LeishMANIAdb
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Major Facilitator Superfamily, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Major Facilitator Superfamily, putative
Gene product:
major facilitator superfamily, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WUW1_LEIDO
TriTrypDb:
LdBPK_171550.1 , LdCL_170022000 , LDHU3_17.2130
Length:
515

Annotations

LeishMANIAdb annotations

An MFS-superfamily protein homologous to human FLVCR2 hem transporter. Only duplicated extensively in Strigomonas

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 7
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A0A3S7WUW1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUW1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 9
GO:0022857 transmembrane transporter activity 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 28 32 PF00656 0.707
CLV_NRD_NRD_1 226 228 PF00675 0.575
CLV_NRD_NRD_1 475 477 PF00675 0.397
CLV_PCSK_KEX2_1 475 477 PF00082 0.386
CLV_PCSK_KEX2_1 496 498 PF00082 0.536
CLV_PCSK_PC1ET2_1 496 498 PF00082 0.536
CLV_PCSK_SKI1_1 274 278 PF00082 0.338
DEG_Nend_Nbox_1 1 3 PF02207 0.768
DOC_CDC14_PxL_1 176 184 PF14671 0.369
DOC_CDC14_PxL_1 384 392 PF14671 0.470
DOC_CYCLIN_yCln2_LP_2 110 116 PF00134 0.417
DOC_CYCLIN_yCln2_LP_2 309 315 PF00134 0.266
DOC_CYCLIN_yCln2_LP_2 393 399 PF00134 0.428
DOC_PP2B_LxvP_1 110 113 PF13499 0.417
DOC_PP2B_LxvP_1 177 180 PF13499 0.369
DOC_PP2B_LxvP_1 393 396 PF13499 0.428
DOC_PP4_FxxP_1 213 216 PF00568 0.370
DOC_SPAK_OSR1_1 66 70 PF12202 0.470
DOC_USP7_MATH_1 144 148 PF00917 0.417
DOC_USP7_MATH_1 18 22 PF00917 0.746
DOC_USP7_MATH_1 198 202 PF00917 0.358
DOC_USP7_MATH_1 250 254 PF00917 0.263
DOC_USP7_MATH_1 86 90 PF00917 0.425
DOC_USP7_UBL2_3 477 481 PF12436 0.636
DOC_WW_Pin1_4 212 217 PF00397 0.417
DOC_WW_Pin1_4 510 515 PF00397 0.668
DOC_WW_Pin1_4 60 65 PF00397 0.661
LIG_14-3-3_CanoR_1 193 203 PF00244 0.503
LIG_14-3-3_CanoR_1 259 268 PF00244 0.575
LIG_Actin_WH2_2 135 152 PF00022 0.345
LIG_BRCT_BRCA1_1 423 427 PF00533 0.417
LIG_CSL_BTD_1 186 189 PF09270 0.538
LIG_Dynein_DLC8_1 90 96 PF01221 0.228
LIG_FHA_1 240 246 PF00498 0.367
LIG_FHA_1 358 364 PF00498 0.337
LIG_FHA_1 417 423 PF00498 0.503
LIG_FHA_1 454 460 PF00498 0.409
LIG_FHA_2 1 7 PF00498 0.617
LIG_FHA_2 224 230 PF00498 0.328
LIG_FHA_2 261 267 PF00498 0.512
LIG_FHA_2 338 344 PF00498 0.421
LIG_GBD_Chelix_1 243 251 PF00786 0.470
LIG_GBD_Chelix_1 302 310 PF00786 0.417
LIG_GBD_Chelix_1 400 408 PF00786 0.361
LIG_LIR_Apic_2 265 271 PF02991 0.538
LIG_LIR_Apic_2 407 413 PF02991 0.549
LIG_LIR_Gen_1 278 288 PF02991 0.513
LIG_LIR_Gen_1 296 307 PF02991 0.237
LIG_LIR_Gen_1 424 435 PF02991 0.388
LIG_LIR_Gen_1 448 459 PF02991 0.374
LIG_LIR_Nem_3 25 29 PF02991 0.668
LIG_LIR_Nem_3 278 283 PF02991 0.513
LIG_LIR_Nem_3 289 295 PF02991 0.322
LIG_LIR_Nem_3 296 302 PF02991 0.237
LIG_LIR_Nem_3 380 386 PF02991 0.404
LIG_LIR_Nem_3 424 430 PF02991 0.390
LIG_LIR_Nem_3 448 454 PF02991 0.317
LIG_LIR_Nem_3 63 68 PF02991 0.525
LIG_LIR_Nem_3 94 100 PF02991 0.302
LIG_LYPXL_yS_3 159 162 PF13949 0.328
LIG_NRBOX 106 112 PF00104 0.470
LIG_NRBOX 242 248 PF00104 0.466
LIG_NRBOX 305 311 PF00104 0.266
LIG_NRBOX 449 455 PF00104 0.263
LIG_PDZ_Class_1 510 515 PF00595 0.692
LIG_Pex14_1 155 159 PF04695 0.279
LIG_REV1ctd_RIR_1 466 475 PF16727 0.550
LIG_SH2_CRK 127 131 PF00017 0.532
LIG_SH2_CRK 134 138 PF00017 0.388
LIG_SH2_CRK 268 272 PF00017 0.520
LIG_SH2_NCK_1 127 131 PF00017 0.528
LIG_SH2_PTP2 384 387 PF00017 0.417
LIG_SH2_PTP2 451 454 PF00017 0.408
LIG_SH2_STAT5 116 119 PF00017 0.369
LIG_SH2_STAT5 384 387 PF00017 0.417
LIG_SH2_STAT5 451 454 PF00017 0.360
LIG_SH2_STAT5 84 87 PF00017 0.393
LIG_SH2_STAT5 97 100 PF00017 0.263
LIG_SH3_3 151 157 PF00018 0.370
LIG_SH3_3 21 27 PF00018 0.740
LIG_SH3_3 393 399 PF00018 0.415
LIG_SH3_3 492 498 PF00018 0.630
LIG_SUMO_SIM_anti_2 241 248 PF11976 0.417
LIG_SUMO_SIM_anti_2 359 366 PF11976 0.439
LIG_SUMO_SIM_par_1 247 254 PF11976 0.388
LIG_SUMO_SIM_par_1 417 424 PF11976 0.524
LIG_SUMO_SIM_par_1 451 456 PF11976 0.468
LIG_TRFH_1 384 388 PF08558 0.404
LIG_TYR_ITIM 132 137 PF00017 0.528
LIG_UBA3_1 247 255 PF00899 0.470
LIG_UBA3_1 272 277 PF00899 0.575
LIG_WRC_WIRS_1 338 343 PF05994 0.484
LIG_WRC_WIRS_1 427 432 PF05994 0.349
MOD_CDK_SPxK_1 60 66 PF00069 0.611
MOD_CK1_1 233 239 PF00069 0.408
MOD_CK1_1 25 31 PF00069 0.750
MOD_CK1_1 261 267 PF00069 0.486
MOD_CK1_1 460 466 PF00069 0.373
MOD_CK2_1 223 229 PF00069 0.328
MOD_CK2_1 260 266 PF00069 0.538
MOD_CK2_1 275 281 PF00069 0.369
MOD_CK2_1 42 48 PF00069 0.686
MOD_CK2_1 98 104 PF00069 0.331
MOD_DYRK1A_RPxSP_1 510 514 PF00069 0.620
MOD_GlcNHglycan 100 103 PF01048 0.531
MOD_GlcNHglycan 319 322 PF01048 0.506
MOD_GlcNHglycan 325 328 PF01048 0.374
MOD_GlcNHglycan 459 462 PF01048 0.393
MOD_GlcNHglycan 489 492 PF01048 0.483
MOD_GSK3_1 18 25 PF00069 0.725
MOD_GSK3_1 194 201 PF00069 0.345
MOD_GSK3_1 258 265 PF00069 0.502
MOD_GSK3_1 293 300 PF00069 0.395
MOD_GSK3_1 313 320 PF00069 0.140
MOD_GSK3_1 412 419 PF00069 0.558
MOD_GSK3_1 442 449 PF00069 0.356
MOD_GSK3_1 453 460 PF00069 0.407
MOD_GSK3_1 483 490 PF00069 0.628
MOD_N-GLC_1 487 492 PF02516 0.478
MOD_NEK2_1 175 180 PF00069 0.355
MOD_NEK2_1 238 243 PF00069 0.432
MOD_NEK2_1 275 280 PF00069 0.537
MOD_NEK2_1 323 328 PF00069 0.365
MOD_NEK2_1 337 342 PF00069 0.361
MOD_NEK2_1 35 40 PF00069 0.702
MOD_NEK2_1 446 451 PF00069 0.346
MOD_NEK2_1 453 458 PF00069 0.404
MOD_NEK2_1 483 488 PF00069 0.703
MOD_NEK2_1 98 103 PF00069 0.306
MOD_PIKK_1 233 239 PF00454 0.441
MOD_PIKK_1 275 281 PF00454 0.458
MOD_PIKK_1 489 495 PF00454 0.665
MOD_PIKK_1 91 97 PF00454 0.331
MOD_PKA_1 496 502 PF00069 0.635
MOD_PKA_2 258 264 PF00069 0.575
MOD_PKA_2 496 502 PF00069 0.742
MOD_PKA_2 91 97 PF00069 0.375
MOD_Plk_1 191 197 PF00069 0.538
MOD_Plk_1 342 348 PF00069 0.575
MOD_Plk_1 406 412 PF00069 0.532
MOD_Plk_1 446 452 PF00069 0.338
MOD_Plk_2-3 42 48 PF00069 0.719
MOD_Plk_2-3 442 448 PF00069 0.429
MOD_Plk_4 144 150 PF00069 0.417
MOD_Plk_4 18 24 PF00069 0.701
MOD_Plk_4 198 204 PF00069 0.472
MOD_Plk_4 239 245 PF00069 0.346
MOD_Plk_4 337 343 PF00069 0.388
MOD_Plk_4 416 422 PF00069 0.488
MOD_Plk_4 446 452 PF00069 0.324
MOD_Plk_4 93 99 PF00069 0.290
MOD_ProDKin_1 212 218 PF00069 0.417
MOD_ProDKin_1 60 66 PF00069 0.654
MOD_SUMO_rev_2 25 35 PF00179 0.638
MOD_SUMO_rev_2 311 320 PF00179 0.375
TRG_DiLeu_BaEn_1 104 109 PF01217 0.331
TRG_DiLeu_BaEn_2 280 286 PF01217 0.369
TRG_DiLeu_BaLyEn_6 157 162 PF01217 0.328
TRG_DiLeu_BaLyEn_6 178 183 PF01217 0.369
TRG_DiLeu_BaLyEn_6 268 273 PF01217 0.575
TRG_ENDOCYTIC_2 127 130 PF00928 0.519
TRG_ENDOCYTIC_2 134 137 PF00928 0.408
TRG_ENDOCYTIC_2 159 162 PF00928 0.309
TRG_ENDOCYTIC_2 384 387 PF00928 0.386
TRG_ENDOCYTIC_2 451 454 PF00928 0.404
TRG_ENDOCYTIC_2 84 87 PF00928 0.419
TRG_ENDOCYTIC_2 97 100 PF00928 0.276
TRG_ER_diArg_1 474 476 PF00400 0.579
TRG_Pf-PMV_PEXEL_1 481 485 PF00026 0.436

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJH4 Leptomonas seymouri 21% 100%
A0A0N1ILZ7 Leptomonas seymouri 61% 96%
A0A0S4J692 Bodo saltans 31% 86%
A0A0S4J989 Bodo saltans 23% 100%
A0A0S4JN91 Bodo saltans 27% 100%
A0A1X0NWR8 Trypanosomatidae 28% 100%
A0A1X0PA49 Trypanosomatidae 26% 90%
A0A3R7LY82 Trypanosoma rangeli 27% 94%
A0A3S7WW86 Leishmania donovani 23% 100%
A4H9A1 Leishmania braziliensis 74% 100%
A4HBK5 Leishmania braziliensis 23% 100%
A4HXM1 Leishmania infantum 99% 100%
B2RXV4 Mus musculus 26% 92%
D0A244 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 94%
E9AGU5 Leishmania infantum 23% 100%
E9ARB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9AUX4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
O01735 Caenorhabditis elegans 24% 88%
P60815 Rattus norvegicus 27% 94%
Q11073 Caenorhabditis elegans 24% 100%
Q28FF3 Xenopus tropicalis 26% 100%
Q4H425 Epichloe festucae (strain Fl1) 22% 100%
Q4QCK8 Leishmania major 23% 100%
Q4QE46 Leishmania major 90% 100%
Q501I9 Xenopus tropicalis 26% 100%
Q503P5 Danio rerio 24% 100%
Q66H95 Rattus norvegicus 24% 100%
Q6GNV7 Xenopus laevis 25% 100%
Q6UXD7 Homo sapiens 27% 92%
Q8BFQ6 Mus musculus 23% 100%
Q8CE47 Mus musculus 26% 100%
Q91X85 Mus musculus 28% 93%
Q96SL1 Homo sapiens 23% 100%
Q9ES43 Mus terricolor 26% 92%
Q9N1F2 Felis catus 27% 92%
Q9UPI3 Homo sapiens 28% 98%
Q9Y5Y0 Homo sapiens 26% 93%
V5BQV3 Trypanosoma cruzi 28% 94%
V5DGX2 Trypanosoma cruzi 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS