_SH2_STAT5	127	130	PF00017	0.671
LIG_SH3_3	120	126	PF00018	0.635
LIG_SH3_3	150	156	PF00018	0.738
LIG_SUMO_SIM_anti_2	177	185	PF11976	0.514
LIG_TRAF2_1	157	160	PF00917	0.720
LIG_UBA3_1	187	196	PF00899	0.429
MOD_CK1_1	151	157	PF00069	0.688
MOD_CK1_1	6	12	PF00069	0.838
MOD_CK2_1	7	13	PF00069	0.754
MOD_GlcNHglycan	148	151	PF01048	0.793
MOD_GlcNHglycan	234	238	PF01048	0.412
MOD_GlcNHglycan	34	37	PF01048	0.809
MOD_GlcNHglycan	46	49	PF01048	0.683
MOD_GlcNHglycan	73	76	PF01048	0.729
MOD_GlcNHglycan	86	90	PF01048	0.727
MOD_GSK3_1	2	9	PF00069	0.707
MOD_GSK3_1	27	34	PF00069	0.839
MOD_GSK3_1	38	45	PF00069	0.647
MOD_GSK3_1	76	83	PF00069	0.806
MOD_N-GLC_1	42	47	PF02516	0.741
MOD_N-GLC_1	7	12	PF02516	0.754
MOD_NEK2_1	19	24	PF00069	0.747
MOD_NEK2_1	31	36	PF00069	0.817
MOD_NEK2_2	241	246	PF00069	0.385
MOD_PIKK_1	87	93	PF00454	0.717
MOD_PKA_2	31	37	PF00069	0.711
MOD_Plk_4	241	247	PF00069	0.412
MOD_ProDKin_1	122	128	PF00069	0.666
MOD_ProDKin_1	151	157	PF00069	0.630
MOD_SUMO_for_1	174	177	PF00179	0.514
MOD_SUMO_rev_2	109	119	PF00179	0.672
TRG_DiLeu_BaEn_1	178	183	PF01217	0.466
TRG_ENDOCYTIC_2	171	174	PF00928	0.412
TRG_ENDOCYTIC_2	222	225	PF00928	0.515
TRG_ENDOCYTIC_2	240	243	PF00928	0.238

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7KQL0	Trypanosoma rangeli	44%	100%
A4H9I4	Leishmania braziliensis	70%	99%
A4HXU8	Leishmania infantum	100%	100%
E9ARL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QDW9	Leishmania major	94%	100%