Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paralyzed flagella protein 20

Species:

Leishmania donovani

UniProt:

A0A3S7WUV4_LEIDO

TriTrypDb:

LdBPK_180470.1 , LdCL_180009600 , LDHU3_18.0590

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0032991	protein-containing complex	1	11
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	2
GO:1990904	ribonucleoprotein complex	2	11
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

A0A3S7WUV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUV4

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0060294	cilium movement involved in cell motility	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	213	215	PF00675	0.549
CLV_NRD_NRD_1	41	43	PF00675	0.608
CLV_NRD_NRD_1	538	540	PF00675	0.411
CLV_PCSK_KEX2_1	213	215	PF00082	0.527
CLV_PCSK_KEX2_1	41	43	PF00082	0.544
CLV_PCSK_KEX2_1	538	540	PF00082	0.411
CLV_PCSK_PC7_1	209	215	PF00082	0.522
CLV_PCSK_SKI1_1	172	176	PF00082	0.449
CLV_PCSK_SKI1_1	202	206	PF00082	0.401
CLV_PCSK_SKI1_1	403	407	PF00082	0.234
CLV_PCSK_SKI1_1	72	76	PF00082	0.459
DOC_ANK_TNKS_1	295	302	PF00023	0.536
DOC_CYCLIN_RxL_1	199	208	PF00134	0.447
DOC_MAPK_gen_1	200	207	PF00069	0.421
DOC_MAPK_gen_1	538	546	PF00069	0.382
DOC_PP2B_LxvP_1	50	53	PF13499	0.646
DOC_PP2B_LxvP_1	61	64	PF13499	0.577
DOC_PP4_FxxP_1	18	21	PF00568	0.610
DOC_PP4_FxxP_1	289	292	PF00568	0.482
DOC_USP7_MATH_1	252	256	PF00917	0.613
DOC_USP7_MATH_1	304	308	PF00917	0.676
DOC_USP7_MATH_1	341	345	PF00917	0.496
DOC_USP7_MATH_1	355	359	PF00917	0.377
DOC_USP7_MATH_1	373	377	PF00917	0.332
DOC_USP7_MATH_1	397	401	PF00917	0.434
DOC_USP7_MATH_1	517	521	PF00917	0.410
DOC_USP7_MATH_1	566	570	PF00917	0.391
DOC_USP7_MATH_1	593	597	PF00917	0.545
DOC_USP7_MATH_1	86	90	PF00917	0.509
DOC_WW_Pin1_4	17	22	PF00397	0.656
DOC_WW_Pin1_4	270	275	PF00397	0.694
DOC_WW_Pin1_4	321	326	PF00397	0.714
LIG_14-3-3_CanoR_1	157	164	PF00244	0.550
LIG_14-3-3_CanoR_1	16	21	PF00244	0.534
LIG_14-3-3_CanoR_1	268	274	PF00244	0.748
LIG_14-3-3_CanoR_1	3	10	PF00244	0.601
LIG_14-3-3_CanoR_1	364	369	PF00244	0.564
LIG_14-3-3_CanoR_1	41	45	PF00244	0.610
LIG_14-3-3_CanoR_1	414	420	PF00244	0.471
LIG_14-3-3_CanoR_1	458	462	PF00244	0.466
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_BIR_III_2	51	55	PF00653	0.409
LIG_BRCT_BRCA1_1	5	9	PF00533	0.604
LIG_BRCT_BRCA1_1	519	523	PF00533	0.472
LIG_BRCT_BRCA1_1	595	599	PF00533	0.513
LIG_BRCT_BRCA1_1	602	606	PF00533	0.464
LIG_Clathr_ClatBox_1	204	208	PF01394	0.429
LIG_Clathr_ClatBox_1	543	547	PF01394	0.502
LIG_CSL_BTD_1	290	293	PF09270	0.452
LIG_deltaCOP1_diTrp_1	328	335	PF00928	0.543
LIG_deltaCOP1_diTrp_1	424	431	PF00928	0.418
LIG_FHA_1	116	122	PF00498	0.405
LIG_FHA_1	277	283	PF00498	0.678
LIG_FHA_1	325	331	PF00498	0.523
LIG_FHA_1	337	343	PF00498	0.465
LIG_FHA_1	402	408	PF00498	0.434
LIG_FHA_1	421	427	PF00498	0.434
LIG_FHA_1	432	438	PF00498	0.402
LIG_FHA_1	444	450	PF00498	0.457
LIG_FHA_1	475	481	PF00498	0.434
LIG_FHA_1	5	11	PF00498	0.725
LIG_FHA_1	55	61	PF00498	0.669
LIG_FHA_1	571	577	PF00498	0.351
LIG_FHA_1	596	602	PF00498	0.516
LIG_FHA_1	79	85	PF00498	0.512
LIG_FHA_1	97	103	PF00498	0.536
LIG_FHA_2	185	191	PF00498	0.412
LIG_FHA_2	3	9	PF00498	0.694
LIG_FHA_2	531	537	PF00498	0.418
LIG_LIR_Apic_2	287	292	PF02991	0.506
LIG_NRBOX	169	175	PF00104	0.498
LIG_PCNA_yPIPBox_3	162	174	PF02747	0.545
LIG_PDZ_Class_2	615	620	PF00595	0.466
LIG_PDZ_Wminus1_1	618	620	PF00595	0.466
LIG_Pex14_1	427	431	PF04695	0.434
LIG_Pex14_2	70	74	PF04695	0.485
LIG_Pex14_2	87	91	PF04695	0.468
LIG_RPA_C_Fungi	533	545	PF08784	0.485
LIG_SH3_3	103	109	PF00018	0.673
LIG_SH3_3	238	244	PF00018	0.731
LIG_SH3_3	287	293	PF00018	0.512
LIG_SH3_3	294	300	PF00018	0.555
LIG_SH3_3	346	352	PF00018	0.321
LIG_SH3_3	50	56	PF00018	0.560
LIG_SUMO_SIM_par_1	203	208	PF11976	0.425
LIG_SUMO_SIM_par_1	575	581	PF11976	0.376
LIG_UBA3_1	204	211	PF00899	0.410
LIG_WRC_WIRS_1	500	505	PF05994	0.368
MOD_CK1_1	2	8	PF00069	0.752
MOD_CK1_1	203	209	PF00069	0.543
MOD_CK1_1	256	262	PF00069	0.723
MOD_CK1_1	272	278	PF00069	0.597
MOD_CK1_1	318	324	PF00069	0.613
MOD_CK1_1	420	426	PF00069	0.426
MOD_CK1_1	525	531	PF00069	0.429
MOD_CK1_1	609	615	PF00069	0.296
MOD_CK2_1	184	190	PF00069	0.422
MOD_CK2_1	21	27	PF00069	0.653
MOD_GlcNHglycan	258	261	PF01048	0.704
MOD_GlcNHglycan	308	311	PF01048	0.692
MOD_GlcNHglycan	355	358	PF01048	0.359
MOD_GlcNHglycan	375	378	PF01048	0.239
MOD_GlcNHglycan	399	402	PF01048	0.299
MOD_GlcNHglycan	419	422	PF01048	0.128
MOD_GlcNHglycan	439	442	PF01048	0.174
MOD_GlcNHglycan	483	486	PF01048	0.299
MOD_GlcNHglycan	608	611	PF01048	0.337
MOD_GSK3_1	140	147	PF00069	0.445
MOD_GSK3_1	17	24	PF00069	0.663
MOD_GSK3_1	184	191	PF00069	0.544
MOD_GSK3_1	252	259	PF00069	0.685
MOD_GSK3_1	272	279	PF00069	0.670
MOD_GSK3_1	300	307	PF00069	0.658
MOD_GSK3_1	315	322	PF00069	0.712
MOD_GSK3_1	336	343	PF00069	0.378
MOD_GSK3_1	355	362	PF00069	0.284
MOD_GSK3_1	36	43	PF00069	0.440
MOD_GSK3_1	363	370	PF00069	0.400
MOD_GSK3_1	378	385	PF00069	0.292
MOD_GSK3_1	391	398	PF00069	0.233
MOD_GSK3_1	4	11	PF00069	0.677
MOD_GSK3_1	495	502	PF00069	0.482
MOD_GSK3_1	518	525	PF00069	0.468
MOD_GSK3_1	566	573	PF00069	0.344
MOD_GSK3_1	608	615	PF00069	0.422
MOD_NEK2_1	1	6	PF00069	0.665
MOD_NEK2_1	188	193	PF00069	0.531
MOD_NEK2_1	340	345	PF00069	0.371
MOD_NEK2_1	395	400	PF00069	0.277
MOD_NEK2_1	40	45	PF00069	0.542
MOD_NEK2_1	410	415	PF00069	0.395
MOD_NEK2_1	431	436	PF00069	0.304
MOD_NEK2_1	437	442	PF00069	0.292
MOD_NEK2_1	443	448	PF00069	0.287
MOD_NEK2_1	479	484	PF00069	0.325
MOD_NEK2_1	606	611	PF00069	0.282
MOD_NEK2_1	80	85	PF00069	0.576
MOD_NEK2_2	401	406	PF00069	0.277
MOD_NEK2_2	457	462	PF00069	0.296
MOD_PIKK_1	140	146	PF00454	0.555
MOD_PIKK_1	244	250	PF00454	0.794
MOD_PIKK_1	525	531	PF00454	0.457
MOD_PKA_2	115	121	PF00069	0.571
MOD_PKA_2	140	146	PF00069	0.533
MOD_PKA_2	156	162	PF00069	0.432
MOD_PKA_2	168	174	PF00069	0.401
MOD_PKA_2	2	8	PF00069	0.599
MOD_PKA_2	363	369	PF00069	0.396
MOD_PKA_2	391	397	PF00069	0.416
MOD_PKA_2	40	46	PF00069	0.610
MOD_PKA_2	457	463	PF00069	0.321
MOD_Plk_1	330	336	PF00069	0.387
MOD_Plk_1	401	407	PF00069	0.277
MOD_Plk_1	612	618	PF00069	0.355
MOD_Plk_4	115	121	PF00069	0.404
MOD_Plk_4	200	206	PF00069	0.444
MOD_Plk_4	330	336	PF00069	0.313
MOD_Plk_4	391	397	PF00069	0.300
MOD_Plk_4	469	475	PF00069	0.444
MOD_Plk_4	518	524	PF00069	0.515
MOD_Plk_4	530	536	PF00069	0.404
MOD_ProDKin_1	17	23	PF00069	0.656
MOD_ProDKin_1	270	276	PF00069	0.694
MOD_ProDKin_1	321	327	PF00069	0.706
TRG_DiLeu_BaEn_2	284	290	PF01217	0.645
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.545
TRG_ER_diArg_1	212	214	PF00400	0.531
TRG_ER_diArg_1	40	42	PF00400	0.544
TRG_ER_diArg_1	538	540	PF00400	0.412
TRG_NES_CRM1_1	36	49	PF08389	0.616
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCN2	Leptomonas seymouri	70%	97%
A0A0S4JA64	Bodo saltans	46%	100%
A0A1X0P716	Trypanosomatidae	52%	100%
A0A3R7NP23	Trypanosoma rangeli	51%	100%
A0A3S7WR72	Leishmania donovani	31%	100%
A1DDL6	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	23%	94%
A2R3Z3	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	23%	94%
A4H666	Leishmania braziliensis	31%	100%
A4H9F5	Leishmania braziliensis	84%	100%
A4HUJ0	Leishmania infantum	31%	100%
A4HXS2	Leishmania infantum	100%	100%
A6ZQL5	Saccharomyces cerevisiae (strain YJM789)	23%	87%
D0A054	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ARI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P47025	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	87%
P93107	Chlamydomonas reinhardtii	36%	100%
Q4QDZ5	Leishmania major	94%	100%
Q4QHD6	Leishmania major	31%	100%
Q4WVS4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	94%
Q5I0B9	Xenopus tropicalis	22%	100%
Q8K450	Mus musculus	33%	97%
Q8N0X2	Homo sapiens	33%	98%
Q9P7I3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	95%