HEAT_repeats/HEAT_repeat_putative/Pfam:PF13646/Pf am:PF02985

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HEAT repeats, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUV3_LEIDO

TriTrypDb:

LdBPK_180670.1 , LdCL_180011800 , LDHU3_18.0880

Length:

711

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUV3

Function

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Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.402
CLV_C14_Caspase3-7	603	607	PF00656	0.660
CLV_C14_Caspase3-7	9	13	PF00656	0.638
CLV_NRD_NRD_1	210	212	PF00675	0.455
CLV_NRD_NRD_1	367	369	PF00675	0.368
CLV_PCSK_KEX2_1	210	212	PF00082	0.570
CLV_PCSK_KEX2_1	406	408	PF00082	0.504
CLV_PCSK_KEX2_1	450	452	PF00082	0.528
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.504
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.528

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHR7	Leptomonas seymouri	88%	97%
A0A0S4J1S0	Bodo saltans	55%	100%
A0A1X0NWU2	Trypanosomatidae	22%	100%
A0A1X0P6U3	Trypanosomatidae	58%	100%
A0A3R7KDP1	Trypanosoma rangeli	56%	100%
A4H9H6	Leishmania braziliensis	93%	100%
A4HXU2	Leishmania infantum	100%	100%
C9ZZW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AIC2	Leishmania braziliensis	25%	100%
E9ARK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%

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