HEAT_repeats/HEAT_repeat_putative/Pfam:PF13646/Pf am:PF02985

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HEAT repeats, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUV3_LEIDO

TriTrypDb:

LdBPK_180670.1 , LdCL_180011800 , LDHU3_18.0880

Length:

711

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUV3

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.402
CLV_C14_Caspase3-7	603	607	PF00656	0.660
CLV_C14_Caspase3-7	9	13	PF00656	0.638
CLV_NRD_NRD_1	210	212	PF00675	0.455
CLV_NRD_NRD_1	367	369	PF00675	0.368
CLV_PCSK_KEX2_1	210	212	PF00082	0.570
CLV_PCSK_KEX2_1	406	408	PF00082	0.504
CLV_PCSK_KEX2_1	450	452	PF00082	0.528
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.504
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.528
CLV_PCSK_SKI1_1	231	235	PF00082	0.480
CLV_PCSK_SKI1_1	313	317	PF00082	0.476
CLV_PCSK_SKI1_1	46	50	PF00082	0.380
CLV_PCSK_SKI1_1	516	520	PF00082	0.453
CLV_PCSK_SKI1_1	526	530	PF00082	0.366
CLV_PCSK_SKI1_1	574	578	PF00082	0.464
CLV_PCSK_SKI1_1	85	89	PF00082	0.360
CLV_Separin_Metazoa	310	314	PF03568	0.533
DEG_APCC_DBOX_1	424	432	PF00400	0.387
DEG_SPOP_SBC_1	484	488	PF00917	0.411
DOC_CKS1_1	419	424	PF01111	0.535
DOC_CYCLIN_RxL_1	412	421	PF00134	0.521
DOC_MAPK_gen_1	450	457	PF00069	0.513
DOC_MAPK_MEF2A_6	231	240	PF00069	0.434
DOC_MAPK_MEF2A_6	450	459	PF00069	0.393
DOC_MAPK_NFAT4_5	231	239	PF00069	0.528
DOC_PP1_RVXF_1	266	272	PF00149	0.537
DOC_PP1_RVXF_1	359	366	PF00149	0.393
DOC_PP4_FxxP_1	271	274	PF00568	0.524
DOC_USP7_MATH_1	291	295	PF00917	0.427
DOC_USP7_MATH_1	319	323	PF00917	0.451
DOC_USP7_MATH_1	436	440	PF00917	0.456
DOC_USP7_MATH_1	471	475	PF00917	0.460
DOC_USP7_MATH_1	686	690	PF00917	0.723
DOC_USP7_MATH_1	693	697	PF00917	0.616
DOC_WW_Pin1_4	305	310	PF00397	0.441
DOC_WW_Pin1_4	324	329	PF00397	0.582
DOC_WW_Pin1_4	418	423	PF00397	0.584
DOC_WW_Pin1_4	457	462	PF00397	0.493
DOC_WW_Pin1_4	648	653	PF00397	0.819
LIG_14-3-3_CanoR_1	210	214	PF00244	0.429
LIG_14-3-3_CanoR_1	231	237	PF00244	0.525
LIG_14-3-3_CanoR_1	297	303	PF00244	0.471
LIG_14-3-3_CanoR_1	313	320	PF00244	0.551
LIG_14-3-3_CanoR_1	368	372	PF00244	0.384
LIG_14-3-3_CanoR_1	485	490	PF00244	0.403
LIG_APCC_ABBA_1	312	317	PF00400	0.393
LIG_BIR_III_2	79	83	PF00653	0.496
LIG_BRCT_BRCA1_1	462	466	PF00533	0.529
LIG_CtBP_PxDLS_1	264	268	PF00389	0.403
LIG_EH1_1	375	383	PF00400	0.428
LIG_FHA_1	1	7	PF00498	0.758
LIG_FHA_1	189	195	PF00498	0.471
LIG_FHA_1	531	537	PF00498	0.448
LIG_FHA_1	562	568	PF00498	0.504
LIG_FHA_1	617	623	PF00498	0.681
LIG_FHA_1	703	709	PF00498	0.676
LIG_FHA_2	116	122	PF00498	0.530
LIG_FHA_2	223	229	PF00498	0.502
LIG_FHA_2	237	243	PF00498	0.440
LIG_FHA_2	666	672	PF00498	0.670
LIG_GBD_Chelix_1	173	181	PF00786	0.359
LIG_LIR_Gen_1	105	116	PF02991	0.371
LIG_LIR_Gen_1	118	128	PF02991	0.383
LIG_LIR_Gen_1	235	245	PF02991	0.525
LIG_LIR_Gen_1	289	299	PF02991	0.434
LIG_LIR_Gen_1	347	357	PF02991	0.425
LIG_LIR_Gen_1	414	423	PF02991	0.486
LIG_LIR_LC3C_4	564	568	PF02991	0.535
LIG_LIR_Nem_3	105	111	PF02991	0.378
LIG_LIR_Nem_3	118	123	PF02991	0.361
LIG_LIR_Nem_3	16	22	PF02991	0.522
LIG_LIR_Nem_3	168	173	PF02991	0.408
LIG_LIR_Nem_3	235	240	PF02991	0.521
LIG_LIR_Nem_3	289	295	PF02991	0.437
LIG_LIR_Nem_3	330	335	PF02991	0.431
LIG_LIR_Nem_3	347	352	PF02991	0.412
LIG_LIR_Nem_3	414	419	PF02991	0.393
LIG_LIR_Nem_3	463	469	PF02991	0.522
LIG_LIR_Nem_3	486	492	PF02991	0.513
LIG_LIR_Nem_3	504	510	PF02991	0.360
LIG_LIR_Nem_3	56	62	PF02991	0.384
LIG_NRBOX	294	300	PF00104	0.513
LIG_PCNA_PIPBox_1	109	118	PF02747	0.458
LIG_PCNA_PIPBox_1	230	239	PF02747	0.422
LIG_PCNA_PIPBox_1	86	95	PF02747	0.511
LIG_PCNA_yPIPBox_3	85	93	PF02747	0.512
LIG_Pex14_2	185	189	PF04695	0.535
LIG_SH2_CRK	108	112	PF00017	0.453
LIG_SH2_CRK	170	174	PF00017	0.382
LIG_SH2_CRK	335	339	PF00017	0.513
LIG_SH2_GRB2like	507	510	PF00017	0.547
LIG_SH2_NCK_1	489	493	PF00017	0.512
LIG_SH2_PTP2	237	240	PF00017	0.410
LIG_SH2_SRC	489	492	PF00017	0.514
LIG_SH2_SRC	62	65	PF00017	0.536
LIG_SH2_STAP1	356	360	PF00017	0.387
LIG_SH2_STAP1	62	66	PF00017	0.535
LIG_SH2_STAT5	237	240	PF00017	0.424
LIG_SH2_STAT5	332	335	PF00017	0.464
LIG_SH2_STAT5	510	513	PF00017	0.467
LIG_SH2_STAT5	531	534	PF00017	0.391
LIG_SH3_3	322	328	PF00018	0.597
LIG_SH3_3	458	464	PF00018	0.484
LIG_Sin3_3	416	423	PF02671	0.531
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.391
LIG_SUMO_SIM_anti_2	468	474	PF11976	0.435
LIG_SUMO_SIM_anti_2	490	496	PF11976	0.514
LIG_SUMO_SIM_anti_2	590	596	PF11976	0.582
LIG_SUMO_SIM_par_1	131	136	PF11976	0.525
LIG_SUMO_SIM_par_1	190	197	PF11976	0.527
LIG_SUMO_SIM_par_1	46	52	PF11976	0.466
LIG_SUMO_SIM_par_1	468	474	PF11976	0.528
LIG_TRAF2_1	13	16	PF00917	0.679
LIG_TRAF2_1	225	228	PF00917	0.574
LIG_TRAF2_1	600	603	PF00917	0.642
LIG_UBA3_1	398	406	PF00899	0.525
LIG_UBA3_1	549	555	PF00899	0.493
LIG_WRC_WIRS_1	73	78	PF05994	0.542
MOD_CDK_SPxxK_3	418	425	PF00069	0.574
MOD_CK1_1	187	193	PF00069	0.558
MOD_CK1_1	202	208	PF00069	0.361
MOD_CK1_1	327	333	PF00069	0.522
MOD_CK1_1	40	46	PF00069	0.394
MOD_CK1_1	460	466	PF00069	0.482
MOD_CK1_1	65	71	PF00069	0.522
MOD_CK1_1	698	704	PF00069	0.861
MOD_CK2_1	115	121	PF00069	0.539
MOD_CK2_1	222	228	PF00069	0.515
MOD_CK2_1	236	242	PF00069	0.441
MOD_CK2_1	371	377	PF00069	0.383
MOD_CK2_1	477	483	PF00069	0.421
MOD_CK2_1	484	490	PF00069	0.387
MOD_CK2_1	598	604	PF00069	0.590
MOD_CK2_1	665	671	PF00069	0.667
MOD_GlcNHglycan	260	263	PF01048	0.588
MOD_GlcNHglycan	500	503	PF01048	0.482
MOD_GlcNHglycan	546	549	PF01048	0.573
MOD_GlcNHglycan	64	67	PF01048	0.462
MOD_GlcNHglycan	688	691	PF01048	0.899
MOD_GSK3_1	184	191	PF00069	0.557
MOD_GSK3_1	199	206	PF00069	0.444
MOD_GSK3_1	232	239	PF00069	0.504
MOD_GSK3_1	301	308	PF00069	0.446
MOD_GSK3_1	367	374	PF00069	0.387
MOD_GSK3_1	694	701	PF00069	0.818
MOD_N-GLC_1	202	207	PF02516	0.415
MOD_NEK2_1	189	194	PF00069	0.510
MOD_NEK2_1	236	241	PF00069	0.419
MOD_NEK2_1	298	303	PF00069	0.424
MOD_NEK2_1	371	376	PF00069	0.369
MOD_NEK2_1	381	386	PF00069	0.452
MOD_NEK2_1	477	482	PF00069	0.420
MOD_NEK2_1	53	58	PF00069	0.433
MOD_NEK2_1	6	11	PF00069	0.607
MOD_NEK2_1	702	707	PF00069	0.637
MOD_NEK2_1	72	77	PF00069	0.397
MOD_PIKK_1	598	604	PF00454	0.639
MOD_PIKK_1	616	622	PF00454	0.690
MOD_PIKK_1	7	13	PF00454	0.591
MOD_PIKK_1	74	80	PF00454	0.551
MOD_PKA_2	209	215	PF00069	0.431
MOD_PKA_2	367	373	PF00069	0.408
MOD_PKA_2	484	490	PF00069	0.400
MOD_Plk_1	202	208	PF00069	0.433
MOD_Plk_1	24	30	PF00069	0.423
MOD_Plk_1	281	287	PF00069	0.453
MOD_Plk_1	40	46	PF00069	0.423
MOD_Plk_1	477	483	PF00069	0.439
MOD_Plk_2-3	631	637	PF00069	0.674
MOD_Plk_4	189	195	PF00069	0.484
MOD_Plk_4	232	238	PF00069	0.486
MOD_Plk_4	355	361	PF00069	0.393
MOD_Plk_4	465	471	PF00069	0.411
MOD_Plk_4	477	483	PF00069	0.482
MOD_Plk_4	510	516	PF00069	0.466
MOD_Plk_4	695	701	PF00069	0.691
MOD_ProDKin_1	305	311	PF00069	0.435
MOD_ProDKin_1	324	330	PF00069	0.570
MOD_ProDKin_1	418	424	PF00069	0.578
MOD_ProDKin_1	457	463	PF00069	0.487
MOD_ProDKin_1	648	654	PF00069	0.821
TRG_DiLeu_BaEn_1	377	382	PF01217	0.521
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.506
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.394
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.424
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.386
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.407
TRG_ENDOCYTIC_2	108	111	PF00928	0.366
TRG_ENDOCYTIC_2	170	173	PF00928	0.395
TRG_ENDOCYTIC_2	237	240	PF00928	0.424
TRG_ENDOCYTIC_2	292	295	PF00928	0.409
TRG_ENDOCYTIC_2	356	359	PF00928	0.390
TRG_ENDOCYTIC_2	489	492	PF00928	0.511
TRG_ER_diArg_1	209	211	PF00400	0.567
TRG_ER_diArg_1	287	290	PF00400	0.555
TRG_ER_diArg_1	442	445	PF00400	0.453
TRG_ER_diArg_1	523	526	PF00400	0.513
TRG_NES_CRM1_1	26	39	PF08389	0.546
TRG_NES_CRM1_1	426	440	PF08389	0.419
TRG_NES_CRM1_1	90	102	PF08389	0.467
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHR7	Leptomonas seymouri	88%	97%
A0A0S4J1S0	Bodo saltans	55%	100%
A0A1X0NWU2	Trypanosomatidae	22%	100%
A0A1X0P6U3	Trypanosomatidae	58%	100%
A0A3R7KDP1	Trypanosoma rangeli	56%	100%
A4H9H6	Leishmania braziliensis	93%	100%
A4HXU2	Leishmania infantum	100%	100%
C9ZZW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AIC2	Leishmania braziliensis	25%	100%
E9ARK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P30153	Homo sapiens	21%	100%
P30154	Homo sapiens	21%	100%
P36179	Drosophila melanogaster	22%	100%
P54612	Sus scrofa	21%	100%
P54613	Sus scrofa	21%	100%
Q32PI5	Bos taurus	21%	100%
Q38950	Arabidopsis thaliana	21%	100%
Q38951	Arabidopsis thaliana	22%	100%
Q4QCX5	Leishmania major	23%	100%
Q4QDX5	Leishmania major	97%	100%
Q4QQT4	Rattus norvegicus	20%	100%
Q54QR9	Dictyostelium discoideum	24%	100%
Q6NUP7	Homo sapiens	20%	81%
Q76MZ3	Mus musculus	21%	100%
Q8C0Y0	Mus musculus	20%	81%
V5DN32	Trypanosoma cruzi	55%	100%