TMEM135_C_rich domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUW0_LEIDO

TriTrypDb:

LdBPK_180540.1 , LdCL_180010300 , LDHU3_18.0680

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WUW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.430
CLV_NRD_NRD_1	223	225	PF00675	0.629
CLV_NRD_NRD_1	284	286	PF00675	0.367
CLV_NRD_NRD_1	351	353	PF00675	0.312
CLV_NRD_NRD_1	409	411	PF00675	0.452
CLV_NRD_NRD_1	494	496	PF00675	0.532
CLV_NRD_NRD_1	498	500	PF00675	0.529
CLV_PCSK_KEX2_1	283	285	PF00082	0.411
CLV_PCSK_KEX2_1	351	353	PF00082	0.301
CLV_PCSK_KEX2_1	409	411	PF00082	0.452
CLV_PCSK_KEX2_1	494	496	PF00082	0.532
CLV_PCSK_KEX2_1	498	500	PF00082	0.529
CLV_PCSK_PC7_1	494	500	PF00082	0.451
CLV_PCSK_SKI1_1	144	148	PF00082	0.614
CLV_PCSK_SKI1_1	260	264	PF00082	0.536
CLV_PCSK_SKI1_1	285	289	PF00082	0.379
CLV_PCSK_SKI1_1	299	303	PF00082	0.220
CLV_PCSK_SKI1_1	331	335	PF00082	0.449
CLV_PCSK_SKI1_1	365	369	PF00082	0.404
CLV_PCSK_SKI1_1	412	416	PF00082	0.397
CLV_PCSK_SKI1_1	57	61	PF00082	0.591
CLV_PCSK_SKI1_1	94	98	PF00082	0.590
DEG_APCC_DBOX_1	143	151	PF00400	0.418
DEG_APCC_DBOX_1	411	419	PF00400	0.590
DEG_APCC_DBOX_1	56	64	PF00400	0.464
DEG_APCC_DBOX_1	85	93	PF00400	0.386
DEG_Nend_UBRbox_3	1	3	PF02207	0.813
DOC_CKS1_1	95	100	PF01111	0.392
DOC_CYCLIN_RxL_1	13	26	PF00134	0.605
DOC_CYCLIN_RxL_1	410	423	PF00134	0.640
DOC_CYCLIN_yClb5_NLxxxL_5	368	377	PF00134	0.519
DOC_CYCLIN_yCln2_LP_2	269	275	PF00134	0.305
DOC_MAPK_gen_1	123	133	PF00069	0.326
DOC_MAPK_gen_1	349	357	PF00069	0.517
DOC_MAPK_gen_1	409	419	PF00069	0.641
DOC_MAPK_HePTP_8	407	419	PF00069	0.637
DOC_MAPK_MEF2A_6	126	135	PF00069	0.299
DOC_MAPK_MEF2A_6	260	269	PF00069	0.278
DOC_MAPK_MEF2A_6	349	357	PF00069	0.528
DOC_MAPK_MEF2A_6	410	419	PF00069	0.638
DOC_MAPK_NFAT4_5	126	134	PF00069	0.318
DOC_MAPK_NFAT4_5	412	420	PF00069	0.639
DOC_USP7_MATH_1	335	339	PF00917	0.415
DOC_USP7_MATH_1	363	367	PF00917	0.328
DOC_USP7_MATH_1	434	438	PF00917	0.761
DOC_USP7_MATH_1	449	453	PF00917	0.783
DOC_USP7_MATH_1	461	465	PF00917	0.639
DOC_USP7_MATH_2	64	70	PF00917	0.441
DOC_USP7_UBL2_3	48	52	PF12436	0.459
DOC_WW_Pin1_4	113	118	PF00397	0.369
DOC_WW_Pin1_4	3	8	PF00397	0.738
DOC_WW_Pin1_4	420	425	PF00397	0.664
DOC_WW_Pin1_4	430	435	PF00397	0.771
DOC_WW_Pin1_4	94	99	PF00397	0.392
LIG_14-3-3_CanoR_1	136	142	PF00244	0.331
LIG_14-3-3_CanoR_1	18	24	PF00244	0.593
LIG_14-3-3_CanoR_1	193	198	PF00244	0.370
LIG_14-3-3_CanoR_1	274	279	PF00244	0.535
LIG_14-3-3_CanoR_1	409	419	PF00244	0.641
LIG_14-3-3_CanoR_1	498	502	PF00244	0.743
LIG_Actin_WH2_2	258	276	PF00022	0.275
LIG_Actin_WH2_2	303	319	PF00022	0.475
LIG_BRCT_BRCA1_1	101	105	PF00533	0.425
LIG_BRCT_BRCA1_1	303	307	PF00533	0.315
LIG_BRCT_BRCA1_1	317	321	PF00533	0.337
LIG_BRCT_BRCA1_1	391	395	PF00533	0.372
LIG_BRCT_BRCA1_1	55	59	PF00533	0.423
LIG_BRCT_BRCA1_1	83	87	PF00533	0.390
LIG_FHA_1	138	144	PF00498	0.371
LIG_FHA_1	24	30	PF00498	0.621
LIG_FHA_1	262	268	PF00498	0.394
LIG_FHA_1	286	292	PF00498	0.610
LIG_FHA_1	310	316	PF00498	0.411
LIG_FHA_1	328	334	PF00498	0.370
LIG_FHA_1	368	374	PF00498	0.462
LIG_FHA_1	385	391	PF00498	0.319
LIG_FHA_1	430	436	PF00498	0.768
LIG_FHA_2	123	129	PF00498	0.321
LIG_FHA_2	194	200	PF00498	0.384
LIG_FHA_2	342	348	PF00498	0.328
LIG_FHA_2	426	432	PF00498	0.730
LIG_LIR_Apic_2	142	148	PF02991	0.404
LIG_LIR_Gen_1	102	110	PF02991	0.407
LIG_LIR_Gen_1	304	315	PF02991	0.318
LIG_LIR_Gen_1	34	44	PF02991	0.449
LIG_LIR_Gen_1	65	73	PF02991	0.418
LIG_LIR_Nem_3	102	108	PF02991	0.440
LIG_LIR_Nem_3	156	160	PF02991	0.347
LIG_LIR_Nem_3	186	190	PF02991	0.355
LIG_LIR_Nem_3	304	310	PF02991	0.318
LIG_LIR_Nem_3	34	39	PF02991	0.425
LIG_LIR_Nem_3	392	398	PF02991	0.361
LIG_LIR_Nem_3	65	70	PF02991	0.411
LIG_NRBOX	341	347	PF00104	0.437
LIG_NRBOX	414	420	PF00104	0.613
LIG_NRBOX	88	94	PF00104	0.399
LIG_PCNA_PIPBox_1	361	370	PF02747	0.413
LIG_Pex14_1	253	257	PF04695	0.394
LIG_Pex14_1	75	79	PF04695	0.351
LIG_PTB_Apo_2	30	37	PF02174	0.606
LIG_PTB_Phospho_1	30	36	PF10480	0.608
LIG_SH2_CRK	160	164	PF00017	0.307
LIG_SH2_CRK	174	178	PF00017	0.293
LIG_SH2_CRK	270	274	PF00017	0.384
LIG_SH2_CRK	311	315	PF00017	0.455
LIG_SH2_CRK	36	40	PF00017	0.413
LIG_SH2_NCK_1	36	40	PF00017	0.385
LIG_SH2_STAP1	160	164	PF00017	0.323
LIG_SH2_STAP1	248	252	PF00017	0.433
LIG_SH2_STAP1	311	315	PF00017	0.409
LIG_SH2_STAT5	132	135	PF00017	0.321
LIG_SH2_STAT5	145	148	PF00017	0.381
LIG_SH2_STAT5	220	223	PF00017	0.409
LIG_SH2_STAT5	311	314	PF00017	0.376
LIG_SH2_STAT5	358	361	PF00017	0.328
LIG_SH2_STAT5	389	392	PF00017	0.343
LIG_SH3_1	145	151	PF00018	0.385
LIG_SH3_3	1	7	PF00018	0.730
LIG_SH3_3	145	151	PF00018	0.329
LIG_SH3_3	469	475	PF00018	0.730
LIG_SH3_3	58	64	PF00018	0.438
LIG_SUMO_SIM_anti_2	161	166	PF11976	0.323
LIG_TYR_ITIM	172	177	PF00017	0.289
LIG_UBA3_1	146	152	PF00899	0.431
LIG_UBA3_1	255	260	PF00899	0.369
LIG_WRC_WIRS_1	364	369	PF05994	0.344
LIG_WRC_WIRS_1	82	87	PF05994	0.366
MOD_CK1_1	137	143	PF00069	0.385
MOD_CK2_1	122	128	PF00069	0.341
MOD_CK2_1	193	199	PF00069	0.411
MOD_CK2_1	341	347	PF00069	0.328
MOD_CK2_1	425	431	PF00069	0.711
MOD_Cter_Amidation	349	352	PF01082	0.346
MOD_GlcNHglycan	113	116	PF01048	0.566
MOD_GlcNHglycan	136	139	PF01048	0.574
MOD_GlcNHglycan	205	208	PF01048	0.588
MOD_GlcNHglycan	234	237	PF01048	0.582
MOD_GlcNHglycan	303	306	PF01048	0.335
MOD_GlcNHglycan	317	320	PF01048	0.549
MOD_GlcNHglycan	436	439	PF01048	0.565
MOD_GlcNHglycan	461	464	PF01048	0.598
MOD_GSK3_1	179	186	PF00069	0.341
MOD_GSK3_1	19	26	PF00069	0.636
MOD_GSK3_1	232	239	PF00069	0.396
MOD_GSK3_1	285	292	PF00069	0.578
MOD_GSK3_1	297	304	PF00069	0.421
MOD_GSK3_1	327	334	PF00069	0.363
MOD_GSK3_1	363	370	PF00069	0.336
MOD_GSK3_1	425	432	PF00069	0.744
MOD_GSK3_1	434	441	PF00069	0.768
MOD_GSK3_1	62	69	PF00069	0.397
MOD_N-GLC_1	23	28	PF02516	0.301
MOD_NEK2_1	134	139	PF00069	0.387
MOD_NEK2_1	165	170	PF00069	0.307
MOD_NEK2_1	23	28	PF00069	0.567
MOD_NEK2_1	232	237	PF00069	0.346
MOD_NEK2_1	301	306	PF00069	0.362
MOD_NEK2_1	357	362	PF00069	0.391
MOD_NEK2_1	367	372	PF00069	0.287
MOD_NEK2_1	384	389	PF00069	0.253
MOD_NEK2_2	81	86	PF00069	0.324
MOD_PIKK_1	167	173	PF00454	0.292
MOD_PIKK_1	367	373	PF00454	0.339
MOD_PIKK_1	454	460	PF00454	0.725
MOD_PKA_2	192	198	PF00069	0.375
MOD_PKA_2	31	37	PF00069	0.531
MOD_PKA_2	484	490	PF00069	0.698
MOD_PKA_2	497	503	PF00069	0.688
MOD_PKB_1	283	291	PF00069	0.640
MOD_Plk_1	23	29	PF00069	0.586
MOD_Plk_1	481	487	PF00069	0.658
MOD_Plk_2-3	66	72	PF00069	0.335
MOD_Plk_4	104	110	PF00069	0.368
MOD_Plk_4	274	280	PF00069	0.516
MOD_Plk_4	290	296	PF00069	0.485
MOD_Plk_4	31	37	PF00069	0.544
MOD_Plk_4	341	347	PF00069	0.327
MOD_Plk_4	384	390	PF00069	0.392
MOD_Plk_4	88	94	PF00069	0.353
MOD_ProDKin_1	113	119	PF00069	0.373
MOD_ProDKin_1	3	9	PF00069	0.736
MOD_ProDKin_1	420	426	PF00069	0.668
MOD_ProDKin_1	430	436	PF00069	0.771
MOD_ProDKin_1	94	100	PF00069	0.394
MOD_SUMO_rev_2	401	407	PF00179	0.621
TRG_DiLeu_BaEn_1	402	407	PF01217	0.628
TRG_DiLeu_BaEn_4	402	408	PF01217	0.627
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.422
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.424
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.604
TRG_ENDOCYTIC_2	132	135	PF00928	0.322
TRG_ENDOCYTIC_2	160	163	PF00928	0.305
TRG_ENDOCYTIC_2	174	177	PF00928	0.283
TRG_ENDOCYTIC_2	187	190	PF00928	0.281
TRG_ENDOCYTIC_2	270	273	PF00928	0.305
TRG_ENDOCYTIC_2	311	314	PF00928	0.395
TRG_ENDOCYTIC_2	358	361	PF00928	0.341
TRG_ENDOCYTIC_2	36	39	PF00928	0.413
TRG_ER_diArg_1	210	213	PF00400	0.437
TRG_ER_diArg_1	283	285	PF00400	0.629
TRG_ER_diArg_1	351	353	PF00400	0.523
TRG_ER_diArg_1	373	376	PF00400	0.417
TRG_ER_diArg_1	409	412	PF00400	0.599
TRG_ER_diArg_1	497	499	PF00400	0.748
TRG_ER_diLys_1	508	513	PF00400	0.746
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXD2	Leptomonas seymouri	74%	100%
A0A0S4IY50	Bodo saltans	35%	100%
A0A1X0P7N6	Trypanosomatidae	45%	100%
A0A3R7MN24	Trypanosoma rangeli	43%	100%
A4H9G2	Leishmania braziliensis	82%	100%
A4HXS9	Leishmania infantum	100%	100%
D0A061	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ARJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDY8	Leishmania major	94%	100%
V5BWB3	Trypanosoma cruzi	42%	100%